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First-line pazopanib in patients with advanced non-clear cell renal carcinoma:An Italian case series

World Journal of Clinical Oncology 2021年第11期12卷 1037-1046页

作者： Sebastiano Buti Melissa Bersanelli Francesco Massari Ugo De giorgi Orazio Caffo Gaetano Aurilio Umberto Basso Giacomo Carteni Claudia Caserta Luca Galli Francesco Boccardo Giuseppe Procopio Gaetano Facchini Giuseppe Fornarini Alfredo Berruti Elena Fea Emanuele Naglieri Fausto Petrelli Roberto Iacovelli Camillo Porta Alessandra Mosca Medical Oncology Unit University Hospital of ParmaParma 43126Italy Medicine and Surgery Department University of ParmaParma 43126Italy Division of Oncology Policlinico Sant’Orsola-Malpighi HospitalBologna 40138Italy Department of Oncology IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori(I.R.S.T.)Meldola 47014Italy Department of Medical Oncology Santa Chiara HospitalTrento 38122Italy Department of Medical Oncology Division of Urogenital and Head and Neck TumoursEuropean Institute of Oncology IRCCSMilan 20141Italy Medical Oncology Unit 3 Istituto Oncologico Veneto IOV IRCCSCastelfranco VenetoPadova 31033Italy Division of Oncology Azienda Ospedaliera di Rilievo Nazionale A.CardarelliNapoli 80131Italy Medical Oncology Unit Azienda Ospedaliera S.MariaTerni 05100Italy Oncology Unit 2 University Hospital of PisaPisa 56126Italy Academic Unit of Medical Oncology IRCCS San Martino Polyclinic HospitalGenova 16132Italy Medical Oncology Genitourinary Section Fondazione IRCCS Istituto Nazionale Dei TumoriMilan 20133Italy Departmental Unit of Clinical and Experimental Uro-Andrologic Oncology Istituto Nazionale Tumori IRCCS Fondazione G.PascaleNapoli 80131Italy Medical Oncology Unit Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)Ospedale Policlinico San MartinoGenova 16132Italy University of Brescia ASST-Spedali CiviliBresciaBrescia 25123Italy Medical Oncology Unit S Croce and Carle Teaching HospitalCuneo 12100Italy Division of Medical Oncology Istituto Tumori G Paolo IIIRCCSBari 70124Italy Medical Oncology Unit ASST Bergamo OvestTreviglioBergamo 24047Italy Medical Oncology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00161Italy Division of Oncology AOU Consorziale Policlinico di BariBari 70124Italy Department of Biomedical Sciences and Human Oncology University of Bari"A.Moro"Bari 70124Italy Multidisciplinary Outpatient Oncology Clinic Candiolo Cancer InstituteFPO-IRCCSCandioloTurin 10060Italy

BACKGROUND Non-clear cell(ncc)metastatic renal-cell carcinoma(RCC)has dismal results with standard systemic therapies and a generally worse prognosis when compared to its clear-cell *** systemic combination therapies have emerged for metastatic RCC(mRCC),but the pivotal phase III trials excluded patients with nccRCC,which constitute about 30%of metastatic RCC *** To provide a piece of real-life evidence on the use of pazopanib in this patient *** The present study is a multicenter retrospective observational analysis aiming to assess the activity,efficacy,and safety of pazopanib as first-line therapy for advanced nccRCC patients treated in a real-life *** Overall,48 patients were *** the median follow-up of 40.6 mo,the objective response rate was 27.1%,the disease control rate was 83.3%,and the median progression-free survival and overall survival were 12.3(95%confidence interval[CI]:3.6-20.9)and 27.7(95%CI:18.2-37.1)mo,*** 3 adverse events occurred in 20%of patients,and no grade 4 or 5 toxicities were *** Pazopanib should be considered as a good first-line option for metastatic RCC with variant histology.

关键词： Pazopanib Non-clear cell Kidney cancer Renal-cell carcinoma Variant histology Tyrosine kinase inhibitors

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Transarterial radioembolization for hepatocellular carcinoma:An update and perspectives

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World Journal of Gastroenterology 2015年第21期21卷 6518-6525页

作者： Rodolfo Sacco Valeria Mismas Sara Marceglia Antonio Romano Luca Giacomelli Marco Bertini Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Ambra Corti Manuel Tredici Michele Piccinno Luigi giorgi Carlo Bartolozzi Irene Bargellini Department of Gastroenterology Pisa University Hospital Department of Electronics Information technology and BioengineeringEngineering School of Milan Department of Nuclear Medicine Pisa University Hospital Division of Health Physics Pisa University Hospital Department of Radiology Pisa University Hospital

In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability *** technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of *** is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical ***,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for *** addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for *** might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib.

关键词： Hepatocellular carcinoma Radioembolization Transarterial chemoembolization Sorafenib Staging RECIST, Modified RECIST Downsizing Clinical trial

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Development of Biotechnology for Microbial Synthesis of Gold and Silver Nanoparticles

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Journal of Life Sciences 2013年第2期7卷 110-122页

作者： Tamaz Levan Kalabegishvili Ivane giorgi Murusidze Elena Ivan Kirkesali Alexander Nikoloz Rcheulishvil Eteri Nikoloz Ginturi Eteri Simon Gelagutashvili Nana Eremey Kuchava Nanuli Vakhtang Bagdavadze Dodo Trofim Pataraya Manana Amiran Gurielidze Hoi-Ying Holman Marina Vladimirovna Frontasyeva Inga Ivanovna Zinicovscaia Sergey Sergeevich Pavlov Vasiliy Timofeevich Gritsyna Department of Biological System Physics E. Andronikashvili Institute of Physics Javakhishvili State University Tbilisi O177Georgia . Ilia State University Institute of Applied Physics Tbilisi 0162 Georgia S. Durmishidze Institute of Biochemistry and Biotechnology of N.L.E. Georgian Agrarian University Tbilisi 0159 Georgia Department of Ecology Center for Environmental Biotechnology Lawrence Berkeley National Laboratory Berkeley 94720United States Department of Nuclear Physics Joint Institute for Nuclear Research Dubna 141980 Russia Departement of Solid State Physics V.N. Karazin Kharkiv National University Kharkiv 01077 Ukraine

Several bacterial strains of Actinomycetes belonging to Streptomyces and Arthrobacter genera for the first time were used to study the biotechnology of synthesis of gold and silver nanoparticles. The experimental conditions of gold and silver nanoparticles production by the cells of studied strains in aqueous chloroauric acid （HAuCIq） and in silver nitrate （AgNO3） solutions, respectively, were determined. Concentration and time-dependences of nanoparticle formation were investigated. The complex of optical and analytical methods was used for testing the gold and silver nanoparticles in the bacterial biomass. The TEM （Transmission Electron Microscopy） and XRD （X-ray Diffraction） data in all cases demonstrated the presence of crystals with fcc （face centered cubic） structure. The results obtained show that the Actinomycetes are capable of producing gold and silver nanoparticles of spherical shape extracellularly when exposed to suitable compounds. The particle size distribution shows that the sizes of nanoparticles are in the range of 5 nm to 80 nm. The biomass obtained may be used for industrial as well as medical and pharmaceutical purposes.

关键词： Microbial synthesis nanoparticles gold silver biotechnology.

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口服他达拉非和阿呋唑嗪联合治疗的疗效和安全性：一种综合治疗下尿路症状和勃起功能障碍患者的初步报告

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中华男科学杂志 2009年第12期15卷 1150-1150页

作者： Liguori G Trombetta C De giorgi G(et al.) 武志刚不详温州医学院附属第一医院泌尿外科 325000

α1-阻断剂（AB）是治疗下尿路症状（LUTS）的一线单药治疗药物。5型磷酸二酯酶抑制剂（PDE5）则是治疗勃起功能障碍（ED）的一线治疗药物。大量的临床研究提示ED和LUTS之间具有明显的相关性,但是目前还未能确定两者存在因果关系。为了... 详细信息

α1-阻断剂（AB）是治疗下尿路症状（LUTS）的一线单药治疗药物。5型磷酸二酯酶抑制剂（PDE5）则是治疗勃起功能障碍（ED）的一线治疗药物。大量的临床研究提示ED和LUTS之间具有明显的相关性,但是目前还未能确定两者存在因果关系。为了确定AB（阿呋唑嗪）和PDE5抑制剂（他达拉非）综合治疗LUTS和ED的疗效,Liguori等进行了一项随机化、开放式、三分组临床研究。共有66例主诉ED和LUTS的男性患者入选了该研究。在基线时以及试验性治疗12周后,分别对患者进行评估。

关键词：勃起功能障碍下尿路症状综合治疗阿呋唑嗪他达拉非联合治疗疗效 5型磷酸二酯酶抑制剂

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Electroconvulsive therapy in catatonic patients: Efficacy and predictors of response

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World Journal of Psychiatry 2015年第2期5卷 182-192页

作者： Federica Luchini Pierpaolo Medda Michela giorgi Mariani Mauro Mauri Cristina Toni Giulio Perugi Department of Experimental and Clinic Medicine Section of Psychiatry University of Pisa Institute of Behavioural Science

Recent evidence favors the view of catatonia as an autonomous syndrome, frequently associated with mood disorders, but also observed in neurological, neurodevelop-mental, physical and toxic conditions. From our systematic literature review, electroconvulsive therapy(ECT) results effective in all forms of catatonia, even after pharmacotherapy with benzodiazepines has failed. Response rate ranges from 80% to 100% and results superior to those of any other therapy in psychiatry. ECT should be considered first-line treatment in patients with malignant catatonia, neuroleptic malignant syndrome, delirious mania or severe catatonic excitement, and in general in all catatonic patients that are refractory or partially responsive to benzodiazepines. Early intervention with ECT is encouraged to avoid undue deterioration of the patient's medical condition. Little is known about the long-term treatment outcomes following administration of ECT for catatonia. The presence of a concomitant chronic neurologic disease or extrapyramidal deficit seems to be related to ECT non-response. On the contrary, the presence of acute, severe and psychotic mood disorder is associated with good response. Severe psychotic features in responders may be related with a prominent GABAergic mediated deficit in orbitofrontal cortex, whereas non-responders may be characterized by a prevalent dopaminergic mediated extrapyramidal deficit. These observations are consistent with the hypothesis that ECT is more effective in "top-down" variant of catatonia, in which the psychomotor syndrome may be sustained by a dysregulation of the orbitofrontal cortex, than in "bottom-up" variant, in which an extrapyramidal dysregulation may be prevalent. Future research should focus on ECT response in different subtype of catatonia and on efficacy of maintenance ECT in long-term prevention of recurrent catatonia. Further research on mechanism of action of ECT in catatonia may also contribute to the development of other brain

关键词： Electroconvulsive therapy Catatonia Mood disorders Schizophrenia Benzodiazepines Antipsychotics

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Mood Spectrum Model:Evidence reconsidered in the light of DSM-5

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World Journal of Psychiatry 2015年第1期5卷 126-137页

作者： Antonella Benvenuti Mario Miniati Antonio Callari Michela giorgi Mariani Mauro Mauri Liliana Dell’Osso Department of Clinical and Experimental Medicine University of Pisa

AIM: to investigate studies conducted with the Mood Spectrum Structured Interviews and Self-Report versions(SCI-MOODS and MOODS-SR).METHODS: We conducted a review of studies published between 1997 and August 2014. The search was performed using Pubmed and Psyc INFO databases. Analysis of the papers followed the inclusion and exclusion criteria recommended by the PRISMA Guidelines, namely:(1) articles that presented a combination of at least two terms, "SCI-MOODS" [all fields] or "MOODS-SR" [all fields] or "mood spectrum" [all fields];(2) manuscript in English;(3) original articles; and(4) prospective or retrospective original studies(analytical or descriptive), experimental or quasi-experimental studies. Exclusion criteria were:(1) other study designs(case reports, case series, and reviews);(2) non-original studies including editorials, book reviews and letters to the editor; and(3) studies not specifically designed and focused on SCI-MOODS or ***: The search retrieved 43 papers, including 5 reviews of literature or methodological papers, and 1 case report. After analyzing their titles and abstracts, according to the eligibility criteria, 6 were excluded and 37 were chosen and included. The SCI-MOODS and the MOODS-SR have been tested in published studies involving 52 different samples across 4 countries(Italy, United States, Spain and Japan). The proposed mood spectrum approach has demonstrated its usefulness mainly in 3 different areas:(1) Patients with the socalled "pure" unipolar depression that might manifest hypomanic atypical and/or sub-threshold aspects systematically detectable with the mood questionnaire;(2) Spectrum features not detected by other instruments are clinically relevant, because they might manifest in waves during the lifespan, sometimes together, sometimes alone, sometimes reaching the severity for a full-blown disorder, sometimes interfering withother mental disorders or complicating the course of somatic diseases; and(3) Higher

关键词： Mood disorders Dimensional Categorical Unipolar Spectrum Bipolar Diagnostic and Statistical Manual of Mental Disorders 5

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Retroileal trans-mesenteric colorectal anastomosis

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World Journal of Surgical Procedures 2013年第3期3卷 25-28页

作者： Pierpaolo Sileri Ilaria Capuano Carolina Ilaria Ciangola Luana Franceschilli Federica giorgi Achille Lucio Gaspari Department of Surgical Sciences University of Rome Tor Vergata00133 RomeItaly

Colorectal anastomosis after extended left colectomies may result difficult, and, sometimes, impossible due to the shortness of the vascular pedicles and the distance between the two ends. Total colectomy with ileo-rectal or ileo-anal anastomosis with sacrifice of healthy colon and ileocaecal valve is usually preferred to overcome this problem. In this manuscript we describe the stepby-step surgical technique of retroileal transmesenteric colorectal anastomosis which can be used as a salvage technique for both open and laparoscopic surgeries. We also discuss the advantages and disadvantages of this approach compared to other techniques. We believe that the widespread of laparoscopic colorectal surgery as well as the raising volume of metachronous colorectal resections will revive this vintage overlooked approach.

关键词： Colorectal anastomosis Retroileal anastomosis Extended left colectomy

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研究新型高压直流连接线的环境要求

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电力建设 2007年第10期28卷 97-100页

作者： C.imario A.giorgi R.Guandalini L.Mattiello R.Noccolai G.Pazienza C.Pincella M.Rebolini R.Rendina G.Simioli 马明(摘译) TERNA Rete Elettrica Nazionale -罗马 CESI Centro Elettrotecnico Sperimentale Italiano 米兰 Marine Electronics and Sea-Surveying - Lerici (SV) 意大利不详

意大利撒丁岛与意大利半岛之间新建的高压直流海底输电项目(SAPEI)的额定输送容量为1000MW,±500kV直流,跨海长度超过400km。在开发此项目过程中,环保要求起到了非常重要的作用。在项目立项报批过程中,解决了几项技术问题。

关键词：高压直流环保项目海水电极海洋勘测噪音

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Heart and lung, a dangerous liaison-Tako-tsubo cardiomyopathy and respiratory diseases: A systematic review

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World Journal of Cardiology 2014年第5期6卷 338-344页

作者： Roberto Manfredini Fabio Fabbian Alfredo De giorgi Marco Pala Alessandra Mallozzi Menegatti Claudia Parisi Elisa Misurati Ruana Tiseo Massimo Gallerani Raffaella Salmi Eduardo Bossone Clinica Medica Azienda Ospedaliera-Universitaria of Ferrara 44124 Cona Ferrara Italy 1st Internal Medicine Unit Azienda Ospedaliera-Universitaria of Ferrara 44124 Cona Ferrara Italy 2nd Internal Medicine Unit Azienda Ospedaliera-Universitaria of Ferrara 44124 Cona Ferrara Italy Cardiology Unit Azienda Ospedaliera-Universitaria of Salerno 84131 Salerno Italy

AIM: To investigate the possible association between Tako-tsubo cardiomyopathy(TTC)-a reversible clini-cal condition mimicking an acute myocardial infarction characterized by multifactorial pathophysiologic mecha-nisms- and respiratory system diseases. METHODS: We systematically searched PubMed and EMBASE medical information sources, to identify the different triggering causes, limiting our search to ar-ticles in English. The search keywords were: "tako-tsubo cardiomyopathy", "takotsubo", "takotsubo cardiomyopa-thy", "broken heart syndrome", "stress-induced cardio-myopathy", "apical ballooning syndrome", and "ampulla cardiomyopathy in combination with respiratory dis-eases, lung, pulmonary disease. For each kind of dis-ease, we registered: author, year and country of study, patient sex, age, concurring situation, and outcome. RESULTS: Out of a total of 1725 articles found, we se-lected 37 papers reporting a total of 38 patients. As ex-pected, most patients were women(81.6%), mean age was 65 ± 10 years. Outcome was favorable in 100% of cases, and all the patients have been discharged un-eventfully in a few days. CONCLUSION: An association between respiratory diseases and TTC is likely to exist. Patients with severe respiratory diseases, due to the high dosages of β2-agonists used or to the need of invasive procedures, are highly exposed to the risk of developing TTC.

关键词： Tako-tsubo cardiomyopathy Stress cardiomyopathy Respiratory diseases Lung Chronic obstructive pulmonary disease Asthma

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Synthesis, structural and spectroscopic characterization of the bis(nitrito-N) octaethylporphyrin cobalt(III) complex

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Open Journal of Inorganic Chemistry（无机化学期刊） 2011年第3期 39-46页

作者： Bader Belhaj Ali Mohamed Salah Belkhiria Michel giorgi Habib Nasri

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