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Peripheral Arterial Disease among Patient Undergoing Maintenance Hemodialysis in Dakar (Senegal)

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open Journal of Nephrology 2021年第2期11卷 242-251页

作者： Habin Yabama Aida Lengani Mouhamadou Moustapha Cissé Hamadoun Yattara Alassane Mbaye Gérard Coulibaly Joseph Salvador Mingou el Hadj fary ka Abdou Niang Abdoul kane Boucar Diouf Departement of Nephrology University Hospital Yalgado Ouédraogo Ouagadougou Burkina Faso Departement of Nephrology University Hospital Aristide le Dantec Dakar Sénégal Departement of Nephrology University Hospital of Point G Bamako Mali Departement of Cardiology National Hospital Grand Yoff Dakar Sénégal Cheikh Anta Diop University Dakar Sénégal

Background: Peripheral arterial disease (PAD) is common in patients with chronic kidney disease (CKD). It is a surrogate marker of generalized atherosclerosis. In sub-Saharan Africa, PAD remains understudied in CKD. A... 详细信息

ong>Background:ong> Peripheral arterial disease (PAD) is common in patients with chronic kidney disease (CKD). It is a surrogate marker of generalized atherosclerosis. In sub-Saharan Africa, PAD remains understudied in CKD. Ankle-brachial index (ABI) is a non-invasive and cost-effective tool to diagnose PAD. ong>objectives:ong> our aim was to determine the prevalence and associated risk factors for PAD in hemodialysis patients. ong>Patients and Methods:ong> We conducted a cross-sectional study from July 1 to December 31, 2012 in the department of Nephrology of the University Hospital Aristide le Dantec of Dakar. All consenting patients, aged above 18 years, on hemodialysis for at least 6 months were included. ABI measurements were performed using a handled pulse doppler. PAD was defined as an ABI of or the history of surgical revascularization and/or amputation due to vascular disease. The patients were divided into two groups according to the presence or not of PAD. Standard blood tests and anthropometrical parameters were recorded. ong>Results:ong> A total of 53 patients with a mean age of 49.15 ± 15.18 were included. The sex ratio was 0.70. Hypertension (83.01%), low HDL-cholesterol (26.41%) and cigarette smoking (20.75%) were the main cardiovascular risk factors. Prevalence of PAD was 47.16%. Among patients with PAD, 52% had no suggestive symptoms. Lower pre-dialysis (p = 0.0384) and post-dialysis (p = 0.0447) diastolic blood pressure (BP) were significantly associated with PAD. The conventional risk factors (tobacco consumption, diabetes, alcohol consumption, dyslipidemia, hypertension, age), iPTH and CRP levels were not correlated with PAD. ong>Conclusion:ong> PAD is common among patients undergoing maintenance hemodialysis in Senegal. Early diagnosis and management of PAD should be routinely performed in CKD patients.

关键词： Ankle Brachial Index Peripheral Arterial Disease Hemodialysis

Synthesis of 6-chloro and 6-fluoro-4-hydroxyl-2-quinolone and their azo disperse dyes

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Chinese Chemical Letters 2010年第5期21卷 542-546页

作者： Enayat o'llah Moradi-e-Rufchahi Department of Chemistry Faculty of ScienceIslamic Azad UniversityLahijan BranchLahijanIran

In this study,6-chloro-4-hydroxy-2-quinolone and 6-flouro-4-hydroxy-2-quinolone were synthesized from corresponding *** compounds were coupled with some diazotized aromatic amines to give the corresponding azo disperse *** structures of the quinolone derivatives and new azo dyes were confirmed by UV-vis,FT-IR,;H NMR and elemental analysis.

关键词： Azo dyes Hydroxy quinolone Heterocyclic amines Solvatochromism Polyphosphoric acid Heterocyclic dyes

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

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Translational Neurodegeneration 2020年第2期9卷 168-177页

作者： Nour K.Majbour Jan o.Aasly eldbjørg Hustad Mercy A.Thomas Nishant N.Vaikath Naser elkum Wilma D.Jvan de Berg Takahiko Tokuda Brit Mollenhauer Henk W.Berendse omar M.A.el-Agnaf Neurological Disorders Research Center Qatar Biomedical Research InstituteHamad Bin Khalifa UniversityQatar FoundationP.O.Box 5825DohaQatar Department of Neuroscience Norwegian University of Science and Technology(NTNU)TrondheimNorway Department of Neurology St.Olav’s HospitalUniversity Hospital of TrondheimTrondheimNorway Clinical Epidemiology Sidra Medical and Research CenterDohaQatar Department of Anatomy and Neurosciences Neuroscience Campus AmsterdamVU University Medical CentreAmsterdamthe Netherlands Department of Neurology Research Institute for GeriatricsKyoto Prefectural University of MedicineKyoto602-0841Japan Paracelsus-elena-Klinik KlinikstraßeKasseland University Medical Center GöttingenDepartment of NeurologyGöttingenGermany Department of Neurology Amsterdam UMClocation VU University Medical CentreAmsterdamThe Netherlands

Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRK2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation *** We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRK2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the *** that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal *** Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRK2 mutation carriers from both symptomatic PD and healthy *** the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was *** The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal *** findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD.

关键词： Parkinson's disease LRRK2 mutation carriers Alpha-synuclein oligomers Biomarkers Inflammatory markers

on the Generalization of Seismic Tomography Algorithms

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American Journal of Computational Mathematics 2014年第1期4卷 37-46页

作者： Mihály Dobróka Hajnalka Szegedi Department of Geophysics University of Miskolc Miskolc Hungary MTA-ME Applied Geosciences Research Group Miskolc Hungary

The seismic tomography problem often leads to underdetermined and inconsistent system of equations. Solving these problems, care must be taken to keep the propagation of data errors under control. Especially, the non-Gaussian nature of the noise distribution (for example outliers in the data sets) can cause appreciable distortions in the tomographic imaging. In order to reduce the sensitivity to outlier, some generalized tomography algorithms are proposed in the paper. The weighted version of the Conjugate Gradient method is combined with the Iteratively Reweighted Least Squares (IRLS) procedure leading to a robust tomography method (W-CGRAD). The generalized version of the SIRT method is introduced in which the (Cauchy-Steiner) weighted average of the ART corrections is used. The proposed tomography algorithms are tested for a small sized tomography example by using synthetic traveltime data. It is proved that—compared to their traditional versions—the outlier sensitivities of the generalized tomography methods are sufficiently reduced.

关键词： Robust Tomography Conjugated Gradients SIRT Cauchy-Steiner Weights

Brahman(梵):印度哲学的核心概念及其特色

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甘肃社会科学 2019年第3期 109-115页

作者：张法浙江师范大学人文学院

Brahman(梵)是印度哲学的核心概念,来自于原始时代之灵,在早期文明中在两方面的演进,在轴心时代的奥义书中定型为哲学根本概念。梵是宇宙的总合,又分为本体的上梵和现象的下梵。梵的本体是空,言说空性之梵只能用遮诠方式。以上几点构成... 详细信息

Brahman(梵)是印度哲学的核心概念,来自于原始时代之灵,在早期文明中在两方面的演进,在轴心时代的奥义书中定型为哲学根本概念。梵是宇宙的总合,又分为本体的上梵和现象的下梵。梵的本体是空,言说空性之梵只能用遮诠方式。以上几点构成了印度哲学不同于其他文化哲学的特色。梵的这一特色在中西印本体概念的比较中,即从印度的梵、西方的Being、中国的道的比较中,可以得到进一步的体会。

关键词：梵两大面相基本特点遮诠方式中西印概念比较

中国急性缺血性脑卒中血管内治疗麻醉管理与患者安全现状调查

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国际麻醉学与复苏杂志 2024年第5期45卷 468-477页

作者：梁发张康大王鑫焱吴侑煊刘海洋王学军韩如泉首都医科大学附属北京天坛医院麻醉科北京100070 青海省交通医院麻醉科西宁810001 青海红十字医院麻醉科西宁810001

目的调查中国急性缺血性脑卒中(AIS)患者行血管内治疗(EVT)围手术期麻醉管理和患者安全现状。方法采用自行设计的问卷星小程序电子问卷,自2023年10月23日至2023年11月23日,通过多个学会和协会渠道进行调查,问卷覆盖中国内地地区31个省... 详细信息

目的调查中国急性缺血性脑卒中(AIS)患者行血管内治疗(EVT)围手术期麻醉管理和患者安全现状。方法采用自行设计的问卷星小程序电子问卷,自2023年10月23日至2023年11月23日,通过多个学会和协会渠道进行调查,问卷覆盖中国内地地区31个省、市以及自治区内的部分二级及以上具有国家EVT资格认证的医疗机构,参与问卷调查者需扫描二维码进入问卷星小程序进行答题,每个微信账户限定提交一份问卷。问卷核心指标包括:①医疗机构概况,机构所在地区、医院认证等级,年度内完成的AIS患者EVT案例数/年有效问卷数及占比;②麻醉医师在AIS患者EVT期间的参与程度,涉及患者交接流程(急诊室‑急诊介入治疗室交接)、治疗团队结构(治疗团队麻醉医师组成)、EVT术前麻醉评估、EVT期间麻醉医师与介入医师的沟通和术后患者转运;③EVT期间麻醉管理的相关信息指标及关注度,涉及循环、呼吸、血糖的维持,相应的药物干预策略、麻醉模式的选择与管理以及围手术期关键信息关注度;④麻醉管理的质量控制。应用以下方法判断问卷的有效性:填写时间超过5 min;同一单位填写多份问卷时,采用大数定律原则处理;在数据分析时,若某选项的反馈数量40%的占比约为84.6%,仅约10.5%的受访者不注重围手术期的血糖管理;约56.0%患者术后带气管导管返回重症监护治疗病房;术后随访患者占比约45.4%;本次问卷中,689份问卷显示倾向选择固定程序型麻醉,407份选择情境适应型麻醉;在麻醉类型与管理倾向性方面,约82.9%的受访者更加注重AIS患者EVT期间的麻醉管理;受访者关注度最高的围手术期关键信息分别为患者的循环系统消息、意识状态及呼吸系统消息(前3位)。约87.5%的问卷(959份)显示,在EVT麻醉管理过程中将参考国内外指南;高达约77%的问卷(844份)显示在围手术期遇到过严重不良事件,包括心搏骤停、导丝穿透血管及过敏性休克等。仅有约40.7%的问卷(446份)显示麻醉科进行了AIS患者EVT神经介入麻醉质量控制报告。结论麻醉医师是AIS患者行EVT团队的重要组成部分,治疗团队更加注重围手术期麻醉管理和相关危险因素控制,麻醉科在麻醉质量控制方面的工作有待改进。

关键词：脑卒中血管内治疗麻醉质量控制问卷调查研究

The effect of the application of cold on hematoma, ecchymosis, and pain at the catheter site in patients undergoing percutaneous coronary intervention

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International Journal of Nursing Sciences 2019年第4期6卷 378-384页

作者： Yeter Kurt Mağfiret kaşıkçı Fundamentals and Management of Nursing Department Faculty of Health SciencesKaradeniz Technical UniversityTrabzonTurkey Nursing faculty Ataturk UniversityErzurumTurkey

objective: This study was conducted to determine the effect of the application of cold on hematoma,ecchymosis,and pain in patients undergoing percutaneous coronary ***: It is a quasi-experimental study with a control group.A total of 200 patients (100 in the control group and 100 in the experimental group) were included in the *** the experimental group,a cold pack was applied to the bottom of the sandbag for the first 15 min after withdrawing the femoral arterial *** groups were assessed and followed up at the first 15th minute and 4th,48th and 72 nd ***: After the femoral arterial catheter was withdrawn,ecchymosis and hematoma were smaller and pain was less in the experimental group at the catheter entry site compared to the control group,and the difference was statistically significant (P onclusion: It was determined that the application of cold reduced the formation of hematomas,ecchymoses and pain in patients after the withdrawal of the femoral arterial catheter.

关键词： Cold compress Ecchymosis Hematoma Nursing care Pain Percutaneous coronary intervention

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浅析生乳滋气味管控

中国奶牛 2024年第2期 7-11页

作者：于有利黎玉琼时发亿陈松睿从志鹏宁夏农林科学院银川750002 固原市职业技术学校固原756000 西北农林科技大学杨凌712000

本文以生乳的气味为主要研究对象。通过对奶牛场生产过程中数据的研究和分析,对奶牛场的整个生产过程进行跟踪,检测出异常气味牛奶中的差异代谢产物。目的是阐明牛奶异味的概念、原因和解决方案,从而为减少乳制品生产中异常奶味和异味... 详细信息

本文以生乳的气味为主要研究对象。通过对奶牛场生产过程中数据的研究和分析,对奶牛场的整个生产过程进行跟踪,检测出异常气味牛奶中的差异代谢产物。目的是阐明牛奶异味的概念、原因和解决方案,从而为减少乳制品生产中异常奶味和异味的发生提供依据。

关键词：生乳滋气味产生原因预防解决方案

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皮肤组织的热力学行为表征：Ⅰ.拉压行为

西安交通大学学报（医学版） 2008年第3期29卷 247-251页

作者：卢天健徐峰 Seffen ka 西安交通大学强度与振动教育部重点实验室陕西西安710049 剑桥大学工程系英国剑桥CB2 1PZ

目的重点研究在不同温度下猪皮肤组织的拉压行为,探讨温度和真皮层胶原质热变性对皮肤组织力学性质的影响。方法实验采用新鲜猪皮,在特殊设计的温控制拉伸系统和压缩系统条件下观察猪皮肤在不同温度下的拉压行为。结果在拉伸实验中,皮... 详细信息

目的重点研究在不同温度下猪皮肤组织的拉压行为,探讨温度和真皮层胶原质热变性对皮肤组织力学性质的影响。方法实验采用新鲜猪皮,在特殊设计的温控制拉伸系统和压缩系统条件下观察猪皮肤在不同温度下的拉压行为。结果在拉伸实验中,皮肤的刚度随着温度的升高而降低,而在压缩实验中则相反。结论温度对皮肤组织的拉伸和压缩行为都有影响:拉伸性质的变化主要是由于随着温度的升高皮肤胶原蛋白的热变性所引起,而压缩性质的变化则有可能是由于在热变性的影响下水合的变化所引起。

关键词：皮肤组织热变性热力学行为拉伸行为压缩行为