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Latent structure of irritable bowel syndrome symptom severity

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World Journal of Gastroenterology 2015年第1期21卷 292-300页

作者： fabian Jasper Boris Egloff Andrea Roalfe Michael Witthft Department of Psychological Diagnostics University of Salzburg5020 SalzburgAustria Department of Personality Psychology and Diagnostics University of Mainz55099 MainzGermany Primary Care Clinical Sciences University of BirminghamEdgbastonBirmingham B15 2TTUnited Kingdom Department of Health Psychology University of Mannheim68161 MannheimGermany

AIM: To investigate the latent structure of an irritable bowel syndrome(IBS) symptom severity scale in a population of healthy ***: The Birmingham IBS symptom questionnaire which consists of three symptom specific scales(diarrhea,constipation,pain) was evaluated by meansof structural equation *** compared the original 3-factor solution to a general factor model and a bifactor solution in a large internet sample of college students(n = 875).Statistical comparisons of competing models were conducted by means of χ2 difference *** the evaluation of model fit,we examined the comparative fit index(CFI) and the Root Mean Square Error of Approximation(RMSEA).RESULTS: Results clearly favored a bifactor model of IBS symptom severity(CFI = 0.99,RMSEA = 0.05) which consisted of a strong general IBS somatization factor and three symptom specific factors(diarrhea,constipation,pain) based on the subscales of the Birmingham IBS symptom *** fit indices of the competing one factor model(CFI = 0.85,RMSEA = 0.17) and three factor model(CFI = 0.97,RMSEA = 0.08) were clearly inferior.χ2 difference tests showed that the differences between the models were indeed significant in favor of the bifactor model(P < 0.001).Correlations of the four latent factors with measures of pain sensitivity,somatoform dissociation,fatigue severity,and demographic variables support the validity of our bifactor model of IBS specific symptom ***: The findings suggest that IBS symptom severity might best be understood as a continuous and multidimensional construct which can be reliably and validly assessed with the B-IBS.

关键词： Irritable bowel syndrome Bifactor Gastrointestinal

Black holes in asymptotic safety with higher derivatives:accretion and stability analysis

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Chinese Physics C 2021年第7期45卷 293-304页

作者： fabian H.Zuluaga Luis A.Sanchez Escuela de Fisica Universidad Nacional de ColombiaA.A.3840MedellinColombia

We review steady spherically symmetric accretion onto a renormalization group improved Schwarzschild space-time,which is a solution to an asymptotically safe theory(AS)containing high-derivative *** use a Hamiltonian dynamical system approach for the analysis of the accretion of four types of isothermal test fluids:ultra-stiff fluid,ultra-relativistic fluid,radiation fluid,and sub-relativistic *** important outcome of our study is that,contrary to the claim in a recent work,there are physical solutions for the accretion of an ultra-relativistic fluid in AS,which include subsonic,supersonic,and transonic ***,we study quantum corrections to the known stability of the accretion in general relativity(GR).To this end,we use a perturbative procedure based on the continuity equation with the mass accretion rate being the perturbed *** classes of perturbations are studied:standing and traveling *** find that quantum gravity effects either enhance or diminish the stability of the accretion depending on the type of test fluid and the radial distance to the central object.

关键词： asymptotic safety black holes accretion stability

Diagnosis and Treatment of Clear Cell Hidradenocarcinoma of the Scalp

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第6期32卷 931-936页

作者：舒凯肖群根 fabian Büchele 张所军蒋伟雷霆 Department of Neurosurgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Lab of Molecular Neurosurgery Stereotactic and Functional Neurosurgery of Albert-Ludwigs University

Clear cell hidradenocarcinoma (CCH) is an exceedingly rare and highly malignant tumor of the eccrine sweat glands. Its treatment is extremely difficult due to the characteristically aggressive clinical course including repeated local recurrence and uncontrollable distal metastasis coming along with a very poor prognosis. Most published case studies recommend a wide surgical excision followed by adjuvant conservative therapy, which is generally considered to be the standard treatment. Two cases of nodular CCH of the scalp either presenting as a singular primary lesion or at an already metastatic stage were analyzed retrospectively. Wide local excision of the tumor couldn’t prevent the primary carcinoma from recurring and metastasizing. Both cases received various therapies but the results were unsatisfactory. Although most authors have recommended that early wide surgical excision of the tumor is a feasible therapeutic measurement, our results raise doubts on the efficacy of this treatment strategy. As alternative approaches (i.e. chemotherapy, radiotherapy) are similarly controversial, further studies and a wide exchange of clinical experiences are crucial.

关键词： hidradenocarcinoma scalp diagnosis treatment

SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2463-2466页

作者： fabian Zech Stefanie Weber Hanna Dietenberger Linyun Zhang Sabrina Noettger Meta Volcic Tim Bergner Clarissa Read Konstantin M.J.Sparrer Thomas F.E.Barth Frank Kirchhoff Institute of Molecular Virology Ulm University Medical CenterUlmGermany Institute of Pathology Ulm UniversityUlmGermany Central Facility for Electron Microscopy Ulm UniversityUlmGermany

Dear Editor Effective vaccines and some antiviral agents against SARS-CoV-2,the causative agent of coronavirus disease 2019(COVID-19),have been ***,additional therapeutics are needed since emerging SARS-CoV-2 variants evade immunity induced by vaccination or previous infection and are resistant to therapeutic antibodies and fusion inhibitors.^(1)In addition,many patients experience prolonged post-acute sequelae of SARS-CoV-2.

关键词： ACE2 immunity acute

Associations between meeting 24-hour movement guidelines and quality of life among children and adolescents with autism spectrum disorder

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Journal of Sport and Health Science 2023年第1期12卷 73-86页

作者： Chuidan Kong Aiguo Chen Sebastian Ludyga fabian Herold Sean Healy Mengxian Zhao Alyx Taylor Notger G.Muller Arthur F.Kramer Sitong Chen Mark S.Tremblay Liye Zou Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen 518061China College of Physical Education Yangzhou UniversityYangzhou 225127China Department of Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland Research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdam 14476Germany Community Health Academic Group School of NursingPsychotherapy and Community HealthDublin City UniversityDublin 9Ireland School of Rehabilitation Sport and PsychologyAECC University CollegeBournemouthBH52DFUK Research Group Neuroprotection German Center for Neurodegenerative Diseases(DZNE)Magdeburg 39120Germany Center for Behavioral Brain Sciences(CBBS) Magdeburg 39118Germany Center for Cognitive and Brain Health Northeastern UniversityBostonMA 02115USA Beckman Institute University of Illinois at Urbana-ChampaignChampaignIL 61820USA Institute for Health and Sport Victoria UniversityMelbourne 8001Australia Healthy Active Living and Obesity Research Group CHEO Research InstituteOttawaOntario K1H8L1Canada Department of Pediatrics University of OttawaOttawaOntario K1N 6N5Canada

Background:The Canadian 24-hour movement behavior(24-HMB)guidelines suggest that a limited amount of screen time use,an adequate level of physical activity(PA),and sufficient sleep duration are beneficial for ensuring and optimizing the health and quality of life(QoL)of children and ***,this topic has yet to be examined for children and adolescents with autism spectrum disorder(ASD)*** aim of this cross-sectional observational study was to examine the associations between meeting 24-HMB guidelines and several QoLrelated indicators among a national sample of American children and adolescents with ***:Data were taken from the 2020 *** Survey of Children’s Health ***(n=956)aged 617 years and currently diagnosed with ASD were *** exposure of interest was adherence to the 24-HMB *** were QoL indicators,including learning interest/curiosity,repeating grades,adaptive ability,victimization by bullying,and behavioral *** variables were described with unweighted sample counts and weighted ***,sex,race,preterm birth status,medication,behavioral treatment,household poverty level,and the educational level of the primary caregivers were included as *** ratio(OR)and 95%confidence interval(95%CI)were used to present the strength of association between adherence to 24-HMB guidelines and QoL-related ***:Overall,452 participants(45.34%)met 1 of the 3 recommendations,216(22.65%)met 2 recommendations,whereas only 39 participants(5.04%)met all 3 *** with meeting none of the recommendations,meeting both sleep duration and PA recommendations(OR=3.92,95%CI:1.639.48,p<0.001)or all 3 recommendations(OR=2.11,95%CI:1.034.35,p=0.04)was associated with higher odds of showing learning interest/*** both screen time and PA recommendations(OR=0.15,95%CI:0.040.61,p<0.05)or both sleep duration and PA recommendations(OR=0.24,95

关键词： 24-hour movement guidelines Autism spectrum disorder Physical activity Quality of life

All-dielectric silicon metalens for two-dimensional particle manipulation in optical tweezers

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Photonics Research 2020年第9期8卷 1435-1440页

作者： TEANCHAI CHANTAKIT CHRISTIAN SCHLICKRIEDE BASUDEB SAIN fabian MEYER THOMAS WEISS NATTAPORN CHATTHAM AND THOMAS ZENTGRAF Department of Physics Faculty of ScienceKasetsart UniversityBangkok 10900Thailand College of Advanced Manufacturing Innovation King Mongkut’s Institute of Technology LadkrabangBangkok 10520Thailand Department of Physics Paderborn UniversityWarburger Str.10033098 PaderbornGermany 4th Physics Institute and Research Center SCoPE University of StuttgartPfaffenwaldring 5770569 StuttgartGermany

Dynamic control of compact chip-scale contactless manipulation of particles for bioscience applications remains a challenging endeavor,which is restrained by the balance between trapping efficiency and scalable *** offer the implementation of feasible optical tweezers on a planar platform for shaping the exerted optical force by a microscale-integrated *** we design and experimentally demonstrate a highly efficient silicon-based metalens for two-dimensional optical trapping in the *** metalens concept is based on the Pancharatnam–Berry phase,which enables the device for polarization-sensitive particle *** optical trapping setup is capable of adjusting the position of both the metasurface lens and the particle chamber freely in three directions,which offers great freedom for optical trap adjustment and ***-dimensional(2D)particle manipulation is done with a relatively low-numerical-aperture metalens(NA(ML)=0.6).We experimentally demonstrate both 2D polarization-sensitive drag and drop manipulation of polystyrene particles suspended in water and transfer of angular orbital momentum to these particles with a single tailored *** work may open new possibilities for lab-on-a-chip optical trapping for bioscience applications and microscale to nanoscale optical tweezers.

关键词： particle trapping dimensional

Forestry projections for species diversity-oriented management:an example from Central Europe

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Ecological Processes 2018年第1期7卷 244-261页

作者： Astor Toraño Caicoya Peter Biber Werner Poschenrieder fabian Schwaiger Hans Pretzsch Chair of Forest Growth and Yield Science Center of Life and Food Sciences WeihenstephanTechnische Universität MünchenHans-Carl-von-Carlowitz 2D-85354 FreisingGermany

Introduction:Changes in socio-economy and climate are affecting the demand of wood products *** the same time,society requires that forest supporting structures like biodiversity are maintained and preserved while the demand for wood products is also *** support systems,like forest simulation models,that are able to analyze connections as well as quantify trade-offs between forest structure management and biodiversity indicators are highly ***,such models are generally developed for the local plot or stand scale only and ecosystem-scale analyses are *** this study,we analyzed ways to interpret results from the single-tree forest simulator SILVA from the local to the ecosystem *** also analyzed the impacts of forest management on biodiversity using two species diversity indicators,the species profile index and the species intermingling,for scenarios adapted from the GLOBIOM model in the case study“Augsburg Western Forests”,a high productive region in *** order to evaluate diversity tendencies across the ecosystem,we applied a moving window ***:The relevance of scale for the interpretation of management effects on species diversity was shown and clear differences between scenarios *** differences between scenarios were particularly visible when comparing the two diversity indicators,especially because the species profile index focuses on vertical and horizontal information and the species intermingling focuses mainly on horizontal *** a multifunctional scenario,biodiversity values could be preserved at all scales in the vertical ***,under a bio-energy-oriented scenario diversity at the local scale was reduced,although at the ecosystem level,and only in the horizontal dimension,diversity remained at relatively high ***:With this work,we can conclude that integrative modeling,with multiple scenarios,is highly needed to support forestry decision m

关键词： Forest model Multifunctional forestry Growing window GLOBIOM

Validation of the Chinese Version of the Affective Exercise Experiences Questionnaire (AFFEXX-C)

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International Journal of Mental Health Promotion 2023年第7期25卷 799-812页

作者： Ting Wang Boris Cheval Silvio Maltagliati Zachary Zenko fabian Herold Sebastian Ludyga Markus Gerber Yan Luo Layan Fessler Notger GMüller Liye Zou Body-Brain-Mind Laboratory School of PsychologyShenzhen UniversityShenzhen518060China Swiss Center for Affective Sciences University of GenevaGenevaSwitzerland Department of Psychology Laboratory for the Study of Emotion Elicitation and Expression(E3Lab)University of GenevaGenevaSwitzerland University Grenoble Alpes SENSGrenobleF-38000France Department of Kinesiology California State University BakersfieldBakersfieldCAUSA Research Group Degenerative and Chronic Diseases MovementFaculty of Health Sciences BrandenburgUniversity of PotsdamPotsdamGermany Department of Sport Exercise&HealthUniversity of BaselBaselSwitzerland Department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignIllinois61801USA

Despite the well-established benefits of regular physical activity(PA)on health,a large proportion of the world population does not achieve the recommended level of regular *** affective experiences toward PA may play a key role to foster a sustained engagement in PA,they have been largely overlooked and crudely measured in the existing *** address this shortcoming,the Affective Exercise Experiences(AFFEXX)questionnaire has been developed to measure such ***,this questionnaire was developped to assess the following three domains:antecedent appraisals(e.g.,liking *** exercise in groups),core affective exercise experiences(i.e.,pleasure ***,energy ***,and calmness ***),and exercise motivation(i.e.,attraction *** toward exercise).The current study aimed to validate a Chinese version of the AFFEXX questionnaire(AFFEXX-C).In study 1,722 Chinese college students provided data for analyses of factorial,convergent,discriminant,criterion validity,and test-retest reliability of the *** addition,1,300 college students were recruited in study 2 to further validate its structural *** showed that the AFFEXX-C demonstrates a goodfit and ***,results further supported the hypothesized model based on previous research:antecedent appraisals predicted core affective exercise experiences,which in turn predicted attraction-antipathy toward physical *** AFFEXX-C was found to be a reliable and valid measure of affective exercise experiences in a population of Chinese college students.

关键词： Affective exercise experiences questionnaires reliability validity college students Chinese translation

An approach for the coupled simulation of machining processes using multibody system and smoothed particle hydrodynamics algorithms

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Theoretical & Applied Mechanics Letters 2013年第1期3卷 44-50页

作者： fabian Spreng Peter Eberhard Florian Fleissner Institute of Engineering and Computational Mechanics University of Stuttgart

The prediction accuracy of a simulation method is limited by its theoretical background. This fact can lead to disadvantages regarding the simulation quality when investigating systems of high complexity, e.g. containing components showing a fairly different behavior. To overcome this limitation, co-simulation approaches are used more and more, combining the advantages of different simulation disciplines. That is why we propose a new strategy for the dynamic simulation of cutting processes. The method couples Lagrangian particle methods, such as the smoothed particle hydrodynamics （SPH） method, and multibody system （MBS） tools using co-simulations. We demonstrate the capability of the new approach by providing simulation results of an orthogonal cutting process and comparing them with experimental data. @ 2013 The Chinese Society of Theoretical and Applied Mechanics. [doi：10.1063/2.1301305]

关键词： multibody dynamics smoothed particle hydrodynamics co-simulation machining contact modeling