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Physical-Chemical and Mechanical Characterization of the Bast Fibers of <i>triumfetta cordifolia</i>***. from the Equatorial Region of Cameroon

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Journal of Minerals and Materials Characterization and Engineering 2020年第4期8卷 163-176页

作者： Armel Edwige Mewoli César Segovia fabien Betene Ebanda Atangana Ateba Pierre Marcel Anicet Noah Benoit Ndiwe Abel Emmanuel Njom Department of Mechanical Engineering ENSET University of Douala Douala Cameroon Laboratory of Mechanics University of Douala Cameroon Douala Cameroon CEtELOR University of Lorraine CETELOR/27 rue Philippe SEGUIN Epinal France Laboratory of Mechanics Materials and Modelization National School of AGRO-Industrial Sciences (ENSAI) Physics Application and Engineering Ngaoundere University Ngaoundere Cameroon Laboratory of Mechanics Materials Structures and Integrated Manufacturing National Advanced School of Engineering University of Yaounde 1 Yaounde Cameroon

the project consists in the implementation of a biocomposite based on tannin resin and natural rubber matrices with the bast fibres of triumfetta cordifolia ***.“Okong” from the equatorial region of Cameroon as reinforcement. A study of this still little known fibre is necessary. this paper evaluates the physico-chemical and mechanical characteristics of the fibers. the fibers are extracted by us. A series of experiments is conducted for this purpose: morphological observation with a scanning electron microscope (SEM);density evaluation with a helium pycnometer;absorption rate evaluation according to the protocol available in the literature, Fourier transform Infrared Spectrometry (Ft-IR), chemical composition evaluation according to AStM 1972 and AStM 1977 standards, thermogravimetric analysis (tGA) and tensile tests on fiber bundles according to NF t25-501-3. the results show that the fiber is made up of several elementary fibers with oval cross-sections. A density of 1.477g/cm3 close to that of hemp. these fibers have a water absorption rate of 342.5%, which correlates with the presence of free hydroxyl functional groups obtained from the spectrometry study (Ft-IR). Chemical analysis reveals that the fiber is made up of celluloses (44.4%), hemicelluloses (30.8%), lignins (18.9%), pectins (3.3%), waxes (0.5%) and minerals (2.1%). In addition, we learn that the fibers studied dehydrate at 11.49%, showinga notable thermal stability around 235°C with a peak thermal decomposition of cellulose located at 420°C. In terms of mechanical behaviour, the results reveal that the fibers offer a Young’s modulus in traction of 12.4 ± 6.9 GPa, a tensile strength of 526 ± 128 MPa and an elongation at break of 2.25%. the information thus obtained makes it possible to place these fibers in the same fiber group as flax and jute. they could therefore be used for the same types of applications. they also inform us that these fibers can withstand the temperat

关键词： triumfetta cordifolia Fibers Morphology Chemical Analysis thermal Degradation Mechanical Behavior

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8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2152-2175页

作者： Damijan Knez Daniel Diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic fabien Chantegreil Florian Nachon Xavier Brazzolotto Anna Skrzypczak-Wiercioch Ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga Saat Julia Serrano Ana Patricia Fernández Aitana Sánchez-García Ricardo Martínez-Murillo Claudia Binda Francisco López-Muoz Stanislav Gobec JoséMarco-Contelles University of Ljubljana Faculty of PharmacyLjubljana 1000Slovenia Laboratory of Medicinal Chemistry(Institute of Organic Chemistry CSIC)Madrid 28006Spain Departamento de Química Orgánicay Química Inorgánica Alcaláde HenaresMadrid 28871Spain Department of Biology and Biotechnology University of PaviaPavia 27100Italy Département de toxicologie et Risques Chimiques Institut de Recherche Biomédicale des ArméesParis 91220France Department of Animal Anatomy and Preclinical Sciences University Centre of Veterinary Medicine JU-UAUniversity of Agriculture in KrakowKrakow 30-059Poland Institute of Biochemistry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Pharmacodynamics Chair of PharmacodynamicsFaculty of PharmacyJagiellonian University Medical CollegeKrakow 30-688Poland Department of translational Neurobiology Neurovascular Research GroupCajal Institute(CSIC)Madrid 28002Spain Biotechnology and Vegetal Biology Department Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Health Camilo JoséCela University of Madrid(UCJC)Neuropsychopharmacology Unit“Hospital 12 de Octubre”Research InstituteMadrid 28692Spain

We describe the development of quinolylnitrones(QNs)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h BChE)and monoamine oxidases(hMAO-A/B)for the therapy of neurodegenerative *** identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available *** 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition,yet unexpectedly showed potent inhibition of h BChE(IC50=1.06±0.31 nmol/L)and h MAO-B(IC_(50)=4.46±0.18μmol/L).the crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding,which was further studied by enzyme *** 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's *** addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and ***,chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19.

关键词： Quinolylnitrone Butyrylcholinesterase Monoamine oxidase B Alzheimer's disease Multifunctional ligands 6-Hydroxydopamine model Passive avoidance task Novel object recognition

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Characterization of the Activity, Mineralogy and Correlations between the Properties of Clayey Soils

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Journal of Minerals and Materials Characterization and Engineering（矿物质和材料特性和工程） 2022年第5期

作者： louis ahouet sorel dzaba brice dublin mbossa elenga sylvain ndinga okina fabien t. kimbatsa2

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State of Knowledge on Starch as an Alternative Solution to Petrochemical Resources—A Review

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Journal of Minerals and Materials Characterization and Engineering（矿物质和材料特性和工程） 2023年第2期

作者： Jonas Peequeur Essome Mbang Pierre Marcel Anicet Noah Laurent Libog téclaire Ngoup Michel Mbere taoga fabien Betene Ebanda

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外周神经病理性疼痛的病理生理学：免疫细胞和分子机制

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麻醉与镇痛 2008年第5期4卷 78-88页

作者： Michael A. thacker Anna K. Clark fabien Marchand Stephen B. McMahon 娄景盛(译) 徐波(译) 邓小明(校) Neurorestoration group Wolfson Centre for Age Related Diseases Academic Department of Physiotherapy Kings College London London Pain Consortium London UK 不详

外周神经系统损伤常常导致慢性神经病理性疼痛，其特征表现为自发痛、痛觉过敏以及痛觉异常。这种疼痛状态常使患者极度虚弱且难以治疗。虽然人们一般认为炎性疼痛和神经病理性疼痛综合征的本质是不同的，但是显现出来的一些现象却与这... 详细信息

外周神经系统损伤常常导致慢性神经病理性疼痛，其特征表现为自发痛、痛觉过敏以及痛觉异常。这种疼痛状态常使患者极度虚弱且难以治疗。虽然人们一般认为炎性疼痛和神经病理性疼痛综合征的本质是不同的，但是显现出来的一些现象却与这一严格的分类不符。炎症极具特征性，涉及一系列不同的免疫细胞，如肥大细胞、中性粒细胞、巨噬细胞以及t淋巴细胞。此外，这些细胞还释放多种致痛复合物。最近研究表明，免疫细胞在外周神经病理性疼痛中起到了一定作用。本综述阐述了不同类型免疫细胞在外周神经病理性疼痛中的作用，及其致痛过程中释放出来的一些关键因子。

关键词：慢性神经病理性疼痛免疫细胞病理生理学分子机制神经系统损伤疼痛综合征中性粒细胞 t淋巴细胞

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米洛德住宅

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城市环境设计 2016年第5期 70-77页

作者：威尼·马斯雅各布·凡·里斯娜塔莉·德·弗里斯 Ignacio Borrego Stefan Witteman Guillermo Reynes Pedro García Martinez Gabriela Bojalil Antonio Lloveras Nieves Mestre Marjolijn Guldemond fabien Mazenc Dagmar Niecke Renzo Leeghwater Florian Jenewein Rob't Hart

欧洲边界的开放直接导致了西班牙房地产的繁荣。土地价格大幅上升,随之迎来了住宅建筑的大规模生产。在马德里,这一情形被围绕在老城周边的巨型新建住宅区所进一步推动。这一系列新城主要以围绕内部庭院的形式建造,形成街区,而且几乎都... 详细信息

欧洲边界的开放直接导致了西班牙房地产的繁荣。土地价格大幅上升,随之迎来了住宅建筑的大规模生产。在马德里,这一情形被围绕在老城周边的巨型新建住宅区所进一步推动。这一系列新城主要以围绕内部庭院的形式建造,形成街区,而且几乎都是开窗较小的内向型建筑。这种形态与西班牙传统的热情奔放的文化相冲突。圣齐纳若是坐落在马德里东北边的一个新城,四周环绕着高速公路,并可以观赏到瓜达拉玛山脉的美景。

关键词：住宅洛德街区平面图图(数学)

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Lymphadenectomy for Colorectal Cancer: Experience of the Brazzaville teaching Hospital

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Surgical Science 2022年第3期13卷 79-90页

作者： Pierlesky Elion Ossibi Murielle Etiennette Julie Note Madzele Noé Hensnel Motoula Latou Didace Massamba Miabaou Prude Pertinie Avala Jile Florient Mimiesse-Monamou Arnaud Mongo-Onkouo Rody Stéphane Ngami fabien Gael Mouamba Eliane Ndounga Alexis Fortuné Bolenga Liboko Régis Franck Moyikoua Freznel Ngoma Mabonzo Apendi Philestine Clausina Ahoui Gilbert Fabrice Otiobanda Blaise Irénée Atipo Ibara Department of Digestive Surgery Brazzaville Teaching Hospital Brazzaville Congo Department of Gastroenterology Brazzaville Teaching Hospital Brazzaville Congo Anatomy and Pathological Cytology Department Brazzaville Teaching Hospital Brazzaville Congo Department of Oncology Brazzaville Teaching Hospital Brazzaville Congo Department of Radiology Brazzaville Teaching Hospital Brazzaville Congo Department of Intensive Care Brazzaville Teaching Hospital Brazzaville Congo

Introduction: Lymph node (LN) metastasis are important biomarkers in the resection of colorectal cancer translating into accurate disease staging. It is therefore obvious that lymph node dissection in the curative treatment of colorectal cancer is a prognostic factor that influences survival and guides management strategy. this study aims to evaluate lymph node dissection in colorectal cancers (CRC) managed at the teaching Hospital, Brazzaville, Congo. Patients and Method: We carried out a descriptive prospective study during a period of 18 months from October 2020 to March 2021 involving patients who underwent curative treatment for colorectal cancer at the visceral surgery department of the Brazzaville teaching Hospital. Results: thirty (30) cases of CRC were recorded out of 738 hospitalizations in the visceral surgery departments, which constitute 4.06% of the in-patient activity of the department during the period under study. Mean age was 55.13 years and a male predominance was observed with a sex ratio of 1.14. Colonic involvement was predominant in our series and was found in 22 of the patients. 25 patients underwent surgical resection while 5 patients could not undergo operative treatment. 17 out of the 25 patients underwent curative treatment, 6 were offered palliative care, whereas surgical abstention was decided in 2 patients. the average number of lymphadenectomies per patient was 16.43. Lymphadenectomy was greater than or equal to 12 in 88% of patients. Nine patients had vascular emboli whereas 10 patients had perineural invasion. the tumor was staged as t3 in 15 patients;six patients had a negative lymph node and 11 patients had at least one lymph node invasion. Distant metastasis status could not be determined in 10 patients. Conclusion: Lymphadenectomy is a hallmark in the curative treatment of colorectal cancer as it allows for optimal staging. this represents a strong prognostic factor that defines adjuvant therapy and overall patient outcome.

关键词： Lymphadenectomy Surgery Cancer Colorectal

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低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验

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英国医学杂志中文版 2019年第2期22卷 123-123页

作者： Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) 不详北京大学第一医院

背景调节性t(tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活tregs细胞,因此ld-IL2具有广泛的治疗潜力。... 详细信息

背景调节性t(tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的tregs细胞均被特异性地扩增激活,而效应t细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCt01988506.

关键词：白细胞介素-2 自身免疫疾病临床疗效临床试验低剂量自身免疫性疾病免疫学免疫表型分析

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