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以L-亮氨酸为底物一步法生物合成α-酮异己酸

2017年

作者： (美)艾·里斯(al Ries) (美)杰克·特劳特(Jack Trout)

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食品与发酵工业 2021年第13期47卷 1-8页

作者： al-ADEEB Abdulqader 乔郅钠徐美娟杨套伟张显邵明龙饶志明江南大学生物工程学院江苏无锡214122

α-酮异己酸是重要的有机合成和药物合成中间体,在食品、医药和化工行业中应用广泛。目前,α-酮异己酸的合成以化学法为主,需要高成本的催化剂或特殊的起始结构,导致α-酮异己酸生产成本较高。首次在食品安全性菌株枯草芽孢杆菌(Bacillu... 详细信息

α-酮异己酸是重要的有机合成和药物合成中间体,在食品、医药和化工行业中应用广泛。目前,α-酮异己酸的合成以化学法为主,需要高成本的催化剂或特殊的起始结构,导致α-酮异己酸生产成本较高。首次在食品安全性菌株枯草芽孢杆菌(Bacillus subtilis)168中异源表达了普通变形杆菌(Proteus vulgaris)来源的L-氨基酸脱氨酶,以重组枯草芽孢杆菌作为全细胞催化剂、L-亮氨酸为底物实现了α-酮异己酸的一步法生物合成。其次,针对全细胞催化条件进行优化,最优条件(全细胞催化剂20 g/L、L-亮氨酸浓度100 mmol/L、反应温度45℃、pH 10.0、MgCl 2浓度5 mmol/L)下,转化24 h,可获得3.66 g/L的α-酮异己酸,且重复转化3次后,固定化细胞比游离细胞的再利用率提高了37.3%。该研究成功实现了以食品安全菌株*** 168为宿主一步法生物合成α-酮异己酸,为α-酮异己酸以及其他重要α-酮酸的工业化安全合成提供了新策略。

关键词：普通变形杆菌 L-氨基酸脱氨酶枯草芽孢杆菌 L-亮氨酸全细胞催化固定化细胞 α-酮异己酸

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Pulmonary Hypertension Induced by Thalidomide (and Derivatives) in Patients with Multiple Myeloma: A Systematic Review

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Journal of Cancer Therapy 2016年第13期7卷 971-978页

作者： Abdulqadir J. Nashwan Nader I. al-Dewik Hisham M. al Sabah Mohamed A. Yassin Shehab F. Mohamed Nabil H. Omar Dana B. Mansour National Center for Cancer Care & Research (NCCCR)-Hamad Medical Corporation Doha Qatar University of Calgary Doha Qatar Qatar Medical Genetics Center Hamad General Hospital (HGH) Hamad Medical Corporation (HMC) Doha Qatar Interim Translational Research Institute (iTRI) HMC Doha Qatar Medical Oncology/Hematology Department National Center for Cancer Care and Research Hamad Medical Corporation Doha Qatar National Center for Cancer Care & Research (NCCCR)-Hamad Medical Corporation Doha Qatar Qatar Cancer Society Doha Qatar

Thalidomide is widely used in the treatment of multiple myeloma (MM). In recent years, several cases of pulmonary hypertension have been reported following treatment with thalidomide. The aim of this review was to evaluate the published literature on multiple myeloma patients with pulmonary hypertension following thalidomide treatment. A literature search was performed between 2000 and 2016. A total of 7 eligible studies were identified and deemed eligible, including 11 cases—approximately 37% (4 cases) with IgA (k), 27% (3 cases) with IgG (λ) MM, 27% (3 cases) with IgG (k) MM, and one case (9%) with primary plasma cell leukemia (PPCL). The vast majority of cases—82% (9 cases)—are associated with thalidomide, while only 18% (2 cases) are related to thalidomide derivatives (lenalidomide and pomalidomide). In conclusion, pulmonary hypertension induced by thalidomide or derivatives in multiple myeloma (MM) patients is related to a multifactorial etiology including the pathophysiology of the disease, thromboembolic events, preexisted cardiovascular conditions, comorbidities, and combination with other chemo- or bio-therapeutic agents. MM patients should be evaluated for signs and symptoms underlying cardiopulmonary disease before initiating, and during treatment with thalidomide.

关键词： Thalidomide Thalidomide Derivatives Pulmonary Hypertension Multiple Myeloma

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基于信道状态信息的人体行为识别系统

武汉理工大学学报 2016年第4期38卷 76-80页

作者： Mohammed Abdulaziz Aide al-qaness 李方敏马小林梅华锋武汉理工大学信息工程学院武汉430070 长沙学院数学与计算机科学系长沙410022

提出了一种基于无设备的人体行为识别系统,利用Wi-Fi信号的信道状态信息(CSI)来识别3个动态活动:行走、摔倒和坐。该系统只需要一台Wi-Fi路由器作为发射器和一台装有无线网卡的笔记本电脑作为接收器。系统从WiFi信号中提取CSI,然后经过... 详细信息

提出了一种基于无设备的人体行为识别系统,利用Wi-Fi信号的信道状态信息(CSI)来识别3个动态活动:行走、摔倒和坐。该系统只需要一台Wi-Fi路由器作为发射器和一台装有无线网卡的笔记本电脑作为接收器。系统从WiFi信号中提取CSI,然后经过低通滤波以消除噪声,并且为了降低CSI的维度和避免周围噪声所带来的不良影响,在整个CSI数据流中采用了主成分分析(PCA)算法。因此,该系统能够从CSI的时域和频域中得到有用的信号特征值。继而,采用支持向量机(SVM)算法来对人体行为进行分类。为了评优系统的可用性和稳定性,跟5个用户在动态环境中,分别在视距(LOS)和非视距(NLOS)的条件下做了大量的实验,这些实验表明该系统能够得到较高的准确率。

关键词：人体行为识别信道状态信息无设备 Wi-Fi

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Clinical Analysis of 525 Cases of Anemic Heart Disease Caused by Ancylostomias’s

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四川医学院学报 1981年第3期 250-251页

作者： Xu Chucai et al. Department of Internal Medicine, Sichuan Medical College.

Hockworm disease is usually found in thecountryside in Sichuan province, and the severecases may lead to anemic heart disease. 525 casesof anemic heart disease caused by ancylostomiasiswere analysed and discussed. 104 were males and421 females, ranging in age from 12 to 63. The prominent features of the clinical mani-festation were: 1. Most cf the patients with severe

关键词： Clinical Analysis of 525 Cases of Anemic Heart Disease Caused by Ancylostomias’s

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人生定位

Surveillance of Australian Hajj pilgrims for carriage of potentially pathogenic bacteria:Data from two pilot studies

作者： (美)艾·里斯(al Ries) (美)杰克·特劳特(Jack Trout)

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World Journal of Clinical Cases 2017年第3期5卷 102-111页

作者： Mohammad Irfan Azeem Mohamed Tashani al-Mamoon Badahdah Leon Heron Kristen Pedersen Neisha Jeoffreys Jen Kok Elizabeth Haworth Dominic E Dwyer Grant Hill-Cawthorne Harunor Rashid Robert Booy National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases Kids Research Institutethe Children’s Hospital at Westmead the Discipline of Child and Adolescent Health Sydney Medical Schoolthe University of Sydney Marie Bashir Institute for Infectious Diseases and Biosecurity the University of Sydney Department of Family and Community Medicine Faculty of Medicine in RabighKing Abdulaziz Uni-versity Centre for Infectious Diseases and Microbiology Laboratory Services Institute of Clinical Pathology and Medical ResearchPathology WestWestmead Hospital Menzies Research Institute Tasmania School of Public Health the University of Sydney World Health Organization Collaborating Centre for Mass Gatherings and High Consequence/High Visibility Events Flinders University

AIM To estimate the pharyngeal carriage rate of Neisseria meningitidis(N. meningitidis), Streptococcus pneumoniae(S. pneumoniae) and Staphylococcus aureus(S. aureus) among Australian Hajj *** In 2014, surveillance was conducted in two phases among Australian Hajj pilgrims: The first phase during Hajj in Mina, and the second phase soon after returning home to Australia. Nasopharyngeal or oropharyngeal swabs were taken from participants then tested, firstly by nucleic acid testing, and also by standard *** Of 183 participants recruited in the first phase, 26(14.2%) tested positive for S. pneumoniae; 4 had received pneumococcal conjugate vaccine(PCV13). Only one tested positive for N. meningitidis(W). Of 93 2^(nd) phase samples cultured, 17(18.3%) grew S. aureus, all methicillin sensitive, 2(2.2%) grew N. meningitidis(on subculture; one serotype B, one negative), and 1(1%), from an unvaccinated pilgrim, grew S. *** Relatively high carriage of S. pneumoniae and little meningococcal carriage was found. This indicates the importance of a larger study for improved infection surveillance and possible vaccine evaluation.

关键词： Carriage Conjugate vaccine Staphylococcus aureus Neisseria meningitidis Streptococcus pneumoniae Hajj

Elevated alanine aminotransferase activity is not associated with dyslipidemias,but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

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Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 702-706页

作者： Mohammad Ebrahim Ghamar-Chehreh Mohsen Amini Hossein Khedmat Seyed Moayed alavian Fatemeh Daraei Reza Mohtashami Reza Hadi Bent-al-Hoda Beyram Saeed Taheri The Internist Research Center Baqiyatallah Research Center for Gastroenterology and Liver Diseases Baqiyatallah University of Medical Sciences Dr.Taheri Medical Research Group

Objective:To explore demographic and metabolic factors associated with increased alanine aminotransferase(alT)activity in non-diabetic non-alcoholic fatty liver disease(NAFLD)***:Overall 372 patients who consecutively attended to Gastroenterology Clinic of Baqiyatallah University of Medical Sciences,Tehran,Iran awere diagnosed as NAFLD entered into *** criteria were having diabetes mellitus and fasting blood glucose over126 mg/dL,active hepatitis B virus infection,having hepatitis C virus positive serology,and to be under corticosteroid *** levels were considered pathologically high when it was over30 IU/L for men and over 19 IU/L for ***:Bivariate analyses using t test and chisquare test showed that patients with pathologically augmented alT levels had significantly higher NAFLD grades in their ultrasonographic evaluations(P=0.003).Moreover,these patients represented significantly higher homeostatic model assessment levels(P=0.003),levels of serum insulin(P=0.002),fasting blood glucose(Palence of insulin resistance was also higher in patients with increased serum alT *** logistic regression models showed that ultrasonographic grading of NAFLD(P=0.027)and insulin resistance(P=0.013)were the only variables significantly associated with abnormal alT ***:This study shows that the associations of increased alT serum levels in NAFLD patients are different from what are supposed *** excluding diabetic patients from our population,we find that increased alT levels are not associated with dyslipidemias but are independently associated with insulin resistance and NAFLD grading on ultrasonographic *** studies are needed to confirm our results.

关键词： alanine aminotransferase Non-alcoholic fatty liver disease Insulin resistance Fasting blood glucose Ultrasonographic evaluation Diabetes mellitus Metabolic factor Serum insulin Dyslipidemia

Bispectrum and asymmetry of wave shape

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Acta Oceanologica Sinica 1996年第3期15卷 297-305页

作者： Ding Pingxing Kong Yazhen and Sun Fu (State Key Laboratory Of Estuarine and ￣al R￣h, Institute of EStuarine and ￣al R￣h, East China NOrmalUniversity. Shanghai 2(XX)62, China Laboratory of Physical ￣raphy, ￣n University Of Qngdao, ￣ac 266003, Chin State Key Laboratory of Estuarine and Coastal Research Institute of Estuarine and Coastal Research East China Normal University Shanghai 200062 China Laboratory of Physical Oceanography Ocean University of Qingdao Qingdao 266003 China

on the definition and concept introduced in this paper, the theoretical expareion of surface slope bispectrum for two-dimensional waves is derived. Furthermore,the skewness of surface elevation distribution and that of surface slope distribution are respectively employed to define the up-down and front-back asymmetry of a wavee hape so that the relations between bispectrum and skewness are proposed. Through these relations, the updownand front-back asymmetry of the wave shape can be quantitatively determined by means of the bispectral analyses of observed wave data.

关键词： Bispecrum wave shape asymmetry nonlinear

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Studies of 2312 Normal Electrocardiograms in Children

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四川医学院学报 1982年第1期 121-122页

作者： Tang Shengcai et al, Section of cardialogy, Department of Pediatrics, Sichuan Medical College.

A study of 2312 noxmal electrocardiograms ofchildren from new born to 16 years of age inChengdu was made. The ECG was recorded by Ni-hon kohden 1101 type Electrocardiograph withpaper speed of 50 mm/sec. Electrode paddles adaptedto infants and children wcre used. Thirteen leads,Ⅰ, Ⅱ, Ⅲ, aVR, aVL, aVF, V3R, V1, V2, V3,V4, V5, and V6 were recorded. In infants urder

关键词： ECG Studies of 2312 Normal Electrocardiograms in Children