检索结果-南通市图书馆

Evaluation of antibacterial and toxicological activities of essential oil of ocimum gratissimum *** its major constituent eugenol

引用

Food Bioscience 2022年第6期50卷 2152-2159页

作者： Julio Cesar Silva Raimundo Luiz Silva Pereira Thiago Sampaio de Freitas Janaína Esmeraldo Rocha Nair Silva Macedo Carla de Fatima Alves Nonato Marina Leite Linhares Daniely Sampaio Arruda Tavares Francisco Assis Bezerra da Cunha Henrique Douglas Melo Coutinho Sidney Gonçalo de Lima Francisco Nascimento Pereira-Junior Francisco Paulo Araújo Maia Ivo Cavalcante Pita Neto fabiola fernandes galvão rodrigues George Joaquim Garcia Santos Department of Biological Chemistry Regional University of CaririR.Cel.Antonio Luis 116163105000CratoCEBrazil University Center Doutor Leão Sampaio Av.Leão Sampaio 40063040000Juazeiro do NorteCEBrazil Research and Development Center for Medicines Federal University of CearaR.Coronel Nunes de Melo 100060430275FortalezaCEBrazil Chemistry Department Federal University of PiauiCampus Universitário Ministro Petrônio Portella64049550TeresinaPIBrazil Center for Agricultural and Biodiversity Sciences - CCAB Federal University of CaririCratoCearáBrazil CECAPE - College of Dentistry Juazeiro do NorteCE63024-015Brazil

The present study aimed to comparatively analyze the antibacterial activity,combined with antibiotics,and toxicological activity of the essential oil of *** *** its major compound,*** phytochemical analysis of the essential oil was performed by gas chromatography coupled with mass *** minimum inhibitory concentration and combined antibiotic activity were performed by *** melanogaster was the model organism chosen to evaluate the toxicological response of *** chromatographic assay showed eugenol as the major compound of the essential oil of *** *** microbiological assays showed that in terms of antibacterial activity,both products showed similar activity,quite significant in Gram-negatives,such as those of strains of Pseudomonas *** results were verified in the modulatory activity,allowing the verification that the bioactivity performed by the essential oil of *** *** mainly influenced by its major *** the EC50 of the compounds varied subtly,the essential oil was less toxic compared to *** information obtained in the present study demonstrates that the essential oil of *** *** a promising antibacterial agent and better tolerated than its majority compound alone,in the model organism ***.

关键词： Antibacterial agents Drosophila melanogaster Eugenol ocimum gratisismumum L.essential oils

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2^(V617F)-positive myeloproliferative neoplasm cells

引用

Signal Transduction and Targeted Therapy 2020年第1期5卷 2440-2449页

作者： Bruna Alves Fenerich Jaqueline Cristina fernandes Ana Paula Nunes rodrigues Alves Juan Luiz Coelho-Silva Renata Scopim-Ribeiro Priscila Santos Scheucher Christopher A.Eide Cristina E.Tognon Brian J.Druker Eduardo Magalhães Rego João Agostinho Machado-Neto fabiola Traina Department of Medical Images Hematologyand Clinical OncologyUniversity of Sao Paulo at Ribeirao Preto Medical SchoolRibeirao PretoSao PauloBrazil Center for Cell-Based Therapy Sao Paulo Research FoundationRibeirao PretoSao PauloBrazil Knight Cancer Institute Oregon Health&Science UniversityPortlandORUSA Howard Hughes Medical Institute PortlandORUSA Department of Internal Medicine University of Sao Paulo Medical SchoolSao PauloBrazil Department of Pharmacology Institute of Biomedical Sciences of the University of Sao PauloSao PauloBrazil

Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms(MPN);in this pathway,IRS2 is involved in the malignant transformation induced by JAK2^(V617F),and upregulation of IGF1R signaling induces the MPN ***157,a synthetic compound designed as an IGF1R-IRS1/2 inhibitor,has been shown to induce antineoplastic effects in solid ***,we aimed to characterize the molecular and cellular effects of NT157 in JAK2^(V617F)positive MPN cell lines(HEL and SET2)and primary patient hematopoietic *** JAK2^(V617F)cell lines,NT157 decreased cell viability,clonogenicity,and cell proliferation,resulting in increases in apoptosis and cell cycle arrest in the G2/M phase(pomplex,downregulated four oncogenes(CCND1,MYB,WT1,and NFKB1),and upregulated three apoptotic-related genes(CDKN1A,FoS,and JUN)(potoxic stress in a JAK2/STAT-independent ***157 inhibited erythropoietin-independent colony formation in cells from polycythemia vera patients(pof NT157 action in a MPN context and suggest that targeting IRS1/2 proteins may represent a promising therapeutic strategy for MPN.

关键词： JAK2 IGF1R neoplasms STAT3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nutrients Available and Stable Carbon from Archaeological Black Earth

引用

Journal of Environmental Protection 2021年第11期12卷 873-886页

作者： Antônio Roberto de oliveira Meireles Vanda Porpino Lemos orivan Maria Marques Teixeira Kelly das Graças fernandes Dantas Dantas Marcelly Christian galvão rodrigues Machado Milena Carvalho de Moraes School Tenente Rego Barros Bel&eacute m Brazil College of Chemistry Institute of Exact and Natural Sciences Federal University of Par&aacute Bel&eacute m Brazil Soil and Plant Laboratory Brazilian Agricultural Research Corporation Bel&eacute m Brazil Coordination of Earth Sciences and Ecology Emílio Goeldi Museum of Par&aacute Bel&eacute m Brazil

The present study aims affinity between available concentrations of phosphorus, micronutrients (Cu, Zn and Mn) and stable carbon (SC) in archaeological black earth (ABE) from area “Ilha de Terra”/Caxiuanã—Pará. The relevance of this study refers especially to the determination of carbon concentrations (total, oxidable and semi-labile carbon) directly associated with those of pyrogenic carbon, common in ABE, which should add their contributions to the understanding of soil organic matter recalcitrance. Chemical properties such as CEC and base saturation were determined for ABE and subjacent Latossoil. The available concentrations of nutrients were performed from sequential extraction F1 to F5 phases. Phosphorus was obtained by spectrophotometric method and micronutrients by MP-AES. ToC was determined by the combustion method;stable carbon was obtained from thermoxidation method CTo-375. The following results were obtained from ABE: CEC effective = 21 to 28 (cmolc·L-1);base saturation = 58% to 69%;Carbon concentrations (%): ToC = 2.95 to 3.94;SC = 0.25 to 0.88;semi-labile carbon = 1.75 to 3.63;oxidable = 2.11 to 3.65;inorganic carbon 0.01 to 0.38;P2o5 concentrations (mg·kg-1) in the ABE phases F3 (Fe-Mn oxides, F4 (organic ) and F5 (residual)) in the following order: 35 to 65;200 to 400;140 to 230. It was concluded that the chemical properties in ABE from Ilha de Terra site fall within the range of fertile and the high concentrations of phosphorus are biogenic origin. Phases F3 and F4 are those considered nutrient stocks from ABE studied area.

关键词： Pyrogenic Carbon oxidable Carbon Phosphorus Micronutrients Soil organic Matter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：