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Journal of Biosafety and Biosecurity 2024年第1期6卷 16-26页

作者： Alina CTeuscher Charlotte Ruhnau Nicole Stöcklin fabienne Wichmann Evelyn Ilg Hampe Claudia Bagutti State Laboratory Basel-City Biosafety LaboratoryBaselSwitzerland Novatis Lichtstrasse 354056 BaselSwitzerland1 IQVIA AG Kirschgartenstrasse 144051 BaselSwitzerland1 Becton Dickinson AG Binningerstrasse 944123 AllschwilSwitzerland1

Laboratory wastewater has been suggested as an important escape route for microorganisms from research *** reasons for the unintentional release of laboratory organisms are shortcomings in the handling of infectious liquid biological waste(LBW)and inadequate inactivation *** developed an analytical approach to investigate the use of chemical inactivation(CI)procedures in Swiss research laboratories by on-site random sampling of presumably inactivated infectious LBW and testing it for the presence of infectious lentiviruses(HIV-1)and adenoviruses(AdV).In addition,standard operating procedures(SOPs)for CI were collected and evaluated,and laboratorystaff knowledge of CI processes was assessed using a *** we found several deficiencies in the technical knowledge and training of laboratory staff on the CI of LBW,as documented by 27 returned questionnaires,no infectious viruses were detected in the eight LBW samples *** we acknowledge that the number of LBW samples and SOPs is small,we conclude that CI of LBW containing infectious lentiviruses and adenoviruses does not result in the systematic release of considerable amounts of infectious viruses into the environment from research laboratories in Switzerland.

关键词： Chemical inactivation Infectious liquid biological waste Lentivirus(HIV-1) Adenovirus

Interest of thoracic ultrasound after cardiac surgery or interventional cardiology

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World Journal of Cardiology 2024年第3期16卷 118-125页

作者： Martin Boussuges Philippe Blanc fabienne Bregeon Alain Boussuges Service de Pneumologie Centre Hospitalier Universitaire Sud ReunionSaint Pierre 97410Ile de la ReunionFrance Department of Cardiac and Pulmonary Rehabilitation Ste Clotilde&YlangYlang Rehabilitation CenterSainte Clotilde 97491Ile de la ReunionFrance Service d’Explorations Fonctionnelles Respiratoires Centre Hospitalier Universitaire NordAssistance Publique des Hôpitaux de MarseilleMarseille 13015France Institut Hospitalo-Universitaire-Méditerranée Infection Aix Marseille UniversitéMarseille 13005France Center for Cardiovascular and Nutrition Research Aix Marseille UniversitéInstitut National de la Santéet de la Recherche MédicaleInstitut National de Recherche pour l’Agriculturel’Alimentation et l’EnvironnementMarseille 13005France

Thoracic ultrasound has attracted much interest in detecting pleural effusion or pulmonary consolidation after cardiac *** 2016,Trovato reported,in the World Journal of Cardiology,the interest of using,in addition to echocardiography,thoracic *** this editorial,we highlight the value of assessing diaphragm function after cardiac surgery and interventional cardiology *** factors are able to impair diaphragm function after such *** motion may be decreased by chest pain secondary to sternotomy,pleural effusion or impaired muscle *** paralysis may be secondary to phrenic nerve damage complicating cardiac surgery or atrial fibrillation *** may be ***,respi-ratory troubles induced by diaphragm dysfunction are frequently attributed to pre-existing heart disease or pulmonary complications secondary to *** addition,elevated hemidiaphragm secondary to diaphragm dysfunction is sometimes not observed on chest X-ray performed in supine position in the intensive care *** of diaphragm function by ultrasound during the recovery period appears *** hemidiaphragms can be studied by two complementary ultrasound *** mobility of each hemidiaphragms is measured by M-mode *** addition,recording the percentage of inspiratory thickening provides important information about the quality of muscle *** two approaches make it possible to detect hemidiaphragm paralysis or *** a diagnosis is important because persistent diaphragm dysfunction after cardiac surgery has been shown to be associated with adverse respiratory *** respiratory physio-therapy is able to improve respiratory function through strengthening of the inspiratory muscles *** and accessory inspiratory muscles.

关键词： Ultrasonography Diaphragm Phrenic nerve Hemidiaphragm Thickening fraction Physiotherapy

3D Modelling of Thermal Replication for Designing Progressive Glass Moulds

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New Journal of Glass and Ceramics 2013年第1期3卷 34-42页

作者： Dominique Lochegnies Philippe Moreau fabienne Hanriot Patrick Hugonneaux ESSILOR International Saint- Maur-des Fosses Paris France ESSILOR International Saint- Maur-des Fosses Paris France. Pole de Recherches et d’Enseignement Supérieur Université Lille Nord de France Lille France

Worldwide, ESSILOR International provides customers with Progressive Addition Lenses (PAL), which replace bifocal lenses. Thermal replication is one process to produce glass moulds for PAL, using sagged glass on a ceramic slumping block. In this paper, thermal replication for producing PAL glass moulds is developed through 3D modelling and experimentation. Our numerical approach is validated by comparing it with experimentation on the global 3D topology of the sagged glass. It is also validated by using more severe optical comparison criteria, developed by ESSILOR International to analyze the conformity of their products. Through modelling, the thermal replication is analyzed by studying the evolving contact between the sagged glass and the ceramic slumping block during the thermal cycle and the glass flow on the upper side of the sagged glass.

关键词： Aspherical Lens Finite Element Model Precision Glass Forming Thermal Replication Metrology

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《语法结构中的致使研究》述评

现代外语 2016年第1期39卷 141-144页

作者：周晓君 Bridget Copley fabienne Martin 浙江大学

致使范畴是国内外语言学界的研究热点之一，不论是传统语法、结构主义语言学还是生成语言学，都对其有着浓厚的研究兴趣。《语法结构中的致使研究》结合语言学、哲学和心理学，把致使范畴纳入更为广阔的视野进行考察，让我们进一步了解... 详细信息

致使范畴是国内外语言学界的研究热点之一，不论是传统语法、结构主义语言学还是生成语言学，都对其有着浓厚的研究兴趣。《语法结构中的致使研究》结合语言学、哲学和心理学，把致使范畴纳入更为广阔的视野进行考察，让我们进一步了解了致使概念是如何通过致使意义得以表达，而致使意义又是如何通过语法结构得以实现的，其成果揭示了致使范畴研究的最新动向。本文拟对该书内容做一简单介绍和简要评述。

关键词：语法结构生成语言学结构主义语言学述评致使范畴传统语法范畴研究国内外

An atypical NLR gene confers bacterial wilt susceptibility in Arabidopsis

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Plant Communications 2023年第5期4卷 277-294页

作者： Choghag Demirjian Narjes Razavi Gang Yu Baptiste Mayjonade Lu Zhang Fabien Lonjon Fabien Chardon Se bastien Carrere Je rome Gouzy Ste phane Genin Alberto PMacho Fabrice Roux Richard Berthome fabienne Vailleau LIPME Universite de ToulouseINRAECNRSCastanet-TolosanFrance Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghaiChina Universite Paris-Saclay INRAEAgroParisTechInstitut Jean-Pierre Bourgin(IJPB)78000 VersaillesFrance Present address:Department of Cell&Systems Biology University of TorontoTorontoONCanada Present address:Department of Biology NYU12 Waverly PlaceNew YorkNY 10003USA

Quantitative disease resistance(QDR)remains the most prevalent form of plant resistance in crop fields and wild ***-wide association studies(GWAS)have proved to be successful in deciphering the quantitative genetic basis of complex traits such as *** unravel the genetics of QDR to the devastating worldwide bacterial pathogen Ralstonia solanacearum,we performed a GWAS by challenging a highly polymorphic local mapping population of Arabidopsis thaliana with four *** type III effector(T3E)mutants,identified as key pathogenicity determinants after a first screen on an *** core collection of 25 *** most quantitative trait loci(QTLs)were highly specific to the identity of the T3E mutant(ripAC,ripAG,ripAQ,and ripU),we finely mapped a common QTL located on a cluster of nucleotide-binding domain and leucine-rich repeat(NLR)genes that exhibited structural *** functionally validated one of these NLRs as a susceptibility factor in response to ***,named it Bacterial Wilt Susceptibility 1(BWS1),and cloned two alleles that conferred contrasting levels of *** characterization indicated that expression of BWS1 leads to suppression of immunity triggered by different *** *** addition,we showed a direct interaction between BWS1 and RipAC T3E,and BWS1 and SUPPRESSOR OF G2 ALLELE OF skp1(SGT1b),the latter interaction being suppressed by ***,our results highlight a putative role for BWS1 as a quantitative susceptibility factor directly targeted by the T3E RipAC,mediating negative regulation of the SGT1-dependent immune response.

关键词： Ralstonia solanacearum typeⅢeffectors Arabidopsis thaliana GWAS R gene susceptibility

A Consistent Set of Thermodynamic Data for Iron and Reevaluation of Green Rusts and Fougerite Solubilities

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Journal of Environmental Science and Engineering(A) 2016年第8期5卷 383-396页

作者： Jihaine Ben Nacib Guilhem Bourrie Bechir Ben Thayer fabienne Trolard UMR 1114- INRA-University of Avignon Avignon 84419 France Superior School of Rural Equipment Engineers of Mdjez el Bab Medjez-el-Bab 9070 Tunisia

Over the last ten years, several comprehensive reviews of iron thermodynamics data were published. This work aims to：（i） propose a consistent set of Gibbs free energies （AfG~） of ferrous hydroxide, Fe（OH）*** and of synthetic Green rusts I and II; （ii） check the consistency of the data of these isostructural compounds by means of a correlation obtained with electronegativities of the anions. Experimental data are concentrations in aqueous solutions and pH, and must be processed to obtain ionic activity products （lAP）. The model of Specific Interaction Theory （SIT） was used here. Firstly, some complexes whose existences are doubtful were removed from the SIT database. The new modified database is given here. Secondly, experimental data were processed. Thirdly, the following relation of regression between Gibbs free energies of formation of Green rusts and normalized Allred-Rochow electronegativities of anions was obtained as： △fG0 = -488.354 -353.11 （x/n）, r = -0.994. This relation was then used to assess the Gibbs free energy of formation for GR1-OH, simply written as Fe3（OH）7.

关键词： Fe database Green rusts ferrous hydroxide fougerite Specific Interaction Theory geochemistry.

Immunosuppression for in vivo research： state-of-the-at protocols and experimental approaches

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Cellular & Molecular Immunology 2017年第2期14卷 146-179页

作者： Rita Diehl fabienne Ferrara Claudia Müller Antje Y Dreyer Damian D McLeod Stephan Fricke Johannes Boltze Fraunhofer-lnstitute for Cell Therapy and Immunology Leipzig 04103 Germany Institute of Vegetative Physiology Charite University Medicine and Center for Cardiovascular Research Berlin 10115 Germany University of Newcastle Callaghan NSW 2308 Australia Fraunhofer Research Institution for Marine Biotechnolegy and Institute for Medical and Marine Bietechnolegy University of LObeck LObeck 23562 Germany These authors contributed equally to this work

Almost every experimental treatment strategy using non-autologous cell, tissue or organ transplantation is tested in small and large animal models before clinical translation. Because these strategies require immunosuppression in most cases, immunosuppressive protocols are a key element in transplantation experiments. However, standard immunosuppressive protocols are often applied without detailed knowledge regarding their efficacy within the particular experimental setting and in the chosen model species. Optimization of such protocols is pertinent to the translation of experimental results to human patients and thus warrants further investigation. This review summarizes current knowledge regarding immunosuppressive drug classes as well as their dosages and application regimens with consideration of species-specific drug metabolization and side effects. It also summarizes contemporary knowledge of novel immunomodulatory strategies, such as the use of mesenchymal stem cells or antibodies. Thus, this review is intended to serve as a state-of-the-art compendium for researchers to refine applied experimental immunosuppression and immunomodulation strategies to enhance the predictive value of preclinical transplantation studies.

关键词： animal models immunomodulation immunosuppression transplantation translational research

Understand SLE heterogeneity in the era of omics,big data,and artificial intelligence

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Rheumatology & Autoimmunity 2021年第1期1卷 40-51页

作者： Prianka Puri Simon H.Jiang Yang Yang fabienne Mackay Di Yu Kidney Health Service Royal Brisbane and Women's HospitalBrisbaneQueenslandAustralia The University of Queensland Diamantina Institute Faculty of MedicineThe University of QueenslandWoolloongabbaQueenslandAustralia Department of Immunology and Infectious Disease John Curtin School of Medical ResearchActonAustralian Capital TerritoryAustralia Centre for Personalised Immunology NHMRC Centre for Research ExcellenceActonAustralian Capital TerritoryAustralia Department of Renal Medicine The Canberra HospitalGarranAustralian Capital TerritoryAustralia QIMR Berghofer Medical Research Institute in Brisbane QLD HerstonQueenslandAustralia

Systemic lupus erythematosus(SLE)is a systemic autoimmune disease characterized by extraordinary heterogeneity,due to the complex pathogenesis and diverse *** of patients for therapy and prognosis represents a major challenge to manage *** biomarkers for disease diagnosis and activity assessment provide very limited insight into immunological pathogenesis and therapeutic response *** advancement of“omics”technologies including genomics,transcriptomics,proteomics,and metabolomics has constituted an unprecedented opportunity to characterize the immunopathological landscape in individual patients with ***,genomic studies reveal a subset of SLE patients carrying one or more functional single nucleotide polymorphisms(SNPs)underlying immune dysregulation while transcriptomic studies have revealed subgroups in SLE patients showing distinct signatures for Type I interferon(TI-IFN)pathway activation or aberrant differentiation of B cells into plasma *** review will summarize results from the latest studies using omics technology to understand SLE *** addition,we propose that the application of artificial intelligence,such as by machine learning-based nonlinear dimensionality reduction method uniform manifold approximation and projection(UMAP)can further strengthen the analysis of omics big *** combination of new technology and novel analysis pipeline can lead to breakthroughs in stratifying SLE patients for a better monitoring of disease activity and more precise design of treatment regime,not only for conventional immunosuppression but also novel immunotherapies targeting B-cell activating factor(BAFF),TI-IFN,and interleukin 2(IL-2).

关键词： classification genomics metabolomics proteomics transcriptomics

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“冰桶挑战赛”——关注渐冻人！

英语学习 2014年第12期 8-11页

作者： fabienne Faur

在2014年炎热的夏天，一桶冰水当头泼下，微软的比尔·盖茨、Facebook的扎克伯格跟桑德伯格、亚马逊的贝索斯、苹果的库克全都在镜头中被冰水浇遍全身。这些硅谷的科技人，飞蛾扑火似地牺牲演出，其实全为了慈善。该活动旨在让更多人知... 详细信息

在2014年炎热的夏天，一桶冰水当头泼下，微软的比尔·盖茨、Facebook的扎克伯格跟桑德伯格、亚马逊的贝索斯、苹果的库克全都在镜头中被冰水浇遍全身。这些硅谷的科技人，飞蛾扑火似地牺牲演出，其实全为了慈善。该活动旨在让更多人知道被称为“渐冻症”的罕见疾病，同时也达到募款帮助治疗的目的。

关键词：挑战赛 Facebook 贝索斯亚马逊盖茨微软库克苹果

博士制造者:“我在职场上推了那些饭桶一把”

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学习博览 2013年第4期 42-43页

作者： fabienne Hurst

又有新的活儿来了。企业经济学，用英文，200页，四星期内完成。克里斯蒂安·阿尼西戴着眼镜，围着围巾，穿着套头毛衣和舒适的家居拖鞋，坐在自己的小房间里。这是法兰克福的一个合租公寓，他的房间非常简陋：一张床，一张书桌和一个... 详细信息

又有新的活儿来了。企业经济学，用英文，200页，四星期内完成。克里斯蒂安·阿尼西戴着眼镜，围着围巾，穿着套头毛衣和舒适的家居拖鞋，坐在自己的小房间里。这是法兰克福的一个合租公寓，他的房间非常简陋：一张床，一张书桌和一个装满了书的壁橱。壁橱中，一排古典文学书旁放着文件夹和法律书籍。现在他喜欢看小说和戏剧，以前一般看专业书。“14岁那年，我想要的圣诞礼物是尼采的书。”33岁的他说。

关键词：制造者职场博士企业经济学克里斯蒂法兰克福圣诞礼物文件夹