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Multimodal abnormalities of brain structures in adolescents and young adults with major depressive disorder:An activation likelihood estimation meta-analysis

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World Journal of Psychiatry 2024年第7期14卷 1106-1117页

作者： Yan-Ping Shu Qin Zhang Yong-Zhe Hou Shuang Liang Zu-Li Zheng Jia-Lin Li Gang wu Department of Psychiatry of Women and Children The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina Medical Humanities College Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Major depressive disorder(MDD)in adolescents and young adults contributes significantly to global morbidity,with inconsistent findings on brain structural changes from structural magnetic resonance imaging *** likeli-hood estimation(ALE)offers a method to synthesize these diverse findings and identify consistent brain *** We performed a comprehensive literature search in PubMed,Web of Science,Embase,and Chinese National Knowledge Infrastructure databases for neuroi-maging studies on MDD among adolescents and young adults published up to November 19,*** independent researchers performed the study selection,quality assessment,and data *** ALE technique was employed to synthesize findings on localized brain function anomalies in MDD patients,which was supplemented by sensitivity *** Twenty-two studies comprising fourteen diffusion tensor imaging(DTI)studies and eight voxel-based morphome-try(VBM)studies,and involving 451 MDD patients and 465 healthy controls(HCs)for DTI and 664 MDD patients and 946 HCs for VBM,were ***-based ALE demonstrated significant reductions in fractional anisotropy(fa)values in the right caudate head,right insula,and right lentiform nucleus putamen in adolescents and young adults with MDD compared to HCs,with no regions exhibiting increased fa ***-based ALE did not demonstrate significant alterations in gray matter *** analyses highlighted consistent findings in the right caudate head(11 of 14 analyses),right insula(10 of 14 analyses),and right lentiform nucleus putamen(11 of 14 analyses).CONCLUSION Structural alterations in the right caudate head,right insula,and right lentiform nucleus putamen in young MDD patients may contribute to its recurrent nature,offering insights for targeted therapies.

关键词： Major depressive disorder Adolescent Young adults Neuroimaging Diffusion tensor imaging Voxel-based morphometry Activation likelihood estimation Meta-analysis

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皂角豆象成虫触角转录组及嗅觉相关基因分析

昆虫学报 2024年第8期67卷 1039-1049页

作者：彭启艳潘秀奎张苏芳武承旭杨茂发贵州大学林学院贵阳550025 中国林业科学研究院森林生态环境与自然保护研究所国家林业和草原局森林保护学重点实验室北京100091 贵州大学昆虫研究所贵州省山地农业病虫害重点实验室贵阳550025 贵州大学烟草学院贵阳550025

【目的】本研究旨在建立皂角豆象Megabruchidius dorsalis雌雄成虫触角转录组数据库,挖掘皂角豆象嗅觉相关基因。【方法】采用高通量测序平台Illumina HiSeq对皂角豆象雌雄成虫触角进行转录组测序、序列组装、功能注释及差异表达基因分... 详细信息

【目的】本研究旨在建立皂角豆象Megabruchidius dorsalis雌雄成虫触角转录组数据库,挖掘皂角豆象嗅觉相关基因。【方法】采用高通量测序平台Illumina HiSeq对皂角豆象雌雄成虫触角进行转录组测序、序列组装、功能注释及差异表达基因分析;通过qRT-PCR技术测定和验证皂角豆象雌雄成虫触角中部分高丰度表达基因的表达量。【结果】皂角豆象雌雄成虫触角转录组共获得42 053条unigenes, N50长度为2 066 bp。与NR, Swiss-Prot, Pfam, eggNOG, GO和KEGG六大公共数据库比对共注释到18 039条unigenes(占43.57%),其中注释到NR数据库的unigenes数量最多,为17 687条;注释到KEGG数据库的unigenes数量最少,为9 779条。依据注释信息分析,鉴定出183个皂角豆象候选嗅觉相关基因,包括25个气味结合蛋白(odorant binding protein, OBP)基因、 3个化学感受蛋白(chemosensory protein, CSP)基因、 126个气味受体(odorant receptor, OR)基因(包括125个典型OR基因和1个非典型OR基因)、 8个离子型受体(ionotropic receptor, IR)基因、 18个味觉受体(gustatory receptor, GR)基因和3个感觉神经元膜蛋白(sensory neuron membrane protein, SNMP)基因。通过比较皂角豆象雌雄成虫触角转录组,共筛选出357个差异表达基因,其中包含8个OR基因和1个IR基因;这357个差异表达基因中,152个基因在雌性触角中高表达,205个基因在雄性触角中高表达。此外,qRT-PCR验证结果显示,6个嗅觉相关基因(MdorCSP3,MdorIR2,MdorIR6,MdorGR10,MdorSNMP2和MdorSNMP3)在皂角豆象雌成虫触角中高表达,4个嗅觉相关基因(MdorOBP15,MdorOBP22,MdorORco和MdorGR8)在雄成虫触角中高表达。【结论】本研究获得了皂角豆象成虫触角转录组数据,并鉴定筛选出候选嗅觉相关基因,结果为进一步研究皂角豆象的基因功能及嗅觉感受机制奠定分子基础。

关键词：皂角豆象触角转录组高通量测序嗅觉相关基因 qRT-PCR

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红麻HcKAN4基因克隆、表达及在类黄酮合成中的功能

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作物学报 2024年第3期50卷 645-655页

作者：吴法轩李秦杨昕李新根徐建堂陶爱芬方平平祁建民张立武福建农林大学作物遗传育种与综合利用教育部重点实验室/农业农村部闽台作物生物育种重点实验室/福建省作物设计育种重点实验室福建福州350002 福建农林大学农业农村部东南黄红麻实验观测站/福建省麻类种质资源共享平台/福建省南方经济作物遗传育种与多用途开发国际科技合作基地福建福州350002

MYB类转录因子KAN4(KANADI4)在红麻类黄酮合成和纤维发育中发挥着重要作用。本研究以红麻品种‘福红952’为材料,对HcKAN4基因进行克隆和表达模式分析,探讨TRV-VIGS诱导该基因沉默对类黄酮合成途径中关键酶基因表达量改变的影响。基因... 详细信息

MYB类转录因子KAN4(KANADI4)在红麻类黄酮合成和纤维发育中发挥着重要作用。本研究以红麻品种‘福红952’为材料,对HcKAN4基因进行克隆和表达模式分析,探讨TRV-VIGS诱导该基因沉默对类黄酮合成途径中关键酶基因表达量改变的影响。基因克隆显示,HcKAN4基因开放阅读框(open reading frame,ORF)全长为966 bp,编码322个氨基酸,包含一个MYB保守结构域。进化树分析发现,其与拟南芥和木槿KAN4s的亲缘关系较近。表达分析表明,该基因在红麻不同组织中均有表达,且转录水平随着植物生长而递增。VIGS诱导基因沉默显示,6株HcKAN4的转录水平显著下调,达到基因沉默效果。进一步实时荧光定量PCR检测发现,类黄酮合成相关基因HcCHS、HcF3’5’H、HcANS、HcANR的转录水平显著下调,分别是对照组的0.51、0.14、0.23、0.11倍,表明HcKAN4基因可调控红麻类黄酮生物合成相关基因。这些结果为阐明红麻MYB转录因子调控类黄酮合成提供了依据,同时为改善纤维品质提供了研究思路。

关键词：红麻 HcKAN4 类黄酮合成 VIGS

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The AaBBX21–AaHY5 module mediates light-regulated artemisinin biosynthesis in Artemisia annua L.

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Journal of Integrative Plant Biology 2024年第8期66卷 1735-1751页

作者： Weizhi He Hang Liu Zhangkuanyu wu Qing Miao Xinyi Hu Xin Yan Hangyu Wen Yaojie Zhang Xueqing Fu Li Ren Kexuan Tang Ling Li Frontiers Science Center for Transformative Molecules Joint International ResearchLaboratory of Metabolic and Developmental SciencesKey Laboratory of Urban Agriculture(South)Ministry of AgriculturePlant Biotechnology Research CenterFudan-SJTU-Nottingham Plant Biotechnology R&D CenterSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Institute for Agri-Food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

The sesquiterpene lactone artemisinin is an important anti-malarial component produced by the glandular secretory trichomes of sweet wormwood(Artemisia annua L.).Light was previously shown to promote artemisinin production,but the underlying regulatory mechanism remains *** this study,we demonstrate that ELONGATED HYPOCOTYL5(HY5),a central transcription factor in the light signaling pathway,cannot promote artemisinin biosynthesis on its own,as the binding of AaHY5 to the promoters of artemisinin biosynthetic genes failed to activate their *** analysis and yeast two-hybrid screening revealed the B-box transcription factor AaBBX21 as a potential interactor with ***21 showed a trichome-specific expression ***,the AaBBX21–AaHY5 complex cooperatively activated transcription from the promoters of the downstream genes AaGSW1,AaMYB108,and AaORA,encoding positive regulators of artemisinin ***,AaHY5 and AaBBX21 physically interacted with the *** E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1(COP1).In the dark,AaCOP1 decreased the accumulation of AaHY5 and AaBBX21 and repressed the activation of genes downstream of the AaHY5–AaBBX21 complex,explaining the enhanced production of artemisinin upon light *** study provides insights into the central regulatory mechanism by which light governs terpenoid biosynthesis in the plant kingdom.

关键词： AaBBX21 AaHY5 AaCOP1 Artemisia annua L. artemisinin biosynthesis light

Nine new species of the spider genus Stedocys (Araneae, Scytodidae) from China and Thailand

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Zoological Research 2017年第5期38卷 215-242页

作者： Jiang-Lang wu Yu-fa Luo Shu-Qiang Li Southeast Asia Biodiversity Research Institute Chinese Academy of Sciences Yezin Nay Pyi Taw 05282 Myanmar Institute of Zoology Chinese Academy of Sciences Beijing 100101 China School of Life and Environment Sciences Gannan Normal University Ganzhou Jiangxi 341000 China University of Chinese Academy of Sciences Beijing 100049 China

Nine new species of the genus Stedocys Ono, 1995 are described： Stedocys gaolingensis wu ＆ Lisp. n. （♂♀, Guangxi）, S. huangniuensis wu ＆ Lisp. n. （♀, Guangxi）, S. ludiyanensis wu ＆ Lisp. n. （♂♀, Guangxi）, S. matuoensis wu ＆ Lisp. n. （♀, Guangxi）, S. pulianensis wu ＆ Lisp. n. （♂, Guangxi）, S. shilinensis wu ＆ Lisp. n. （♂♀, Hainan）, S. xianrenensis wu ＆ Li sp. n. （♂♀, Guangxi）, S. xiangzhouensis wu ＆ Li sp. n. （♂♀, Guangxi） from China, and S. zhaoi wu ＆ Li sp. nov. （♂♀, Kanchanaburi） from Thailand. Diagnoses of nine new species are provided. DNA barcodes for six new species are documented for future use and as proof of molecular differences between these species.

关键词： Taxonomy Morphology Diagnosis Biodiversity Caves

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多元连杆多种冲击方式载荷及响应特性分析

航空发动机 2024年第1期50卷 109-116页

作者：苏军田常棵安中彦刘亮亮吴法勇李岩中国航发沈阳发动机研究所沈阳110015

为了获取并分析多元连杆的冲击力以及各传力路径上的应变响应特征,采用气炮、悬臂落锤、液压等3种冲击加载方法对发动机多元连杆进行冲击加载。对冲击力和冲击应变响应曲线进行了时间域和频率域的特征分析,获取了冲击力和应变响应的波... 详细信息

为了获取并分析多元连杆的冲击力以及各传力路径上的应变响应特征,采用气炮、悬臂落锤、液压等3种冲击加载方法对发动机多元连杆进行冲击加载。对冲击力和冲击应变响应曲线进行了时间域和频率域的特征分析,获取了冲击力和应变响应的波形特征和频谱特征。通过与静载应变响应的对比获得动静响应系数,以及动静响应系数随波形宽度的变化规律。结果表明:在气炮、悬臂落锤、液压等3种冲击力的波形特征近似的情况下,在频谱上反映出各自不同的频率成分。在各传力路径上的冲击应变响应,除了响应幅值不同外,其余波形特征如峰值特征和频谱特性均较为一致。各应变之和作为连杆冲击力测试方法的表征参数,随波形中高频成分的增多,动静响应系数逐步增大。在进行多元连杆冲击载荷标定时,需要充分考虑所测试冲击力的载荷特征,选取合适的冲击载荷标定或者静载荷标定方法。

关键词：多元连杆冲击响应航空发动机

基于离子交换的Ag^(+)修饰聚合物填料的制备及其性能研究

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分析测试学报 2024年第5期43卷 782-786页

作者：任兴发谷继鹏吴伟华周林娟王卓张维冰华东理工大学化学与分子工程学院上海市功能材料化学重点实验室上海200237 月旭科技(上海)股份有限公司上海201600

金属离子与不同结构的分析样品之间可产生特异性相互作用,因此金属离子修饰的色谱填料具有特殊的分离选择性。该文以粒径均一、比表面积大、孔径均匀的聚苯乙烯-二乙烯基苯微球为基质,采用浓硫酸对微球中的苯基进行磺化处理,使其被修饰... 详细信息

金属离子与不同结构的分析样品之间可产生特异性相互作用,因此金属离子修饰的色谱填料具有特殊的分离选择性。该文以粒径均一、比表面积大、孔径均匀的聚苯乙烯-二乙烯基苯微球为基质,采用浓硫酸对微球中的苯基进行磺化处理,使其被修饰上磺酸基团,具备阳离子交换的功能。并进一步采用离子交换法,将填料上的H+交换成Ag^(+),制备了具有分离选择性的Ag^(+)修饰聚合物填料。随后将该填料装填成固相萃取(SPE)小柱探讨了其稳定性、使用条件及分离选择性。该文所发展的Ag^(+)修饰聚合物填料具有制备方法简单、稳定性好、对离子吸附能力强等特点,具有良好的分离选择性,装填成SPE柱可满足复杂实际样品预处理的需要。

关键词：色谱填料离子交换金属离子固相萃取聚苯乙烯-二乙烯基苯微球

Photocatalytic Activity of Nanosized ZnWO_4 Prepared by the Sol-gel Method

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Chemical Research in Chinese Universities 2007年第4期23卷 465-468页

作者： wu Yan ZHANG Shi-cheng ZHANG Li-wu ZHU Yong-fa Department of Chemistry Tsinghua University Beijing 100084 P. R. China

Nanosized ZnWO4 photocatalysts were successfully synthesized via the sol-gel process in a temperature range of 450-800℃. The grain size, crystal size, and crystallinity of ZnWO4 particles increased with the increase of calcina- tion temperature and prolonging calcination time. The photocatalytic activity was measured for the degradation of an aqueous Rhodamine-B（RhB） solution and gaseous formaldehyde（faD）. With the increase of calcination temperature and time, the activities increased to a maximum and then decreased. ZnWO4 photocatalyst prepared at 550℃ for I0 h showed the highest activity, which is similar to the photocatalytic activity of P25TiO2 for the degradation of gase-ous faD. High crystallinity, large surface area, and good dispersion are responsible for the high photocatalytic per- formance of the prepared ZnWO4.

关键词： Nanosized Sol-gel method Photocatalyst ZnWO4

Inverse Leaf Aging Sequence (ILAS) and Its Significance of Wheat

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Agricultural Sciences in China 2011年第2期10卷 207-219页

作者： Zhang Song-wu Wang Chang-fa Yao You-hua Reseach Laboratory of Low-Temperature Plants College of SciencesNorthwest A＆F UniversityYangling 712100P.R.China

The implication of the revelation of the inverse leaf aging sequence（ILAS） of wheat needs to be probed in theory and *** 2005,the comparison experiment of the ILAS and the conventional leaf aging sequence（CLAS） has been carried out to measure the canopy temperature and some important biological parameters of *** nature,there existed the phenomenon that the wheat leaves aged in an sequence opposite to the conventional sequence and some of the leaves of ILAS wheat aged sequentially differed from those of CLAS wheat,i.e.,the penultimate leaves rather than the flag leaves aged last among the leaves at different leaf positions;in correspondence with the inverse leaf aging sequence,there appeared an unconventional leaf color structure at the late fruiting stage,which had yellow upper leaves and green lower leaves,opposite to the conventional leaf color structure that had green upper leaves and yellow lower leaves;the chlorophyll concentrations,soluble protein concentrations,transpiration rates,and net photosynthetic rates of the penultimate leaves of ILAS wheat unconventionally surpassed those of their flag leaves as their growth moved forward from one stage to another stage,and the ILAS wheat characteristically presented cold canopy temperature,i.e.,a cold tail canopy temperature at the late fruiting stage,or a cold canopy temperature at the whole fruiting stage;because ILAS wheat was unique in physiological process,its kernel weights were obviously higher than those of CLAS wheat,which closely related to the ＂relay＂ kernel-filling mode,which was different from the kernel-filling mode of CLAS wheat under which the flag leaves act as the main nutrient supply source at the whole fruiting *** study provided a new idea and approach for the theoretical exploration on wheat fruiting and aging,wheat yield further improvement,and cold type wheat and cold tail wheat breeding.

关键词： wheat inverse leaf aging sequence canopy temperature biological parameters