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Diagnosis and Treatment of Clear Cell Hidradenocarcinoma of the Scalp

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第6期32卷 931-936页

作者：舒凯肖群根 fabian Büchele 张所军蒋伟雷霆 Department of Neurosurgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Lab of Molecular Neurosurgery Stereotactic and Functional Neurosurgery of Albert-Ludwigs University

Clear cell hidradenocarcinoma (CCH) is an exceedingly rare and highly malignant tumor of the eccrine sweat glands. Its treatment is extremely difficult due to the characteristically aggressive clinical course including repeated local recurrence and uncontrollable distal metastasis coming along with a very poor prognosis. Most published case studies recommend a wide surgical excision followed by adjuvant conservative therapy, which is generally considered to be the standard treatment. Two cases of nodular CCH of the scalp either presenting as a singular primary lesion or at an already metastatic stage were analyzed retrospectively. Wide local excision of the tumor couldn’t prevent the primary carcinoma from recurring and metastasizing. Both cases received various therapies but the results were unsatisfactory. Although most authors have recommended that early wide surgical excision of the tumor is a feasible therapeutic measurement, our results raise doubts on the efficacy of this treatment strategy. As alternative approaches (i.e. chemotherapy, radiotherapy) are similarly controversial, further studies and a wide exchange of clinical experiences are crucial.

关键词： hidradenocarcinoma scalp diagnosis treatment

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AI如何助力提高人类表现

商学院 2024年第1期 14-14页

作者： fabian Gaessler Henning Piezunka 庞培法布拉大学经济与商业系宾夕法尼亚大学沃顿商学院

宾夕法尼亚大学沃顿商学院最近的研究揭示了AI(人工智能)训练和增强人类表现的能力,特别是在复杂的战略互动中要了解AI如何培训企业员工并提高绩效,不妨先回顾一下过去。国际象棋计算机一直处于AI的前沿,体现在复杂性和模仿人类思维过... 详细信息

宾夕法尼亚大学沃顿商学院最近的研究揭示了AI(人工智能)训练和增强人类表现的能力,特别是在复杂的战略互动中要了解AI如何培训企业员工并提高绩效,不妨先回顾一下过去。国际象棋计算机一直处于AI的前沿,体现在复杂性和模仿人类思维过程的能力两个基本方面。我们的分析表明,使用国际象棋计算机可以加快棋手的学习速度,并为棋手带来竞争优势,不过AI系统必须超越棋手的技术水平,才能提供有效的训练,否则,棋手就能预测AI的棋步,会限制训练价值。

关键词：宾夕法尼亚大学沃顿商学院人工智能技术水平国际象棋思维过程 AI 战略互动

All-dielectric silicon metalens for two-dimensional particle manipulation in optical tweezers

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Photonics Research 2020年第9期8卷 1435-1440页

作者： TEANCHAI CHANTAKIT CHRISTIAN SCHLICKRIEDE BASUDEB SAIN fabian MEYER THOMAS WEISS NATTAPORN CHATTHAM AND THOMAS ZENTGRAF Department of Physics Faculty of ScienceKasetsart UniversityBangkok 10900Thailand College of Advanced Manufacturing Innovation King Mongkut’s Institute of Technology LadkrabangBangkok 10520Thailand Department of Physics Paderborn UniversityWarburger Str.10033098 PaderbornGermany 4th Physics Institute and Research Center SCoPE University of StuttgartPfaffenwaldring 5770569 StuttgartGermany

Dynamic control of compact chip-scale contactless manipulation of particles for bioscience applications remains a challenging endeavor,which is restrained by the balance between trapping efficiency and scalable *** offer the implementation of feasible optical tweezers on a planar platform for shaping the exerted optical force by a microscale-integrated *** we design and experimentally demonstrate a highly efficient silicon-based metalens for two-dimensional optical trapping in the *** metalens concept is based on the Pancharatnam–Berry phase,which enables the device for polarization-sensitive particle *** optical trapping setup is capable of adjusting the position of both the metasurface lens and the particle chamber freely in three directions,which offers great freedom for optical trap adjustment and ***-dimensional(2D)particle manipulation is done with a relatively low-numerical-aperture metalens(NA(ML)=0.6).We experimentally demonstrate both 2D polarization-sensitive drag and drop manipulation of polystyrene particles suspended in water and transfer of angular orbital momentum to these particles with a single tailored *** work may open new possibilities for lab-on-a-chip optical trapping for bioscience applications and microscale to nanoscale optical tweezers.

关键词： particle trapping dimensional

Forestry projections for species diversity-oriented management:an example from Central Europe

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Ecological Processes 2018年第1期7卷 244-261页

作者： Astor Toraño Caicoya Peter Biber Werner Poschenrieder fabian Schwaiger Hans Pretzsch Chair of Forest Growth and Yield Science Center of Life and Food Sciences WeihenstephanTechnische Universität MünchenHans-Carl-von-Carlowitz 2D-85354 FreisingGermany

Introduction:Changes in socio-economy and climate are affecting the demand of wood products *** the same time,society requires that forest supporting structures like biodiversity are maintained and preserved while the demand for wood products is also *** support systems,like forest simulation models,that are able to analyze connections as well as quantify trade-offs between forest structure management and biodiversity indicators are highly ***,such models are generally developed for the local plot or stand scale only and ecosystem-scale analyses are *** this study,we analyzed ways to interpret results from the single-tree forest simulator SILVA from the local to the ecosystem *** also analyzed the impacts of forest management on biodiversity using two species diversity indicators,the species profile index and the species intermingling,for scenarios adapted from the GLOBIOM model in the case study“Augsburg Western Forests”,a high productive region in *** order to evaluate diversity tendencies across the ecosystem,we applied a moving window ***:The relevance of scale for the interpretation of management effects on species diversity was shown and clear differences between scenarios *** differences between scenarios were particularly visible when comparing the two diversity indicators,especially because the species profile index focuses on vertical and horizontal information and the species intermingling focuses mainly on horizontal *** a multifunctional scenario,biodiversity values could be preserved at all scales in the vertical ***,under a bio-energy-oriented scenario diversity at the local scale was reduced,although at the ecosystem level,and only in the horizontal dimension,diversity remained at relatively high ***:With this work,we can conclude that integrative modeling,with multiple scenarios,is highly needed to support forestry decision m

关键词： Forest model Multifunctional forestry Growing window GLOBIOM

An approach for the coupled simulation of machining processes using multibody system and smoothed particle hydrodynamics algorithms

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Theoretical & Applied Mechanics Letters 2013年第1期3卷 44-50页

作者： fabian Spreng Peter Eberhard Florian Fleissner Institute of Engineering and Computational Mechanics University of Stuttgart

The prediction accuracy of a simulation method is limited by its theoretical background. This fact can lead to disadvantages regarding the simulation quality when investigating systems of high complexity, e.g. containing components showing a fairly different behavior. To overcome this limitation, co-simulation approaches are used more and more, combining the advantages of different simulation disciplines. That is why we propose a new strategy for the dynamic simulation of cutting processes. The method couples Lagrangian particle methods, such as the smoothed particle hydrodynamics （SPH） method, and multibody system （MBS） tools using co-simulations. We demonstrate the capability of the new approach by providing simulation results of an orthogonal cutting process and comparing them with experimental data. @ 2013 The Chinese Society of Theoretical and Applied Mechanics. [doi：10.1063/2.1301305]

关键词： multibody dynamics smoothed particle hydrodynamics co-simulation machining contact modeling

In vivo evaluation of riboflavin receptor targeted fluorescent USPIO in mice with prostate cancer xenografts

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Nano Research 2016年第5期9卷 1319-1333页

作者： Jabadurai Jayapaul Susanne Ares Matt Bunker Marek Weiler Sandra Rutherford Peter Comba fabian Kiessling Institute for Experimental Molecular Imaging RWTH Aachen University Pauwelsstrasse 30 Aachen 52074 Germany Anorganisch-Chemisches Institut Universit#t Heidelberg Im Neuenheimer Feld 270 Heidelberg 59120 Germany Molecular Imaging Group Department of Structural Biology Leibniz Institut fur Molekulare Pharmakologie (FMP) Robert-Rossle-Str. 10 Berlin 13125 Germany AstraZeneca Pharmaceutical Development Charter Way Macclesfield Cheshire SK10 2NA UK Molecular Profiles Ltd. 8 Orchard Place Nottingham Business Park Nottingham NG8 6PX UK

Riboflavin （Rf） receptors bind and translocate Rf and its phosphorylated forms （e.g. flavin mononucleotide, FMN） into cells where they mediate various cellular metabolic pathways. Previously, we showed that FMN-coated ultrasmall superparamagnetic iron oxide （FLUSPIO） nanoparticles are suitable for labeling metabolically active cancer and endothelial cells in vitro. In this study, we focused on the in vivo application of FLUSPIO using prostate cancer xenografts. Size, charge, and chemical composition of FLUSPIO were evaluated. We explored the in vitro specificity of FLUSPIO for its cellular receptors using magnetic resonance imaging （MRI） and Prussian blue staining. Competitive binding experiments were performed in vivo by injecting free FMN in excess. Bio-distribution of FLUSPIO was determined by estimating iron content in organs and tumors using a colorimetric assay. AFM analysis and zeta potential measurements revealed a particulate morphology approximately 20-40 nm in size and a negative zeta potential （-24.23±0.15 mV） in water. X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry data confirmed FMN present on the USPIO nanoparticle surface. FLUSPIO uptake in prostate cancer cells and human umbilical vein endothelial cells was significantly higher than that of control USPIO, while addition of excess of free FMN reduced accumulation. Similarly, in vivo MRI and histology showed specific FLUSPIO uptake by prostate cancer cells, tumor endothelial cells, and tumor-associated macrophages. Besides prominent tumor accumulation, FLUSPIO accumulated in the liver, spleen, lung, and skin. Hence, our data strengthen our hypothesis that targeting riboflavin receptors is an efficient approach to accumulate nanomedicines in tumors opening perspectives for the development of diagnostic and therapeutic systems.

关键词： flavin mononucleotide iron oxide nanoparticles magnetic resonance imaging molecular imaging riboflavin carrier protein riboflavin transporters

Data-driven comparison of federated learning and model personalization for electric load forecasting

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Energy and AI 2023年第4期14卷 3-16页

作者： fabian Widmer Severin Nowak Benjamin Bowler Patrick Huber Antonios Papaemmanouil Lucerne University of Applied Science and Arts Institute of Electrical EngineeringCompetence Center Digital Energy and Electric PowerTechnikumsstrasse 216048HorwLucerneSwitzerland

Residential short-term electric load forecasting is essential in modern decentralized power *** forecasting methods mostly rely on neural networks and require access to private and sensitive electric load data for model *** neural network training aggregates all data on a centralized server to train one global ***,the aggregation of user data introduces security and data privacy *** contrast,this study investigates the modern neural network training methods of federated learning and model personalization as potential solutions to security and data privacy *** an extensive simulation approach,the investigated methods are compared to the conventional centralized method and a pre-trained baseline predictor to compare their respective *** study identifies that the underlying data structure of electric load data has a significant influence on the loss of a *** therefore conclude that a comparison of loss distributions will in fact be considered a comparison of data structures,rather than a comparison of the model *** an alternative method of comparison of loss values,this study develops the"differential comparison".The method allows for the isolated comparison of model loss differences by only comparing the losses of two models generated by the same data sample to build a distribution of *** differential comparison method was then used to identify model personalization as the best performing model training method for load forecasting among all analyzed methods,with a superior performance in 59.1%of all cases.

关键词： Federated learning Machine learning Model personalization Temporal convolutional network Electric load forecast Differential comparison

A New Set of Reversibly Photoswitchable Fluorescent Proteins for Use in Transgenic Plants

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Molecular Plant 2013年第5期6卷 1518-1530页

作者： Martina Lummer fabian Humpert Matthias Wiedenubbert Markus Sauer Mark Schuttpelz Dorothee Staiger Molecular Cell Physiology Bielefeld University Universitatsstr. 25 33615 Bielefeld Germany Institute for Genome Research and Systems Biology CeBiTec 33615 Bielefeld Germany Biomolecular Photonics Bielefeld University Universitatsstr. 25 33615 Bielefeld Germany Biotechnology and Biophysics Julius-Maximilians-University Wurzburg Am Hubland 97074 Wurzburg Germany

Fluorescent reporter proteins that allow repeated switching between a fluorescent and a non-fluorescent state in response to specific wavelengths of light are novel tools for monitoring of protein trafficking and super-resolu- tion fluorescence microscopy in living organisms. Here, we describe variants of the reversibly photoswitchable fluores- cent proteins rsFastLime, bsDronpa, and Padron that have been codon-optimized for the use in transgenic Arabidopsis plants. The synthetic proteins, designated rsFastLIME-s, bsDRONPA-s, and PADRON C-s, showed photophysical properties and switching behavior comparable to those reported for the original proteins. By combining the ＇positively switchable＇ PADRON C-s with the ＇negatively switchable＇ rsFastLIME-s or bsDRONPA-s, two different fluorescent reporter proteins could be imaged at the same wavelength upon transient expression in Nicotiana benthamiana cells. Thus, co-localiza- tion analysis can be performed using only a single detection channel. Furthermore, the proteins were used to tag the RNA-binding protein AtGRP7 （Arabidopsis thaliana glycine-rich RNA-binding protein 7） in transgenic Arabidopsis plants. Because the new reversibly photoswitchable fluorescent proteins show an increase in signal strength during each pho- toactivation cycle, we were able to generate a large number of scans of the same region and reconstruct 3-D images of AtGRP7 expression in the root tip. Upon photoactivation of the AtGRP7：rsFastLIME-s fusion protein in a defined region of a transgenic Arabidopsis root, spreading of the fluorescence signal into adjacent regions was observed, indicating that movement from cell to cell can be monitored. Our results demonstrate that rsFastLIME-s, bsDRONPA-s, and PADRON C-s are versatile fluorescent markers in plants, Furthermore, the proteins also show strong fluorescence in mammalian cells including COS-7 and HeLa cells.

关键词： reversibly photoswitchable fluorescent protein codon usage Arabidopsis rsFastLIME-s bsDRONPA-s PADRON-s.

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关于大G,比想象的更加完美

汽车之友 2024年第6期 11-11页

作者： Michael Knöller fabian Schossau 梅赛德斯-奔驰G级越野车有限责任公司

Q:“大G”在燃油车时代,自己细分市场一直都是最好的,作为行业标杆级产品,全新纯电G级越野车将如何树立新的豪华标准,为整个行业树立标杆,并获得用户的认可?A:G级越野车45年未曾改变,我们未来也将延续这样的传承。对于G级越野车来说,我... 详细信息

Q:“大G”在燃油车时代,自己细分市场一直都是最好的,作为行业标杆级产品,全新纯电G级越野车将如何树立新的豪华标准,为整个行业树立标杆,并获得用户的认可?A:G级越野车45年未曾改变,我们未来也将延续这样的传承。对于G级越野车来说,我们的首要任务是打造市场上最顶尖的越野车型。无论是过去,现在,还是将来。纯电G级越野车同样需要做到这一点,成为电动时代的越野标杆。

关键词：越野车燃油车标杆细分市场 G级电动