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Nonalcoholic fatty liver disease, spleen and psoriasis:New aspects of low-grade chronic inflammation

World Journal of Gastroenterology 2015年第22期21卷 6892-6897页

作者： Nicola Balato Maddalena Napolitano fabio ayala Cataldo Patruno Matteo Megna Giovanni Tarantino Department of Dermatology Federico II University of Naples Department of Clinical Medicine and Surgery Medical School Federico II University of Naples National Cancer Institute "Pascale Foundation " IRCS

AIM: To investigate spleen status in psoriasis and itsrelationship with hepatic steatosis, Psoriasis Area and Severity Index, and insulin ***: Seventy-nine psoriatic patients who were not suffering from any chronic inflammatory disease were retrospectively selected for inclusion in this study,and their complete medical records were *** age- and sex-matched group of 80 non-psoriatic,obese patients was included as a control. The following relevant data were collected: age, sex, weight, height,body mass index, waist circumference, blood pressure,insulin resistance status, age at psoriasis onset, and severity of psoriasis. Abdominal ultrasonography was performed to determine spleen longitudinal diameter(SLD), and hepatic steatosis ***: The SLD of control obese patients was greater than that of psoriatic subjects(P = 0.013),but body mass index predicted the size of the spleen in psoriatic patients(P < 0.001). The SLD of psoriatic patients with normal weight was significantly reduced with respect to the overweight/obese psoriatic patients(P = 0.002). A multiple regression analysis revealed that body mass index was a unique predictor of the spleen size(P < 0.001). Finally, the disease duration predicted the spleen size in psoriatic subjects(P =0.038).CONCLUSION: This study shows a correlation between the SLD and the duration of psoriasis.

关键词： Hepatic steatosis Inflammation nonalcoholicfatty liver disease Psoriasis Spleen size

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