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High Power Laser Science and Engineering 2016年第2期4卷 14-28页

作者： Mario Ferianis Enrico Allaria Eugenio Ferrari Giulio Gaio Giuseppe Penco fabio rossi Marco Veronese Elettra-Sincrotrone Trieste S.C.p.A.

FERMI, the seeded free electron laser(FEL) in operation in Italy, is providing the User Community with unique fully coherent radiation, in the wavelength range 100–4 nm. FERMI is the first FEL fully synchronized by means of optical fibers. The optical timing system ensures an ultra-stable phase reference to its distributed clients. Several femtosecond longitudinal diagnostics verify the achieved performance; the bunch length monitor(BLM) and the bunch arrival monitor(BAM) will be presented in this paper. Feedback systems play a crucial role to guarantee the needed longterm electron beam stability. A real-time infrastructure allows shot-to-shot communication between front-end computers and the servers. Orbit feedbacks are useful in machine tuning, whereas longitudinal feedbacks control electron energy,compression and arrival time. A flexible software framework allows a rapid implementation of heterogeneous multiinput–multi-output(MIMO) longitudinal loops simply by selecting the appropriate sensors and actuators.

关键词： feedback system femtosecond longitudinal diagnostics optical timing

PGR5-PGRL1-Dependent Cyclic Electron Transport Modulates Linear Electron Transport Rate in Arabidopsis thaliana

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Molecular Plant 2016年第2期9卷 271-288页

作者： Marjaana Suorsa fabio rossi Luca Tadini Mathias Labs Monica Colombo Peter Jahns Martin M. Kater Dario Leister Giovanni Finazzi Eva-Mari Aro Roberto Barbato Paolo Pesaresi Molecular Plant Biology Department of Biochemistry University of Turku 20014 Turku Finland Dipartimento di Bioscienze Unlversit~ degli studi di Milano 20133 Milano Italy Plant Molecular Biology (Botany) Department Biology I Ludwig-Maximilians-Universit~t MSnchen 82152 Planegg-Martinsded Germany Centro Ricerca e Innovazione Fondazione Edmund Mach 38010 San Michele all'Adige Italy Plant Biochemistry Heinrich-Heine-University Dusseldorf Universitstsstrasse 140225 Dusseldorf Germany Laboratoire de Physiologie Cellulaire & Vegetale Unite Mixte de Recherche 5168 Centre National de la Recherche Scientifique 38054 Grenoble France Dipartimento di Scienze dell'Ambiente e della Vita Universita del Piemonte Orientale viale Teresa Michel 11 15121 Alessandria Italy These authors contributed equally to this article

Plants need tight regulation of photosynthetic electron transport for survival and growth under environ- mental and metabolic conditions. For this purpose, the linear electron transport （LET） pathway is supple- mented by a number of alternative electron transfer pathways and valves. In Arabidopsis, cyclic electron transport （CET） around photosystem I （PSI）, which recycles electrons from ferrodoxin to plastoquinone, is the most investigated alternative route. However, the interdependence of LET and CET and the relative importance of CET remain unclear, largely due to the difficulties in precise assessment of the contribution of CET in the presence of LET, which dominates electron flow under physiological conditions. We there- fore generated Arabidopsis mutants with a minimal water-splitting activity, and thus a low rate of LET, by combining knockout mutations in Psb01, PsbP2, PsbQ1, PsbQ2, and PsbR loci. The resulting 45 mutant is viable, although mature leaves contain only ~20% of wild-type naturally less abundant Psb02 protein. 45 plants compensate for the reduction in LET by increasing the rate of CET, and inducing a strong non-photochemical quenching （NPQ） response during dark-to-light transitions. To identify the molecular origin of such a high-capacity CET, we constructed three sextuple mutants lacking the qE component of NPQ （45 npq4-1）, NDH-mediated CET （45 crr4-3）, or PGR5-PGRLl-mediated CET （45 pgrS）. Their analysis revealed that PGR5-PGRLl-mediated CET plays a major role in ~pH formation and induction of NPQ in C3 plants. Moreover, while pgr5 dies at the seedling stage under fluctuating light conditions, 45 pgr5 plants are able to survive, which underlines the importance of PGR5 in modulating the intersystem electron transfer.

关键词： Arabidopsis Photosynthesis Linear Electron Transport Cyclic Electron Transport Oxygen EvolvingComplex PGR5

Driving pressure:A useful tool for reducing postoperative pulmonary complications

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World Journal of Critical Care Medicine 2024年第3期13卷 91-94页

作者： Domenico Posa fabio Sbaraglia Giuliano Ferrone Marco rossi Department of Emergency Intensive Care Medicine and AnaesthesiaFondazione Policlinico Universitario A.Gemelli IRCCSRome 00168LazioItaly

The operating room is a unique environment where surgery exposes patients to non-physiological changes that can compromise lung ***,raising clinicians’awareness of the potential risk of ventilator-induced lung injury(VILI)is *** pressure is a useful tool for reducing lung complications in patients with acute respiratory distress syndrome and those undergoing elective *** pressure has been most extensively studied in the context of single-lung ventilation during thoracic ***,the awareness of association of VILI risk and patient positioning(prone,beach-chair,parkbench)and type of surgery must be raised.

关键词： Ventilator-induced lung injury Protective ventilation Driving pressure Mechanical ventilation Surgery room Single-lung ventilation Operative room Surgery

New insights in the management of the middle hepatic vein dilemma

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 101-102页

作者： Quirino Lai fabio MelANDro Gianluca Mennini Massimo rossi Hepato-Bilio-Pancreatic and Liver Transplant Unit Department of General Surgery and Organ Transplantation Sapienza University of Rome Umberto I Policlinic of Rome

When the first series of adult-to-adult living donor liver transplantation(A2A-LDLT)were performed in Hong Kong[1],it was immediately clear that great technical challenges existed,mainly concerning the middle hepatic ... 详细信息

关键词： New insights middle hepatic vein dilemma

Proximal-distal motor unit number estimationdynamic changes in patients with amyotrophic lateral sclerosis A one-year follow-up

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Neural Regeneration Research 2010年第8期5卷 597-601页

作者： Sartucci Ferdinando Moscato Gianluca rossi Chiara Caleo Matteo Bocci Tommaso Murri Luigi Giannini fabio rossi Alessandro Department of Neuroscience Unit of NeurologyPisa University Medical School Institute of Neuroscience Unit of Neurophysiopathology Pontedera Hospital Pisa Department of Neurological Neurosurgical and Behavioural Sciences Siena University Medical School

BACKGROUND：Amyotrophic lateral sclerosis （ALS） is the most common of all the motor neuron diseases and the absence of a biologic marker has made both diagnosis and tracking evolution of the disease difficult, Electrodiagnostic tests play a fundamental role in quantifying pathological changes in the motor unit ***：We assessed distal-proximal Motor Unit （MU） loss and changes using the method of motor unit number estimation （MUNE）.DESIGN, TIME AND SETTING：A case-control study was performed at the Department of Neuroscience, Pisa University Medical School, Italy from December 1999 to November 2009. PARTICIPANTS：A total of 50 ALS patients were recruited, 30 males：mean age （59.6 ± 13.3） years; 20 females：mean age （63.9 ± 11.7） years; range （30-82） years; all patients had probable or definite ALS. Thirty healthy volunteers were recruited from department staffs, including 20 males and 10 females; mean age （57.7 ± 13.8） years served as ***：MUNE was performed for both the biceps brachii and abductor digiti minimi muscles of the same side. The technique used relayed substantially on manual incremental stimulation of the motor nerve, known as the McComas technique （50 ms sweep duration, a gain of 2 mV/Div for M wave, 0.5 mV/Div for each step; filters 10-20 kHz）.MAIN OUTCOME MEASURES：MUNE results were ***：Functioning MU numbers, measured by MUNE, decreased in the biceps brachii and abductor digiti minimi muscles over the entire one-year follow-up period （one assessment every three months） compared with baseline determination, the rate of MU decrease was similar in both muscles, but steeper ***：MUNE is a feasible method for ALS patients both proximally and distally to track changes over time in muscle MUs during the disease＇s evolution.

关键词： motor unit number estimation amyotrophic lateral sclerosis motor neuron disease time changes denervation reinnervation

Safety,immunogenicity,efficacy,and acceptability of COVID-19 vaccination in people with multiple sclerosis:a narrative review

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Neural Regeneration Research 2023年第2期18卷 284-288页

作者： Fioravante Capone Mariagrazia rossi Alessandro Cruciani Francesco Motolese fabio Pilato Vincenzo Di Lazzaro Neurology Neurophysiology and Neurobiology UnitDepartment of MedicineCampus Bio-Medico of Rome UniversityRomeItaly

In the last two years,a new seve re acute res piratory syndrome coronavirus(SARS-CoV)infection has spread worldwide leading to the death of *** ccination represents the key factor in the global strategy against this pandemic,but it also poses several problems,especially for vulnerable people such as patients with multiple scle *** this review,we have briefly summarized the main findings of the safety,efficacy,and acceptability of Coronavirus Disease 2019(COVID-19)vaccination fo r multiple sclerosis *** the acceptability of COVID-19 vaccines has progressively increased in the last year,a small but significant part of patients with multiple sclerosis still has relevant concerns about vaccination that make them hesitant about receiving the COVID-19 ***,available data suggest that the COVID-19 vaccination is safe and effective in multiple scle rosis patients,even though some pharmacological treatments such as anti-CD20 therapies or sphingosine I-phosphate receptor modulato rs can reduce the immune response to ***,COVID-19 vaccination should be strongly recommended for people with multiple scle rosis and,in patients treated with anti-CD20 therapies and sphingosine I-phosphate receptor modulato rs,and clinicians should evaluate the appropriate timing for vaccine *** studies are necessary to understand the role of cellular immunity in COVID-19 vaccination and the possible usefulness of booster *** the other hand,it is mandatory to learn more about the reasons why people refuse *** would help to design a more effective communication campaign aimed at increasing vaccination coverage among vulnerable people.

关键词： COVID-19 multiple sclerosis SARS-CoV-2 vaccination vaccine

Hypothermic oxygenated perfusion for a steatotic liver graft

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 88-90页

作者： Quirino Lai Franco Ruberto fabio Melandro Zoe Larghi Laureiro Massimo rossi Gianluca Mennini Department of General Surgery and Organ Transplantation Sapienza University of RomeRomeItaly Department of Anaesthesiology Critical Care Medicine and Pain TherapySapienza University of RomeRomeItaly

To the Editor:Donor steatosis represents a well-known risk factor for primary non-function,early allograft dysfunction,and biliary complications after liver transplantation(LT)[1,2].Recently,machine perfusion(MP)technology has been implemented in the clinical practice,with the primary intent to assess the graft quality and to optimize the organ selection process[3].A limited number of articles has been published specifically investigated the role of MP in steatotic livers[4–10],with few of them looking at the role of hypothermic MP.

关键词： perfusion liver graft

Electrical probing of carrier separation in InAs/InP/GaAsSb core-dualshell nanowires

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Nano Research 2020年第4期13卷 1065-1070页

作者： Sedighe Salimian Omer Arif Valentina Zannier Daniele Ercolani Francesca rossi Zahra Sadre Momtaz fabio Beltram Sefano Roddaro Francesco Rossella Lucia Sorba NEST Istituto Nanoscienze-CNR and Scuola Normale SuperiorePiazza S.Silvestro 121-56127 PisaItaly IMEM-CNR Institute Parco Area delle Scienze 37/A43124 ParmaItaly Department of Physics"E.Fermi" Universita di PisaLargo Pontecorvo 31-56127 PisaItaly

We investigate the tunnel coupling between the outer p-type GaAsSb shell and the n-type InAs core in catalyst-free InAs/lnP/GaAsSb core-dualshell *** present a device fabrication protocol based on wet-etching processes on selected areas of the nanostructures that enables multiple configurations of measurements in the same nanowire-based device(***-shell,core-core and core-shell).Low-temperature(4.2 K)transport in the shell-shell configuration in nanowires with 5 nm-thick InP barrier reveals a weak negative differential ***,when the InP barrier thickness is increased to 10 nm,this negative differential resistance is fully *** electrical resistance between the InAs core and the GaAsSb shell,measured in core-shell configuration,is significantly higher with respect to the resistance of the InAs core and of the GaAsSb *** field effect,applied via a back-gate,has an opposite impact on the electrical transport in the core and in the shell *** results show that electron and hole free carriers populate the InAs and GaAsSb regions respectively and indicate InAs/InP/GaAsSb core-dualshell nanowires as an ideal system for the investigation of the physics of interacting electrons and holes at the nanoscale.

关键词： core-dualshell nanowires charge carrier separation semiconductor nanowires nanoelectronics

Interventional treatment options for management of delayed arterial hemorrhage after major hepato-pancreatic-biliary surgery

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 648-649页

作者： Benedetto Ielpo Salvatore Alborino Emmanuel Melloul fabio Salvatori Quirino Lai Massimo rossi Nicolas Demartines Salomone Di Saverio Unidad de Cirugía Hepatobiliopancreática Hospital del MarBarcelonaSpain Interventional Radiology Unit Macerata HospitalMacerataAV4ASUR MarcheItaly HBP and Liver Transplant Surgery Unit Visceral Surgery DeptCHUVUniversity of LausanneLausanneSwitzerland HBP and Liver Transplant Surgery Unit Policlinico Umberto ILa Sapienza University of RomeRomeItaly General Surgery Unit San Benedetto del Tronto HospitalSan Benedetto del TrontoAV5ASUR MarcheItaly

Hilar cholangiocarcinoma is a biliary malignancy arising from the perihilar biliary tree,which is associated with poor oncological outcomes due to its aggressive biology,chemo-resistance and insidious onset[1].As stated by Di Martino et al.,the standard of care is radical resection,and during the last decades,there have been great efforts to improve survival of potentially resectable hilar cholangiocarcinoma,with surgery being the treatment associated with longer survival[2].However,radical resection still represents a challenging operation with high risk of intraoperative and postoperative complications.

关键词： biliary surgery

Donor-to-recipient gender match in liver transplantation: A systematic review and meta-analysis

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World Journal of Gastroenterology 2018年第20期24卷 2203-2210页

作者： Quirino Lai Francesco Giovanardi fabio Melandro Zoe Larghi Laureiro Manuela Merli Barbara Lattanzi Redan Hassan Massimo rossi Gianluca Mennini Hepato-bilio-pancreatic and Liver Transplant Unit Department of Surgery Sapienza University of Rome Division of Gastroenterology Department of Clinical Medicine Sapienza University of Rome

AIM To perform a systematic review and meta-analysis on donor-to-recipient gender mismatch as a risk factor for post-transplant graft loss. METHODS A systematic literature search was performed using PubM ed, Cochrane Library database and EMBASE. The primary outcome was graft loss after liver transplantation. Odds ratios and 95% confidence intervals were calculated to compare the pooled data between groups with different donor-to-recipient gender matches. Three analyses were done considering(1) gender mismatches(F-M and M-F) vs matches(M-M and F-F);(2) Femaleto-Male mismatch vs other matches; and(3) Male-toFemale mismatch vs other *** A total of 7 articles were analysed. Gender mismatch(M-F and F-M) was associated with a significant increase of graft loss respect to match(M-M and F-F)(OR: 1.30; 95%CI: 1.13-1.50; P < 0.001). When F-M mismatch was specifically investigated, it confirmed its detrimental role in terms of graft survival(OR: 1.83; 95%CI: 1.20-2.80; P = 0.005). M-F mismatch failed to present a significant role(OR: 1.09; 95%CI: 0.73-1.62; P = 0.68).CONCLUSION Gender mismatch is a risk factor for poor graft survival after liver transplantation. Female-to-male mismatch represents the worst combination. More studies are needed with the intent to better clarify the reasons for these results.

关键词： Graft survival Female-to-male mismatch Liver transplantation Donor-to-recipient match Gender