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CFG桩+土工织物联合冲碾压技术在公路软土地基的应用

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工程建设 2024年第9期56卷 49-54页

作者：刘法宝中铁二十三局集团第一工程有限公司山东日照276800

为探究软土地基施工技术,文章结合川中多雨潮湿地区的软土地况特点,以四川某高速公路为例,对单CFG桩软土地基处理和CFG桩+土工织物联合冲碾压两种软土地基施工技术进行研究,并对两种技术成果进行沉降测试。结果表明:1)在CFG桩处理软基... 详细信息

为探究软土地基施工技术,文章结合川中多雨潮湿地区的软土地况特点,以四川某高速公路为例,对单CFG桩软土地基处理和CFG桩+土工织物联合冲碾压两种软土地基施工技术进行研究,并对两种技术成果进行沉降测试。结果表明:1)在CFG桩处理软基路段工程初期阶段,软土地基的沉降速率较快,但随着时间的推移,土体逐步固结,沉降速度开始减缓直至稳定;2)工程完成后产生的整体沉降量小于25 cm,最大不均匀沉降量小于4 cm;3)施工后路基整体表现较为稳定,未发生开裂变形现象,满足设计施工要求标准;4)在软土地基处理上,CFG桩+土工织物结合冲碾压技术不仅在沉降量控制上优于单CFG桩处理法,且在均衡荷载分布、提升路基稳定性方面展现出优良的性能。

关键词： CFG桩土工织物软土地基复合地基

Discovery of GluN2A subtype-selective N-methyl-d-aspartate(NMDA)receptor ligands

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1987-2005页

作者： Liyang Jiang Na liu fabao Zhao Boshi Huang Dongwei Kang Peng Zhan Xinyong liu Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

The N-methyl-d-aspartate(NMDA)receptors,which belong to the ionotropic Glutamate receptors,constitute a family of ligand-gated ion *** the various subtypes of NMDA receptors,the GluN1/2A subtype plays a significant role in central nervous system(CNS)*** present article aims to provide a comprehensive review of ligands targeting GluN2A-containing NMDA receptors,encompassing negative allosteric modulators(NAMs),positive allosteric modulators(PAMs)and competitive ***,the ligands’structure–activity relationships(SARs)and the binding models of representative ligands are also discussed,providing valuable insights for the clinical rational design of effective drugs targeting CNS diseases.

关键词： NMDA receptors GluN2A subtype Subtype-selective ligands SARs Protein ligand interactions

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全钢载重子午胎垫胶自动定长裁切机的研制

橡塑技术与装备 2016年第17期42卷 40-43页

作者：陆永高王锡花王联韵徐敬志刘法宝山东峰鸣科技有限公司山东潍坊261057

根据全钢载重子午线轮胎生产工艺,我公司研制了全钢子午胎垫胶自动定长裁切机。垫胶自动定长裁切工艺后与以前的工艺比较:省掉裁切面过水冷却工序;增加裁断接头的黏合力,降低成本(原来要刷胶浆接头);解决了在压延工序定长裁断后切口收... 详细信息

根据全钢载重子午线轮胎生产工艺,我公司研制了全钢子午胎垫胶自动定长裁切机。垫胶自动定长裁切工艺后与以前的工艺比较:省掉裁切面过水冷却工序;增加裁断接头的黏合力,降低成本(原来要刷胶浆接头);解决了在压延工序定长裁断后切口收缩变形、刷胶浆增加黏合力、不方便接头的问题;解决了百叶车打扫不干净,单条垫胶在百叶车上黏上灰尘而出现垫胶脱层的问题。实现载重子午线轮胎各胶部件除胎面外全部大卷化生产,提高生产效率和轮胎质量。

关键词：全钢子午胎垫胶自动定长裁切海绵垫布激光传感器大卷化

嘉峪关市某医院2006年-2015年住院患者死因分析

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中国病案 2017年第2期18卷 62-65页

作者：湘宁刘兴荣苏东峰刘发宝李世雄马丽君师范兰州大学公共卫生学院兰州市730000 酒钢医院嘉峪关市735100 嘉峪关市社区卫生管理办公室嘉峪关市735100 嘉峪关市疾病预防控制中心嘉峪关市735100

目的通过对嘉峪关市某医院住院死亡患者的基本情况及死因构成进行统计,为明确威胁住院患者生命的主要疾病,确定医院医疗工作重点提供依据。方法收集2006年-2015年医院住院死亡病例资料,采用ICD-10对死因进行分类,采用Excel 2007和SPSS 2... 详细信息

目的通过对嘉峪关市某医院住院死亡患者的基本情况及死因构成进行统计,为明确威胁住院患者生命的主要疾病,确定医院医疗工作重点提供依据。方法收集2006年-2015年医院住院死亡病例资料,采用ICD-10对死因进行分类,采用Excel 2007和SPSS 20.0对数据进行统计分析。结果 2006年-2015年该医院共有住院死亡病例1323人,男性死亡人数远高于女性,随年龄增长死亡人数随之上升,十年间住院患者病死率为1.02%,随年份增长病死率呈下降趋势,住院死亡病例死因顺位前四位为肿瘤、循环系统疾病、呼吸系统疾病和消化系统疾病。结论十年间住院患者病死率有所下降。死亡患者多为男性、老年人,死因构成以慢性非传染性疾病为主。提示当地应加强重点人群的健康管理,提高居民健康水平。

关键词：住院患者病死率死因构成

Ferric perchlorate-mediated radical reactions of [60]fullerene

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Science China Chemistry 2012年第10期55卷 2009-2017页

作者： LI fabao WANG GuanWu Hefei National Laboratory for Physical Sciences at Microscale Department of ChemistryUniversity of Science and Technology of ChinaHeJei 230026China Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules School of Chemistry and Chemical Engineering Hubei UniversityWuhan 430062China

Transition-metal-salt-mediated radical reactions of fullerenes have attracted extensive attention as a new and important method for fullerene functionalization. The application of relatively cheap and easily available ferric perchlorate (Fe(ClO 4 ) 3 ) to the synthesis of [60]fullerene (C 60 ) has demonstrated remarkable advantages and afforded a series of novel fullerene derivatives. In this review we present our recent progress in this area and summarize the reactions of C 60 with malonate esters, β-keto esters, nitriles, aldehydes/ketones, and arylboronic acids in the presence of Fe(ClO 4 ) 3 to afford the C 60-fused disubstituted lactones, C 60-fused hemiketal, C 60-fused dihydrofuran, C 60-fused oxazoles, C 60-fused 1,3-dioxolanes, and fullerenyl boronic esters. The possible reaction mechanisms for the above-mentioned reactions are also described in detail.

关键词： fullerene ferric perchlorate malonate esters β-keto esters nitriles aldehydes/ketones arylboronic acids

Attractive nanofiber structure based on Cu-Ti/metal sandwich film with excellent electrocatalytic performance for ethanol oxidation

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Journal of Materials Science & Technology 2020年第23期58卷 215-221页

作者： Qingzhuo Hu fabao Zhang Jinjun Zhang Wei Jiang Bo Zhang Engineering Research Center of High-Performance Copper Alloy Materials and Processing Ministry of EducationHefei University of TechnologyHefei 230009China School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China Office of Academic Affairs Hefei University of TechnologyHefei 230009China

The support materials are an important part of catalysts and they are the dispersant,adhesive,and support for other *** this study,three types of thin films with different structures were used as the precursor to prepare loading Pd *** one-step dealloying method was used to prepare a semiconductor nanofiber film(NFF)support material with upward directional growth from the ***/NFF and Pd/Ni O/NFF loaded Pd catalysts were prepared using NFF as the support material,and the electrochemical catalytic properties for ethanol oxidation in alkaline media were *** votammetry showed that the NFF support material effectively inhibited agglomeration of palladium,increased the number of active sites of Pd,and improved the electrocatalytic properties of Pd for ethanol *** addition,the Pd/Ni O/NFF loaded Pd catalyst obtained by modification with nickel oxide significantly improved the electrocatalytic performance for ethanol oxidation compared with the Pd/NFF loaded Pd *** results show that Ni O is conductive to absorption of oxygen-containing groups on the surface of the catalyst and can further improve the electrocatalytic ability of Pd for ethanol *** of the above results demonstrate that the support material prepared by the dealloying method has application prospects in load-type catalysts.

关键词： Dealloying Support material Load-type catalyst Pd/NFF Pd/NiO/NFF

Manganese(Ⅲ) acetate-mediated radical reaction of [60]fullerene with bromoacetic acid,3-chloropropionic acid or 1-naphthylacetic acid

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Chinese Science Bulletin 2010年第25期55卷 2909-2914页

作者： LI fabao ZHU SanE WANG GuanWu Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry University of Science and Technology of China Hefei 230026 China State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China

The manganese(Ⅲ) acetate-mediated radical reaction of [60]fullerene (C60) with three carboxylic acids,that is,bromoacetic acid,3-chloropropionic acid,and 1-naphthylacetic acid,was investigated. The reaction of C60 with bromoacetic acid in the presence of 4-(dimethylamino)pyridine afforded the anticipated C60-fused lactone,while the reaction with 3-chloropropionic acid unexpectedly led to the formation of a novel C60-fused lactone with the loss of one molecule of HCl. Interestingly,the reaction with 1-naphthylacetic acid under similar conditions gave both C60-fused lactone and 1,4-adduct,yet each of them could be selectively obtained by controlling reaction conditions. It was also observed that the C60-fused lactone bearing a bulky naphthyl group existed as two isomers.

关键词：富勒烯自由基反应萘乙酸溴酸介导醋酸氯酸锰

Ferric perchlorate-promoted reaction of [60]fullerene with β-keto esters

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Chinese Science Bulletin 2012年第18期57卷 2269-2272页

作者： fabao Li SanE Zhu Xun You GuanWu Wang Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules School of Chemistry and Chemical Engineering Hubei University Wuhan China Hefei National Laboratory for Physical Sciences at Microscale Department of Chemistry University of Science and Technology of China Hefei China

The ferric perchlorate-promoted reaction of [60]fullerene (C60) with ethyl 2-methylacetoacetate generates fullerenyl hemiketal as a mixture of trans and cis isomers,while the reaction with ethyl acetoacetate gives a C... 详细信息

关键词：反应机制高氯酸盐甲酸乙酯富勒烯缩酮乙酰乙酸乙酯铁呋喃衍生物

Design and optimization of piperidinesubstituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3110-3124页

作者： Yanying Sun Zhenzhen Zhou Zhongling Shi fabao Zhao Minghui Xie Zongji Zhuo Erik De Clercq Christophe Pannecouqueb Dongwei Kang Peng Zhan Xinyong liu Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China Rega Institute for Medical Research Laboratory of Virology and ChemotherapyK.U.LeuvenLeuven B-3000Belgium China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Jinan 250012China

HIV-1 reverse transcriptase(RT)has received great attention as an attractive therapeutic target for acquired immune deficiency syndrome(AIDS),but the inevitable drug resistance and side effects have always been major challenges faced by non-nucleoside reverse transcriptase inhibitors(NNRTIs).This work aimed to identify novel chemotypes of anti-HIV-1 agents with improved drugresistance profiles,reduced toxicity,and excellent druggability.A series of diarylpyrimidine(DAPY)derivatives were prepared via structural modifications of the leads K-5a2 and *** them,15a with dimethylphosphine oxide moiety showed the most prominent antiviral potency against all of the tested viral panel,being 1.6-fold(WT,EC_(50) Z 1.75 nmol/L),3.0-fold(L100I,EC_(50) Z 2.84 nmol/L),2.4-fold(K103N,EC_(50) Z 1.27 nmol/L),3.3-fold(Y181C,EC50 Z 5.38 nmol/L),2.9-fold(Y188L,EC_(50) Z 7.96 nmol/L),2.5-fold(E138K,EC_(50) Z 4.28 nmol/L),4.8-fold(F227L/V106A,EC_(50) Z 3.76 nmol/L)and 5.3-fold(RES056,EC_(50) Z 15.8 nmol/L)more effective than that of the marketed drug *** docking results illustrated the detailed interactions formed by compound 15a and WT,F227L/V106A,and RES056 ***,15a-HCl carried outstanding pharmacokinetic(t1/2 Z 1.32 h,F Z 40.8%)and safety profiles(LD_(50)>2000 mg/kg),which demonstrated that 15a HCl is a potential anti-HIV-1 drug candidate.

关键词： HIV-1 NNRTIs NNIBP Structural alert Anti-HIV-1 drug candidate