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Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers

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World Journal of Gastroenterology 2008年第7期14卷 1053-1059页

作者： Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre fabienne escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur Centre de RechercheJean-Pierre Aubert-JPARC INSERM U837Equipe Mucinesdifférenciation et cancérogenèseépithélialesLaboratoire deBiochimie et Biologie MoléculaireCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Laboratoire d'Anatomie et CytologiePathologiques CHRU de LilleLilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Service de Chirurgie Digestiveet GénéraleCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Laboratoire d'Anatomie et Cytologie PathologiquesCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837and Laboratoire de Biochimie etBiologie MoléculaireCHRU de LilleLilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Laboratoire de Biochimie et Biologie MoléculaireCHRU de LilleLilleFrance Laboratoire d'Immunologie et GénétiqueTunis-ElManarTunisie Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837LilleFrance Laboratoire de Biochimie et Biologie Moléculaire CHRU de LilleLilleFrance Centre de RechercheJean-Pierre Aubert-JPARC INSERM U837Equipe Mucinesdifférenciation et cancérogenèseépithélialesLaboratoire de Biochimie et Biologie MoléculaireCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance present address INSERMU843 Université Paris 7Hpital R.DebréParisFrance

AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal ***:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal *** effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and ***:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal ***:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer.

关键词： Epidermal growth factor receptor Microsatellite instability Allelic imbalance Gene polymorphism Expression Colorectal cancer

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Towards Specifications for Automatic Recognition Software:An Example of a User-Centred Design

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Journal of Software Engineering and Applications 2013年第10期6卷 1-4页

作者： Sylvain Fleury Eric Jamet Emilie Loup-escande Achraf Ghorbel Aurélie Lemaitre Eric Anquetil Centre de Recherche en Psychologie Cognition et Communication(CRPCC)University of Rennes 2RennesFrance Institut de Recherche en Informatique et Systèmes Aléatoires(IRISA) INSA Campus de BeaulieuRennesFrance

This article describes a user-centred method used to design innovative pattern recognition software for technical paper documents. This kind of software can make some errors of interpretation. It will therefore be important that human operators are able to identify and correct these mistakes. The identification of errors is a difficult task because operators need to establish co-reference between the initial document and it interpretation. Moreover, users must be able to checks the interpretation without forgetting any area. This task requires the interface is easy to use. The experiments showed that the sequential display of interpretation is the most effective and that the interruptions by user reduce task duration. Moreover, queries by the system may improve error detection. This paper summarizes the main results of the research conducted in the context of this design for enhance the interface, and describes the specifications to which it gave rise.

关键词： User-Centred Design Interpretation of Document Error Detection

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中国书画中的“手”

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亚太艺术 2017年第1期 94-104页

作者： [法]幽兰翟月(译) 法国国家科学研究院法国高等社会科学院艺术与语言研究所不详

手,象形字,发音为shǒu,在中国书画中指的是手的活动,与精神活动相对。手尤其与手工艺有关。手同样指动作、活动,比如,在表示“开始工作”的下手,或表示“实际操作”方面的“技术”甚至是“灵活性”的手法等词中。在实践中,手持毛笔并... 详细信息

手,象形字,发音为shǒu,在中国书画中指的是手的活动,与精神活动相对。手尤其与手工艺有关。手同样指动作、活动,比如,在表示“开始工作”的下手,或表示“实际操作”方面的“技术”甚至是“灵活性”的手法等词中。在实践中,手持毛笔并运用自如,这样毛笔便成了身体和心思的假体。

关键词：中国书画手工艺象形字毛笔灵活性

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Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent

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World Journal of Gastroenterology 2007年第16期13卷 2312-2318页

作者： S Desplat-Jégo C Johanet A escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel CHU de la Conception Marseille 13005 France CHU Saint-Antoine Paris France CHU Saint-Eloi Montpellier France CHU Hautepierre Strasbourg France CHU Lyon-Sud Pierre-Bénite France CHU Dijon France CHU Timone Marseille France Hpital Trousseau Paris France CHU Nord Marseille 13005 France Laboratoire Luxembourgeois d’Immunopathologie Esch-sur-Alzette Luxembourg. Services de gastro-entérologie et pédiatrie France

AIM： Anti-Saccharomyces anti-nuclear associated cerevisiae antibodies （ASCA）, anti-neutrophil antibodies （NANA） and antibodies to exocrine pancreas （PAB）, are serological tools for discriminating Crohn＇s disease （CrD） and ulcerative colitis （UC）. Like CrD, coeliac disease （COD） is an inflammatory bowel disease （IBD） associated with （auto） antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS： Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence （IIF）. RESULTS： ASCA＋/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active *** were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION： ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value.

关键词： Inflammatory bowel disease Coeliac disease Anti-Saccharomyces cerevisiae antibodies Anti-neutrophil cytoplasmic antibodies Anti-pancreatic antibodies

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儿童重症急性胰腺炎接受天冬酰胺酶治疗后的多中心回顾性研究

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 20-20页

作者： Laugel V. escande B. Entz-Werle N. 刘健

Asparaginase is frequently used in the treatment of lymphoblastic malignancies in children and is a major cause of drug-induced acute pancreatitis. Severe cases of iatrogenic pancreatitis are uncommon but potentially lethal, and represent a diagnostic and therapeutic challenge. Patients and method. -We have retrospectively collected pediatric cases of severe acute pancreatitis induced by asparaginase, having occurred since January 1996 in participating centers from France and Belgium. Results. -Eleven patients, between four and 15 years old, have been included. Pancreatitis has been observed in all treatment phases, after 6 to 21 doses of asparaginase, 2 to 16 days after the last injection. Circulatory collapse (5/11), insulin-dependent diabetes (6/11) and pancreatic pseudokysts (7/11) were the major complications. Non-surgical treatment mainly included digestive rest, broad-spectrum antibiotic therapy and prolonged use of morphine. Asparaginase has been eventually reintroduced in three cases, and has caused a recurrence of pancreatitis in two of them. Conclusion. -Intensive supportive management should enable a favourable outcome in most cases of acute pancreatitis induced by asparaginase in children. There is no way to predict the occurrence of this adverse event. Re-use of asparaginase should probably be ruled out.

关键词：儿童重症天冬酰胺酶淋巴母细胞胰腺假性囊肿休息状态最后一次支持疗法循环衰竭广谱抗生素调查方法

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