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Melatonin restores zinc levels,activates the Keap1/Nrf2 pathway,and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2022年第2期13卷 11-22页

作者： Silvia Bona Sabrina Alves Fernandes Andrea C Janz Moreira Graziella Rodrigues Elizângela G Schemitt fabio cang.ri di naso Cláudio A Marroni Norma P Marroni Medical Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Posgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90040-001Rio Grande do SulBrazil Biological Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Rio Grande do SulBrazil Postgraduate Program in Pneumological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90000-000Rio Grande do SulBrazil

BACKGROUND Melatonin(MLT)is a potent antioxidant molecule that is shown to have a beneficial effect in various pathological situations,due to its action against free *** To evaluate the effect of MLT on carbon tetrachloride(CCl_(4))induced liver injury in rats in terms of oxidative stress,reticular stress,and cell *** Twenty male Wistar rats(230-250 g)were divided into four groups:Control rats,rats treated with MLT alone,rats treated with CCl_(4)alone,and rats treated with CCl_(4)plus ***_(4)was administered as follows:Ten doses every 5 d,ten every 4 d,and seven every 3 *** was administered intraperitoneally at a dose of 20 mg/kg from the 10th wk to the end of the experiment(16th wk).RESULTS MLT was able to reduce the release of liver enzymes in the bloodstream and to decrease oxidative stress in CCl_(4)treated rats by decreasing the level of thiobarbituric acid reactive substances and increasing superoxide dismutase activity,with a lower reduction in serum zinc levels,guaranteeing a reduction in liver damage;additionally,it increased the expression of nuclear factor(erythroid-derived 2)-like 2 and decreased the expression of Kelch-like ECH-associated protein *** also decreased the expression of the proteins associated with endoplasmic reticulum stress,i.e.,glucose-regulated protein 78 and activating transcription factor 6,as well as of heat shock factor 1 and heat shock protein *** MLT has a hepatoprotective effect in an experimental model of CCl_(4)-induced liver injury,since it reduces oxidative stress,restores zinc levels,and modulates endoplasmic reticulum stress.

关键词： Liver injury Cell damage Antioxidant Melatonin Carbon tetrachloride

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鼻咽癌病理组织中CXCR4表达与患者临床病理特征、新辅助化疗疗效及预后的关系

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实用癌症杂志 2021年第8期36卷 1273-1276页

作者：余花艳仓顺东史中州河南省平顶山市第二人民医院 467000 河南省人民医院 450003

目的探究鼻咽癌(NPC)病理组织中趋化因子受体4(CXCR4)表达与患者临床病理特征、新辅助化疗疗效及预后的关系。方法以97例NPC患者为研究对象,以其活检病理癌组织标本作为观察组(n=97),癌旁组织标本作为对照组(n=60)。比较癌组织及癌旁组... 详细信息

目的探究鼻咽癌(NPC)病理组织中趋化因子受体4(CXCR4)表达与患者临床病理特征、新辅助化疗疗效及预后的关系。方法以97例NPC患者为研究对象,以其活检病理癌组织标本作为观察组(n=97),癌旁组织标本作为对照组(n=60)。比较癌组织及癌旁组织中CXCR4表达情况,并分析癌组织中CXCR4表达情况与患者临床病理特征、化疗疗效以及生存情况的关系。结果CXCR4在观察组中阳性表达率显著高于在对照组中的阳性表达率(46.39%vs.15.00%,P0.05);而TNM分期为Ⅲ期及Ⅳ期、淋巴结转移、化疗效果为疾病稳定(SD)以及疾病进展(PD)的NPC患者癌组织中的CXCR4阳性表达率显著高于阴性表达率(P<0.05)。癌组织中CXCR4表达阳性的鼻咽癌患者治疗后3年生存率、3年无进展生存率显著低于CXCR4表达阴性的鼻咽癌患者(57.78%vs.96.15%,40.00%vs.71.15%P<0.05)。结论NPC癌组织中CXCR4表达水平高于癌旁组织,且与患者临床病理特征、化疗效果及生存时间密切相关。

关键词：鼻咽癌趋化因子受体4 新辅助化疗生存时间病理特征预后

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闭合式入路自体肋软骨颗粒移植隆鼻术的临床效果观察

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中国美容整形外科杂志 2021年第9期32卷 528-531页

作者：苏永鹏苏日跃韦昌延钦州市第一人民医院烧伤整形外科广西钦州535000

目的探讨采用闭合式入路行自体肋软骨颗粒移植隆鼻手术的美学效果的优势。方法回顾自2019年6月至2020年9月,钦州市第一人民医院烧伤整形外科收治的86例要求行鼻整形手术患者的临床资料,将接受闭合式入路自体肋软骨颗粒移植隆鼻术的44例... 详细信息

目的探讨采用闭合式入路行自体肋软骨颗粒移植隆鼻手术的美学效果的优势。方法回顾自2019年6月至2020年9月,钦州市第一人民医院烧伤整形外科收治的86例要求行鼻整形手术患者的临床资料,将接受闭合式入路自体肋软骨颗粒移植隆鼻术的44例患者设为观察组;接受膨体聚四氟乙烯假体置入隆鼻术的42例患者设为对照组。比较两组手术前后鼻面角、鼻额角、鼻尖凸度、鼻唇角的变化和统计学意义,以及两组术后并发症的发生率和患者的满意度。结果术后6个月随访时,两组的鼻唇角、鼻面角比较其差异无统计学意义(P>0.05);而鼻额角和鼻尖凸度观察组较对照组改善明显,其差异具有统计学意义(P0.05)。术后3个月和6个月随访时,观察组患者的满意度明显高于对照组,其差异具有统计学意义(P<0.05)。结论采用闭合式入路行自体肋软骨颗粒移植隆鼻术具有塑造鼻背、鼻尖形态,可达到与e-PTFE假体同样支撑力的优势,且患者满意度较高,值得临床推广应用。

关键词：隆鼻术自体肋软骨颗粒闭合式入路膨体聚四氟乙烯效果观察

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio di Micco Ran ding Siqin dingl Yadong ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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