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Elevated interleukin-6 levels are associated with impaired outcome in cardiac transthyretin amyloidosis

World Journal of Cardiology 2021年第3期13卷 55-67页

作者： Selina J Hein Maximilian Knoll fabian aus dem siepen Jennifer Furkel Stefan Schoenland Ute Hegenbart Hugo A Katus Arnt V Kristen Mathias Konstandin Department of Cardiology Pneumology and AngiologyUniversity Hospital HeidelbergHeidelbergBW 69120Germany Department of Radiation Oncology Heidelberg Ion-Beam Therapy CenterGerman Cancer Research CenterUniversity Hospital HeidelbergHeidelbergBW 69120Germany Department of Radiation Oncology Heidelberg University HospitalHeidelbergBW 69120Germany Department of Hematology Oncology and RheumatologyAmyloidosis CenterHeidelberg University HospitalHeidelbergBW 69120Germany Department of Hematology Amyloidosis CenterHeidelberg University HospitalHeidelbergBW 69120Germany Department of Cardiology Medical University Hospital HeidelbergHeidelbergBW 69120Germany Department of Cardiology Amyloidosis CenterUniversity of HeidelbergHeidelbergBW 69120Germany

BACKGROUND Elevated interleukin(IL)-6-levels have been described in familial variant transthyretin amyloidosis(ATTRv)associated polyneuropathy and heart ***,IL-6 in cardiac ATTR amyloidosis(ATTR-CM)and its prognostic value have not been investigated *** We aim to study the correlation between IL-6 levels with clinical presentation(Gillmore-class)and outcome[heart transplantation or death(htx/death)],or the combined endpoint of cardiac decompensation or htx/death in *** IL-6 levels of 106 ATTR-CM patients[54 wild-type ATTRwt,52 ATTRv-CM],15 asymptomatic carriers of ATTR mutations(aATTRv-CM)and 27 healthy donors were quantified using Luminex *** analysis was performed using parametric survival regression *** We found that IL-6 levels from wild-type ATTR patients were significantly elevated compared to healthy controls,while aATTRv-CM carriers and ATTRv-CM patients did not show a significant ***-6 levels showed significantly higher values in increasing Gillmore *** analyses revealed association of low IL-6 levels with cardiac decompensation and htx/death[odds ratio:0.26(0.09-0.72),P=0.01]and htx/death[odds ratio:0.15(0.04-0.58),P=0.006].However,in the multivariate model,no significant improvement of risk prediction was seen for IL-6,while established prognostic factors were significantly associated with *** Raised IL-6 levels correlate with clinical presentation and are associated with worse outcome in ATTR-CM but do not improve stratification in addition to established risk factors.

关键词： Transthyretin amyloidosis Inflammation Heart failure Interleukin-6 Outcome Risk stratification

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