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Ursolic Acid Derivatives Induced Apoptosis and Reduces the NF-κB in Human Lung Adenocarcinoma Cells

Journal of Cancer Therapy 2019年第10期10卷 863-876页

作者： Elaine Carlos Scherrer Ydia Mariele Valadares Caio Cesar Souza Alves Gabriella Freitas Ferreira Marcela Pereira Leao Jessica Aline Soares Fernando Sa Silva Alessandra Paula Carli Oswaldo Cardoso Jr. fabiana simao machado Sandra Bertelli Ribeiro Castro Life Sciences Institute Federal University of Juiz de ForaGovernador ValadaresMGBrazil Faculty of Medicine Federal University of the Valleys of Jequitinhonha and MucuriTeofilo OtoniMGBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo HorizonteMGBrazil

Lung cancer is the major cause of death in the neoplastic diseases. In spite of the advances in the chemotherapy, the lung cancer treatments are still complex and costly, being necessary the seeking of new drugs. In this context, the ursolic acid (UA) becomes the target of studies that investigate its antitumor potential and, thus, structural modifications can enhance its biological activities. Eight UA semisynthetic derivative compounds (UAD1-8) were synthesized and evaluated their cytotoxic activity against human alveolar adenocarcinoma cells (A549). UAD1, UAD3, UAD5, UAD6 and UAD8 were able to reduce the viability of the A549 cells. Only UAD1 and UAD6 reduced the viability at 24 h, and only UAD3 didn’t reduce the NF-κB expression. The compound UAD1 showed the greater apoptosis induction. Moreover, the compound UAD1 showed better results than UA in all assays. The present study shows, for the first time, the action of these compounds in the apoptotic effect, in the expression of NF-κB and in the A549 cell line. The ursolic acid derivatives showed substantial results in the apoptosis, cytotoxicity and NF-κB inhibition of A549 cells, and further studies are necessary for the development of possible new therapeutic drugs.

关键词： Ursolic Acid Apoptosis NF-κB A549 Cells Tumoral

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Thought in Motion:Helena Buescu's The Experience of the Uncommon and Good Neighborhood:Comparative Literature and World Literature

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Journal of Foreign Languages and Cultures 2023年第1期7卷 38-42页

作者： simao Valente University of Porto-ILCML

An analysis of Helena Buescu's book The Experience of the Uncommon and Good Neighborhood:Comparative Literature and World Literature,published in Portuguese by Porto Editora,is undertaken as the best way of introducing her work to an international readership.A pride of place is given to the broadening of the concept of world literature as well as to the importance of translation.

关键词： Helena Buescu world literature comparative literature concept of literary canon translation

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The Geochemical Characteristics and Minerogenic Model for the Amo Hypothermal Tin Deposit in Ximeng County, Yunnan Province

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Acta Geologica Sinica(English Edition) 1991年第3期65卷 271-287页

作者： Zhao Daxian Tang Guangting The Fifth Geological Party, Yunnan Bureau of Geology and Mineral Resources, simao,Yunnan Liu Linqun The Fifth Geological Party Yunnan Bureau of Geology and Mineral Resources Sirnao Yunnan

Through studies on the element geochemistry, alteration of country rocks, ore-forming fluids and isotopegeochemistry of the Arno tin deposit in the metamorphic rocks of the Upper Proterozoic Ximeng Group, theauthors consider that the concentration of the B-F-Li-Rb-Cs-Sn association is related to acidic magmatism inthe study area. The Fe-Mg-Li tourmaline in the ore is the replaced product of the country rocks byhypothermal fluid. The δ^(18)O values of mineral separates are +2.01- +13.16‰ and their δ^(34)S values, +2.6-+7.2‰. The ore-forming materials were derived from hydrothermal fluid of granitic magma. For themineralization, the temperature is 450°-350℃, the pressure, 450-1000×10~5 Pa, and the age, Himalayan(21.5 Ma). According to the geochemical characteristics, a minerogenic model is established: the deposit is ahypothermal cassiterite-quartz vein type tin deposit controlled by the hidden Himalayan granites.

关键词： The Geochemical Characteristics and Minerogenic Model for the Amo Hypothermal Tin Deposit in Ximeng County Yunnan Province

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Trends in in ovo sexing technologies:insights and interpretation from papers and patents

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2239-2262页

作者： Matthias Corion simao Santos Bart De Ketelaere Dragana Spasic Maarten Hertog Jeroen Lammertyn KU Leuven BIOSYST-MeBioS Biosensors GroupWillem de Croylaan 42Leuven B‑3001Belgium. KU Leuven BIOSYST-MeBioS Biostatistics GroupKasteelpark Arenberg 30Leuven B‑3001Belgium. KU Leuven BIOSYST-MeBioS Postharvest GroupWillem de Croylaan 42Leuven B‑3001Belgium.

Numerous researchers and institutions have been developing in ovo sexing technologies to improve animal welfare by identifying male embryos in an early embryonic stage and disposing of them before pain *** review gives a complete overview of the technological approaches reported in papers and patents by performing a thorough search using Web of Science and Patstat/Espacenet databases for papers and patents,*** on a total of 49 papers and 115 patent families reported until May 2023 worldwide,11 technology categories were defined:6 non-optical and 5 optical *** category was described for its characteristics while assessing its potential for ***,the dynamics of the publications of in ovo sexing techniques in both paper and patent fields were described through growth curves,and the interest or actual status was visualized using the number of paper citations and the actual legal status of the *** comparing the reported technologies in papers to those in patents,scientific gaps were observed,as some of the patented technologies were not reported in the scientific literature,e.g.,ion mobility and mass spectrometry ***,more diverse approaches in all categories were found in patents,although they do require more scientific evidence through papers or industrial adoption to prove their ***,although there is a recent trend for non-invasive techniques,invasive methods like analyzing DNA through PCR or hormones through immunosensing are still being reported(and might continue to be)in papers and *** was also observed that none of the technologies complies with all the industry requirements,although 5 companies already entered the *** the one hand,more research and harmony between consumers,industry,and governments is *** the other hand,close monitoring of the market performance of the currently available techniques will offer valuable insights into the potential an

关键词： Animal welfare In ovo sexing Male day-old chick culling Optical and non-optical techniques Patents and papers

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Novel Air Purification System for Installation in Air Handling Units： Development, Assembly and Experimental Analysis

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Journal of Chemistry and Chemical Engineering 2013年第9期7卷 885-891页

作者： Rafael simao Ferreira de Sousa Department of Mechanical Engineering University of Minho Guimaraes 4800-058 Portugal Research & Development Department Vieira Lopes Braga 4700-152 Portugal

Nowadays, people pass 90% of their time in closed spaces, therefore, an increasing care in the creation and upkeep of healthier environments as a personal and as professional level become a major issue. The present project has as goal the verification and optimization of the implicit need of an OCRAMclima~ AHU （air handling units） in IAQ （indoor air quality） and its effectiveness in treatment and/or air purification, having as basis the legal national and European requirements for IAQ. This work was based on the study of the state of the art of the techniques in air purification and in the evaluation of their performance, culminating in the production of the prototype OCRAMclima~ NPS （nano purifying system）. The purifying phenomena involved are UVGI （ultraviolet germicidal irradiation） and catalytic ionization of air. The performance test was accomplished in a closed loop circuit, which results, obtained by an independent IAQ analyst, were satisfactory, indicating the viability of application of this system to indoor air disinfection. The outcome revealed that the conjugating of both phenomena, the air sterilizing by UV and catalytic ionization, is efficient when used for air purification, mainly for volatile organic compounds and bioaerosols.

关键词： Indoor air quality ultraviolet germicidal irradiation catalytic ionization titanium dioxide air microbiologicalpurification volatile organic compounds oxidation.

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Effects of mRNA, Protein Expression and Activity for Myocardial SOD2 by a Single Bout of or Long-Term Strenuous Endurance Exercise in Rats

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Chinese Medicine 2014年第4期5卷 251-258页

作者： simao Xu Weichun Liu Minhua Li Department of Physical Education Guangxi Normal University Guilin China

Objective: To explore the effects of myocardial SOD2 by strenuous endurance exercise. Methods: 27 grown male SD rats were randomly divided into control group (C), a single bout of strenuous endurance exercise group (E1) and seventh-week strenuous endurance exercise group (E2). Real-time PCR was used to observe the changes of mRNA expression for myocardial SOD2. Western bolt was used to observe the changes of SOD2 protein expression. In addition, SOD2, T-SOD and SOD1 activity changes were observed. Results: Myocardial SOD2 expression level at mRNA and protein of Group E1, E2 was significantly higher than that in group C, and SOD2 and T-SOD activity in group E2 were significantly higher than those in group C. Those changes were more obvious in group E2. Conclusions: Strenuous endurance exercise can improve level of myocardial SOD2 expression at mRNA and protein, and enhance the activity for SOD2, thus increasing the activity for T-SOD. Effect of long-term strenuous endurance exercise was better than a single bout of one.

关键词： SOD2 Strenuous Endurance Exercise Myocardia

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Getting a Grip on Lost Luggage

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当代外语研究 2002年第5期 10-12页

作者： Paul simao 严凼杉

在美国的阿拉巴马,有一处游人如织的好去处。不是因为什么风景名胜,而是因为在那里能淘到真正价廉物美的东西。更令人吃惊的是,那里出售的东西都是观光客(sightseers)遗失的行李——作者将它们戏称为sight unseen items。生意人真会动脑... 详细信息

在美国的阿拉巴马,有一处游人如织的好去处。不是因为什么风景名胜,而是因为在那里能淘到真正价廉物美的东西。更令人吃惊的是,那里出售的东西都是观光客(sightseers)遗失的行李——作者将它们戏称为sight unseen items。生意人真会动脑筋,此举不仅使自己盈利,让买主捡到大便宜。而且还繁荣了当地的其他服务业。即便在9.1l之后,任何一件无人认领的行李都会引起机场一片恐慌的情势下,Unclaimed Baggage的老板还是相信他的生意不会夭折。

关键词： Getting a Grip on Lost Luggage

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Individuals with Spinal Cord Injury in Rehabilitation:Quality of Life Study

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Open Journal of Medical Psychology 2017年第2期6卷 66-75页

作者： Ana Jessica simao Anabela Sousa Pereira Department of Education and Psychology CIDTFFCINTESISUniversity of AveiroAveiroPortugal

Among the various types of disability that can affect humans, spinal cord injury (SCI) is undoubtedly one of the most devastating. This type of injury is a disruptive incident in the individual’s life, entails significant changes and requires a biopsychosocial adaptation. The following research aims to contribute to the study about the quality of life in individuals with SCI. The sample was composed of 36 individuals with SCI, inpatients of the Portuguese Central Region Center of Rehabilitation Medicine-Rovisco Pais, aged between 20 and 82 years old (M = 53.56, SD = 18.27). Participants completed a sociodemographic and clinical information questionnaire and measures of functioning independence and quality of life. The results indicate that individuals with SCI present a good perception of quality of life, which is promising of psychological adaptation. The results highlight the need for health professionals and family/caregivers to acquire knowledge which facilitates the process of adaptation to the clinical condition consequently contributing to the health and well-being of individuals with SCI.

关键词： Spinal Cord Injury Quality of Life Rehabilitation

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Nicotinic cholinergic receptors in esophagus:Early alteration during carcinogenesis and prognostic value

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World Journal of Gastroenterology 2016年第31期22卷 7146-7156页

作者： Marina Chianello Nicolau Luis Felipe Ribeiro Pinto Pedro Nicolau-Neto Paulo Roberto Alves de Pinho Ana Rossini Tatiana de Almeida simao Sheila Coelho Soares Lima Departamento de Bioquímica Instituto de Biologia Roberto Alcantara GomesUniversidade do Estado do Rio de Janeiro Programa de Carcinogênese Molecular Instituto Nacional de CancerCoordenacao de Pesquisa Gastroenterologia Hospital Universitário Pedro ErnestoUniversidade do Estado do Rio de Janeiro

AIM: To compare expression of nicotinic cholinergic receptors(CHRNs) in healthy and squamous cell carcinoma-affected esophagus and determine the prognostic ***: We performed RT-q PCR to measure the expression of CHRNs in 44 esophageal samples from healthy individuals and in matched normal surrounding mucosa, and in tumors from 28 patientsdiagnosed with esophageal squamous cell carcinoma(ESCC). Next, we performed correlation analysis for the detected expression of these receptors with the habits and clinico-pathological characteristics of all study participants. In order to investigate the possible correlations between the expression of the different CHRN subunits in both healthy esophagus and tissues from ESCC patients, correlation matrices were generated. Subsequently, we evaluated whether the detected alterations in expression of the various CHRNs could precede histopathological modifications during the esophageal carcinogenic processes by using receiver operating characteristic curve analysis. Finally, we evaluated the impact of CHRNA5 and CHRNA7 expression on overall survival by using multivariate ***: CHRNA3, CHRNA5, CHRNA7 and CHRNB4, but not CHRNA1, CHRNA4, CHRNA9 or CHRNA10, were found to be expressed in normal(healthy) esophageal mucosa. In ESCC, CHRNA5 and CHRNA7 were overexpressed as compared with patient-matched surrounding non-tumor mucosa(ESCC-adjacent mucosa; P < 0.0001 and P = 0.0091, respectively). Positive correlations were observed between CHRNA3 and CHRNB4 expression in all samples analyzed. Additionally, CHRNB4 was found to be differentially expressed in the healthy esophagus and the normalappearing ESCC-adjacent mucosa, allowing for distinguishment between these tissues with a sensitivity of 75.86% and a specificity of 78.95%(P = 0.0002). Finally, CHRNA5 expression was identified as an independent prognostic factor in ESCC; patients with high CHRNA5 expression showed an increased overall survival, in comparison with those

关键词： Nicotinic cholinergic receptors Esophagus Esophageal squamous cell carcinoma Tobacco Alcohol Gene expression

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Treatment of 86 Cases of Auditory Vertigo with Acupuncture

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中国针灸 1995年第S2期15卷 268-270页

作者： Wang Guangding Wang Hen Liu Jia(Attached Hospital of Yunnan TCM College Red Cross of China,Yunnan simao)

Ｔｒｅａｔｍｅｎｔｏｆ８６ＣａｓｅｓｏｆＡｕｄｉｔｏｒｙＶｅｒｔｉｇｏｗｉｔｈＡｃｕｐｕｎｃｔｕｒｅ￥ＷａｎｇＧｕａｎｇｄｉｎｇ；ＷａｎｇＨｅｎ；ＬｉｕＪｉａ（ＡｔｔａｃｈｅｄＨｏｓｐｉｔａｌｏｆＹｕｎｎａｎＴＣＭＣ... 详细信息

Ｔｒｅａｔｍｅｎｔｏｆ８６ＣａｓｅｓｏｆＡｕｄｉｔｏｒｙＶｅｒｔｉｇｏｗｉｔｈＡｃｕｐｕｎｃｔｕｒｅ￥ＷａｎｇＧｕａｎｇｄｉｎｇ；ＷａｎｇＨｅｎ；ＬｉｕＪｉａ（ＡｔｔａｃｈｅｄＨｏｓｐｉｔａｌｏｆＹｕｎｎａｎＴＣＭＣｏｌｌｅｇｅＲｅｄＣｒｏｓｓｏｆＣ...

关键词： Acupuncture

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