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Quality of Drugs Based on Ferrous Sulfate Dispensed in a Basic Health and Commercial Pharmacy in a City in the Amazon Region

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Pharmacology & Pharmacy 2022年第9期13卷 331-339页

作者： Amanda Gabryelle Nunes Cardoso Mello Marceonia Costa dos Santos Ana Gabriela Lisboa Santos danila Teresa Valeriano Alves daniella Paternostro de Araújo Grisolia Alan Barroso Araújo Grisólia Mariceli Baia Leão Barros fabrícia de jesus paiva da fonseca Manoel Samuel da Cruz Neto Faculty of Pharmacy FIBRA University Center Belém Brazil Faculty of Biotechnology Federal University of Pará Belém Brazil Biological Sciences Center Federal University of Pará Belém Brazil FACI WYdeN Faculty Belém Brazil

Background: For the WHO, anemia is a serious public health problem, with an emphasis on deprivation anemia, which has socioeconomic conditions as determining factors for its development. Among nutritional anemias, the most relevant is iron deficiency, whose main form of prevention and treatment is supplementation with ferrous sulfate dispensed in the public health system, with the need to periodically check whether the drug has the quality required by regulatory health agencies. Thus, the objective of this study was to analyze the quality of the ferrous sulfate medication, from the same laboratory, and dispensed in a basic health unit (BHU) and a commercial pharmacy (CF). Materials and Methods: An analytical, qualitative and quantitative study of ferrous sulfate heptahydrate (25 mg/mL in 100 mL syrup), carried out on 20 BHU and 10 from CF, both from the same laboratory, but in different batches. Samples were subjected to organoleptic analysis and verification of iron content, pH, volume and density. data were compared with values recommended by the Brazilian pharmacopoeia 5th edition. Results: Three batches were evaluated: 4659 of from the CF;4574 from the BHU1, and 4576 from the BHU2, stored in accordance with RDC 304/19 of ANVISA. All showed compliance with some organoleptic characteristics;and stable values in pH (3.61 - CF;3.67 - BHU1;3.65 - BHU2), density (1.079 - CF;1.088 - BHU1;1.086 - BHU2) and individual volume (not less than 95% of the declared value). However, it was not possible to detect the odor of herbs;the average volume of batch BHU1 was below the declared value, and the iron content of both BHUs was above the maximum value of pharmacopoeia standards. Conclusion: Samples did not show full compliance with the physical and chemical parameters evaluated, suggesting deviation in the quality of the medication.

关键词： Physical and Chemical Quality Control Ferrous Sulfate Heptahydrate Syrup

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Quality of Drugs Based on Ferrous Sulfate Dispensed in a Basic Health and Commercial Pharmacy in a City in the Amazon Region

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Pharmacology & Pharmacy（药理与制药） 2022年第9期

作者： amanda gabryelle nunes cardoso mello marceonia costa dos santos ana gabriela lisboa santos danila teresa valeriano alves daniella paternostro de araújo grisolia alan barroso araújo grisólia mariceli baia leão barros fabrícia de jesus paiva da fonseca manoel samuel da cruz neto

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Advanced glycation end product:A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study

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World Journal of Gastroenterology 2021年第29期27卷 4913-4928页

作者： Evelyn Nunes Goulart da Silva Pereira daniela Polessa Paula Beatriz Peres de Araujo Maria de jesus Mendes da fonseca Maria de Fátima Haueisen Sander Diniz Anissa daliry Rosane Harter Griep Laboratory of Cardiovascular Investigation Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil National School of Statistical Sciences Brazilian Institute of Geography and StatisticsRio de Janeiro 20231-050Brazil department of Epidemiology and Quantitative Methods in Health Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil Faculty of Medicine Universidade Federal de Minas GeraisMinas Gerais 31270-901Brazil Laboratory of Health and Environment Education Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil

BACKGROUND Liver diseases are associated with the excess formation of advanced glycation end products(AGEs),which induce tissue inflammation and oxidative ***,the trend of oxidative marker levels according to the steatosis grade in non-alcoholic fatty liver disease(NAFLD)is *** To compare serum AGE levels between participants with NAFLD accordingly to steatosis severity in the baseline ELSA-Brasil *** In 305 individuals at baseline ELSA-Brasil,NAFLD-associated steatosis was classified by ultrasound hepatic *** participants were grouped according to the severity of steatosis:mild and moderate/severe *** measurement of serum fluorescent AGE concentrations was based on spectrofluorimetric *** AGE content and clinical and laboratory characteristics of the participants were compared between *** correlation between serum AGE levels and the grade of steatosis was *** regression analysis was used to investigate the relationship between serum AGE levels and steatosis severity.A P valuedered statistically *** According to the steatosis severity spectrum in NAFLD,from mild to moderate/severe,individuals with the most severe steatosis grade had a higher incidence of metabolic syndrome(63%vs 34%,P≤0.001),diabetes mellitus(37%vs 14%,P≤0.001),and high cholesterol levels(51%vs 33%,Pdex,systolic and diastolic blood pressure,fasting blood glucose,glycated hemoglobin,insulin,triglycerides,alanine aminotransferase,gamma-glutamyl transferase,C-reactive protein,and uric acid levels and lower high-density *** serum AGE content was present in the moderate/severe group of individuals than in the mild group(P=0.008).In addition,the serum AGE levels were correlated with the steatosis grade in the overall sample(rho=0.146,P=0.010).Logistic regres

关键词： Advanced glycation end products Non-alcoholic fatty liver disease Steatosis ELSA-Brasil study Spectroscopy

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Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

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International Journal of Oral Science 2020年第3期12卷 199-208页

作者： Mohit Sharma Felipe paiva fonseca Keith D.Hunter Raghu Radhakrishnan department of Oral Pathology Sudha Rustagi College of Dental Sciences and ResearchFaridabadHaryanaIndia department of Oral Surgery and Pathology School of DentistryFederal University of Minas GeraisBelo HorizonteMGBrazil Academic Unit of Oral and Maxillofacial Medicine and Pathology School of Clinical DentistryUniversity of SheffieldClaremont CrescentSheffieldUK department of Oral Pathology Manipal College of Dental SciencesManipal Academy of Higher EducationManipalKarnatakaIndia

The integrity of the basal stem cell layer is critical for epithelial *** this paper,we review the expression of oral mucosal stem cell markers(OM-SCMs)in oral submucous fibrosis(OSF),oral potentially malignant disorders(OPMDs)and oral squamous cell carcinoma(OSCC)to understand the role of basal cells in potentiating cancer stem cell behaviour in *** the loss of basal cell clonogenicity triggers epithelial atrophy in OSF,the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal *** vacillating expression patterns of OM-SCMs confirm the role of keratins 5,14,19,CD44,β1-integrin,p63,sex-determining region Y box(SOX2),octamer-binding transcription factor 4(Oct-4),c-MYC,B-cell-specific Moloney murine leukaemia virus integration site 1(Bmi-1)and aldehyde dehydrogenase 1(ALDH1)in OSF,OPMDs and *** downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.

关键词： epithelium malignant mucosal

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The Role of States in Controlling the Obesity Epidemic, and a Personal Autonomy to decide

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Open Journal of Endocrine and Metabolic Diseases 2017年第1期7卷 35-43页

作者： Priscila Rosa da fonseca Ana Maria Anjo Toloi Larissa Bianca paiva Cunha de Sá Alberto Krayyen Arbex Division of Endocrinology IPEMED Medical School S&atilde o Paulo Brazil Diabetology department MalteserKrankenhaus St. Franziskus-Hospital Flensburg Germany PPGBIOS Funda&ccedil &atilde o Oswaldo Cruz Rio de Janeiro Brazil

Obesity has reached pandemic proportions in the world. Who is to blame for this: the person or the State (or both?). An increase in diseases associated with excess weight is also worldwide reported, such as Diabetes, Hypertension and some types of cancers. Therefore, the economic impacts of these comorbidities are an important issue to be discussed by States and citizens. Although the World Health Organization (WHO) has set and classified obesity as a disease more than 30 years ago, the American Medical Society was until recently (2010) not so sure about this definition. This article discusses the relevance of the implementation of public health policies for prevention and control of obesity, along with the possible ethical limitations to these actions, considering the autonomy of individuals regarding their health.

关键词： Obesity Comorbidities Public Health Policies Autonomy of the Citizen

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Clinical and environmental isolates of Burkholderia pseudomallei from Brazil: Genotyping and detection of virulence gene

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Asian Pacific Journal of Tropical Medicine 2017年第10期10卷 945-951页

作者： Tereza de jesus Pinheiro Gomes Bandeira debora de Souza Collares Maia Castelo-Branco Marcos Fabio Gadelha Rocha Rossana de Aguiar Cordeiro Crister Jose Ocadaque Manoel de Araújo Neto paiva Raimunda Samia Nogueira Brilhante Jose Júlio Costa Sidrim Specialized Medical Mycology Center Postgraduate Program in Medical Microbiology Federal University of Ceará Christus School of Medicine Postgraduate Program in Veterinary Sciences State University of Ceará Federal Institute of Education Science and Technology of Ceará

Objective: To evaluate the genetic diversity of clinical and environmental isolates of Burkholderia pseudomallei(***) recovered in Ceara, Brazil, and screen these isolates for the presence of type three secretion system virulence ***: Nineteen *** isolates(9 from clinical cases and 10 from soils)were *** amplified polymorphic DNA was performed with primers OPQ-2, OPQ-4 and OPQ-16 to evaluate the genetic diversity, and type three secretion system gene was detected through polymerase chain ***: Random amplified polymorphic DNA showed a genetic relatedness of approximately 50% among the tested *** isolates, which were grouped into two clades, of which the biggest ones comprised 18/19 isolates for primer OPQ-2, and 17/19 isolates for primer *** OPQ-4 grouped the isolates into three clades comprising 1/19, 3/19 and 15/19 ***, type three secretion system gene was detected in all tested ***: This is an effort to type *** strains from Ceara, which is important for better understanding this pathogen, contributing for the epidemiological surveillance of melioidosis in this endemic region.

关键词： Burkholderia pseudomallei Melioidosis RAPD TTSS gene

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Minimally invasive tenodesis for peroneus longus tendon rupture: A case report and review of literature

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World Journal of Orthopedics 2020年第2期11卷 137-144页

作者： danilo Ryuko Cândido Nishikawa Fernando Aires Duarte Guilherme Honda Saito Cesar de Cesar Netto Fábio Correia paiva fonseca Bruno Rodrigues de Miranda Augusto César Monteiro Marcelo Pires Prado department of Orthopedics Foot and Ankle SurgeryHospital of the Municipal Public Servant of São Paulo(HSPM)Aclimação 01532-000São PauloBrazil Ortocity Orthopaedic Clinic Lapa 05078-000São PauloBrazil department of Orthopaedics Foot and Ankle SurgeryHospital Israelita Albert EinsteinJardim Leonor 05652-900São PauloBrazil department of Orthopedics Foot and Ankle SurgeryUniversity of IowaIowa CityIA 52242United States

BACKGROUND Peroneal tendon disorders are common causes of lateral hindfoot ***,total rupture of the peroneal longus tendon is *** treatment for this condition is usually a side-to-side tenodesis of the peroneal longus tendon to the peroneal brevis *** the traditional procedure involves a long lateral curved incision,this approach is associated with damage to the lateral soft tissues(up to 24%incidence).CASE SUMMARY A 50-year-old female had developed pain at the lateral aspect of the hindfoot 1 mo after an ankle sprain while walking in the *** treatments were anti-inflammatory drugs,ice,rest and Cam-walker *** physical exam,there was pain and swelling over the course of the peroneal *** instability and cavovarus foot deformity were ruled *** strength was weak(4/5).Imaging showed complete rupture of the peroneal longus tendon associated with a sharp hypertrophic peroneal *** repair was indicated after failure of conservative treatment(physiotherapy,rest,analgesics,and ankle stabilizer).A less invasive approach was performed for peroneal longus tendon debridement and side-to-side tenodesis to the adjacent peroneal brevis tendon,with successful clinical and functional *** Peroneus longus tendon tenodesis can be performed through a less invasive approach with preservation of the lateral soft tissue integrity.

关键词： Peroneus longus tendon Complete rupture Tenodesis Minimally invasive surgery Wound breakdown Case report

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Isotropic Double Index for Quantum Errors in One Qubit

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Journal of Chemistry and Chemical Engineering 2011年第11期5卷 1053-1058页

作者： Andre L. fonseca de Ohvelra Efrain Buksman jesus Garcia-Lopez Facultad de Ingenieria Universidad ORT Uruguay Montevideo Uruguay Escuela Universitaria de Informatica Universidad Politecnica de Madrid Madrid Spain

This article describes a proposal for a double index to estimate the isotropic components of unitary errors in a quantum computation circuit. In the context of this work the error is considered isotropic if it has spherical symmetry about the state of interest. The theoretical definition is given, as well the numerical approximation for practical purposes. The index is tested in some simple examples and the geometric distortion of the propagated error is studied for an inaccurate Shor 9-qubits correcting code.

关键词： Isotropic index unitary quantum errors quantum correcting codes

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Fatigue Strength Evaluation of Resin-Injected Bolted Connections Using Statistical Analysis

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Engineering 2017年第6期3卷 795-805页

作者： Jose Antonio fonseca de Oliveira Correia Bruno Alexandre Silva Pedrosa Patricia Cordeiro Raposo Abilio Manuel Pinho de jesus Helena Maria dos Santos Gervisio Grzegorz Stanislaw Lesiukc Carlos Alberto da Silva Rebelo Rui Artur Bartolo Calcada Luis Alberto Proenca Simoes da Silva Faculty of Engineering University of Porto Porto 4200-465 Portugal Institute for Sustainability and Innovation in Structural Engineering (ISISE) Department of Civil Engineering University of Coimbra Coimbra 3030-788 Portugal department of Mechanics Materials Science and Engineering Faculty of Mechanical Engineering Wroclaw University of Technology Wroctaw 50-370 Poland

Different strategies can be used to perform reparations and reinforcements of ancient bolted and riveted metallic bridges. As the riveting process is not currently a common practice, it requires proper equipment and skilled workers. Another solution is the use of welding. However, the weldability of old steels is poor. Bolts are very attractive alternative solutions, and are most commonly used to repair old metallic bridges. Fitted bolts are expensive solutions; the alternative is the use of resin-injected bolts. The behavior of bolted joints with preloaded resin-injected bolts has been studied using quasi-static and creep tests; however, few studies on the slip and fatigue behavior of these joints can be found in the literature. This paper presents an overview of a few experimental programs that were carried out by several authors aiming at evaluating the fatigue behavior of single and double shear resin-injected bolted connections. A comparison between the experimental data of joints with preloaded standard bolts and preloaded resin- injected bolts shows a fatigue strength reduction in the latter. Since Eurocode 3 （EC3） suggests the same fatigue strength curve for joints made of resin-injected bolts and standard bolts, this may raise some con- cerns. Furthermore, research on the feasibility of using both bonded and bolted connections is shown. This last study was performed with high-strength low-alloy structural steel plates and an acrylic struc- tural adhesive for metal bonding. For both case studies, a statistical analysis is performed on fatigue experimental data using linearized boundaries and the Castillo and Fernandez-Canteli model. Fatigue design curves are proposed and compared with the design suggestions of several European and North American standards,

关键词： Fatigue Connections Structural reinforcements Structural adhesives S-N curves Resin-injected bolts

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Vibrio *** Macrobrachium amazonicum prawn farming are inhibited by Moringa oleifera extracts

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Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 899-902页

作者： Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Celia Maria de Souza Sampaio Francisco Geraldo Barbosa Manoel de Araujo Neto paiva Glaucia Morgana de Melo Guedes Lucas Pereira de Alencar Yago Brito de Ponte Tereza de jesus Pinheiro Gomes Bandeira Jose Luciano Bezerra Moreira debora de Souza Collares Maia Castelo-Branco Waldemiro de Aquino Pereira-Neto Rossana de Aguiar Cordeiro Jose Julio Costa Sidrim Marcos Fabio Gadelha Rocha department of Pathology and Legal Medicine Postgraduate Program in Medical MicrobiologySpecialized Medical Mycology CenterFederal University of Ceara School of Veterinary Medicine Postgraduate Program in Veterinary SciencesState University of Ceara department of Organic and Inorganic Chemistry Federal University of Ceara

Objective:To investigate the in vitro antimicrobial potential of extracts of stem,leaves,flowers,pods and seeds of Moringu okifera(***) against Vibrio *** hatchery water and the prawn Mmrobrachium ***:The ethanol extracts of stem,leaves,pods and seeds and chloroform extract of flowers of *** were tested against Vibrio cholerue(***) serogroups non-O1/non-O139(n=4).Vibrio vulnificus(n=l) and Vibrio mimicus(n=1).Escherichia coli(***)(ATCC(?) 25922) was used as quality *** species were obtained from Macmbrachium amazonicum prawns and from hatchery water from prawn *** Minimum Inhibitory Concentration(MIC) was determined by broth microdilution ***:The best result was obtained with the ethanol extract of pods,which inhibited three strains of the ***,Vibrio vulnificus,Vibrio minimis and ***(MIC range 0.312-5.000 mg/mL).The chloroform extract of flowers was effective against all *** strains and ***(MIC range 0.625-1.250 mg/mL).However,the ethanol extracts of stem and seeds showed low effectiveness in inhibiting the bacterial ***:The extracts of pods,flowers and leaves of *** have potential for the control of Vibrio *** studies are necessary to isolate the bioaetive compounds responsible for this antimicrobial activity.

关键词： Prawn Macrobrachium amazonicum Moringa oleifera Vi

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