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Journal of Forestry Research 2019年第1期30卷 121-127页

作者： Giada Bertini Claudia Becagli Ugo Chiavetta fabrizio Ferretti Gianfranco Fabbio Luca Salvati CREA Research Centre for Forestry and Wood

The present study introduces an exploratory data analysis based on structural indicators with the aim to assess the effect of silvicultural practices on tree stand structure. The study was carried out in three Italian beech forests of different ages with stand structures that originated from dissimilar regeneration and cultivation techniques(Cansiglio, northern Italy, Chiarano, central Italy,and Mongiana, southern Italy). Ten structural indicators were considered when investigating the latent multivariate relationship between stand structure attributes before and after thinning operations by using a multiway factor analysis(MFA). The MFA results identified the older stand at Cansiglio as more homogeneous for cultivation regimes,and more stable to practices when compared with the younger sites(Chiarano and Mongiana). Heterogeneous stands were sensitive to silvicultural practice thus suggesting their possible impact on forest attributes. The proposed approach proved to be an operational tool to evaluate comprehensively the response of forest structure to planned interventions.

关键词： Forest diversity Multiway factor analysis Silviculture Structural diversity indicators Tree stand structure

Stem cells sources for intervertebral disc regeneration

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World Journal of Stem Cells 2016年第5期8卷 185-201页

作者： Gianluca Vadalà fabrizio Russo Luca Ambrosio Mattia Loppini Vincenzo Denaro Department of Orthopedic and Trauma Surgery University Campus Bio-Medico of Rome

Intervertebral disc regeneration field is rapidly growing since disc disorders represent a major health problem in industrialized countries with very few possible ***, current available therapies are symptomatic, and surgical procedures consist in disc removal and spinal fusion, which is not immune to regardable concerns about possible comorbidities, cost-effectiveness, secondary risks and long-lasting outcomes. This review paper aims to share recent advances in stem cell therapy for the treatment of intervertebral disc degeneration. In literature the potential use of different adult stem cells for intervertebral disc regeneration has already been reported. Bone marrow mesenchymal stromal/stem cells, adipose tissue derived stem cells, synovial stem cells, muscle-derived stem cells, olfactory neural stem cells, induced pluripotent stem cells, hematopoietic stem cells, disc stem cells, and embryonic stem cells have been studied for this purpose either in vitro or in vivo. Moreover, several engineered carriers(e.g., hydrogels), characterized by full biocompatibility and prompt biodegradation, have been designed and combined with different stem cell types in order to optimize the local and controlled delivery of cellular substrates in situ. The paper overviews the literature discussing the current status of our knowledge of the different stem cells types used as a cell-based therapy for disc regeneration.

关键词： Stem cells Intervertebral disc degeneration Spine Tissue engineering Cell therapy

Cytotoxic synergism of Clostridioides difficile toxin B with proinflammatory cytokines in subjects with inflammatory bowel diseases

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World Journal of Gastroenterology 2023年第4期29卷 582-596页

作者： Gabrio Bassotti Alessandro Fruganti fabrizio Stracci Pierfrancesco Marconi Katia Fettucciari Department of Medicine and Surgery GastroenterologyHepatology&Digestive Endoscopy Section University of Perugia Medical SchoolPiazza Lucio SeveriPerugia 06132Italyand Santa Maria della Misericordia HospitalGastroenterology&Hepatology Unit Perugia 06156Italy School of Biosciences and Veterinary Medicine University of CamerinoMatelica 62024Italy Medicine and Surgery Hygiene and Public Health SectionUniversity of PerugiaPerugia 06123Italy Medicine and Surgery Biosciences&Medical Embryology SectionUniversity of PerugiaPerugia 06132Italy

Clostridioides difficile(***)is progressively colonizing humans and animals living with *** this process,hypervirulent strains and mutated toxin A and B of ***(TcdA and TcdB)are originating and *** in healthy subjects colonization by *** becomes a risk after the use of antibiotics that alter the microbiome,other categories of people are more susceptible to infection and at risk of relapse,such as those with inflammatory bowel disease(IBD).Recent in vitro studies suggest that this increased susceptibility could be due to the strong cytotoxic synergism between TcdB and proinflammatory cytokines the tumor necrosis factor-alpha and interferon-gamma(CKs).Therefore,in subjects with IBD the presence of an inflammatory state in the colon could be the driver that increases the susceptibility to *** infection and its progression and *** is internalized in the cell via three receptors:chondroitin sulphate proteoglycan 4;poliovirus receptor-like 3;and Wnt receptor frizzled *** sulphate proteoglycan 4 and Wnt receptor frizzled family are involved in cell death by apoptosis or necrosis depending on the concentration of TcdB and cell types,while poliovirus receptor-like 3 induces only *** is possible that cytokines could also induce a greater expression of receptors for TcdB that are more involved in necrosis than in ***,in subjects with IBD there are the conditions:(1)For greater susceptibility to *** infection,such as the inflammatory state,and abnormalities of the microbiome and of the immune system;(2)for the enhancement of the cytotoxic activity of TcdB+Cks;and(3)for a greater expression of TcdB receptors stimulated by cytokines that induce cell death by necrosis rather than *** only therapeutic approach currently possible in IBD patients is monitoring of *** colonization for interventions aimed at reducing tumor necrosis factor-alpha and interfero

关键词： Inflammatory bowel diseases Clostridioides difficile infection Cytokines Tumor necrosis factor-alpha Interferon-gamma Necrosis Apoptosis Cytotoxic synergism

Novel technique of extracorporeal intrauterine morcellation after total laparoscopic hysterectomy: Three emblematic case reports

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World Journal of Clinical Cases 2021年第20期9卷 5655-5660页

作者： Antonio Macciò Elisabetta Sanna fabrizio Lavra Piergiorgio Calò Clelia Madeddu Department of Gynecologic Oncology Businco HospitalARNAS G.BrotzuCagliari 09100Italy Department of Surgical Sciences University of CagliariCagliari 09100Italy Department of Medical Sciences and Public Health University of CagliariCagliari 09100Italy

BACKGROUND In the presence of a large uterus,total laparoscopic hysterectomy(TLH),always requires morcellation to allow removal of the tissues from the abdominal ***,uncontained morcellation has been scrutinized because of the possible spread of occult ***,in-bag extracorporeal morcellation has been ***,tissue containment and extraction are extremely challenging,especially when considering the increasing uterine size to be removed through minimally invasive *** SUMMARY Herein,we describe a novel technique for extracorporeal intrauterine morcellation using the uterus outermost layer as a bag to achieve tissue extraction of very large uteri with suspected occult leiomyosarcoma after *** study enrolled patients who were planned for TLH for large uteri(weight>500 g).TLH was performed following the procedure reported in our previous *** novel technique has been described step-by-step in a video,which representatively describes the preoperative imaging and morcellation procedure of three very large uteri weighing 1500 g,1700 g,and 3700 g,*** procedures were performed without any *** patients had an uneventful postoperative course,and in all cases,the pathology was benign *** Extracorporeal intrauterine morcellation using the uterus outmost layer as a bag was found to be a feasible technique that allows a careful diagnosis and safe removal of suspected occult *** technique herein presented may be adopted in surgical practice,by adding it to the other available techniques of contained *** may represent a valid and feasible alternative,especially useful in cases of very large uteri exceeding the capacity of specimen retrieval bags.

关键词： Laparoscopy Minimally invasive surgery Morcellation myomas Large uterus Total laparoscopic hysterectomy Case report

Light propagation through biological tissue and other diffusive media : theory, solutions, and software

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ResIoT:An IoT Social Framework Resilient to Malicious Activities

1000年

作者： fabrizio Martelli et al

Includes bibliographical references and index.

ISBN: (纸本)9780819476586;0819476587

Includes bibliographical references and index.

关键词： Light Tissues

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IEEE/CAA Journal of Automatica Sinica 2020年第5期7卷 1263-1278页

作者： Giancarlo Fortino fabrizio Messina Domenico Rosaci Giuseppe M.L.Sarnè IEEE the Department DIMES University of CalabriaVia P.Bucci87036 Rende(CS)Italy the Department DMI University of CataniaViale Andrea Doria 695126 Catania(CT)Italy the Department DIIES University MediterraneaLoc.Feo di Vito89122 Reggio Cal.(RC)Italy the Department DICEAM University MediterraneaLoc.Feo di Vito89122 Reggio Cal.(RC)Italy

The purpose of the next internet of things(Io T)is that of making available myriad of services to people by high sensing intelligent devices capable of reasoning and real time *** convergence of Io T and multi-agent systems(MAS)provides the opportunity to benefit from the social attitude of agents in order to perform machine-to-machine(M2 M)cooperation among smart ***,the selection of reliable partners for cooperation represents a hard task in a mobile and federated context,especially because the trustworthiness of devices is largely *** issues discussed above can be synthesized by recalling the well known concept of social resilience in Io T systems,i.e.,the capability of an Io T network to resist to possible attacks by malicious agent that potentially could infect large areas of the network,spamming unreliable information and/or assuming unfair *** this sense,social resilience is devoted to face malicious activities of software agents in their social interactions,and do not deal with the correct working of the sensors and other information *** this setting,the use of a reputation model can be a practicable and effective solution to form local communities of agents on the basis of their social *** this paper,we propose a framework for agents operating in an Io T environment,called Res Io T,where the formation of communities for collaborative purposes is performed on the basis of agent *** order to validate our approach,we performed an experimental campaign by means of a simulated framework,which allowed us to verify that,by our approach,devices have not any economic convenience to performs misleading ***,further experimental results have shown that our approach is able to detect the nature of the active agents in the systems(i.e.,honest and malicious),with an accuracy of not less than 11%compared to the best competitor tested and highlighting a high resilience with respect to some

关键词： Group formation internet of things(IoT) multiagent system reputation

Endoscopic management of gastrointestinal leaks and fistulae: Whatoption do we have?

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World Journal of Gastroenterology 2020年第29期26卷 4198-4217页

作者： fabrizio Cereatti Roberto Grassia Andrea Drago Clara Benedetta Conti Gianfranco Donatelli Digestive Endoscopy and Gastroenterology Unit Cremona HospitalCremonaCremona 26100Italy Department of Interventional Endoscopy Hospital Prive PeupliersRamsay SantéParis 75013France

Gastrointestinal leaks and fistulae are serious, potentially life threateningconditions that may occur with a wide variety of clinical presentations. Leaks aremostly related to post-operative anastomotic defects and are responsible for animportant share of surgical morbidity and mortality. Chronic leaks and longstanding post-operative collections may evolve in a fistula between twoepithelialized structures. Endoscopy has earned a pivotal role in the managementof gastrointestinal defects both as first line and as rescue treatment. Endotherapyis a minimally invasive, effective approach with lower morbidity and mortalitycompared to revisional surgery. Clips and luminal stents are the pioneer ofgastrointestinal (GI) defect endotherapy, whereas innovative endoscopic closuredevices and techniques, such as endoscopic internal drainage, suturing systemand vacuum therapy, has broadened the indications of endoscopy for themanagement of GI wall defect. Although several endoscopic options are currentlyused, a standardized evidence-based algorithm for management of GI defect isnot available. Successful management of gastrointestinal leaks and fistulaerequires a tailored and multidisciplinary approach based on clinical presentation,defect features (size, location and onset time), local expertise and the availabilityof devices. In this review, we analyze different endoscopic approaches, which weselected on the basis of the available literature and our own experience. Then, weevaluate the overall efficacy and procedural-specific strengths and weaknesses ofeach approach.

关键词： Leak Fistula Endotherapy Over-the-scope clip Suturing system Endovacuum therapy Endoscopic internal drainage Self-expandable metal stent

Launching of the Sultan Qaboos Comprehensive Cancer Care and Research Center(SQCCCRC)in the Sultanate of Oman to manage HBP type of cancers

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 338-339页

作者： Abdallah Al Farai Mansour Al Moundhri fabrizio Panaro Department of Surgical Oncology Sultan Qaboos Comprehensive Cancer Care and Research CentreMuscatSultanate of Oman Sultan Qaboos Comprehensive Cancer Care and Research Centre MuscatSultanate of Oman Department of Surgery/Division of HBP Surgery and Transplantation St.Eloi HospitalMontpellier University Hospital-School of MedicineMontpellierFrance

In July 2021 a new governmental cancer center,the Sultan Qaboos Comprehensive Cancer Care and Research Centre(SQCCCRC)(Figure 1)open its doors to provide excellent,evidenced-based patient-centered care for cancer patients in the Sultanate of *** is dedicated to treat cancer patients while building an environment to continuously advance clinical and scientific innovation in the treatment of Cancer.

关键词： Cancer Care cancer

T-cells in myocardial infarction:Culprit instigators or mere effectors?

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World Journal of Cardiology 2018年第10期10卷 123-126页

作者： Luca Liberale Aldo Bonaventura fabrizio Montecucco Center for Molecular Cardiology University of ZürichSchlieren 8952Switzerland First Clinic of Internal Medicine Department of Internal MedicineUniversity of GenoaGenoa 16132Italy

Immune system activation and dysfunction characterize the early phase of reperfusion after a myocardial infarction(MI). Despite initially neglected, adaptive immunity has been recently showed to play an important role in this setting. In fact, the immune system can recognize sequestered antigens released by the necrotic tissue, initiating a deleterious autoimmune vicious circle leading to worse outcome. In their recent work, Angelini et al shed the light on a new feature of post-MI which involves two "old players" of post-ischemic myocardial injury: CD31 and matrix metalloproteinase(MMP)-9. Specifically, the authors showed that an enhancement of MMP-9 release could determine the cleavage of inhibitory CD31 from CD4+ T-cells surface in patients with Acute Coronary Syndromes(ACS). These findings open the room for new studies investigating the role of MMP9 in other pathological processes associated with a reduction of CD31 functionality, such as plaque instability and rupture. Of interest, in the case of a causative role for CD31 shedding in ACS would be confirmed, there might be a potential role for the administration of CD31 protein or analogue compounds to blunt post-ischemic cardiac inflammation and improve ACS outcome.

关键词： Matrix metalloproteinase Lymphocytes Autoimmunity Inflammation Myocardial infarction Adaptive immunity

Bartonella infection in asymptomatic horses and donkeys from Tuscany,Central Italy

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1077-1079页

作者： Edoardo Magni fabrizio Bertelloni Micaela Sgorbini Valentina V.Ebani Department of Veterinary Science University of PisaViale Delle Piagge 256124 PisaItaly

Objective: To investigate the occurrence of Bartonella sp. infection in asymptomatic horses and donkeys living in Tuscany, Central ***: Blood samples were collected from 77 horses and 15 donkeys and tested by indirect immunofluorescent test to detect antibodies against Bartonella sp. and by PCR to detect the ***: Fifty-four(58.69%; 95% CI: 47.95%–68.87%) animals, 9 donkeys and 45 horses, were seropositive with antibody titers ranging from 1:64 to 1:512. PCR assays detected 9 horses positive for Bartonella sp. and 3 donkeys for Bartonella henselae genotype ***: The detected sero-prevalence suggests a common and frequent exposure of equids living in Central Italy to bartonellae and PCR results show that Bartonella *** is possible both in horses and donkeys. At the best of our knowledge, this is the first report of Bartonella henselae infection in donkeys.

关键词： Bartonella Horse Donkey PCR Zoonosis