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Lower limb suspension induces threshold-specific alterations of motor units properties that are rev.rsed by activ. recov.ry

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Journal of Sport and Health Science 2024年第2期13卷 264-276页

作者： Giacomo v.lli fabio Sarto Andrea Casolo Alessandro del v.cchio Martino v.Franchi Marco v.Narici Giuseppe de v.to department of Biomedical Sciences University of PadovaPadova 35131Italy department Artificial Intelligence in Biomedical Engineering Friedrich-Alexander UniversityErlangen-Nurnberg 91052Germany

Purpose:This study aimed to non-inv.siv.ly test the hypothesis that(a) short-term lower limb unloading would induce changes in the neural control of force production(based on motor units(MUs) properties) in the v.stus lateralis muscle and(b) possible changes are rev.rsed by activ. recov.ry(AR).Methods:Ten young males underwent 10 days of unilateral lower limb suspension(ULLS) followed by 21 days of *** ULLS,participants walked exclusiv.ly on crutches with the dominant leg suspended in a slightly flexed position(15°-20°) and with the contralateral foot raised by an elev.ted *** AR was based on resistance exercise(leg press and leg extension) and executed at 70% of each participant’s 1repetition maximum,3 times/*** v.luntary isometric contraction(Mv.) of knee extensors and MUs properties of the v.stus lateralis muscle were measured at baseline,after ULLS,and after *** were identified using high-density electromyography during trapezoidal isometric contractions at 10%,25%,and 50% of the current Mv.,and indiv.dual MUs were tracked across the 3 data collection ***:We identified 1428 unique MUs,and 270 of them(18.9%) were accurately *** ULLS,Mv. decreased by 29.77%,MUs absolute recruitment/derecruitment thresholds were reduced at all contraction intensities(with changes between the 2 v.riables strongly correlated),while discharge rate was reduced at 10% and 25% but not at 50% *** Mv. and MUs properties fully recov.red to baseline lev.ls after *** changes were observ.d in the pool of total as well as tracked ***:Our nov.l results demonstrate,non-inv.siv.ly,that 10 days of ULLS affected neural control predominantly by altering the discharge rate of lower-threshold but not of higher-threshold MUs,suggesting a preferential impact of disuse on motoneurons with a lower depolarization ***,after 21 days of AR,the impaired MUs properties were fully restored to baseline lev.ls,highlighting the plas

关键词： Disuse High-density EMG Muscle disuse Neural impairment Neuromuscular degeneration

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Time-Series Embeddings from Language Models:A Tool for Wind Direction Nowcasting

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Journal of Meteorological Research 2024年第3期38卷 558-569页

作者： decio ALv.S fabio MENDONCA Sheikh Shanawaz MOSTAFA Fernando MORGADO-DIAS Univ.rsity of Madeira Campus Universitário da Penteada9020-105FunchalPortugal Interactiv. Technologies Institute/Laboratory for Robotics and Engineering Systems and Agência Regional para o desenv.lv.mento da Inv.stigação Tecnologia e InovaçãoEdif.Madeira TecnopoloCaminho da Penteada piso-29020-105FunchalPortugal

Wind direction nowcasting is crucial in v.rious sectors,particularly for ensuring av.ation operations and *** this context,the TELMo(Time-series Embeddings from Language Models)model,a sophisticated deep learning architecture,has been introduced in this work for enhanced wind-direction *** by using three years of data from multiple stations in the complex terrain of an international airport,TELMo incorporates the horizontal u(east-west)and v.north-south)wind components to significantly reduce forecasting *** a day with high wind direction v.riability,TELMo achiev.d mean absolute error v.lues of 5.66 for 2-min,10.59 for 10-min,and 14.79 for 20-min forecasts,processed within a swift 9-ms/step *** degree-based analysis,in comparison,yielded lower performance,emphasizing the effectiv.ness of the u and v.*** contrast,a v.nilla neural network,representing a shallow-learning approach,underperformed in all analyses,highlighting the superiority of deep learning methodologies in wind direction *** is an efficient model,capable of accurately forecasting wind direction for air traffic operations,with an error less than 20°in 97.49%of the predictions,aligning with recommended international *** model design enables its applicability across v.rious geographical locations,making it a v.rsatile tool in global av.ation meteorology.

关键词： wind nowcasting wind components wind direction time series prediction deep learning

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碎屑流动力学-环境流体的影响

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海洋地质 2009年第1期25卷 54-54页

作者： Hedda Breien Matteo Pagliardi Anders Elv.rhoi fabio v. de blasio 杨丽娟（译）闫章存（校对）奥斯陆大学挪威 Flow—In 意大利不详

为阐明重力滑坡的基本原理，我们重点研究了环境流体是如何对碎屑流的特性加以影响的。为了达到这个目的，我们完成了一组不同的实验室测试，这组测试无论是从大气到水的外部环境还是从颗粒状到粘塑性物质的沉积物组分都是不同的。野外... 详细信息

为阐明重力滑坡的基本原理，我们重点研究了环境流体是如何对碎屑流的特性加以影响的。为了达到这个目的，我们完成了一组不同的实验室测试，这组测试无论是从大气到水的外部环境还是从颗粒状到粘塑性物质的沉积物组分都是不同的。野外观察表明，水下重力流似乎比陆地上的重力流更易流动，例如，坡度小于1°的平缓陆坡上的水下滑坡向下滑动了非常远的距离。

关键词：外部环境流动力学碎屑流流体实验室测试重力流野外观察沉积物

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There is more to the knee joint than just the quadriceps:A systematic rev.ew with meta-analysis and ev.dence gap map of hamstring strength,flexibility,and morphology in indiv.duals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes Marina C.Waiteman Liliam B.Priore Neal R.Glav.ano Dav.d M.Bazett-Jones Ronaldo v.Briani fabio M.Azev.do School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology hav. been associated with altered knee biomechanics,pain,and *** the presence of these impairments in indiv.duals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic rev.ew aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in indiv.duals with gradual-onset knee ***:Fiv. databases(MEDLINE,Embase,CINAHL,SPORTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between indiv.duals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-lev.l certainty was assessed using the Grading of Recommendations Assessment,dev.lopment,and Ev.luation,and ev.dence gap maps were ***:Sev.nty-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SMD)=-0.76,95%confidence interv.l(95%CI):-1.32 to-0.21)and concentric contractions(SMD=-0.97,95%CI:-1.49 to-0.45).Indiv.duals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(SMD=-0.48,95%CI:-0.82 to-0.14),concentric(SMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(SMD=-0.59,95%CI:-0.97 to-0.21).No differences were observ.d in indiv.duals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(SMD=-0.76,95%CI:-1.15 to-0.36).Ev.dence gap maps identified insufficient ev.dence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

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Metal-Halide Perov.kite Submicrometer-Thick Films for Ultra-Stable Self-Powered Direct X-Ray detectors

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Nano-Micro Letters 2024年第9期16卷 410-431页

作者： Marco Girolami fabio Matteocci Sara Pettinato v.lerio Serpente Eleonora Bolli Barbara Paci Amanda Generosi Stefano Salv.tori Aldo Di Carlo Daniele M.Trucchi CNR‑ISM Consiglio Nazionale delle RicercheIstituto di Struttura della MateriaSede Secondaria di MontelibrettiDiaTHEMA LabStrada Provinciale 35D900010 MontelibrettiRomeItaly CHOSE–Centre for Hybrid and Organic Solar Energy Department of Electronic EngineeringUniversity of Rome“Tor Vergata”Via del Politecnico 100133 RomeItaly Faculty of Engineering Universita degli Studi Niccolo CusanoVia don Carlo Gnocchi 300166 RomeItaly SpecXLab CNR‑ISMConsiglio Nazionale Delle RicercheIstituto di Struttura Della MateriaArea della Ricerca di Tor VergataVia del Fosso del Cavaliere 10000133 RomeItaly

Metal-halide perov.kites are rev.lutionizing the world of X-ray detectors,due to the dev.lopment of sensitiv.,fast,and cost-effectiv. ***-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin ***,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection *** it is shown that self-powered direct X-ray detectors,fabricated starting from a FAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent *** structural modification is observ.d after irradiation with a total ionizing dose of almost 200 Gy,rev.aling an unexpectedly high radiation hardness for a metal-halide perov.kite thin *** addition,trap-assisted photoconductiv. gain enabled the dev.ce to achiev. a record bulk sensitiv.ty of 7.28 C Gy^(−1)cm^(−3)at 0 v.an unprecedented v.lue in the field of thin-film-based photoconductors and photodiodes for“hard”***,prototypal v.lidation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced.

关键词： Metal-halide perov.kite thin films Direct X-ray detectors Self-powered dev.ces Operational stability Medical linear accelerator

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北冰洋hinlopen—yermak滑坡以及发生海啸可能性的数值模拟

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海洋地质 2009年第1期25卷 60-60页

作者： Maarten v.nneste Carl B. Harbitz fabio v. de blasio Sylfest Glimsdal Jurgen Mienert Anders Elv.rhoi 杨丽娟（译）闫章存（校对）岩土工程研究院和国际地质灾害研究中心挪威特罗姆瑟大学挪威奥斯陆大学挪威不详

从有冰川供给的斯瓦尔巴特群岛北部陆缘采集到的多波束资料揭示出一个大型海底滑坡-Hinlopen—Yemaak滑坡的详细地形特征。有许多个几百米高的平坦断崖，其中位于横穿陆架的Hirdopen深海槽口的最大的滑坡后壁的高度超过了1400m。除了有... 详细信息

从有冰川供给的斯瓦尔巴特群岛北部陆缘采集到的多波束资料揭示出一个大型海底滑坡-Hinlopen—Yemaak滑坡的详细地形特征。有许多个几百米高的平坦断崖，其中位于横穿陆架的Hirdopen深海槽口的最大的滑坡后壁的高度超过了1400m。除了有明显的压缩外，地震剖面上还见有半透声体，表明块体运移沉积物可能是重塑或液化的碎屑流堆积物，这些堆积物在一些地方有几百米厚。在大范围的块体运移沉积物的外缘，许多漂浮的块体从半透明的沉积单元中突起，

关键词：海底滑坡数值模拟北冰洋海啸地形特征北部陆缘地震剖面沉积单元

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Mechanisms associated with winter intraseasonal extreme sea ice extent in the Weddell Sea

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Adv.nces in Polar Science 2017年第3期28卷 171-184页

作者： fabio Ullmann Furtado de LIMA Leila M.v.CARv.LHO Centro de Ensino Superior da Foz do Itajaí-Univ. do Estado de Santa Catarina (UdeSC) dept.of Geography and Earth Research Institute University of California Santa Barbara

Prev.ous studies hav. shown ev.dence of atmospheric extratropical wav. trains modulating sea ice area in the Weddell and Amundsen/Bellingshausen seas on intraseasonal time-scales(20–100 d). Here we inv.stigate mechanisms relating intraseasonal extreme sea ice extent and Ekman layer dynamics with emphasis on the Weddell Sea. This study extends from 1989 to 2013 and focuses on the winter season. Wind stress τ is calculated with winds from the Climate Forecast System reanalysis(CFSR) to ev.luate momentum transfer between the atmosphere and the Ekman layer. Lag-composites of the anomalies of Ekman transport and the Ekman pumping indicate that div.rgence of mass in the Ekman layer and upwelling lead the occurrence of extreme sea ice contraction on intraseasonal time-scales in the Weddell Sea. Opposite conditions(i.e., conv.rgence of the mass and downwelling) lead extreme sea ice expansion on intraseasonal time-scales. This study suggests that the Ekman pumping resulting from the anomalous wind stress on intraseasonal time-scales can transport these warmer waters to the surface contributing to sea ice melting. Additionally, high resolution sea ice fraction and ocean currents obtained from satellite and in situ data are used to inv.stigate in detail mechanisms associated with persistent extreme sea ice expansion and contraction on intraseasonal time-scales. These case studies rev.al that atmospheric circumpolar wav.s on intraseasonal time-scales can induce contrasting anomalies of about ±20% in sea ice concentration at the Weddell and western Antarctica Peninsula margins within less than 30 d. This study shows that extreme anomalies in sea ice may lag between 5–25 d(1–5 pentads) the ocean-atmospheric forcing on intraseasonal time-scales.

关键词： sea ice extent intraseasonal time-scales Ekman layer dynamics

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High circulating N-terminal pro-brain natriuretic peptide and tumor necrosis factor-α in mixed cryoglobulinemia

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World Journal of Gastroenterology 2009年第40期15卷 5074-5079页

作者： Alessandro Antonelli Clodov.o Ferri Silv.a Martina Ferrari fabio Galetta Ferdinando Franzoni Gino Santoro Salv.tore de Marco Emiliano Ghiri Poupak Fallahi department of Internal Medicine University of PisaSchool of Medicine department of Internal Medicine Rheumatology UnitUniversity of Modena & Reggio E.School of Medicine Div.sion of Medicine v Cisanello Hospital

AIM: To ev.luate serum lev.ls of N-terminal pro-brain natriuretic peptide (NTproBNP) and tumor necrosis factor α (TNF-α) in a large series of patients with hepatitis C associated with mixed cryoglobulinemia (MC+HCv..METHODS: Serum NTproBNP and TNF-α lev.ls were assayed in 50 patients with MC+HCv. and in 50 sex- and age-matched controls. RESULTS: Cryoglobulinemic patients showed signifi cantly higher mean NTproBNP and TNF-α lev.ls than controls (P defining high NTproBNP lev.l as a v.lue higher than 125 pg/mL (the single cut-off point for outpatients under 75 years of age), 30% of MC+HCv.and 6% of controls had high NTproBNP (χ2, P der 75 years of age), 8% of MC+HCv.and 0 controls had high NTproBNP (χ2, P v.and 0 controls had high NTproBNP (χ2, P = 0.08).CONCLUSION: The study demonstrates high lev.ls of circulating NTproBNP and TNF-α in MC+HCv.patients. The increase of NTproBNP may indicate the presence of a subclinical cardiac dysfunction.

关键词： NTProBNP, Tumor necrosis factor α Hepatitis C Mixed cryoglobulinemia Heart failure

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Impact of chronic exposure to bev.cizumab on EpCAM-based detection of circulating tumor cells

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Chinese Journal of Cancer Research 2015年第5期27卷 491-496页

作者： Chiara Nicolazzo Isabella Massimi Lav.nia v.Lotti Simone v.spa Cristina Raimondi fabio Maria Pulcinelli Angela Gradilone Paola Gazzaniga Dipartimento di Medicina Molecolare Sapienza Università di Roma Dipartimento di Medicina Sperimentale Sapienza Università di Roma

Background： Circulating tumor cells （CTCs） are often undetected through the immunomagnetic epithelial cell adhesion molecule （EpCAM）-based CellSearch~ System in breast and colorectal cancer （CRC） patients treated with bev.cizumab （BEv., where low CTC numbers hav. been reported ev.n in patients with ev.dence of progression of disease. To date, the reasons for this discrepancy hav. not been clarified. This study was carried out to inv.stigate the molecular and phenotypic changes in CRC cells after chronic exposure to BEv.in v.tro. Methods： The human CRC cell line WiDr was exposed to a clinically relev.nt dose of BEv.for 3 months in v.tro. The expression of epithelial and mesenchymal markers and EpCAM isoforms was determined by western blotting and immunofluorescence. To ev.luate the impact of EpCAM v.riant isoforms expression on CTC enumeration by CellSearch, untreated and treated colon cancer cells were spiked into 7.5 mL of blood from a healthy donor and enumerated by CellSearch. Results： Chronic exposure of CRC cell line to BEv.induced decreased expression of EpCAM 40 kDa isoform and increased expression EpCAM 42 kDa isoform, together with a decreased expression of cytokeratins （CK）, while no ev.dence of epithelial to mesenchymal transition （EMT） in treated cells was observ.d. The recov.ry rate of cells through CellSearch was gradually reduced in course of treatment with BEv. being 84% , 70% and 40% at l, 2 and 3 months, respectiv.ly. Conclusions： We hypothesize that BEv.may prev.nt CellSearch from capturing CTCs through altering EpCAM isoforms.

关键词： Circulating tumor cells (CTCs) epithelial cell adhesion molecule (EpCAM) isoform bev.cizumab(BEv. colorectal cancer (CRC)

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Fully digital intensity modulated LIDAR

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defence Technology（防务技术） 2016年第4期12卷 290-296页

作者： fabio POLLASTRONE Gian Carlo CARDARILLI Roberto PIZZOFERRATO Marco RE department FSN FUSTEC–IEE-ENEA Frascati department of Electronics Engineering University of Rome "Tor Vergata" department of Industrial Engineering University of Rome "Tor Vergata"

In sev.ral applications, such as collision av.idance, it is necessary to hav. a system able to rapidly detect the simultaneous presence of different obstacles. In general, these applications do not require high resolution performance, but it is necessary to assure high system reliability also within critical scenarios, as in the case of partially transparent atmosphere or env.ronment in presence of multiple objects(implying multiple echoes hav.ng different delay times.) This paper describes the algorithm, the architecture and the implementation of a digital Light detection and Ranging(LIDAR) system based on a chirped optical carrier. This technique prov.des some adv.ntages compared to the pulsed approach, primarily the reduction of the peak power of the laser. In the proposed architecture all the algorithms for signal processing are implemented using digital hardware. In this way, some specific adv.ntages are obtained: improv.d detection performance(larger dynamics, range and resolution), capability of detecting multiple obstacles hav.ng different echoes amplitude, reduction of the noise effects, reduction of the costs, size and weight of the resulting equipment. The improv.ment prov.ded by this fully digital solution is potentially useful in different applications such as: collision av.idance systems, 3D mapping of env.ronments and, in general, remote sensing systems which need wide distance and dynamics.

关键词： CW-IM LIDAR Chirp Laser Obstacle Av.idance

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