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China Foundry 2024年第4期21卷 360-368页

作者： Jia-ping Fu Can-xu Zhou guo-fa Mi Yuan Liu School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454100HenanChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Diamond/aluminium composites have attracted attention in the field of thermal management of electronic packaging for their excellent *** order to solve the interfacial problem between diamond and aluminium,a novel process combining pressure infiltration with vacuum-assisted technology was proposed to prepare diamond/aluminum *** effect of diamond particle size on the microstructure and properties of the diamond/Al-12Si composites was *** results show that the diamond/Al-12Si composites exhibit high relative density and a uniform *** thermal conductivity and coefficient of thermal expansion increase with increasing particle size,while the bending strength exhibits the opposite *** the average diamond particle size increases from 45μm to 425μm,the thermal conductivity of the composites increases from 455 W·m^(-1)·K^(-1)to 713 W·m^(-1)·K^(-1)and the coefficient of thermal expansion increases from 4.97×10^(-6)K^(-1)to 6.72×10^(-6)K^(-1),while the bending strength decreases from 353 MPa to 246 *** research demonstrates that high-quality composites can be prepared by the vacuum-assisted pressure infiltration process and the thermal conductivity of the composites can be effectively improved by increasing the diamond particle size.

关键词： diamond/aluminum composites thermal conductivity electronic packaging vacuum-assisted pressure infiltration

Numerical Study on the Effect of gap Diffraction on the Hydrodynamic Performance of A Floating Breakwater

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China Ocean Engineering 2024年第4期38卷 663-675页

作者： BIAN Xiang-qian JI Chun-yan xu Sheng gUO Jian-ting HUO fa-li School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Two-dimensional(2D)flume experiments are useful in investigating the performances of floating breakwaters(FBs),including hydrodynamic performances,motion responses,and mooring *** a reasonable gap between the flume wall and the FBs is a critical step in 2D flume ***,research on the effect of the gap on the accuracy of 2D FB experimental results is *** address this issue,a numerical wave tank is developed using CFD to estimate the wave-FB interaction of a moored dual-cylindrical FB,and the results are compared to experimental data from a previously published *** is good agreement between them,indicating that the numerical model is sufficiently *** numerical model is then applied to explore the effect of gap diffraction on the performance of FBs in2D *** was discovered that the nondimensional gap length L_(gap)/W_(Pool)should be smaller than 7.5%to ensure that the relative error of the transmission coefficient is smaller than 3%.The influence of the gap is also related to the entering wave properties,such as the wave height and period.

关键词： floating breakwater diffraction effect gap hydrodynamic performance model experiments CFD numerical simulation

Subclinical paraganglioma of the retroperitoneum:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2672-2677页

作者： Li-Min Kang fa-Kun Yu Fu-Wei Zhang Lei xu Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina

BACKgROUND Paraganglioma(PgL)located in the retroperitoneum presents challenges in diagnosis and treatment due to its hidden location,lack of specific symptoms in the early stages,and absence of distinctive manifestations on *** SUMMARY A 56-year-old woman presented with a left upper abdominal mass discovered 1 wk ago during a physical *** did not have a history of smoking,alcohol consumption,or other harmful habits,no surgical procedures or infectious diseases,and had a 4-year history of *** admission,she did not exhibit fever,vomiting,or abdominal *** examination indicated mild percussion pain in the left upper abdomen,with no palpable enlargement of the liver or *** tests and tumor markers showed no significant *** computed tomography and magnetic resonance imaging of the upper abdomen revealed a cystic solid mass in the left epigastrium measuring approximately 6.5 cm×4.5 cm,with inhomogeneous enhancement in the arterial phase,closely associated with the lesser curvature of the stomach and the *** patient underwent laparoscopic resection of the retroperitoneal mass,which was successfully removed without tumor rupture.A 12-month postoperative follow-up period showed good *** This case report details the successful laparoscopic resection of a retroperitoneal subclinical PgL,resulting in a good recovery observed at the 12-month ***,the patient also experienced unexpected cure of hypertensive disease.

关键词： Paraganglioma Retroperitoneal anatomy Subclinical Pheochromocytoma Laparoscopy Case report

Efficiency and safety of laparoscopic left hemihepatectomy: A study of intrathecal vs extrathecal glissonean pedicle techniques

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World Journal of gastrointestinal Surgery 2024年第8期16卷 2612-2619页

作者： Li-Min Kang Lei xu Fu-Wei Zhang fa-Kun Yu Li Lang Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina Department of Outpatient Puer People's HospitalPuer 665000Yunnan ProvinceChina

BACKgROUND Selective hemihepatic vascular occlusion is utilized in both right and left hemihepatectomies to preserve blood supply to the intact lobe,maintain hemo-dynamic stability,and mitigate surgical *** this technique encompasses both intrathecal and extrathecal glissonean pedicle transection methods,there is a lack of systematic comparative reports on these two *** To retrospectively analyze the clinical data of patients with hepatocellular carcinoma(HCC)undergoing laparoscopic anatomical hepatectomy in our hospital to explore the feasibility,safety,and short-and long-term efficacy of extrathecal and intrathecal glissonean pedicle transection methods in laparo-scopic left *** A retrospective study was performed to analyze the clinical data of 49 HCC patients who underwent laparoscopic left hemihepatectomy from January 2019 to December 2022 in our *** patients were divided into extrathecal glissonean pedicle transection(EgP)group(n=24)and intrathecal glissonean pedicle transection(IgP)group(n=25)according to the different approaches used for selective hemihepatic vascular *** perioperative indicators,liver function indexes,complications,and follow-up findings were compared between these two *** The surgeries were smooth in both groups,and no perioperative death was *** hepatic pedicle transection time and the operation time were(16.1±2.3)minutes and(129.6±19.0)minutes,respectively,in the EgP group,which were significantly shorter than those in the IgP group[(25.5±2.4)minutes and(184.8±26.0)minutes,respectively],both Pgnificant differences in intraoperative blood loss,time to anal exhaust,hospital stay,drain indwelling time,and postoperative liver function between the two groups(all P>0.05).The incidence of postoperative complications showed no significant difference[16.67%(4/24)vs 16.0%(4/25),P>0.05].All the 49 HCC patients were followed up after surgery(range:11.2

关键词： Hepatocellular carcinoma Laparoscopy Extra-glissonian approach Intra-glissonian approach Surgical efficiency Surgical safety

Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu Yu-Ya Wang gui-Tao Huo Yan-Wei Yang Nan xu Hong Wang Yong Wu Yu-fa Miao Rui Fu Yu-Wei Zhao Chang-fa fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

Fiber Bundle Topology Optimization for Surface Flows

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 236-264页

作者： Yongbo Deng Weihong Zhang Jihong Zhu Yingjie xu Jan g Korvink State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China State IJR Center of Aerospace Design and Additive Manufacturing Northwestern Polytechnical UniversityXi’an 710072China Institute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtzplatz 176344 Eggenstein-LeopoldshafenGermany

This paper presents a topology optimization approach for the surface flows on variable design *** this approach,the matching between the pattern of a surface flow and the 2-manifold used to define the pattern can be optimized,where the 2-manifold is implicitly defined on another fixed 2-manifold named as the base *** fiber bundle topology optimization approach is developed based on the description of the topological structure of the surface flow by using the differential geometry concept of the fiber *** material distribution method is used to achieve the evolution of the pattern of the surface *** evolution of the implicit 2-manifold is realized via a homeomorphous *** design variable of the pattern of the surface flow and that of the implicit 2-manifold are regularized by two sequentially implemented surface-PDE *** two surface-PDE filters are coupled,because they are defined on the implicit 2-manifold and base manifold,*** surface Navier-Stokes equations,defined on the implicit 2-manifold,are used to describe the surface *** fiber bundle topology optimization problem is analyzed using the continuous adjoint method implemented on the first-order Sobolev *** numerical examples have been provided to demonstrate this approach,where the combination of the viscous dissipation and pressure drop is used as the design objective.

关键词： Fiber bundle Topology optimization 2-manifold Surface flow Material distribution method Porous medium model

Analytical Solution for the Reissner-Sagoci Problem of a Piezoelectric Half-Space

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Acta Mechanica Solida Sinica 2024年第3期37卷 363-370页

作者： Keqiang Hu Cun-fa.gao Zengtao Chen Zheng Zhong State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Department of Mechanical Engineering University of AlbertaEdmontonABT6G 1H9Canada School of Science Harbin Institute of TechnologyShenzhen518055China

In this paper,a transversely isotropic piezoelectric half-space with the isotropy axis parallel to the z-axis is considered under rotation on a rigid circular disk bonded to the surface of the piezoelectric *** is a type of Reissner-Sagoci mixed boundary value *** utilizing the Hankel transform,the mixed boundary value problem is simplified into solving a pair of dual integral ***-field analytical expressions for displacement,stresses,and electric displacement inside the half-space are *** shear stresses and electric displacement on the surface are found to be singular at the edge of the rigid circular disk,and the stress intensity factors and electric displacement intensity factor are *** results show that material properties and geometric size have significant effects on displacement,shear stresses,and electric displacement.

关键词： Piezoelectric half-space Circular disk Reissner-Sagoci problem Stress intensity factor Electric displacement intensity factor

Comparison of corrosion mechanisms of 510L low alloy steel treated by ACS and EPS techniques under various service environments

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Journal of Iron and Steel Research International 2024年第2期31卷 501-518页

作者： Bao-sheng Liu Peng-fei xu Shao-hua Zhang Yan-rui Li Li-ming Mou Jia-li Li Yue-zhong Zhang Pei-mao Fu fa-cai Shi College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina College of Chemical and Biological Engineering Taiyuan University of Science and TechnologyTaiyuan030024ShanxiChina Technical Center Taiyuan Iron and Steel(Group)Co.Ltd.Taiyuan030003ShanxiChina

The corrosion mechanism of 510L low alloy steel treated by acid-cleaned surface(ACS)and eco-pickled surface(EPS)techniques in three simulated solutions(S0:atmospheric environment;S1:soil environment;S2:industrial environment)and the influence of interaction between different corrosive anions on corrosion were *** results show that the total corrosion rates of samples in three simulated solutions were in order of S2>S0>S1,which is simultaneously correlated with initial corrosion dissolution processes as well as after the formation of corrosion ***3−will inhibit the initial corrosion owing to the formation of films,whereas HSO3−will accelerate the dissolutions of the matrix based on the synergistic action of HSO3−and Cl−.On the other hand,there is no significant difference in corrosion rates between the samples treated by ACS and EPS *** EPS technique that is safe,reusable and environmentally friendly can be further widely used in future work.

关键词： Corrosion mechanism Low alloy steel Simulated solution Surface technique Immersion time

genomic analysis of Nypa fruticans elucidates its intertidal adaptations and early palm evolution

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Journal of Integrative Plant Biology 2024年第4期66卷 824-843页

作者： Weihong Wu Xiao Feng Nan Wang Shao Shao Min Liu fa Si Linhao Chen Chuanfeng Jin Shaohua xu Zixiao guo Cairong Zhong Suhua Shi Ziwen He State Key Laboratory of Biocontrol and guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China greater Bay Area Institute of Precision Medicine School of Life SciencesFudan UniversityGuangzhou 511462China Hainan Academy of Forestry(Hainan Academy of Mangrove) Haikou 571100China

Nypa fruticans(Wurmb),a mangrove palm species with origins dating back to the Late Cretaceous period,is a unique species for investigating long-term adaptation strategies to intertidal environments and the early evolution of ***,we present a chromosome-level genome sequence and assembly for *** integrated the genomes of *** and other palm family members for a comparative genomic analysis,which confirmed that the common ancestor of all palms experienced a whole-genome duplication event around 89 million years ago,shaping the distinctive characteristics observed in this *** also inferred a low mutation rate for the *** genome,which underwent strong purifying selection and evolved slowly,thus contributing to its stability over a long evolutionary ***,ancient duplicates were preferentially retained,with critical genes having experienced positive selection,enhancing waterlogging tolerance in ***,we discovered that the pseudogenization of Early Methionine-labelled 1(EM1)and EM6 in *** underly its crypto-vivipary characteristics,reflecting its intertidal *** study provides valuable genomic insights into the evolutionary history,genome stability,and adaptive evolution of the mangrove *** results also shed light on the long-term adaptation of this species and contribute to our understanding of the evolutionary dynamics in the palm family.

关键词： crypto-vivipary genome stability long-term adaptation mangrove Nypa fruticans palm

Heavy neutral leptons in gauged U(1)Lμ-Lτ at muon collider

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Chinese Physics C 2024年第9期48卷 36-49页

作者： Ru-Yi He Jia-Qi Huang Jin-Yuan xu fa-Xin Yang Zhi-Long Han Feng-Lan Shao School of Physics and Technology University of JinanJinan 250022China School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China

Heavy neutral leptons N are the most appealing candidates to generate tiny neutrino *** studied the signature of heavy neutral leptons in gauged U(1)Lμ-Lτ at a muon *** under the U(1)Lμ-Lτ symmetry,the heavy neutral leptons can be pair produced via the new gauge boson Z' at the muon collider as μ^(+)μ^(-)→Z′*→NN AND μ^(+)μ^(-)→Z′(*)γ→NNγ.We then performed a detailed analysis on the lepton number violation signature μ^(+)μ^(-)→NN→μ^(±)μ^(±)W■W■ and μ^(+)μ^(-)→NN→μ^(±)μ^(±)W■W■γ at the 3 TeV muon collider,where the hadronic decays of W boson are treated as fat-jets *** lepton number violation signatures have quite clean backgrounds at the muon *** simulation shows that a wide range of viable parameter space is within the reach of the 3 TeV muon *** instance,with new gauge coupling g'=0.6 and an integrated luminosity of 1000 fb^(-1),the μ^(±)μ^(±)JJ signal could probe m_(Z′)■13 ***,if the gauge boson mass satisfies 2m_(N)gnature would be more promising than the μ^(±)μ^(±)JJ signature.

关键词： heavy neutral leptons gauged U(1)_(Lμ-Lτ) muon collider lepton number violation