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2018年中国地球科学联合学术年会

作者： fabio speranza Bo Zhang Alessandra Pellegrino Siyu Chen Rosanna Maniscalco Catalina Hernandez Moreno Istituto Nazionale di Geofisica e Vulcanologia Roma Peking University Universit? degli Studi di Catania Catania

The Tertiary intra-continental deformation of SE Asia has been classically related to India-Asia collision and consequent Tibet Plateau rise, supposedly yielding the SE-ward drift of wide lithosphe

关键词： Deciphering late Tertiary intra-continental deformation of SE Asia

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2018年中国地球科学联合学术年会

作者：张波王洋 Paul Kapp Peter W.Reiners fabio speranza 张进江陈思雨钟大赉杨烈坤 Peking University Sun Yat Sen University University of Arizona Istituto Nazionale di Geofisica e Vulcanologia Chinese Academy of Sciences

The Diancang shan(DCS) metamorphic complex preserved the kinematic records of the Ailao Shan-Red River shear zone(ARSZ) activities in the western *** well defines an antiformed dome structure in the core complex, bounded by the sinistral ductile shear flanks on the eastern and western *** kinematics of the two vertical shear flanks

关键词： Strike-slip related metamorphic core complex structural constrains in the Ailao Shan-Red River shear zone

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中国云南地区构造与古地磁旋转模式（英文）

中国云南地区构造与古地磁旋转模式（英文）

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2017中国地球科学联合学术年会

作者： fabio speranza 张波 Alessandra G Pellegrino 阴从元陈思雨 Rosanna Maniscalco Catalina Hernandez Moreno Istituto Nazionale di Geofisica e Vulcanologia 北京大学地球与空间科学学院 Università degli Studi di Catania

＜正＞A wealth of paleomagnetic data from Yunnan（China）showed in the past a predominant post-Cretaceous clockwise（CW）rotation pattern,mostly explained invoking huge（hundreds of km wide）blocks laterally escaping（and rotating）due to India-Asia collision,separated by major strike-slip shear *** we report on the paleomagnetism of the

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Early Surgery in Femoral Neck Fractures in Elderly: Does Preoperative ASA Score Matter?

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International Journal of Clinical Medicine 2016年第12期7卷 829-836页

作者： Stefania De Sanctis Raffaella Alonzo Silvia Frontini Ilaria Nicolosi fabio Belvederi Edoardo Monaco Attilio speranza Carmelo D’Arrigo Università di Roma La Sapienza Rome Italy

Introduction: Early surgical treatment (within 48 hours) has been recommended for femoral neck fractures in order to avoid complications and reduce mortality rate, regardless of presence and severity of comorbidity and preoperative status (ASA score). However some studies evidenced that early surgery doesn’t always have a beneficial effect on mortality and complications. Therefore further studies could be useful in order to better assess risk related factors of patients requiring surgical treatment for femoral neck fracture. The purpose of this study is to evaluate the effect of preoperative ASA score and timing of surgery on mortality, complications and clinical outcome. Methods: All 336 patients operated in our center from January 2013 to December 2014 were selected for this retrospective study. Patients were divided in three groups as follows: group 1 patients treated within 48 hours;group 2 patients treated between 48 to 96 hours;group 3 patients treated over 96 hours. The preoperative ASA score was recorded for each patient. Complication, clinical outcome and mortality at one-year follow-up were evaluated. At follow-up ambulation was graded as: confined to bed, assisted ambulation, and normal ambulation. Complications both local (infections, malunion, dislocation) and systemic (deep vein thrombosis, pulmonary embolism, lung infections, ischemic disorders of heart) were recorded as well as number of transfusions. Statistical analysis was performed with chi square test and P value Results: 308 patients’ data were fully available for this study. At one-year follow-up return to normal ambulation was higher for patients of group 1 as compared with group 2 and 3 and in group 2 as compared with group 3 (P = 0.04). There was no difference in mortality and return to ambulation between patients with ASA score 1 and 2 (P = 0.06);patients with ASA score ≥ 3 showed a statistically significant higher mortality (P = 0.004) and rate of complications (0.0008) regardless of timi

关键词： Femur Fractures ASA Score Early Surgery Elderly Hip Surgery

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Targeting monoamine oxidase to dampen NLRP3 inflammasome activation in inflammation

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Cellular & Molecular Immunology 2021年第5期18卷 1311-1313页

作者： Ricardo Sánchez-Rodríguez fabio Munari Roberta Angioni Francisca Venegas Andrielly Agnellini María Paulette Castro-Gil Alessandra Castegna Roberto Luisetto Antonella Viola Marcella Canton Department of Biomedical Sciences University of Padova35131PadovaItaly Fondazione Istituto di Ricerca Pediatrica Cittàdella speranza-IRP 35129PadovaItaly Venetian Institute of Molecular Medicine PadovaItaly Laboratorio de Enfermedades Hepáticas Instituto Nacional de Medicina GenómicaCDMXMexico Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity of BariBariItaly Department of Surgery Oncology and GastroenterologyUniversity of PadovaPadovaItaly

Inflammasomes represent protective weapons against pathogens and cellular damage,although their uncontrolled activation drives the progression of inflammatory,metabolic,and neurodegenerative *** signals activate the NLRP3 inflammasome,and a few studies have reported that mitochondrial reactive oxygen species(ROS)are involved in this ***,the source of mitochondrial ROS and their specific role in NLRP3 triggering are ***,we show that H2O2 produced by the mitochondrial enzyme monoamine oxidase B(MAO-B)plays a nonredundant role in sustaining NLRP3 inflammasome ***,MAO-B-dependent ROS formation caused mitochondrial dysfunction and NF-κB induction,resulting in NLRP3 and pro-IL-1β*** in vitro and in vivo,MAO-B inhibition by rasagiline prevented IL-1βsecretion,and MAO-B-deficient mice showed an impaired response to LPS-mediated *** findings identify MAO-B as a specific producer of mitochondrial ROS fueling the NLRP3 inflammasome,thereby providing a basis for repurposing MAOB inhibitors to treat inflammasome-mediated pathologies.

关键词： NLRP3 inflam impaired

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