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Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok Chan Fuda Xie Yigan Zhang Li Liang Kam Tong Leung Kwok Wai lo Jun Yu Gary m.K.Tse Wei Kang Ka fai To department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen research Institute The Chinese University of Hong KongShenzhenChina department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical research Taihe HospitalHubei University of MedicineShiyanChina department of Pediatrics The Chinese University of Hong KongHong KongChina department of medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(mTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

15N tracers and microbial analyses reveal in situ N2O sources in contrasting water regimes of a drained peatland forest

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Pedosphere 2024年第4期34卷 749-758页

作者： mohit mASTA mikk ESPENBErG Laura KUUSEmETS Jaan P?rN Sandeep THAYAmKOTTU Holar SEPP Kalle KIrSIm?E Fotis SGOUrIDIS Kuno KASAK Kaido SOOSAAr ülo mANder Institute of Ecology and Earth Sciences University of Tartu School of Geographical Sciences University of Bristol University Road

managed peatlands are a significant source of nitrous oxide（N2O）, a powerful greenhouse gas and stratospheric ozone depleter. Due to the complexity and diversity of microbial N2O processes, different methods such as tracer, isotopomer, and microbiological technologies are required to understand these processes. The combined application of different methods helps to precisely estimate these processes, which is crucial for the future management of drained peatlands, and to mitigate soil degradation and negative atmospheric impact. In this study, we investigated N2O sources by combining tracer, isotopomer,and microbial analysis in a drained peatland forest under flooded and drained treatments. On average, the nitrification genes showed higher abundances in the drained treatment, and the denitrification genes showed higher abundances in the flooded treatment. This is consistent with the underlying chemistry,as nitrification requires oxygen while denitrification is anaerobic. We observed significant differences in labelled N2O fluxes between the drained and flooded treatments. The emissions of N2O from the flooded treatment were nearly negligible, whereas the N2O evolved from the nitrogen -15(15N)-labelled ammonium(15NH4+) in the drained treatment peaked at 147 μg15N m-2h-1. This initially suggested nitrification as the driving mechanism behind N2O fluxes in drained peatlands, but based on the genetic data, isotopic analysis, and N2O mass enrichment, we conclude that hybrid N2O formation involving ammonia oxidation was the main source of N2O emissions in the drained treatment. Based on the15N-labelled nitrate(15NO3-) tracer addition and gene copy numbers, the low N2O emissions in the flooded treatment came possibly from complete denitrification producing inert dinitrogen. At atomic level, we observed selective enrichment of mass 45 of N2O molecule under15NH4+amendment in the drained treatment and enrichment of both masses 45 and 46under15NO3-amendment in the flooded trea

关键词： denitrification field experiment isotopes nitrification nitrous oxide qPCr

Prevalence and factors Associated with Diabetes among City Hall Workers, Bohicon, Benin

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Open Journal of Epidemiology 2024年第2期14卷 366-377页

作者： Adjobimey mênonli Djohoun Frimège mama Cissé Ibrahim mikponhoué rose Gounongbé fabien Ayélo Paul Hinson Vikkey Antoine Unité de Recherche et d&#8217Enseignement en Sant&#233 au Travail et Environnement FSS Cotonou Cotonou Benin Service de Santé au Travail du Centre National Hospitalier Universitaire de Pneumo-Phtisiologie de Cotonou Cotonou Benin Laboratoire d’ Epid&#233miologie des Maladies Chroniques et Neurologiques FSS Cotonou Benin Ecole de mé decine Universit&#233 de Parakou Parakou Benin

Introduction: Living and working conditions are increasingly conducive to a sedentary lifestyle. many administrative workers are exposed daily to long hours of work in a prolonged sitting position, which can favour the onset of diabetes. The aim of the study was to determine the prevalence and factors associated with diabetes among workers at a town hall in Benin in 2019. methods: This was a descriptive cross-sectional study conducted from december 2018 to January 2019. Exhaustive recruitment was carried out. Data were collected during a face-to-face interview, using a standardized questionnaire including socio-professional factors, behavioral factors, anthropometric measurements, and blood glucose. Frequencies were calculated. Frequencies were compared using the chi-square and Fisher tests. The significance threshold was 5%. results: A total of 85 workers were included. Their mean age was 41.55 ± 9.82 years, with a sex ratio of 6.1. = The prevalence of diabetes was estimated at 8.2% [95% CI: 3.38 - 16.23%] and 3 of the workers knew they had diabetes. A family history of diabetes was associated with diabetes (p = 0.032). Occupationally, 10.77% of permanent em.loyees had diabetes, compared with 0.0% of non-permanent em.loyees;12.50% of em.loyees with at least 10 years’ seniority had diabetes, compared with 7.25% of those with less seniority;19.05% of em.loyees who spent at least 6 hours a day sitting at work had diabetes, compared with 4.69% of those who spent less time sitting. Conclusion: Preventing chronic disease in the workplace is part of promoting workers’ health, and must take into account occupational factors such as prolonged sitting.

关键词： Diabetes Prolonged Sitting Workers-Benin

Influence of the Nature of the Incoming Sludge on the Performance of a Vertical Flow reed Beds in Dakar-Senegal

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Journal of Water resource and Protection 2024年第6期16卷 429-449页

作者： Elhadji mamadou Sonko Diomaye Dieng maïmouna lo Cheikh Diop Laboratoire detude Environnemental des milieux Urbains (LEEmUr) Institut des Sciences de lEnvironnement (ISE) Facult des Sciences et Technique (FST) Universit Cheikh Anta Diop de Dakar (UCAD) Dakar-Fann Sngal

This work investigates the influence of the type sludge on drainage, plant development, purification performances and biosolids quality. Drainage properties were measured through the frequency of clogging, the percentage of leachate recovered and the dryness of accumulated sludge. Plant development was measured through the density, the height and the stem diameter. Purification performance was evaluated from the reduction rate. Biosolids quality was measured after 3 months of maturation. The results show that the clogging frequencies were 9.5%;0% and 3.7%;the volume of leachate recovered was 42.2%;20.4% and 24.7% and, the dryness was 33.4%;61.1% and 52.4% for FS-ST, FS-STT and SS respectively. Plants densities were about, with densities 197.1, 171.3 and 178.3 plants/m2 in beds fed respectively with FS-ST, FS-STT and SS. despite the high removal rates, the concentrations of pollutants in the leachates are above the Senegalese standard NS 05-061 for discharge into the environment. The biosolids are all mature with C/N and NH4+/NO3?ratios lower than 12 and 1 respectively. The biosolids are also rich in organic and mineral elements. The concentrations of Ascaris eggs are higher than the WHO recommendations. These biosolids should be stored for additional time or composted.

关键词： Biosolid Quality dewatering Performance Planted Drying Beds Purification Performance Sludge Type

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Occupational Diseases and Environmental medicine 2024年第2期12卷 142-159页

作者： Adjobimey mênonli mikponhoué rose Dégbey Cyriaque Hountohotègbé Esdras Guédou Alexandre Lawani Affousath Ayélo Paul Hinson Antoine Unité de Recherche et d&#8217Enseignement en Sant&#233 au Travail et Environnement FSS Cotonou Benin Service de Santé au Travail du Centre National Hospitalier Universitaire de Pneumo-Phtisiologie Cotonou Benin Occupational Health Service at the referral Hospital Construction Site Abomey-Calavi Benin Inter-faculty Center for Environmental Training and research for Sustainable development (CIFrED) Abomey-Calavi Benin

Introduction: Work-related accidents are frequent and serious in the construction sector. The aim of the study was to determine the frequency and factors associated with occupational accidents on the construction site of a referral hospital in Benin. methods: A cross-sectional study was carried out. The sample size was calculated using the Schwartz form adjusted for the number of workers on site and was 129 workers. random sampling was used. The dependent variable was work-related accidents. The other variables were socio-demographic and occupational characteristics. Data were collected through a questionnaire survey. medians and proportions were calculated. An association was sought using Chi-square and Fisher tests with a threshold of p results: A total of 132 workers were included. Their median age was 30 years with an ITQ of [27 - 38];men were the most represented 126 (95.45%) with a level of education higher than or equal to high school in 101 (76.52%) and in the majority with a permanent status 85 (64.39%). Seniority of more than 5 years was observed in 92 (69.7%). Workers working more than 8 hours of overtime per week numbered 57 (43.18%). Exposure to vibrating objects was 49 (37.12%). In terms of psychosocial constraints, 82.58% had high psychological demands;79.53% low decision-making latitude;50.76% low social support. The frequency of work-related accidents was 6.82%, and the only associated factor was the type of worker (p = 0.016). On the other hand, there were 10.2% accidents among workers handling vibrating objects versus 4.98% among those not using them. With regard to psychosocial constraints, the following frequencies were recorded respectively: 6.42% among those with high psychological demand versus 8.7% among those with low psychological demand;7.62% among those with low decision-making latitude versus 3.7% among those with high decision-making latitude;8.96% among those with low social support versus 4.62% among those with high support. Conclusi

关键词： Occupational Injury Building and Civil Engineering Construction Environment

risk factors for Cardiovascular Disease among Hotel Workers, Bohicon, Benin

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Occupational Diseases and Environmental medicine 2024年第2期12卷 130-141页

作者： mênonli Adjobimey rose mikponhoué Eméline Gbaguidi Esdras Hountohotegbè Hélène Sacca Paul Ayélo Vikkey Antoine Hinson Unité de Recherche et d&#8217Enseignement en Sant&#233 au Travail et Environnement FSS Cotonou Cotonou Benin Service de Santé au Travail du Centre National Hospitalier Universitaire de Pneumo Phtisiologie de Cotonou Cotonou Benin Laboratoire d’ Epid&#233miologie des Maladies Chroniques et Neurologiques FSS Cotonou Benin

Introduction: Non-communicable diseases (NCDs) are on the increase in several sectors of activity. The aim of the study was to determine the frequencies of cardiovascular risk factors (CVrF) and factors associated with hypertension among hotel workers in the city of Bohicon. methods: This was a descriptive and analytical cross-sectional study conducted in the period from december 2018 to January 2019. The variables studied were sociodemographic, occupational, anthropometric and behavioral. Participant recruitment was exhaustive. A standardized questionnaire inspired by the STEPS-WHO questionnaire was used for data collection. After the descriptive analysis, a bivariate analysis was performed using Pearson’s Chi-square test or Fisher’s test at the 5% threshold. results: A total of 101 workers, 53 (52.47%) of them male, participated in the study. The mean age was 30.60 ± 8.20 years, with extremes of 18 and 55 years. The frequencies of the main risk factors were: 68.32% sitting position > 6 hours/day;38.61% shift work;21.78% high psychological demand, 82.18% low decision latitude, 24.75% low social support, 21.78% occupational stress;7 (6.93%) harmful alcohol consumption;6.93% tobacco consumption;48.51% insufficient physical activity;98.02% insufficient fruit and vegetable consumption;59.41% overweight;14.85% HTA. factors associated with hypertension were: sex, age and marital status. Conclusion: Occupational factors need to be taken into account when assessing CVrFs. NCD control programs are needed in all sectors of activity. A larger study is needed in the hotel sector.

关键词： FDrCV Occupational factors Hypertension Hotels Benin

role of nickel-regulated small rNA in modulation of Helicobacter pylori virulence factors

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World Journal of Clinical Cases 2022年第31期10卷 11283-11291页

作者： fa.rício freire de m.lo Hanna Santos marques fabian Fellipe Bueno Lemos marcel Silva Luz Samuel Luca rocha Pinheiro lorena Sousa de Carvalho Cláudio Lima Souza márcio Vasconcelos Oliveira Institution multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

Helicobacter pylori(***)is a Gram-negative bacterium that infects about half of the world's *** infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged *** *** this sense,small regulatory rNAs(srNAs)are important macromolecules capable of inhibiting and activating gene *** function allows srNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial *** discoveries have shown that nickelregulated small rNA(NikS)is a post-transcriptional regulator of virulence properties of ***,including the oncoprotein ***,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of *** addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients *** that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of *** and the potential clinical repercussions of this modulation.

关键词： Helicobacter pylori Small regulatory rNAs Nickel-regulated small rNA Virulence factors Cytotoxin associated antigen A Gastric cancer

Humoral response and Tolerance of Vaccination against SArS-CoV-2 in Adults Senegalese Patients Undergoing Hemodialysis: A multicenter Prospective Study

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Open Journal of Nephrology 2024年第1期14卷 70-80页

作者： lot Nehemie motoula Latou moustapha mbow modou Ndongo Gnagna faye Gora lo Sidy mohamed Seck department of Nephrology and Dialysis Military Hospital of Ouakam Dakar Senegal Immunology Laboratory Military Hospital of Ouakam Dakar Senegal department of Nephrology and Dialysis Regional Hospital of Kedougou Kedougou Senegal department of Nephrology Idrissa Pouye General Hospital Dakar Senegal Bacterioloy and Virology Laboratory CMIA Dakar Senegal IrL-3189 ESS/UGB/CNrS/UCAD/CNrST/USTB Faculty of Health Sciences University Gaston Berger Saint-Louis Senegal

Introduction: Following the COVID-19 pandemic, vaccination has been proposed in several countries as the main preventive measure despite very limited data, particularly in dialysis patients. We conducted this study to assess the immunological response to vaccination in Senegalese hemodialysis patients. Patients and methods: We conducted a prospective study, in two dialysis centers in Dakar from march 30th to August 30th, 2021 including patients on hemodialysis for >6 months, vaccinated against SArS-CoV-2 according to the vaccination schedule recommended by WHO. A vaccine response was considered positive when seroconversion was observed after one dose of vaccine. The clinical efficacy of immunization was defined as the absence of new COVID-19 infection in patients who received a complete vaccination. results: Among the 81 patients included in the study, 7.4% had anti-Spike Igm antibodies before their first vaccination. Seroprevalence of Igm antibodies was 38.3% one month after the first vaccine dose (at m1) and 8.6% one month after the second dose (at m4). Anti-Spike IgG antibodies were present in 40.3% of patients before vaccination, in 90.1% at m1, and in 59.7% at m4. Among patients previously infected with SArS-CoV-2, 10.2% had Igm antibodies at m0, 31.6% at m1, and 10.5% at m4 post-vaccination. Similarly, seroprevalences of IgG antibodies in this subgroup were 31.5%, 61.3%, and 50.0% respectively at m0, m1, and m4 post-vaccination. A comparison of seroconversion rates between m0 and m4 showed significant differences only for IgG in COVID-19 naive patients. mean duration in dialysis and the existence of previous COVID-19 infection were associated with patients’ vaccinal response after the two doses. Age, gender and the use of immunosuppressive treatment did not influence post-vaccinal antibody production. Conclusion: Vaccination against COVID-19 in Senegalese hemodialysis patients induced a low seroconversion rate but it was well tolerated. m

关键词： SArS-Cov2 Vaccination Humoral response Tolerance Hemodialysis Senegal

Immune response modulation in inflammatory bowel diseases by Helicobacter pylori infection

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World Journal of Gastroenterology 2023年第30期29卷 4604-4615页

作者： Gabriella Feilstrecker Balani mariana dos Santos Cortez Jayme Euclydes Picasky da Silveira Freitas fa.rício freire de m.lo Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil Campus Anísio Teixeira Universidade Federal da BahiaInstituto Multidisciplinar em SaúdeVitória da Conquista 45.029-094BahiaBrazil Programa de Pós-graduação em Biotecnologia-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Programa multicêntrico de Pós-graduação em Bioquímica e Biologia molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil

many studies point to an association between Helicobacter pylori(***)infection and inflammatory bowel diseases(IBD).Although controversial,this association indicates that the presence of the bacterium somehow affects the course of *** appears that *** infection influences IBD through changes in the diversity of the gut microbiota,and hence in local chemical characteristics,and alteration in the pattern of gut immune *** gut immune response appears to be modulated by *** infection towards a less aggressive inflammatory response and the establishment of a targeted response to tissue ***,a T helper 2(Th2)/macrophage m2 response is stimulated,while the Th1/macrophage m1 response is *** immunomodulation appears to be associated with intrinsic factors of the bacteria,such as virulence factors-such oncogenic protein cytotoxin-associated antigen A,proteins such *** neutrophil-activating protein,but also with microenvironmental changes that favor permanence of *** in the *** changes include the increase of gastric mucosal pH by urease activity,and suppression of the stomach immune response promoted by evasion mechanisms of the ***,there is a causal relationship between *** infection and components of the innate immunity such as the NLr family pyrin domain containing 3 inflammasome that directs IBD toward a better prognosis.

关键词： Cytotoxin-associated antigen A oncoprotein Gut microbiota Helicobacter pylori Helicobacter pylori neutrophilactivating protein Immunological modulation Inflammatory bowel disease NLr family pyrin domain containing 3 inflammasome