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Liver transplantation for polycystic liver and massive hepatomegaly

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World Journal of Gastroenterology 2010年第11期16卷 1425-1426页

作者： Salvatore Gruttadauria fabrizio di Francesco Bruno Gridelli Mediterranean Institute for Transplant and Advanced Specialized Therapies University of Pittsburgh Medical Center in Italy Bruno Gridelli Department of SurgeryUniversity of Pittsburgh

Liver tumor and other benign liver diseases such as polycystic liver disease can cause massive hepatomegaly and may represent an indication for liver transplantation(LT)in some *** this setting,LT can be extremely difficult and challenging due to its decreased mobility and access to vascular *** from either a right or a left partial liver resection during the transplant procedure has been advocated to safely accomplish the hepatectomy of the native *** we believe that partial hepatectomy adds some risk to intra-operative bleeding,we alternatively advise a different *** have a successful experience with LT in 6 massive hepatomegaly patients due to giant liver *** the transplant procedures were performed without intermediate partial liver resection,showing that selective use of veno-venous bypass can play a significant role in the treatment of massive hepatomegaly.

关键词： Liver transplantation Massive hepatomegaly Polycystic liver

Shape memory composite structures for self-deployable solar sails

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Astrodynamics 2019年第3期3卷 247-255页

作者： Loredana Santo Denise Bellisario Leamdro Iorio fabrizio Quadrini Department of Industrial Engineering University of Rome Tor VergataRome00133Italy

Shape memory composites(SMCs)combine mechanical performances of composite materials with functional behavior of shape memory *** can be used to produce the external frame of self-deployable solar sails with very low weight in comparison with traditional composite ***,heat activation is necessary for deploying instead of complex mechanical *** this study,the mechanical behavior of a solar sail with SMC frame is simulated by means of finite element *** considerations are made on sail deployment configuration,size/weight ratio of solar sails,and SMC *** experimental activity has been also performed to provide suitable candidates for the composite laminates of the SMC *** and instrumented recovery tests have been carried out on 2-plies carbon-fiber laminates with a shape memory interlayer.

关键词： solar sail shape memory composite finite element modeling carbon-fiber composite self-deployable structure

Role of cytokines and chemokines in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第8期18卷 727-735页

作者： Vincent Braunersreuther Giorgio Luciano Viviani Franois Mach fabrizio Montecucco Division of Cardiology Foundation for Medical Researches Faculty of Medicine Geneva University Hospital Department of Internal Medicine Adult Diabetes Centre University of Genoa

Non-alcoholic fatty liver disease (NAFLD) includes a variety of histological conditions (ranging from liver steatosis and steatohepatitis, to fibrosis and hepatocarcinoma) that are characterized by an increased fat content within the liver. The accumulation/deposition of fat within the liver is essential for diagnosis of NAFLD and might be associated with alterations in the hepatic and systemic inflammatory state. Although it is still unclear if each histological entity represents a different disease or rather steps of the same disease, inflammatory processes in NAFLD might influence its pathophysiology and prognosis. In particular, non-alcoholic steatohepatitis (the most inflamed condition in NAFLDs, which more frequently evolves towards chronic and serious liver diseases) is characterized by a marked activation of inflammatory cells and the upregulation of several soluble inflammatory mediators. Among several mediators, cytokines and chemokines might play a pivotal active role in NAFLD and are considered as potential therapeutic targets. In this review, we will update evidence from both basic research and clinical studies on the potential role of cytokines and chemokines in the pathophysiology of NAFLD.

关键词： Inflammation Non-alcoholic fatty liver disease Cytokine Chemokine

IOL repositioning using iris sutures: a safe and effective technique

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1972-1977页

作者： Tomaso Caporossi Ruggero Tartaro fabrizio GS Franco Francesco Barca Lucia Finocchio Daniela Bacherini Dario Giorgio fabrizio Giansanti Stanislao Rizzo Department of Surgical and Translational Medicine Eye Clinic University of Florence Azienda Ospedaliera Universitaria Careggi

This retrospective non-comparative consecutive case series study was conducted at Azienda Ospedaliera Universitaria Careggi, Florence, Italy and describes a useful intraocular lens(IOL) repositioning technique using iris sutures. In our study, 41 consecutive cases of posteriorly dislocated IOLs were surgically treated between January 2015 and May 2017. Six of the cases were post-traumatic luxations, and 20 patients had pseudoexfoliation syndrome. All the patients underwent pars plana vitrectomy and same IOL repositioning using iris sutures. The mean followup was 12.2 mo. The mean preoperative best corrected visual acuity(BCVA) was 0.10±0.15 logMAR, whereas the mean postoperative BCVA was 0.08±0.14 logMAR. The mean postoperative BCVA did not change significantly from the preoperative BCVA. The final mean spherical equivalent was-0.44±0.49 SD. Three lenses(7.31%) were found tilted during post-operative follow-up. Two eyes(4.87%) had postoperative cystoid macular edema. No eyes had endophthalmitis, hypotony, retinal or choroidal detachment. The iris fixation technique seems to be a safe and valid option for the management of dislocated IOLs.

关键词： IOL luxation pars plana vitrectomy cystoid macular edema

Preface:Carbon Geological Utilization and Storage

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Acta Geologica Sinica(English Edition) 2023年第3期97卷 855-857页

作者： XU Tianfu fabrizio GHERARDI TIAN Hailong YANG Leilei College of New Energy and Environment Jilin UniversityChangchun 130021China Institute of Geosciences and Georesource Italy China University of Petroleum(Beijing) Beijing 102249China

Global climate change is a common challenge facing mankind,which has evolved from a scientific issue into a global economic and political issue of universal concern to the international community(IPCC,2007).Global surface temperature was 1.1°C higher in 2011–2020 than that in 1850–1900,and has increased faster since 1970 than in any other 50-year period over at least the last 2000 years(IPCC,2023).

关键词： faster Storage Carbon

The key role of the hepatic veins collaterals in the modern liver surgery

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 643-644页

作者： fabrizio Panaro Boris Guiu Astrid Herrero Division of HBP Surgery&Transplantation Dept.of SurgerySt.Eloi HospitalMontpellier University Hospital-School of MedicineMontpellierFrance

Currently,the terminology for liver anatomy and resection was based on the updates of the Brisbane 2000 system(1).In this setting,Couinaud’s anatomical description serves as the backbone for the classification of resection(2).Based on this classification,an anatomic liver resection was defined as the complete removal of the liver parenchyma confined within the responsible portal *** subsegmentectomy is defined as the removal of the liver parenchyma within the portal territory of less than a Couinaud’s *** are also defined as cone units,and their areas can be intraoperatively assessed by using ischemic demarcation,indocyanine green(ICG)staining,or both.

关键词： anatomy surgery hepatic

French Editorials from the Association de Chirurgie Hépato-Bilio-Pancréatique et Transplantation-France(ACHBPT)

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Hepatobiliary Surgery and Nutrition 2021年第1期10卷 129-130页

作者： fabrizio Panaro Karim Boudjema Editorial Office Department of Surgery St-Eloi University HospitalMontpellierFrance Association de Chirurgie Hépato-Bilio-Pancréatique et Transplantation-France RennesFrance Service de Chirurgie Hépatobiliaire et Digestive CHU RennesUniv RennesRennesFrance Hepatobiliary Surgery and Nutrition AME Publishing Company

The international journal Hepatobiliary Surgery and Nutrition(HBSN)offers a great opportunity to the French Association of Hepato-Biliary Surgery and Liver Transplantation(ACHBPT).Indeed,each of the monthly“analyzed articles”written by our colleagues will be submitted for publication as an editorial in *** course,it has to be written in English and edited by one of our expert members(Video 1,Figures 1,2).

关键词： Surgery Transplantation Liver

Liver transplantation for irresectable colorectal liver metastases:still a contraindication?

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 475-478页

作者： Astrid Herrero Silvio Nadalin fabrizio Panaro Department of General and Liver Transplant Surgery University Hospital MontpellierHopital Saint EloiMontpellierFrance Department of General Visceral and Transplant SurgeryUniversity Hospital TübingenTübingenGermany

Liver transplantation(LT)for irresectable colorectal cancer liver metastases(i-CRLM)has been considered up to now an absolute contraindication due to unfavorable outcomes,scarcity of grafts and ethical ***,promising results of the Norwegian SECA trial raise the question of the utility of LT for i-CRLM with a 5-year survival rate of 60%(1).However,some concerns should be considered as to oncological selection criteria(when to perform the transplantation?)and the source of liver grafts:deceased donor at cost of recipient listed for standard indication or living donor in a population with a higher risk of recurrence.

关键词： colorectal metastases Liver

Liver venous deprivation:a bright future for liver metastases-but what about hepatocellular carcinoma?

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 270-272页

作者： Boris Guiu Astrid Herrero fabrizio Panaro Department of Radiology St-Eloi University HospitalMontpellierFrance Department of HBP Surgery&Transplantation St-Eloi University HospitalMontpellierFrance

Liver venous deprivation(LVD)refers to the percutaneous procedure aiming to simultaneously abrogate both portal inflow and hepatic venous outflow to accelerate liver regeneration of the future liver remnant(FLR),which limits patient drop-out from resection due either to insufficient FLR or tumor *** authors have designated the exact same technique under the acronym RASPE(Radiological Simultaneous Porto-hepatic Vein Embolization)(1)while others reported on‘double embolization’for designating portal vein embolization(PVE)and proximal embolization of one hepatic vein,keeping patent distal venous branches and veno-venous collaterals(2).

关键词： venous Liver deprivation