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Phenotipic Prevalence of Antibiotic Resistance in Gabon

Open Journal of Medical Microbiology 2021年第2期11卷 100-118页

作者： Annicet-Clotaire Dikoumba Richard Onanga Pierre Philippe Mbehang Nguema Laurette G. Mangouka Berthe Amélie Iroungou fabrice kassa kassa Berthold Bivigou Mboumba Elvire Mbongo Kama Jean-fabrice Yala Edgard-Brice Ngoungou Sylvain Godreuil Hô pital d’Instruction des Armées Omar Bongo Ondimba Département de biologie médicale Libreville Gabon Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF) Laboratoire de Bactériologie de Recherche Unité de recherche et d’Analyses Médicales (URAM) Franceville Gabon Centre Hospitalier Universitaire de Montpellier Laboratoire de Bactériologie France Institut de Recherche en Ecologie Tropicale (IRET/CENAREST) Département Ecologie animale Libreville Gabon Hô pital d’Instruction des Armées Omar Bongo Ondimba Département de Médecine Libreville Gabon Unité mixte de Recherche Santé Militaire/CIRMF Libreville Gabon Université des sciences et techniques de Masuku (USTM) Laboratoire de Biologie Moléculaire et Cellulaire équipe de Microbiologie et Immunologie Franceville Gabon Université des Sciences de la Santé Faculté de Médecine Département d’Epidémiologie Biostatistiques et Informatique Médicale (DEBIM)/Unité de Recherche en Epidémiologie des Maladies Chroniques et Santé Environnement (UREMCSE) Libreville Gabon MIVEGEC IRD CNRS Université de Montpellier Montpellier France

Background: The increasing phenomenon of bacterial resistance to antibiotics is a real public health problem. The main causes are poor management of hygiene and water quality, but also the use of antibiotics without precaution. The objective of this study was to isolate and determine the antibiotic resistance profile of the different bacteria found in the main hospitals and bacteriology laboratories in Gabon. Methods: 6034 samples were taken from hospitals in seven main cities of Gabon, and analyzed according to the usual techniques. The pathogenic strains were identified by Matrix-Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry. Antimicrobial susceptibility testing was performed by the agar disc diffusion method, according to the Antibiogram Committee of the French Society for Microbiology guidelines. Results: 974 pathogenic bacterial strains were found, including 890/974 (91.4%) Gram-negative bacilli. The systematic antimicrobial susceptibility testings identified 160/974 (16.4%) multi-resistant strains. Escherichia coli was the most represented species. 12.5% - 25% of Escherichia coli, Klebsiel

关键词： Gabon Antibiotic Resistance Profiles Methicillin-Resistant S. aureus (MRSA) Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae (ESBL-PE) Carbapenems

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Submicroscopic Plasmodial Infection May Lead to Severe Malaria in Children

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Journal of Life Sciences 2014年第2期8卷 120-127页

作者： Berthe Amelie Iroungou Jean Claude Biteghe Bi Essone fabrice kassa Dieudonne Nkoghe Jean-LouisMege Fousseyni S Toure Ndouo Centre International de Recherches Medicales de Franceville (CIRMF) BP 769 Franceville Gabon Ecole Doctorale Regionale de Recherche en Infectiologie Tropicale BP 876 Franceville Gabon Unite de Recherche des Maladies Infectieuses Tropicales Emergentes URMITE-IRD198 CNRS UMR7278 INSERM U1095 Faculte de Medecine 13385 Marseille Cedex 05 France

Malaria is one of the leading causes of consultation in African pediatric hospitals. In Gabon, malaria transmission is perennial. Plasmodium falciparum, responsible for the most severe form of the disease, represents more than 95% of all species. In P. falciparum infection, the hyperparasitemia accounts among the main criteria of disease severity. However, in many endemic countries, a significant decrease of malaria burden accompanying with the diminution of parasite load in infected individuals has been demonstrated. The objective of the study was to analyze the occurrence of febrile syndrome in childhood and investigate whether the acute febrile illness could be associated with P. falciparum submicroscopic infection. A cross-sectional study was carried out during January to March 2013 in Franceville. A total of 203 acute febrile children were enrolled. A clinical examination and biomedical analysis including parasitological diagnosis by microscope were carried out in all the patients and PCR on microscope negative ones. Of 203 children recruited for febrile syndrome, 111 have been diagnosed positive for P. falciparum infection, 73 (35.9%) by microscope (ME) and 38 (18.71%) by PCR (submicroscopic infection = SMI) with an overall prevalence of 54.68%. Of the 111 P. falciparum infected individuals and according to the WHO criteria, 35 (31.53%) children showed a clinical picture of severe malaria against 76 (68.47%) others classified as uncomplicated malaria. The overall prevalence rates were therefore estimated as 17.24 (35/203) for severe cases and 37.43% (76/203) for uncomplicated ones. Clinically, these severe malaria cases (27 ME+ and 8 PCR+) were mainly composed of 85.71% of anaemic patients (30/35), 71.14% of prostrated individuals (25/35) and 57.14% of children with clinical icterus (20/35). However, only two cases of severe anaemia were observed, the remaining others cases were moderate (10) and mild anaemia (18). More interestingly, eight submicroscopic infe

关键词：恶性疟原虫疟疾感染儿童微观可导生物医学分析临床检验

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