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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Physical Layer Security Scheme With Aoi-Awareness for industrial ioT Based on Covert Communications

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iEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： yaping Li Zhi-Xin Liu Jia-Wei Su ya-Zhou Yuan the Key Laboratory of industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,industrial internet of things(iioT) is a typical application of cyberphysical system(CPS). in the iioT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

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Effects and Mechanisms of RE on impact Toughness and Fracture Toughness of Clean Heavy Rail Steel

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Journal of iron and Steel Research international 2011年第3期18卷 52-58页

作者： LiU Cheng-jun HUANG ya-he JiANG Mao-fa School of Materials and Metallurgy Northeastern UniversityShenyang 110004LiaoningChina

Clean high carbon heavy rail steel was prepared by the process of vacuum induction furnace smelting,forging and *** of RE on the impact toughness and fracture toughness for clean high carbon steel were *** addition,the appropriate range of RE content for clean high carbon steel was *** the austenite grain size and pearlite lamellar spacing decreased due to small amount of RE,consequently the impact toughness and fracture toughness were improved *** the RE content exceeded a critical value,the pearlite lamellar spacing was increased,because RE was segregated on the austenite grain boundaries,damaged the orientation relationship of pearlite transformation,caused the disorder growth and morphology degenerating of *** the increasing of RE content,both the impact toughness and fracture toughness of clean high carbon steel were gradually increased at first and then *** was found that when the RE content was between 0.0081% and 0.0088%,both the impact toughness and fracture toughness of clean high carbon heavy rail steel were the *** maximum ballistic work was 21.2 J（20 ℃） and 12.2 J（-20 ℃）,*** maximum plane-strain fracture toughness was 45.67 MPa·m1/2（20 ℃） and 37.04 MPa·m1/2（-20 ℃）,respectively.

关键词： rare earth high carbon steel heavy rail steel clean steel impact toughness fracture toughness

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Collapsing characteristics of gas-bearing cavitation bubble

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Journal of Hydrodynamics 2019年第1期31卷 66-75页

作者： ya-lei Zhang Wei-lin Xu fa-xing Zhang Qi Zhang State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China

The cavitation is directly related to the safety of many large water conservancy *** are two types of cavitation bubbles,one is generated by the gas nucleus,called the non gas-bearing cavitation bubble,and another is generated by the gas bubble,called the gas-bearing cavitation *** have significantly different collapsing *** paper studies the cavitation bubbles,generated by a high voltage pulse bubble generation system,and discusses the gas-bearing cavitation bubble's characteristics a from the aspects of the collapse process,the cycle,the size and the collapse *** is shown that:(1) the collapse of the gas-bearing cavitation bubbles can be divided into two types:the centripetal collapse and the bisected collapse,(2) the cycle period and the size of the gas-bearing cavitation bubble increase significantly,and the increase norm has a certain relationship with the bubble diameter ratio,(3) the collapse strength of the gas-bearing cavitation bubble decreases *** larger the bubble diameter ratio,the greater the effect will be.

关键词： Cavitation gas-bearing cavitation bubble collapse cycle collapse strength

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Coalescence Suppression in Flowing Polymer Blends Using Silica Rods with Different Surface Chemistries

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Chinese Journal of Polymer Science 2021年第4期39卷 474-483,I0007页

作者： Si-Ying Xiang Li-sa-ya Ye ya-Jiang Huang ya-Dong Lv Mi-Qiu Kong Guang-Xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu 610065China

Silica rods with homogeneous(hydrophilic or hydrophobic)and amphiphilic surface properties were synthesized and their efficiencies in suppressing the flow-induced droplet coalescence of immiscible polyisobutylene(PiB)/polydimethylsiloxane(PDMS)blends were evaluated via in situ visualization *** flow-induced coalescence behavior of blends was found to strongly depend on the surface nature and concentration of silica rods added as well as the blend *** a trace amount of rods promoted coalescence,all kinds of rods demonstrated a morphology refinement effect at high rod *** compatibilization effects were obtained at high rod concentrations,especially for hydrophilic and amphiphilic *** on confocal laser scanning microscopy results,these phenomena observed were interpreted reasonably in terms of the selective distribution and aggregation of silica rods,which were suggested to be decisive for the stabilization mechanism and efficiency of these rods.

关键词： immiscible polymer blends Flow Morphology Silica rods Surface chemistry

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Syntheses,Structures,and Luminescent Properties of New Zn~Ⅱ-Y~Ⅲ and Zn~Ⅱ-Ln~Ⅲ Schiff Base Complexes

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Chinese Journal of Structural Chemistry 2015年第8期34卷 1273-1280页

作者： HU Jin-fa QiN ya-Ru Li Yu LiU Wei WANG Yong Li ya-Hong College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Eight new ZnⅡ-yⅢ and ZnⅡ-LnⅢ heterometallic Schiff base complexes： MZnL2（NO3）3 （M = Y （1）, La （2）, Pr （3）, Nd （4）, Eu （5）, Gd （6）, Dy （7）, Er （8）; L = 2-（（（2- （imidazo[1,5-a]pyridin-3-yl）phenyl）imino）methyl）-6-methoxyphenol）, have been rationally synthesized under solvothermal conditions and characterized by iR, elemental analyses （EA）, single-crystal X-ray diffraction, and powder XRD. Furthermore, luminescence in the visible region for solids 1-8 suggested zine/ligand-centered emission at room temperature.

关键词： heterometallic complex, crystal structure, luminescence

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Reaction mechanism of lanthanum nitrate-doped Mo–La material during solid–liquid spray doping processing

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Rare Metals 2015年第11期34卷 814-817页

作者： Peng-fa Feng Qin-Li yang Xiao-Ming Dang Sha Xi ya-Qi Wang Jinduicheng Molybdenum Co. Ltd

At three critical temperatures which were obtained by thermo-gravimetry-differential thermal analysis–differential scanning calorimetry（TG/DTG/DSC）curves of lanthanum nitrate crystal, the air thermal decomposition experiments and solid–liquid spray doping simulation procedures of lanthanum nitrate crystal were carried out, and their products were analyzed by X-ray diffraction（XRD）. Meanwhile, the spray doping processing of Mo O2–50 wt% La（NO3）3composite powder was undergone with lanthanum nitrate solution as the dopant,and doped Mo O2powder was analyzed by XRD. The results demonstrate that during the traditional solid–liquid spray doping processing, lanthanum nitrate, in the form of either crystal or aqueous solution, would be converted into La（NO3）3á4H2O by the dehydration reaction, rather than be decomposed to La2O3and NO or NO2. Therefore, it is inferred that the oxynitride gas produced from the process is attributed to the decomposition of residual HNO3in lanthanum nitrate crystal. The source of HNO3is supported by the chemical composition of lanthanum nitrate crystal.

关键词： Solid–liquid spray doping processing Mo O2 Lanthan

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g-C_(3)N_(4)负载双金属Rh@Ru催化氨硼烷析氢反应机理研究

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原子与分子物理学报 2025年第5期42卷 17-21页

作者：郭雅琼武警警官学院成都610213

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、... 详细信息

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、Ⅱ所需活化能较高,反应路径Ⅲ更容易进行,Ⅰ为最优析氢路径.从微观角度揭示双贵金属Rh@Ru负载g-C_(3)N_(4)催化氨硼烷析氢的三条机理,希望为氨硼烷析氢催化剂的优化和设计提供理论信息.

关键词：双金属催化剂 g-C_(3)N_(4) NH_(3)BH_(3) 密度泛函理论反应机理

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Spatial High Accuracy Analysis of FEM for Two-dimensional Multi-term Time-fractional Diffusion-wave Equations

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Acta Mathematicae Applicatae Sinica 2018年第4期34卷 828-841页

作者： ya-bing WEi yan-min ZHAO Zheng-guang SHi Fen-ling WANG Yi-fa TANG School of Mathematics and Statistics Xuchang University Xuchang 461000 China School of Mathematics and Systems Science Beihang University Beijing 100191 China School of Economic Mathematics Southwestern University of Finance and Economic Chengdu 611130 China LSEC ICMSEC Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190China School of Mathematical Sciences University of Chinese Academy of Sciences Beijing 100049 China

in this paper, high-order numerical analysis of finite element method（FEM） is presented for twodimensional multi-term time-fractional diffusion-wave equation（TFDWE）. First of all, a fully-discrete approximate scheme for multi-term TFDWE is established, which is based on bilinear FEM in spatial direction and Crank-Nicolson approximation in temporal direction, respectively. Then the proposed scheme is proved to be unconditionally stable and convergent. And then, rigorous proofs are given here for superclose properties in H-1-norm and temporal convergence in L-2-norm with order O（h-2＋ τ-（3-α））, where h and τ are the spatial size and time step, respectively. At the same time, theoretical analysis of global superconvergence in H-1-norm is derived by interpolation postprocessing technique. At last, numerical example is provided to demonstrate the theoretical analysis.

关键词： multi-term time-fractional diffusion-wave equation bilinear finite element method Crank-Nicolsonapproximation stability convergence and superconvergence

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