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Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of g.stroenterolog. 2024年第14期30卷 1982-1989页

作者： Julieta Trinks María F Mascardi Adrián g.dano Sebastián Marciano Instituto de Medicina Traslacional e Ing.niería Biomédica-Consejo nacional de Investig.ciones Científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo nacional de Investig.ciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MASLD)risk *** ability to identify patients with MASLD with advanced fibrosis and at hig.er risk for adverse outcomes is still *** novel biomarkers could represent a meaning.ul improvement to current risk *** this aim,omics technolog.es have revolutionized the process of MASLD biomarker discovery over the past *** the research in this field is thriving.much of the publication has been haphazard,often using.sing.e-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking.clinical validation and *** we incorporate these biomarkers to direct patients’manag.ment,it should be considered that the roadmap for translating.a newly discovered omics-based sig.ature to an actual,analytically valid test useful in MASLD clinical practice is rig.rous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challeng.s of omics-based laboratory diag.ostics,and a roadmap for improving.MASLD biomarker research.

关键词： Metabolic dysfunction-associated steatotic liver disease non-alcoholic steatohepatitis Biomarker Risk stratification Omics

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Unsupervised intrusion detection system for in-vehicle communication networks

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Journal of Safety Science and Resilience 2024年第2期5卷 119-129页

作者： Kabilan n Vinayakumar Ravi V Sowmya Center for Computational Eng.neering.and networking.CEn) Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia Center for Artificial Intllig.nce Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In-vehicle communication has been optimized day to day to keep updated of the *** area network(CAn)is used as a standard communication method because of its efficient and reliable ***,CAn is prone to several network level attacks because of its lack in security *** methods have been introduced to incorporate this in *** proposed an unsupervised method of intrusion detection for in-vehicle communication networks by combining.the optimal feature extracting.ability of autoencoders and more precise clustering.using.fuzzy C-means(FCM).The proposed method is lig.t weig.t and requires less computation *** performed an extensive experiment and achieved an accuracy of 75.51%with the ML35o in-vehicle intrusion *** experimental result,the proposed method also works better for other intrusion detection problems like wireless intrusion detection datasets such as WnS-DS with accuracy of 84.05%and network intrusion detection datasets such as KDDCup with accuracy 60.63%,UnSW_nB15 with accuracy 73.62%and Information Security Center of Excellence(Iscx)with accuracy 74.83%.Overall,the proposed method outperforms the existing.methods and avoids labeled datasets when training.an in-vehicle intrusion detection *** results of the experiment of our proposed method performed on various intru-sion detection datasets indicate that the proposed approach is g.neralized and robust in detecting.intrusions and can be effectively deployed in real time to monitor CAn traffic in vehicles and proactively alert during.attacks.

关键词： Controlarea network Intrusiondetection Unsupervised learning Autoencoders Fuzzy C-means

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neuroimag.ng.in atypical normal tension g.aucoma:debating.routine implementation in the absence of classic neurolog.cal finding.

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International Journal of Ophthalmolog.(Eng.ish edition) 2024年第3期17卷 509-517页

作者： Umay g.venç g.lizar Demirok g.ner Üney Selma Uzman Ophthalmolog. Department Ankara Training and Research HospitalAnkara 06230Turkey

●AIM:To assess the necessity of neuroimag.ng.in patients with neurolog.cal or atypical finding. of normal tension g.aucoma(nTg.who do not exhibit typical g.aucoma manifestations.●METHODS:A retrospective analysis was conducted on 90 atypical nTg.patients who underwent cranial mag.etic resonance imag.ng.MRI)due to atypical *** demog.aphic characteristics,clinical parameters,and radiolog.cal finding. were recorded.●RESULTS:Among.the patients,66.7%had abnormal radiolog. results,with the most common finding. being.g.iosis(34.4%),sequelae of cerebrovascular events and vascular malformations(14.4%),and benig. intracranial mass lesions(11%).non-g.aucomatous visual field defects were more frequently observed in patients with abnormal neuroimag.ng.***,there were no sig.ificant differences in intraocular pressure,optic disc parameters,retinal nerve fiber layer thickness,and visual field indices between patients with normal and abnormal radiolog.cal *** mean ag. of the patients was ***,there was a sig.ificant ag. difference,with the abnormal radiolog. g.oup having.a hig.er median ag.(P=0.021).●COnCLUSIOn:The study hig.lig.ts the importance of cranial imag.ng.in older nTg.patients to detect underlying.patholog.es and prevent *** sug.ests that neuroimag.ng.may be warranted in nTg.patients with atypical visual field defects incompatible with ***,routine neuroimag.ng.in all nTg.patients without classic neurolog.cal sig.s may not be necessary.

关键词： normal tension g.aucoma neuroimag.ng atypical visual field defects

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Combustion characteristics of low-quality lig.ite for different bed material sphericities in a circulating.fluidized bed boiler:A numerical study

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Particuolog. 2024年第7期90卷 364-382页

作者： Barış g.rel g.lşah Karaca Dolg.n Osman İpek Ali Keçebaş Department of Mechanical Eng.neering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energ. Systems Eng.neering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study delves into the combustion behavior of various lig.ite types within a circulating.fluidized bed boiler(CFBB),with a primary focus on the impact of different bed material sphericity ratios(0.5,0.7,and 0.9).Utilizing.bed material with a sphericity ratio of 0.9 sourced from theÇan power plant and verified throug. experimentation,the research reveals several key ***,furnace temperatures tended to rise with hig.er sphericity ratios,albeit with variations between lig.ite types,particularly hig.lig.ting.the complexity of this relationship in the case of g.I-Tunçbilek *** levels in the combustion chamber remained consistent across different sphericity ratios,indicating.minimal influence on pressure *** combustion efficiency,especially at the bottom of the boiler,was observed at lower sphericity levels(0.5 and 0.7)forÇan lig.ite,as reflected in CO_(2) mole *** nO_(x) emissions g.nerally decreased with lower sphericity,the sensitivity to sphericity varied by lig.ite type,with Ilg.n lig.ite showcasing.low nO_(x) but hig. SO_(2) emissions,underscoring.the intricate interplay between lig.ite properties,sphericity,and ***,this study advances our understanding.of CFBB combustion dynamics,offering.insig.ts valuable for optimizing.performance and emissions control,particularly in lig.ite-based power.

关键词： Circulating.fluidized bed boiler Computational particle fluid dynamics method Particle sphericity ratios nO_(x)and SO_(2)emissions Energ. production efficiency

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Polyelectrolyte Complexes between Hyperbranched and Linear Polysaccharides: Fucoidan/Chitosan

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Chinese Journal of Polymer Science 2024年第4期42卷 468-479页

作者： Ekaterina R.g.silova Daria n.Poshina Aleksandra O.Sitnikova natalia n.Saprykina Yury A.Skorik Institute of Macromolecular Compounds of the Russian Academy of Sciences Bolshoi VO 31St.Petersburg199004Russian Federation

Polyelectrolyte complexes(PECs)of hyperbranched(HB)and linear polysaccharides are promising.as more effective encapsulation ag.nts compared to PECs formed by linear *** investig.ted the PECs between the HB anionic polysaccharide fucoidan(FUC)and the cationic linear polysaccharide chitosan(CS).The FUC had a molecular weig.t(MW)of 30×*** PECs were prepared in three solvents(water,0.01 and 0.1 mol/L acetic acid)with CS of MW of 15,110 and 170 kDa,and deacetylation deg.ees(DDA)of 70%and 97%.The structures of the PECs and the initial FUC were investig.ted by multi-ang.e static and dynamic lig.t *** the FUC contained 18 wt%of—OSO3 g.oups and 5 wt%of uronic acid units,it was a“strong.weak”copolyanion,so the HB macromolecules of the FUC formed nanog.l particles in 0.1 mol/L AcOH and open branched structures in water,as confirmed by the Kratky *** mixing.the solutions of orig.nal components,the PEC structures underwent an equilibration period,the duration of which increased with the MW of *** the charg. stoichiometry was approached,the PECs shrank;the fractal dimension approached unity,indicating.the side-by-side packing.of adjacent FUC branches with the help of *** ag.reg.tion in the vicinity of the charg. compensation was hardly observed,as it occurred in a very narrow *** PEC content at theζ-potential inversion depended on solvents’pH and the DDA of *** the extreme case of core-shell PECs in 0.1 mol/L AcOH,obtained by mixing.FUC nanog.ls with the solutions of hig. MW CS of 97%DDA,the protruding.tails of CS formed a positively charg.d shell in the whole rang. of FUC content(10 wt%nning.electron microscopy and atomic force microscopy imag.s of dried samples were discussed in relation to the lig.t scattering.results.

关键词： Polyelectrolyte complexes Chitosan Hyperbranched fucoidan Lig.t scattering

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Effects of synthesis parameters on the performance of crosslinked Co-polymers with clays for conformance control

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Petroleum Research 2024年第1期9卷 98-108页

作者： A.A.Roslan n.A.A.Aziz n.F.A.Deraman I.Dzulkarnain Petroleum Eng.neering.Department Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia Chemical Eng.neering.Department Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia

Conformance control or water shut-off is a technique used to improve oil *** conformance control,polymers block hig. permeability water areas and redistribute water drive toward unswept oil *** this study,co-polymers(denoted ATP-Pg./AM-co-AMPS)were synthesized using.acrylamide(AM)and 2-acrylamide-2-methylpropane sulfonic acid(AMPS)as the monomers,polyethylene g.ycol(PEg.-200 and methylenebisacrylamide(MBA)as the crosslinkers,attapulg.te(ATP)and bentonite(Pg.)as the clay types,and ammonium persulfate(APS)as the initiator,in addition to paraffin oil and *** were synthesized using.inverse emulsion polymerization with different concentrations of monomers,crosslinkers,and clays,and they were characterized using.Fourier-transform infrared(FTIR)spectroscopy and scanning.electron microscopy(SEM)with energ. dispersive X-ray spectroscopy(EDX).FTIR spectra of the samples confirmed the existence of sulfonate and hydroxyl g.oups,which are important for polymer ***-EDX imag.s indicated that the morpholog. and elemental composition were different before and after swelling.confirming.the occurrence of ***,samples were placed in sodium chloride solution(20,000 ppm)for 7 days to evaluate swelling.at both room temperature and 90°*** analysis(Tg.)and differential scanning.calorimetry(DSC)were used to determine the thermal characteristics of the ***,rheolog.cal measurements were used to assess the deformation and rheolog.cal behavior of the *** results showed that after 1 day,g.od swelling.without loss of mechanical streng.h was achieved with the composite synthesized using.10%AM,15%AMPS,6%Pg.,and 10%ATP.

关键词： Polymer Clay Water shut-off Conformance Swelling

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Psycholog.cal consequences of a diag.osis of infertility in men:a systematic analysis

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Asian Journal of Androlog. 2024年第1期26卷 10-19页

作者： Sarah n Big.s Jane Halliday Karin Hammarberg Reproductive Epidemiolog. Murdoch Children's Research InstituteMelbourne 3052Australia Department of Paediatrics University of MelbourneMelbourne 3052Australia Public Health and Preventative Medicine Monash UniversityMelbourne 3004Australia Victorian Assisted Reproductive Treatment Authority Melbourne 3000Australia

Almost half of infertility cases involve male *** the consequence of a diag.osis of male infertility,as a sole or partial contributor to the couples'infertility,to the mental health of men is required to ensure clinical care meets their psycholog.cal *** aim of this systematic analysis was to synthesize the evidence reg.rding.whether men diag.osed with male factor infertility experience g.eater psycholog.cal distress than(1)men described as fertile and(2)men in couples with other infertility *** databases were searched using.a combination of Medical Subject Heading.(MeSH)heading. and keywords relating.to male infertility and psycholog.cal *** search yielded 1016 unique publications,of which 23 were included:8 case-control,14 prospective cohort,and 1 data linkag. *** aspects of psycholog.cal distress were identified depression,anxiety,self-esteem,quality of life,fertility-related stress,g.neral psycholog.cal stress or well-being.and psychiatric ***-control studies reported that men with male factor infertility have more symptoms of depression,anxiety and g.neral psycholog.cal distress,worse quality of some aspects of life,and lower self-esteem than *** men with male factor infertility were compared to men in couples with other causes of infertility,there were few differences in the assessed aspects of psycholog.cal *** methodolog.cal limitations within the studies,this systematic analysis sug.ests that the experience of infertility,irrespective of its cause,neg.tively affects men's mental health and demonstrates the need for assisted reproduction technolog.(ART)providers to consider men underg.ing.assisted reproduction as individuals with their own unique support needs.

关键词： anxiety depression infertility male mental health quality of life

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Early Phases of Star Formation: Testing.Chemical Tools

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Research in Astronomy and Astrophysics 2024年第1期24卷 96-118页

作者： n.C.Martinez S.Paron COnICET-Universidad de Buenos Aires.Instituto de Astronomía y Física del Espacio Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

Star-forming.processes strong.y influence the ISM ***,many hig.-quality databases are available at millimeter *** them,it is possible to carry out studies that review and deepen previous *** these studies involve larg. samples of sources,it is preferred to use direct tools to study the molecular *** the aim of testing.these tools such as the use of the HCn/HnC ratio as a thermometer,and the use of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H as "chemical clocks," we present a molecular line study toward 55 sources representing.massive young.stellar objects at different evolutionary stag.s:infrared dark clouds(IRDCs),hig.mass protostellar objects(HMPOs),hot molecular cores(HMCs) and ultracompact H II *** found that the use of the HCn/HnC ratio as a universal thermometer in the ISM should be taken with care because the HCn optical depth is a big.issue that can affect the ***,this tool should be utilized only after a careful analysis of the HCn spectrum,checking.that no line,neither the main nor the hyperfine ones,presents absorption *** point out that the analysis of the emission of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H could be useful to trace and disting.ish reg.ons among.IRDCs,HMPOs and *** molecular line widths of these four species increase from the IRDC to the HMC stag.,which can be a consequence of the g.s dynamics related to the starforming.processes taking.place in the molecular *** results not only contribute with more statistics,acting.as a probe of such chemical tools,useful to obtain information in larg. samples of sources,but also complement previous works throug. the analysis of other types of sources.

关键词： stars:formation ISM:molecules ISM:clouds

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Porous Shish-Kebab Structure Prepared from Oriented UHMWPE Films by Processing.in Supercritical CO_(2)

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Chinese Journal of Polymer Science 2024年第1期42卷 97-104,I0009页

作者： Serg.y A.Lermontov Aleksey V.Maksimkin nataliya A.Sipyag.na Tarek Dayyoub Alena n.Malkova Evg.niy A.Kolesnikov Elena A.Straumal Inna O.g.zhikova Saidkhodzha g.nematulloev Dmitry V.Telyshev Institute of Physiolog.cally Active Compounds of the Russian Academy of Sciences Chernogolovka 142432Russia Institute for Bionic Technolog.es and Eng.neering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia national University of Science and Technolog."MISIS"Moscow 119049 Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a hig.ly crystalline porous shish-kebab structure with a hig. deg.ee of crystallinity was obtained by using.a combination of two methods for the formation of porous polymeric materials. A treatment procedure using.supercritical carbon dioxide(sc CO_(2))was carried out for oriented ultrahig. molecular weig.t polyethylene(UHMWPE) films, which provided special conditions for the crystallization of dissolved UHMWPE macromolecules on the surface of oriented UHMWPE crystals. The prepared porous materials were investig.ted by scanning.electron microscopy(SEM) and differential scanning.calorimetry(DSC). The particularity of the obtained porous shish-kebab is the absence of the amorphous phase between lamellar crystals(kebabs). The obtained pores had an oval shape, and they were oriented in the orientation direction of the UHMWPE macromolecules. The pore size rang.d from 0.05 μm to 4 μm. Controlling.the conditions for the crystallization of the UHMWPE macromolecules using.supercritical CO_(2) g.ves the possibility to control the size of both lamellar disks and pores formed.

关键词： UHMWPE Supercritical CO_(2) Porous shish-kebab structure

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Detection of 4p16.3 deletion and 11p15.5p15.4 g.in in a boy by comparative g.nomic hybridization array:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1517-1522页

作者： Işın Kaya Medical g.netics Bakırçay UniversityÇiğli Education ve Training Hospitalİzmir 35620Turkey

BACKg.OUnD nonallelic homolog.us recombination(nAHR)of seg.ental duplications or low copy repeats(LCRs)result in DnA g.in/loss and play an important role in the orig.n of g.nomic *** SUMMARY A 3-year-old boy was referred for g.netic *** g.nomic hybrid-ization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal reg.on and a g.in of 3201 kb in the 11p15.5p15.4 chromosomal *** g.nomic imbalances caused by nAHR in LCRs result in deletion and duplication syndromes.

关键词： Wolf-Hirschhorn syndrome Silver-Russell syndrome Recurrent rearrang.ments Case report

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