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Epidemiological and Histopathological Profile of Prostate Cancer: A Retrospective Study in the Pathology Department of the University Clinics of Kinshasa

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Journal of Cancer Therapy 2024年第6期15卷 239-249页

作者： Rive Lukuaku Buanza Jérémie Okumadi Lukuke fabrice Bokambandja Lolangwa Andy Mbangama Muela Matthieu Loposo Nkumu François Beya Kabongo Renault Kambere Sitamuina Jean-Marie Mpolesha Kabongo Faculty of Medicine Bel Campus Technological University Kinshasa DRC Department of Pathological Anatomy University Clinics of Kinshasa Kinshasa DRC Gyneco-Obstetrics Department University Clinics of Kinshasa Kinshasa DRC Department of Surgery Urology University Clinics of Kinshasa Kinshasa DRC

Background: Prostate cancer, the most common male cancer, represents a real public health problem in terms of its frequency and severity in different countries around the world. It disproportionately affects people of African descent wherever they live in the world [1]. To the best of our knowledge, its extent and particularities in the African environment are not well known. Objective: To determine the epidemiological and histopathological profile of prostate cancer in the CUK anatomopathology department. Methodology: This is a retrospective study conducted at the University Clinics of Kinshasa Anapathology Department from January 1, 2015 to December 31, 2022, a period of 8 years. Word processing and tables were entered using the Hp brand computer, with Microsoft Office WORD 2016 software. Data analysis was performed with SPSS version 22.0 software. Results were presented in tables and figures. Results: Prostate was diagnosed in 132 cases, i.e. 1.58% of all CUK laboratory analyses and 8% of cancers diagnosed. The age group most affected was 66-75 years, i.e. 59% of all subjects. Adenocarcinoma was the most frequent histological type, and biopsy dominated in 111 cases (84.1%). Conclusion: Prostate cancer is a real public health problem. Worldwide, and in the Democratic Republic of Congo, it is the most frequently diagnosed cancer in men, and the leading cause of cancer-related death in men. In the DRC, because of the delay in consulting our patients and the weakness of systematic screening, patients are seen at an advanced stage of the disease. Treatment is multidisciplinary, involving surgery, radiotherapy and chemotherapy (including targeted therapies). Patient awareness and screening campaigns will help to considerably reduce the delay in diagnosis and the morbidity and mortality associated with prostate cancer.

关键词： Prostate Gleason Score Democratic Republic of Congo

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Dissemination of Resistance Integrons and Genes Coding for Blse and Cabapenemases in the Urban Drainage Network in Cote d’Ivoire

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Advances in Microbiology 2024年第5期14卷 268-286页

作者： Coulibaly Kalpy Julien Diaby Aboubakar Sidik Vakou N’dri Sabine M’bengue Gbonon Valérie Carole Claon Jean Stephane Yao Kouamé Eric Gnali Gbohounou fabrice Yéo Yéfougnini Bagré Issa Djaman Allico Joseph Dosso Mireille Pasteur Institute of Ivory Coast Abidjan C&#244te d&#8217Ivoire Fé lix Houphou&#235t-Boigny University Abidjan C&#244te d&#8217Ivoire

Antibiotic resistance has become a major threat to human health worldwide. Environment, particularly the water environment, has long been overlooked as a player in the antibiotic resistance cycle, although its role remains unclear. These can provide an ideal setting for the acquisition and dissemination of antibiotic resistance, as they are frequently affected by anthropogenic activities. The objective of this study was to establish a diffusion map of resistance integrons used as genetic markers of resistance associated with antibiotic resistance conferring genes (ARGs). Total DNA extracts from non-cultivable bacterial communities were used for the analyses. These communities were obtained from wastewater samples from 14 sites upstream and downstream of drainage channels or effluents in the cities of Abidjan, Bouaké, and Yamoussoukro. The results obtained correspond to the number of positives among the treated samples (n = 39). Among the genetic markers of dissemination, class 1 integrons were the most evident in 94.8% of samples in Abidjan (93.3%), Bouaké (100%) and Yamoussoukro (91.6%). Class 2 integrons and class 3 integrons were found respectively in 41% and 51% of all samples. Genes coding for β-lactamases and blaTEM was identified in almost all samples at a rate of 97.4%. A co-presence of the three genes blaTEM, blaSHV and blaCTX-M is also remarkable in the sites of the city of Yamoussoukro. Among the genes coding for carbapenemases, only blaKPC 17.94%, blaNDM 30.76% and blaOXA48 38.46% were detected in the samples.

关键词： Antibiotic Resistance Wastewater Resistance Integrons (RIs) Resistance Genes

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Laparoscopic Appendectomies at Brazzaville University Hospital

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Surgical Science 2024年第4期15卷 183-194页

作者： Murielle Etiennette Julie Note Madzele Pierlesky Elion Ossibi Bhodeho Medi Monwongui Didace Massamba Miabaou Giresse Bienvenu Tsouassa Wa Ngono Prude Pertinie Avala Gilles Niengo Outsouta Noé Henschel Motoula Latou Carmich Nzaka Moukala Cédrick Du Bonheur Alima Koya Gilbert fabrice Otiobanda Digestive Surgery Department Brazzaville University Hospital Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo General Intensive Care Unit Brazzaville University Hospital Brazzaville Republic of the Congo

Introduction: Acute appendicitis represents an urgent surgical condition, requiring the removal of the vermiform appendix. Laparoscopy is the standard surgical approach. This study aimed to outline the epidemiological, clinical, therapeutic, and outcome characteristics of patients undergoing laparoscopic surgery for acute appendicitis. Patients and Methods: A descriptive, retrospective analysis was carried out in the Emergency and Digestive Surgery departments of the University Hospital Center of Brazzaville, spanning two years from January 1, 2021, to December 31, 2022. The study included all patients who underwent laparoscopic surgery for non-complicated acute appendicitis. Results: The study included 12 cases of non-complicated acute appendicitis treated with urgent laparoscopy. The mean age of the patients was 37 ± 8.9 years, with a sex ratio of 0.7. The predominant symptom leading to consultation was pain in the right iliac fossa, with an average time to consultation of 6.4 ± 5.7 hours. Patient histories included diabetes in one case, obesity in two cases, and one case of prior abdominoplasty. During surgery, a phlegmonous appendix was observed in nine patients. The average duration of hospital stay was 3.6 ± 1.3 days, with all patients experiencing uncomplicated recoveries. Conclusion: The practice of emergency laparoscopic appendectomy is still relatively infrequent in our setting and presents an ongoing challenge.

关键词： Acute Appendicitis Appendectomy Laparoscopy Emergency

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Effect of Biostimulants Based on Natural Products on the Growth and Nutritional Value of Bean (Phaseolus vulgaris L.)

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American Journal of Plant Sciences 2024年第7期15卷 492-518页

作者： Aimé Giresse Tzeuton Flore Eliane Eyenga Arouna Meshuneke Gaston Mbang Elock fabrice Damien Wassom Walter Jospin Timma Kom Marie Paule Djam Kengoum Erica Cabrelle Damtse Damtse Landry Silatsa Fotsing William Asah Che Marlyne Josephine Mananga Nicolas Niemenak Cécile Annie Ewané Laboratory of Plant Physiology and Biochemistry Higher Teachers Training College University of Yaound 1 Yaound Cameroon Department of Biochemistry Faculty of Sciences University of Yaound 1 Yaound Cameroon Laboratory of Food Sciences and Metabolism University of Yaoundé 1 Yaoundé Cameroon Laboratory of Phytoprotection and Valorisation of Genetic Resources of the Biotechnology Centre University of Yaound 1 Yaound Cameroon Department of Biological Sciences Higher Teachers Training College University of Yaound 1 Yaound Cameroon

Beans (Phaseolus vulgaris L.) are widely grown in Cameroon and play a key role in the fight against food insecurity, malnutrition and poverty. However, its cultivation encounters problems due to abiotic and biotic stresses, which leads to the use of synthetic fertilizers and pesticides, which cause significant damage to the environment and human health due to the presence of synthetics residues in the seeds, pods and in the leaves that are eaten. Promoting the use of natural products is becoming a necessity for organic and eco-responsible agriculture that limits contamination problems and improves people’s purchasing power. This study aims to assess the effect of biostimulants based on natural products on the growth and nutritional value of common bean (Phaseolus vulgaris L.). Bean seedlings from white variety (MEX-142) and red variety (DOR-701) were treated every seven days in the field from their pre-emergence, emergence and growth to their maturation under a randomized block experimental design. Six treatments and three repetitions with the biostimulants based on natural products and controls were thus performed and the agromorphological parameters were measured. After 120 days, the contents of growth biomarkers and defense-related enzymes were evaluated in leaves, while the contents of macromolecules, minerals and antinutrients were evaluated in seeds. These biostimulants significantly increased (P P < 0.0001) of antinutrients including oxalates, phytates, tannins and saponins in seeds compared to controls (T+ and T−). Treatment with biostimulants, in particular BS4, improves the performance of bean plants in the field as well as the biofortification of seeds regardless of the variety.

关键词： Phaseolus vulgaris L. Biostimulants Biofortification Growth and Defense Biomarkers Nutritional Value

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Rib Osteosynthesis for Sub-Acute Management of a Flail Chest in a Tertiary Centre in a Low-Middle Income Country of Sub-Saharan Africa: Case Report at Douala Laquintinie Hospital

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Open Journal of Thoracic Surgery 2024年第1期14卷 1-16页

作者： fabrice Stéphane Arroye Betou Nyankoue Mebouinz Ferdinand Guy Aristide Bang Kobe Folkabo Zephany Banga Nkomo Douglas Moussa Seck Diop Abdoul Lahad Mbeng Marcella Derboise Christelle Biyouma Noel Essomba Souleyman Diatta Handy Eone Daniel Arthur Essomba Hassan Ndiaye Maurice Aurelien Sosso Department of Surgery and Specialties Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé (UYI) Yaoundé Cameroon Department of Surgery and Affiliated Disciplines Douala Laquintinie Hospital Douala Cameroon Department of Surgery and Specialties Yaoundé General Hospital Yaoundé Cameroon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences (FMPS) University of Dschang Dschang Cameroon Service de Chirurgie Thoracique et Cardiovasculaire Centre Hospitalier Universitaire de Fann Faculté de Médecine de Pharmacie et d’Odontologie Université de Cheikh Anta Diop Dakar Sénégal UFR des Sciences de la Santé Ziguinchor Sénégal

Background: Costal fracture surgical is still a debate, therefore we shall select between early and delay surgical management. Case Report: We are reporting two cases of post road traffic clash delay ribs fractures osteosynthesis involving a 63-year-old man with multistage fractures on the left and pulmonary pinning of one of the costal arches, complicated by a homolateral haemothorax and a 41-year-old man with a bilateral flail chest. Conclusion: The simple postoperative course and the immediate postoperative improvement in the patient’s clinical respiratory condition enabled us to discuss the time frame for management, in this case the indication for early or later surgery.

关键词： Flail Chest Fixation Plate Rib Fracture Osteosynthesis

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Bending and Free Vibration Analysis of Porous-Functionally-Graded(PFG)Beams Resting on Elastic Foundations

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Fluid Dynamics & Materials Processing 2023年第4期19卷 1043-1054页

作者： Lazreg Hadji fabrice Bernard Nafissa Zouatnia Laboratory of Geomatics and Sustainable Development University of TiaretTiaret14000Algeria Department of Mechanical Engineering University of TiaretTiaret14000Algeria INSA Rennes Laboratory of Civil Engineering and Mechanical EngineeringRennes35043France Department of Civil Engineering University of TiaretTiaret14000Algeria

The bending and free vibration of porous functionally graded(PFG)beams resting on elastic foundations are *** material features of the PFG beam are assumed to vary continuously through the thickness according to the volume fraction of *** foundation medium is also considered to be linear,homogeneous,and isotropic,and modeled using the Winkler-Pasternak *** hyperbolic shear deformation theory is applied for the kinematic relations,and the equations of motion are obtained using the Hamilton’s *** analytical solution is presented accordingly,assuming that the PFG beam is simply *** with the open literature are implemented to verify the validity of such a *** effects of the elastic foundations,porosity volume percentage and span-to-depth ratio are finally discussed in detail.

关键词： Bending free vibration porosity functionally graded material winkler-pasternak elastic foundation

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Traditional Healer’s Medicinal Practice Survey and Clinical Evidence Assessment of “YIKI”: An Antimalarial Phytomedicine Recipe from Bobo-Dioulasso, Burkina Faso

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Pharmacology & Pharmacy 2024年第7期15卷 248-267页

作者： Zachari Kabre Rakiswende Serge Yerbanga Aminata Fofana Roland Nâg-Tiero Meda Anyirekun fabrice Some Alassane Haro Natacha A. J. A. Boro Fazhira B. Ye Benjamin Kouliga Koama Sami Eric Kam Eliasse Zongo Hadidjatou Belèm Windmi Kagambèga Florence Fournet Georges A. Ouedraogo Jean-Bosco Ouedraogo Institut de Recherche en Sciences de la Sant Direction Rgionale de lOuest Bobo-Dioulasso Burkina Faso Laboratoire de Recherche et dEnseignement en Sant et Biotechnologies Animales Universit Nazi BONI Bobo-Dioulasso Burkina Faso Institut des Sciences et Techniques Bobo-Dioulasso Burkina Faso Laboratoire de Recherche en Bactriologie INSP/Centre MURAZ Bobo-Dioulasso Burkina Faso Maladies Infectueuses et Vecteurs: Ecologie Gntique Evolution et Contrle (MIVEGEC) Institut de Recherche pour le Dveloppement Universit de Monpellier Montpellier France

YIKI is an antimalarial phytomedicine used by a traditional healer to treat malaria in Bobo-Dioulasso. However, there is no scientific evidence to support its use by local populations. The aim of this study was to identify the medicinal practices of the healer holder of YIKI and assess the clinical evidence of its phytomedicine in the uncomplicated malaria treatment. Ethnomedical survey based on a semi-structured and open questionnaire was conducted from October to December 2019 with the healer. Malaria knowledge and diagnosis methods, patient treatment and monitoring, and recipe formulation steps were surveyed. Moreover, thick and thin blood smears were taken, haemoglobin levels and temperature of consenting patients were measured before treatment, mid-treatment and at the end of treatment. The survey revealed that the healer has a good knowledge of malaria symptoms and his diagnosis is based on observation and physical examination of patients. The healer’s malaria diagnosis was rudimentary and had accuracy problems, with only 62.79% of malaria cases confirmed by microscopy. The formulation of YIKI and its use to treat malaria follow a standard process for plant harvesting, powder quantities and posology, but do not use any reproducible parameters for dose adjustment. Forty-three patients diagnosed and treated by the healer participated in the study. Laboratory results revealed 27 Plasmodium falciparum infection cases, including 2 with parasitaemia ≥ 200,000 p/µl blood. 25 patients were selected for therapeutic evidence assessment. There was a 48% elimination of parasites, a 28% parasitaemia decrease without complete cure, with gametocytogenesis in some patients, and a 24% parasitaemia increase. Haemoglobin and temperature results suggested that YIKI was not cytotoxic and reduced fever. Encouraging preliminary results have been obtained, but in view of the low number of patients, further YIKI efficacy and toxicity studies will be necessary for patient safety.

关键词： Antimalarial-Phytomedicine Efficacy Traditional Practices Bobo-Dioulasso

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Utility of circulating tumor DNA in patients undergoing hepatectomy for colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 736-739页

作者： Philippine Cnockaert fabrice Muscari Charlotte Maulat Digestive Surgery and Liver Transplantation Department Toulouse University HospitalToulouseFrance

In this study recently published in Annals of Surgery,Newhook et *** the influence of circulating tumor DNA(ctDNA)in the management of patients undergoing hepatic resection for colorectal liver metastases(CRLM)(1).The primary objective was to study the association between the dynamic of ctDNA and somatic mutations with survival after resection of *** secondary objectives were to evaluate the impact of surgery on perioperative ctDNA dynamics and the impact of its detection on survival.

关键词： Circulating tumor DNA(ctDNA) colorectal liver metastases(CRLM) somatic mutations hepatectomy survival

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Formation,stabilization and chemical demulsification of crude oil-in-water emulsions:A review

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Petroleum Research 2022年第4期7卷 459-472页

作者： Edith Yonguep Kashala fabrice Kapiamba Katende Jonathan Kabamba Mahabubur Chowdhury Department of Chemical Engineering Cape Peninsula University of TechnologySymphony WayPO Box 1906Bellville7535Cape TownSouth Africa Department of Civil Architectural and Environmental EngineeringMissouri University of Science and TechnologyRollaMO65401USA

The crude oil recovery process is frequently associated with the formation of stable emulsions due to factors such as turbulent flow in pipelines and the presence of surface-active substances that naturally occur in crude *** emulsions are undesirable for the petroleum industry because their destruction/treatment adds to the overall production cost and causes the loss of valuable amounts of crude ***,it is essential,for economic and environmental reasons,to optimize the crude oil demulsification *** effective treatment of crude oil emulsions requires understanding of the process and factors leading to their formation and *** this sense,suitable treatment methods and possible preventive measures to avoid their formation can be *** present study reviews recent oilfield emulsion types and the factors responsible for their formation and *** different demulsification techniques employed were then extensively *** tech-niques include mechanical,thermal,electrical,and chemical methods with different demulsification mechanisms affected by many factors such as emulsions type and properties,demulsifiers characteris-tics,presence of solids stabilized emulsions,*** demulsification efficiency depends on the operating parameters of the process,the economics involved,and the environmental impact,which are the main factors considered in selecting a suitable demulsification *** research on the demulsifi-cation of crude oil emulsions should focus on real crude oil emulsions studies at a pilot scale level,the effect of aging on crude oil emulsions,the combination of multiple demulsification techniques and their synergistic effects,and the use of natural,ecofriendly demulsifiers.

关键词： Crude oil Enhanced oil recovery Emulsions Stabilization Demulsification Surfactants Demulsifiers Coalescence

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SNAP23-Kif5 complex controls mGlu1 receptor trafficking

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Journal of Molecular Cell Biology 2018年第5期10卷 423-436页

作者： fabrice Raynaud Vincent Homburger Martial Seveno Oana Vigy Enora Moutina laurent Fagni Julie Perroy IGF CNRS INSERM Univ. Montpel[ier F-34094 Montpellier France BioCampus Montpellier CNRS INSERM Univ. Montpellier F-34094 Montpellier France Present address: INSERM U1046 PhyMedExp CNRS UMR9214 Univ. Montpellier F-34094 Montpellier France

Metabotropic glutamate 受体在哺乳动物的大脑在有刺激性的触处和控制 synaptic 传播被表示。这些受体涉及众多的 patho 生理的功能。然而，很少对为他们指向的细胞内部的运输和膜负责的分子的决定因素被知道。这里，我们调查了分子的... 详细信息

Metabotropic glutamate 受体在哺乳动物的大脑在有刺激性的触处和控制 synaptic 传播被表示。这些受体涉及众多的 patho 生理的功能。然而，很少对为他们指向的细胞内部的运输和膜负责的分子的决定因素被知道。这里，我们调查了分子的马达和为 trafficking 和这个组的膜本地化负责的适配器蛋白质的性质我在有教养的海马趾的神经原的 metabotropic glutamate mGlu1 postsynaptic 受体。在 proteomic 研究，我们识别了联系 synaptosome 的蛋白质 23 (SNAP23 ) 并且是的分子的马达 Kif5 kinesin 蛋白质与 mGlu1 交往受体。我们显示出那 SNAP23，然而并非 Kif5，直接与 mGlu1 受体 carboxyl 终点交往。使用一条再结合途径损害或提高在 SNAP23 和 Kif5 之间的相互作用，我们发现 SNAP23-Kif5 建筑群沿着微导管控制 mGlu1 受体的 trafficking。在劈开实验以后的另外的荧光恢复允许我们在指向的受体房间表面识别建筑群的一个角色。在结论，我们的学习显示那树枝状的进程 Kif5-SNAP23 建筑群贡献合适的 mGlu1 受体 trafficking 和房间表面表示。

关键词：复杂控制受体蛋白质建筑群哺乳动物相互作用刺激性分子

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