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CTGF, intestinal stellate cells and carcinoid fi brogenesis

World Journal of Gastroenterology 2007年第39期13卷 5208-5216页

作者： M Kidd im Modlin MD Shapiro Rl Camp SM Mane W Usinger JR Murren Departments of Surgery Yale University School of Medicine New Haven Connecticut 06520-8062 United States Departments of Pathology Yale University School of Medicine New Haven Connecticut 06520-8062 United States Departments of Affymetrix Resource Keck Biotechnology Resource Laboratory Yale University School of Medicine New Haven Connecticut 06520-8062 United States Fibrogen Inc San Francisco CA United States Departments of Medical Oncology Yale University School of Medicine New Haven Connecticut 06520-8062 United States

Aim： To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fibrosis via activation of an ＂intestinal＂ stellate cell. METHODS： GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profiling （AQUA analysis） in a GI carcinoid tissue microarray （TMA） with immunostaining and correlated with clinical and histologically documented fibrosis. Serum CTGF was analyzed using a sandwich ElISA assay. RESUlTS： Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were significantly increased （〉 2-fold, P 〈 0.05） versus normal mucosa and gastric （non-fibrotic） carcinoids. Activated stellate cells and markers of stellate cell-mediated fibrosis （vimentin, desmin） were identified in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 （10-7M） initiated CTGF transcription response （〉 3-fold, P 〈 0.05） demonstrated. In SI carcinoid tumor patients with documented fibrosis, TMA analysis demonstrated higher CTGF immunostaining （AQUA Score： 92 ± 8, P 〈0.05）, as well as elevated TGFβ1 （90.6 ± 4.4, P 〈 0.05）. Plasma CTGF （normal 12.5 ± 2.6 ng/ml） was increased in SI carcinoid tumor patients （31 ± 10 ng/ml, P 〈 0.05） compared to non-fibrotic GI carcinoids （〈 15 ng/ml） CONClUSION： SI carcinoid tumor fibrosis is a CTGF/ TGFβl-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications.

关键词： Carcinoid Connective tissue growth factor fibrosis Small intestine Stellate cell TGFI

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Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells

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World Journal of Gastroenterology 2011年第8期17卷 976-986页

作者： Ho-Keun Kwon Ji-Sun Hwang Choong-Gu lee Jae-Seon So Anupama Sahoo Chang-Rok im Won Kyung Jeon Byoung Seob Ko Sung Haeng lee Zee Yong Park Sin-Hyeog im School of life Sciences and immune Synapse Research Center Gwangju Institute of Science and Technology Global leader program Bugil Academy Cheonan Korea Institute of Orien-tal Medicine Chosun University School of Medicine

Aim:To investigate the anti-inflammatory effects of cinnamon extract and elucidate its mechanisms for targeting the function of antigen presenting ***:Cinnamon extract was used to treat murine macrophage cell line(Raw 264.7),mouse primary antigen-presenting cells(APCs,MHCII+) and CD11c+dendritic cells to analyze the effects of cinnamon extract on APC *** mechanisms of action of cinnamon extract on APCs were investigated by analyzing cytokine production,and expression of MHC antigens and co-stimulatory molecules by quantitative real-time PCR and flow *** addition,the effect of cinnamon extract on antigen presentation capacity and APC-dependent T-cell differentiation were analyzed by [H3]-thymidine incorporation and cytokine analysis,*** confirm the anti-inflammatory effects of cinnamon extract in vivo,cinnamon or PBS was orally administered to mice for 20 d followed by induction of experimental colitis with 2,4,6 trinitrobenzenesulfonic *** protective effects of cinnamon extract against experimental colitis were measured by checking clinical symptoms,histological analysis and cytokine expression prof iles in inflamed ***:Treatment with cinnamon extract inhibited maturation of MHCII+ APCs or CD11c+ dendritic cells(DCs) by suppressing expression of co-stimulatory molecules(B7.1,B7.2,ICOS-l),MHCII and cyclooxygenase(COX)-*** extract induced regulatory DCs(rDCs) that produce low levels of pro-inflammatory cytokines [interleukin(Il)-1β,Il-6,Il-12,interferon(IFN)-γ and tumor necrosis factor(TNF)-α] while expressing high levels of immunoregulatory cytokines(Il-10 and transforming growth factor-β).In addition,rDCs generated by cinnamon extract inhibited APC-dependent T-cell proliferation,and converted CD4+ T cells into Il-10high CD4+ T ***,oral administration of cinnamon extract inhibited development and progression of intestinal colitis by inhibiting expression of COX-2 and pro-inflammatory cytokin

关键词： Cinnamon extract Inflammation CD4 antigen Antigen presenting cells Cyclooxygenase-2 Tumor necrosis factor-α Interleukin-10 Inflammatory bowel disease

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Zero-static-power nonvolatile logic-in-memory circuits for flexible electronics

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Nano Research 2017年第7期10卷 2459-2470页

作者： Byung ChulJang Sang Yoon Yang Hyejeong seong Sung Kyu Kim Junhwan Choi Sung Gap im Sung-Yool Choi School of Electrical Engineering Graphene/2D Materials Research Center Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Department of Chemical and Biomolecular Engineering Graphene/2D Materials Research Center Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Flexible logic circuits and memory with ultra-low static power consumption are in great demand for battery-powered flexible electronic systems. Here, we show that a flexible nonvolatile logic-in-memory circuit enabling normally-off computing can be implemented using a poly（1,3,5-trivinyl-l,3,5-trimethyl cyclotrisiloxane）（pV3D3）-based memristor array. Although memristive logic-in-memory circuits have been previously reported, the requirements of additional components and the large variation of memristors have limited demonstrations to simple gates within a few operation cycles on rigid substrates only. Using memristor-aided logic （MAGIC） architecture requiring only memristors and pV3D3-memristor with good uniformity on a flexible substrate, for the first time, we experimentally demonstrated our implementation of MAGIC-NOT and -NOR gates during multiple cycles and even under bent conditions. Other functions, such as OR, AND, NAND, and a half adder, are also realized by combinations of NOT and NOR gates within a crossbar array. This research advances the development of novel computing architecture with zero static power consumption for battery- powered flexible electronic systems.

关键词： memristor memristive logic circuit flexible nonvolatilelogic-in-memory circuit normally-off computing memristor-aided logic(MAGIC) architecture

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The Use of Secondary Grape Biomass in Beef Cattle Nutrition on Carcass Characteristics, Quality and Shelf life of Meat

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Food and Nutrition Sciences 2024年第6期15卷 447-469页

作者： Vitor l. Molosse Guilherme l. Deolindo Rafa.l V. P. lago Bruna Klein Claiton A. Zotti Marcelo Vedovato Marcylene V. da Silveira Priscila M. Copetti Maria R. C. Schetinger Juscivete F. favero Eliana l. Fiorentin Aleksandro S. da Silva Universidade do Estado de Santa Catarina (UDESC) Chapec Brazil Department of Animal Science UDESC Chapec Brazil Department of Animal Science Universidade do Oeste de Santa Catarina Xanxere Brazil Dean lee Research and Extension Center Louisiana State University Alexandria LA USA Department of Biochemistry Universidade Federal de Santa Maria Santa Maria Brazil Department of Medicina Veterinria UNOCHAPEC Chapec Brasil

We determined whether the inclusion of 100 g/kg dry matter of grape pomace silage (GPS) and grape pomace bran (GPB) as substitutes for other traditional fiber sources in the diet of steers (Charolais x Nellore) would improve carcass characteristics, meat quality and composition, and shelf life. Twenty-four animals (248 ± 19.32 kg of initial body weight) were fed a high concentrate diet for 121 days. Carcass characteristics were measured, and the longissimus dorsi muscle was analyzed for fatty acid (fa) profile and composition. The meat was sliced and stored in air-permeable packages for 10 days. On each sampling day (d 1, 3, 7, and 10), oxidative stability, bacterial load, lipid and protein oxidation, and staining were analyzed. The experimental diets influenced the pH of cold carcasses only. The GPS group had a higher pH than the control. The GPS and GPB groups showed improved oxidant status (i.e., lower lipid peroxidation and concentrations of reactive oxygen species were in the meat of both groups than in control). On the first day of storage, the antioxidant enzyme glutathione S-transferase activity was more significant in the meat of the GPS and GPB groups than in the control. The bacterial loads in the meat were attenuated by GPS inclusion;there were lower total coliform counts and a trend toward lower counts for enterobacteria in the control group. The diets altered the fa profile of the meat;i.e., the GPB diet allowed for a more significant amount of the n-6 omegas in the meat, while the GPS diet showed a tendency for a more significant amount of n-6 and 9 omegas. Both diets (GPS and GPB) increased the amounts of long-chain fas. The GPS diet decreased saturated fa.levels. We conclude that the dietary treatments GPS and GPB are a promising alternative to maintain meat quality standards throughout in real-world retail conditions. These treatments gave rise to an improvement in the nutritional value of the meat due to the more significant amounts of fas that im

关键词： Animal Nutrition Antioxidant Biomass Grape Meat Quality Microbiology Residue

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Debaryomyces hansenii supplementation in low fish meal diets promotes growth,modulates microbiota and enhances intestinal condition in juvenile marine fish

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Journal of Animal Science and Biotechnology 2024年第1期15卷 253-276页

作者： Ignasi Sanahuja Alberto Ruiz Joana P.Firmino Felipe E.Reyes-lópez Juan B.Ortiz-Delgado Eva Vallejos-Vidal lluis Tort Dariel Tovar-Ramírez Isabel M.Cerezo Miguel A.Moriñigo Carmen Sarasquete Enric Gisbert Aquaculture Program Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain Centro de Biotecnologia Acuicola Universidad de Santiago de ChileSantiagoChile Instituto de Ciencias Marinas de Andalucia(ICMAN-CSIC) Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nucleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronomicas Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile Department of Cell Biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain Centro de Investigaciones Biologicas del Noroeste SC CIBNORLa PazMexico Department of Microbiology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain SCBI Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

Background The development of a sustainable business model with social acceptance,makes necessary to develop new strategies to guarantee the growth,health,and well-being of farmed *** hansenii is a yeast species that can be used as a probiotic in aquaculture due to its capacity to i)promote cell proliferation and differen-tiation,ii)have immunostimulatory effects,iii)modulate gut microbiota,and/or iv)enhance the digestive *** provide inside into the effects of *** on juveniles of gilthead seabream(Sparus aurata)condition,we inte-grated the evaluation of the main key performance indicators coupled with the integrative analysis of the intestine condition,through histological and microbiota state,and its transcriptomic *** After 70 days of a nutritional trial in which a diet with low levels of fishmeal(7%)was supplemented with 1.1%of ***(17.2×10^(5) CFU),an increase of ca.12%in somatic growth was observed together with an improve-ment in feed conversion in fish fed a yeast-supplemented *** terms of intestinal condition,this probiotic modu-lated gut microbiota without affecting the intestine cell organization,whereas an increase in the staining intensity of mucins rich in carboxylated and weakly sulphated glycoconjugates coupled with changes in the affinity for certain lectins were noted in goblet *** in microbiota were characterized by the reduction in abundance of several groups of Proteobacteria,especially those characterized as opportunistic *** microarrays-based transcrip-tomic analysis found 232 differential expressed genes in the anterior-mid intestine of ***,that were mostly related to metabolic,antioxidant,immune,and symbiotic *** Dietary administration of *** enhanced somatic growth and improved feed efficiency param-eters,results that were coupled to an improvement of intestinal condition as histochemical and transcriptomic tools *** probiotic ye

关键词： Debaryomyces hansenii Intestine condition low fish meal diet Microbiota Transcriptomics Yeast probiotic

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Differences between radiological findings of COVID-19 and non-COVID-19 infections in pediatric patients

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World Journal of Pediatrics 2021年第1期17卷 79-84页

作者： Beyza Nur Kuzan Bülent Aslan Taha Yusuf Kuzan Aysegül Karahasan Yagci Nuri Cagatay Cimsit Department of Radiology Marmara University School of MedicineIstanbul 34899Turkey Department of Radiology Sancaktepe Sehit Dr.Ilhan Varank Training and Research HospitalIstanbul 34785Turkey Department of Clinical Microbiology Marmara University School of MedicineIstanbul 34899Turkey

Background This study aimed to reveal the differences between coronavirus disease 2019(COVID-19)infections and non-COVID-19 respiratory tract infections in pediatric *** Sixty pediatric patients admitted to the hospital between March 11,2020 and April 15,2020 with respiratory tract infections were evaluated *** them,20 patients with reverse transcription-polymerase chain reaction(RT-PCR)tests and chest computed tomography(CT)examinations were included in the *** to the RT-PCR test results,the patients were divided into the COVID-19 and non-COVID-19 *** clinical observations,laboratory results,and radiological features from the two groups were then *** According to the RT-PCR test results,12 patients were assigned to the COVID-19 group and 8 to the non-COVID-19 *** were no significant differences between the two groups in terms of clinical or laboratory *** terms of radiological features,the presence of bronchiectasis and peribronchial thickening was statistically significantly higher in the non-COVID-19 group(P=0.010 and P=0.010,respectively).Conclusions In pediatric cases,diagnosing COVID-19 using radiological imaging methods plays an important role in deter-mining the correct treatment approach by eliminating the possibility of other infections.

关键词： Chest imaging Computerized tomography COVID-19 Pediatric Pneumonia

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基于广义条件强度参数的水平和竖向地震动联合选取研究

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振动与冲击 2024年第7期43卷 30-41页

作者：王晓磊王浠铭阎卫东吕大刚沈阳建筑大学土木工程学院沈阳110168 哈尔滨工业大学土木工程学院哈尔滨150090

为了合理地考虑竖向地震作用和实现水平和竖向地震动的联合选取,提出了基于广义条件强度参数的水平和竖向地震动联合选取方法:扩展广义条件强度参数的基本理论,提出水平和竖向地震动广义条件强度参数分布的构建方法,并与“无条件分布”... 详细信息

为了合理地考虑竖向地震作用和实现水平和竖向地震动的联合选取,提出了基于广义条件强度参数的水平和竖向地震动联合选取方法:扩展广义条件强度参数的基本理论,提出水平和竖向地震动广义条件强度参数分布的构建方法,并与“无条件分布”对比,提出基于广义条件强度参数的水平和竖向地震动联合选取方法的基本理论,给出以水平强度参数作为条件的实际算例,利用现有水平-水平、水平-竖向强度参数相关系数模型构建水平和竖向地震动广义条件强度参数目标分布,对目标地震动数据库进行联合选取,将选取结果与传统选取方法进行对比,说明该方法的合理性。结果表明:构建出的水平和竖向广义条件强度参数分布与“无条件”分布之间存在一定差异;水平和竖向地震动联合选取结果与目标理论分布匹配良好;与仅考虑水平向广义条件强度参数地震动选取方法相比,联合选取方法能够考虑竖向地震动特性,并且不会对水平向造成影响,提出的水平和竖向地震动联合选取方法能够更加合理地、全面地考虑水平和竖向地震动特性,为工程结构在水平和竖向地震动作用下的抗震性能研究提供地震动输入基础。

关键词：水平和竖向地震动广义条件强度参数(GCim) 地震动选取相关系数模型概率地震危险性分析

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Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice

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World Journal of Gastroenterology 2014年第45期20卷 17084-17091页

作者： Mi Na Kim Seong-Joon Koh Jung Mogg Kim Jong Pil im Hyun Chae Jung Joo Sung Kim Seoul National University Healthcare System Gangnam Center Seoul National University Hospital Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Microbiology Hanyang University College of Medicine Department of Internal Medicine Liver Research Institute Seoul National University College of Medicine

Aim: To investigate the effect of Clostridium difficile (C. difficile) infection in an interleukin 10-deficient (Il-10-/-) mouse model of inflammatory bowel disease.

关键词： Clostridium difficile Inflammatory bowel disease Interleukin 10-deficient mice Interferon-γ Colitis

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A new angiotensin-converting enzyme inhibitor from Peperomia pellucida(l.) Kunth

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Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 257-262页

作者： Islamudin Ahmad Neneng Siti Silfi Ambarwati Berna Elya Hanita Omar Kamarza Mulia Arry Yanuar Osamu Negishi Abdul Mun'im Department of Pharmaceutical Sciences Faculty of PharmacyMulawarman UniversitySamarindaEast KalimantanIndonesia Department of Cosmetology Engineering FacultyUniversitas Negeri JakartaEast JakartaIndonesia Department of Pharmaceutical Sciences Faculty of PharmacyUniversitas IndonesiaDepokWest JavaIndonesia Chemistry Division Centre for Foundation Studies in ScienceUniversity of MalayaKuala LumpurMalaysia Department of Chemical Engineering Faculty of EngineeringUniversitas IndonesiaDepokWest JavaIndonesia Department of Applied Biochemistry Faculty of Life and Environmental SciencesUniversity of TsukubaTsukubaIbarakiJapan

Objective:To isolate,identify,and evaluate a new angiotensin-converting enzyme inhibitor from Peperomia pellucida(l.)Kunth ***:A dried sample of Peperomia pellucida herb was successively macerated with n-hexane and ethyl *** ethyl acetate extract solution was evaporated to obtain the crude *** liquid column chromatography and thin layer chromatography were performed to obtain two pure ***,both compounds were elucidated and identified using the spectroscopic ***-converting enzyme inhibitory activity studies of both compounds were determined using angiotensin-converting enzyme kit WST-1 with spectrophotometer microplate reader 96-well at 450 nm ***:Two bioactive compounds were successfully isolated from Peperomia pellucida herb,including a new compound of 2,3,5-trimethoxy-9-(12,14,15-trimethoxybenzyl)-1 H-indene and pellucidin *** compounds demonstrated angiotensin-converting enzyme inhibitory activity,with IC50 values of 72 μM(27.95 μg/ml)and 1 1μM(4.4 μg/ml),***:In the present study,two active angiotensin-converting enzyme inhibitors were successfully isolated and purified from Peperomia pellucida which is used as an antihypertensive in traditional medicine,and support its use as an angiotensin-converting enzyme-inhibiting drug.

关键词： 2,3,5-trimethoxy-9-(12,14,15-trimethoxybenzyl)-1H-indene Angiotensin-converting enzyme inhibitor Pellucidin A Peperomia pellucida(l) Kunth

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fabrication of Variable Optical Attenuator With low Insertion loss

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光学学报 2003年第S1期23卷 305-306页

作者： Yone-Gon Seo Yong-Tak Kim Jemin Kim Hyung-Do Yoon Young-Min im Korea Electronics Technology Institute 455-6 MaSan-Ri JinWi-Myon PyungTaek-Si KyungGi-Do Korea Department of Advanced Materials Engineering Sungkyunkwan University Jangan-gu Suwon 440-746 Korea

A voltage-controlled variable optical attenuator (VOA) based on silica-based planar lightwave circuits (PlC) was fabricated by flame hydrolysis deposition (FHD). The variable attenuator with Cr heater achieves 20dB attenuation with 318mW electrical power at 1550 nm. The insertion loss and the polarization dependent loss (PDl) at 0 attenuation are 1dB and 0.23dB, respectively.

关键词： electrical power insertion loss

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