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Integrative Zoology 2014年第4期9卷 531-541页

作者： Jérémie BARDIN Isabelle ROUGET Margaret Mary YACOBUCCI fabrizio CECCA Sorbonne University Pierre-and-Marie-Curie University(UPMC-P6)ParisFrance National Museum of Natural History(MNHN) ParisFrance The National Center for Scientific Research(CNRS) ParisFrance Department of Geology Bowling Green State UniversityBowling GreenOhioUSA

Since the introduction of the cladistic method in systematics,continuous characters have been integrated into analyses but no methods for their treatment have received unanimous *** methods require a large number of character states to discretise continuous characters in order to keep the maximum level of information about taxa differences within the coding *** objective was to assess the impact of increasing the character state number on the outcomes of phylogenetic *** of a variety of simulated datasets shows that these methods for coding continuous characters can lead to the generation of well-resolved trees that do not reflect a phylogenetic *** call this phenomenon the flattening of the tree-length distribution;it is influenced by both the relative quantity of continuous characters in relation to discrete characters,and the number of characters in relation to the number of *** tests provide a method to avoid this potential bias.

关键词： cladistics continuous character gap weighting phylogeny

Liver venous deprivation:a bright future for liver metastases-but what about hepatocellular carcinoma?

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 270-272页

作者： Boris Guiu Astrid Herrero fabrizio Panaro Department of Radiology St-Eloi University HospitalMontpellierFrance Department of HBP Surgery&Transplantation St-Eloi University HospitalMontpellierFrance

Liver venous deprivation(LVD)refers to the percutaneous procedure aiming to simultaneously abrogate both portal inflow and hepatic venous outflow to accelerate liver regeneration of the future liver remnant(FLR),which limits patient drop-out from resection due either to insufficient FLR or tumor *** authors have designated the exact same technique under the acronym RASPE(Radiological Simultaneous Porto-hepatic Vein Embolization)(1)while others reported on‘double embolization’for designating portal vein embolization(PVE)and proximal embolization of one hepatic vein,keeping patent distal venous branches and veno-venous collaterals(2).

关键词： venous Liver deprivation

Mesenchymal stromal cell-based therapy: Regulatory and translational aspects in gastroenterology

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World Journal of Gastroenterology 2016年第41期22卷 9057-9068页

作者： Giovanni Dothel Emanuel Raschi Roberto Rimondini fabrizio De Ponti Pharmacology Unit Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna

The past decade has witnessed an outstanding scientific production focused towards the possible clinical applications of mesenchymal stromal cells(MSCs) in autoimmune and chronic inflammatory diseases. This raised the need of novel standards to adequately address quality, efficacy and safety issues of this advanced therapy. The development of a streamlined regulation is currently hampered by the complexity of analyzing dynamic biological entities rather than chemicals. Although numerous pieces of evidence show efficacy in reducing intestinal inflammation, some inconsistencies between the mechanisms of action of rodent vs human MSCs suggest caution before assigning translational value to preclinical studies. Preliminary evidence from clinical trials showed efficacy of MSCs in the treatment of fistulizing Crohn's disease(CD), and preparations of heterologous MSCs for CD treatment are currently tested in ongoing clinical trials. However, safety issues, especially in longterm treatment, still require solid clinical data. In this regard, standardized guidelines for appropriate dosing and methods of infusion could enhance the likelihood to predict more accurately the number of responders and the duration of remission periods. In addition, elucidating MSC mechanisms of action could lead to novel and more reliable formulations such as those derived from the MSCs themselves(e.g., supernatants).

关键词： Mesenchymal stromal cells Mesenchymal stem cells Inflammatory bowel diseases Intestinal disorders Translational medicine

Naturally Occurring Terpenes:A Promising Class of Organic Molecules to Address Influenza Pandemics

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Natural Products and Bioprospecting 2021年第4期11卷 405-419页

作者： Suhad A.A.Al-Salihi fabrizio Alberti Applied Sciences Department University of TechnologyBaghdadIraq School of Life Sciences and Department of Chemistry University of WarwickGibbet Hill RoadCoventry CV47ALUK

Since the olden times,infectious diseases have largely affected human *** newly emerged infections are excessively caused by viruses that are largely associated with mammal *** casualties of these emergencies are significantly influenced by the way human beings interact with the reservoirs,especially the animal *** our review we will consider the evolutionary and the ecological scales of such infections and their consequences on the public health,with a focus on the pathogenic influenza A *** nutraceutical properties of fungal and plant terpene-like molecules will be linked to their ability to lessen the symptoms of viral infections and shed light on their potential use in the development of new *** challenging methods in antiviral discovery will also be discussed in this *** authors believe that pharmacognosy is the“wave of future pharmaceuticals”,as it can be continually produced and scaled up under ecofriendly *** diagnostic methods and strategies however are required to standardise those naturally occurring resources.

关键词： Influenza A Virus Fungal terpenes Plant terpenes Antivirals

Matrix metalloproteinase-9:A deleterious link between hepatic ischemia-reperfusion and colorectal cancer

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World Journal of Gastroenterology 2012年第48期18卷 7131-7133页

作者： Sébastien Lenglet Franois Mach fabrizio Montecucco Cardiology Division Department of MedicineGeneva University HospitalFoundation for Medical Research1211 GenevaSwitzerland

Despite the advent of improved surgical techniques and the development of cytotoxic chemotherapeutic agents useful for the treatment of colorectal cancer,the primary clinical challenge remains that of preventing and combating metastatic *** resection is the best treatment for colorectal metastases isolated to the ***,in rodent models,the hepatic ischemia-reperfusion(I/R) applied during the surgery accelerates the outgrowth of implanted *** the adverse effects of I/R on cellular function,several studies have demonstrated an over expression of the matrix metalloproteinase-9(MMP-9) in the ischemic *** several studies showed high local levels of expression and activity of this proteolytic enzyme in the primary colorectal adenocarcinoma,the role of MMP-9 might be considered as a potential common mediator,favoring both growth of local tumor and the dissemination of colorectal carcinoma metastases.

关键词： Matrix metalloproteinase-9 Ischemia-reperfusion Colorectal cancer Metastasis

Detrital zircon ages of Oligocene to Miocene sandstone suites of the Southern Apennines foreland basin system,Italy

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Journal of Palaeogeography 2022年第2期11卷 222-237页

作者： Annamaria Fornelli Francesca Micheletti Salvatore Gallicchio fabrizio Tursi Sara Criniti Salvatore Critelli Dipartimento Scienze Della Terra e Geoambientali Universit a Degli Studi“Aldo Moro”BariVia E.Orabona470125BariItal Dipartimento di Biologia Ecologia e Scienze Della TerraUniversit a Della CalabriaVia Pietro Bucci87036Arcavacata di RendeCosenzaItaly

U-Pb spot ages on detrital zircons from turbidite quartzarenites,quartz-feldspathic and volcaniclastic sandstones of the Tufiti di Tusa(TTF),Numidian Flysch(NF),Bifurto(BF),Gorgoglione(GF)and Serra Palazzo(SPF)formations,exposed in southern Italy,were detected to define their provenance signatures aiming to contribute to reconstructing the complex geodynamic evolution of the southern Apennine *** deposition ages of these sandstones range from Rupelian(TTF),Burdigalian p.p.-Early Langhian(NF and BF)and Langhian-Serravallian-Early Tortonian(GF and SPF).The detrital zircon ages in each deposit show different *** TTF,the zircon age clusters are:610±6 Ma;390±4 Ma;287±3 Ma;157±2 Ma;78±1 Ma and 67±1 Ma;33±1 *** NF and BF formations,the prevalent zircon ages are clustered at 661±10 Ma,607±8 Ma and 547±8 *** GF sandstones,the ages of detrital zircons are clustered around 672±28 Ma,458±9 Ma,297±8 Ma and 24±1 *** sandstones of SPF contain zircons showing age clusters at649±10 Ma,486±7 Ma and 315±5 *** and lithic fragments from TTF display a dominant provenance from Oligocene calc-alkaline effusive products located on western domains of the Mesomediterranean Microplate,and minor detritus from granitoids and metamorphic rocks of Variscan *** of NF and BF indicate a provenance of detritus from the African Craton without evidence of Variscan or Alpine *** from GF and SPF show a provenance from both Variscan crystalline basement rocks forming the Alpine chain(Calabria-Peloritani Terranes)and Variscan magmatic and metamorphic rocks unaffected by Alpine tectonics,similar to Sardinia-Corsica(pro-parte)*** addition,the Oligocene magmatic component dated at 24 Ma in GF sandstones is evidence for the maximum age of sedimentation for these *** light of the recent and preliminary geochronological data acquired,a revised paleogeographic restoration could be inferred for the location of sedimentary basins during the Apennines t

关键词： U-Pb detrital Zircon ages Provenance of sandstones Southern Apennine chain Southern Circum-Mediterranean paleogeography

An innovative bio-engineering retaining structure for supporting unstable soil

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第2期9卷 247-259页

作者： Gianluca Bella Monica Barbero fabrizio Barpi Mauro Borri-Brunetto Daniele Peila DISEG Politecnico di TorinoCorso Duca degli Abruzzi 24Torino10129Italy DIATI Politecnico di TorinoCorso Duca degli Abruzzi 24Torino10129Italy

The paper presents a new prefabricated bio-engineering structure for the support of unstable *** prefabricated structure is made of a steel frame which is completely filled with soil and a face made of tree trunks among which scions or autochthonous bushes are *** to the difficulties in interpreting the complex interaction between soil and structure during the installation and lifetime,an in situ test was carried out in order to evaluate the state of stress in the steel frame and to understand the global behavior of the structure under service *** the basis of the obtained results,a procedure for checking the structure safety was proposed and *** easy design method was developed during the ***,the use of this type of prefabricated structure shows several advantages,such as good performances in terms of stabilizing effects,and easy assembly and transport.

关键词： Bio-engineering Test site Landslide Live cribwall Unstable soil

Photovoltaic-thermal solar-assisted heat pump systems for building applications:Integration and design methods

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Energy and Built Environment 2023年第1期4卷 39-56页

作者： Alessandro Miglioli NiccolòAste Claudio Del Pero fabrizio Leonforte Architecture Built environment and Construction Engineering DepartmentPolitecnico di MilanoVia Ponzio 3120133 Milan Italy

The photovoltaic-thermal collector is one of the most interesting technology for solar energy conversion,com-bining electric and thermal energy production in a single ***-compression heat pump is already considered the most suitable clean technology for buildings thermal energy *** combination of these two technologies in an integrated“photovoltaic-thermal solar-assisted heat pump”(PVT-SAHP)system allows reaching a high fraction of the building thermal needs covered by renewable energy sources and to improve the performances of both the photovoltaic-thermal collector and the heat *** first is cooled down increasing its energy conversion efficiency,while providing low-temperature thermal energy to the second,which benefits from a higher evaporation *** review study presents the state-of-art of photovoltaic-thermal solar-assisted heat pump systems intended to cover thermal energy needs in buildings,with a particular focus on the integration methodologies,the possible configurations,the use of different sources and the design of sub-system *** issues are addressed by much scientific research,to improve the reliability and applicability of this technology,as an option for the building *** study aims to present PVT-SAHP systems in an organic and critical way to propose a useful tool for future research *** in detail,the work highlights the fact that the integration of photovoltaic-thermal collectors as evaporator of the heat pump in direct-expansion systems allows the highest heat recovery and ***,the distinction of the two circuits lead to more reliable,flexible and robust systems,especially when combined with a second heat source,being able to cover both heating and cooling *** implementation of real-time control strategy,as well as the continuous development of the compressor and refrigerant industries is positively influencing this technology,which is receiving more an

关键词： Solar-assisted heat pump Photovoltaic-thermal collector PVT-SAHP Renewable energy HVAC Technology review

Update on surgical procedures for carpal tunnel syndrome:What is the current evidence and practice?What are the future research directions?

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World Journal of Orthopedics 2023年第1期14卷 6-12页

作者： Valerio Pace fabrizio Marzano Giacomo Placella Department of Trauma&Orthopaedics AOSP Terni-University of PerugiaTerni 05100Italy Department of Trauma&Orthopaedics University of PerugiaPerugia 06100Italy Department of Trauma and Orthopaedics IRCSS San Raffaele HospitalMilan 20132Italy

Carpal tunnel syndrome(CTS)is a multifactorial compression *** is reported to be very common and rising ***’s treatment varies from conservative measures to surgical *** has shown to be an effective method for more severe *** few unclear aspects and room for further research and improvements still *** performed a narrative literature review on the most up to date progress and innovation in terms of surgical treatments for *** simple algorithm of leaving the choice of the surgical method to surgeons’preference and experience(together with consideration of patients’related factors)seem to be the best available option,which is supported by the most recent metanalysis and systematic *** suggest that surgeons(unless in presence of precise indications towards endoscopic release)should tend to perform a minimally invasive open approach release,favoring the advantage of a better neurovascular structures visualization(and a consequent higher chance to perform a complete release with long term relief of symptoms)instead of favoring an early reduction(in the first postoperative days)of immobilization and *** towards a universally accepted standardization should be aimed for by the researchers,who have failed to date to sufficiently limit bias and limitations.

关键词： Carpal tunnel Carpal tunnel release Transverse ligament Endoscopic release Open release

Robotic distal pancreatectomy: can results overcome cost-effectiveness prejudices?

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 304-306页

作者： fabrizio Di Benedetto Roberto Ballarin Paolo Magistri Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModenaMOItaly

Pancreas surgery was historically considered the most challenging type of surgery for surgeons all over the *** is related to higher morbidity and mortality rates as compared to other surgical procedures and survival ... 详细信息

关键词： surgery mortality overcome