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Data-Driven Modeling of Partially Observed Biological Systems

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Communications on Applied Mathematics and Computation 2024年第1期6卷 739-754页

作者： Wei-Hung Su Ching-Shan Chou Dongbin xiu Department of Mathematics The Ohio State UniversityColumbusOH43221USA

We present a numerical approach for modeling unknown dynamical systems using partially observed data,with a focus on biological systems with(relatively)complex dynamical *** an extension of the recently developed deep neural network(DNN)learning methods,our approach is particularly suitable for practical situations when(i)measurement data are available for only a subset of the state variables,and(ii)the system parameters cannot be observed or measured at *** demonstrate that,with a properly designed DNN structure with memory terms,effective DNN models can be learned from such partially observed data containing hidden *** learned DNN model serves as an accurate predictive tool for system *** a few representative biological problems,we demonstrate that such DNN models can capture qualitative dynamical behavior changes in the system,such as bifurcations,even when the parameters controlling such behavior changes are completely unknown throughout not only the model learning process but also the system prediction *** learned DNN model effectively creates a“closed”model involving only the observables when such a closed-form model does not exist mathematically.

关键词： Deep neural network(DNN) Governing equation discovery Biological system Partial observation

Unusual Single Electron Transfer Reactions between Alkenes and Iodine Electrophiles

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Chinese Journal of Chemistry 2024年第5期42卷 471-477页

作者： Zhengzhao Lou Jingyu Hu Chuanfa Ni xiu Wang Jinbo Hu Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Ling Ling RoadShanghai200032 China School of Physical Science and Technology ShanghaiTech University100 Haike RoadShanghai201210 China

The electrophilic addition to an alkene with an electrophile has been widely studied and applied in organic *** organic chemistry textbook describes the classical reaction between an alkene and an iodine electrophile(such as elemental iodine and N-iodosuccinimide(NIS))as a typical ionic reaction,in which an iodonium ion is formed and then attacked by a ***,in this article,we report a new and unusual reaction mode between an alkene and NIS;that is,a single electron transfer(SET)process occurs between these two reactants by forming an electron-donor acceptor *** only does this unusual single electron transfer reaction between an alkene and NIS add fundamentally important knowledge to organic chemistry,it also provides a valuable synthetic method as the new SET reaction mode with opposite regioselectivity as compared with the traditional ionic mode.

关键词： Electrophilic addition Radical ions Reaction mechanisms Alkenes Fluorine

Surface iodine and pyrenyl-graphdiyne co-modified Bi catalysts for highly efficient CO_(2) electroreduction in acidic electrolyte

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Nano Research 2024年第4期17卷 2381-2387页

作者： Min Zhang Juan Wang Xin Rong xiu-Li Lu Tong-Bu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

CO_(2) electroreduction to formic acid/formate would contribute to alleviating the energy and climate *** work reports a Bi-based catalyst derived from the in-situ electroreduction of Bi_(2)O_(2)CO_(3) modified with iodine and pyrenyl-graphdiyne(PGDY)on the surface for efficient electroreduction of CO_(2) in acidic electrolyte,with a high partial current density of 98.71 mA·cm^(-2) and high faradaic efficiency(FE)>90%over the potential range from^(-1).2 to-1.5 V *** hydrogen electrode(RHE),as well as the long-term operational stability over 240 h without degradation in H-type *** results and density function theory calculations show that the synergistic effect of surface iodine and PGDY is responsible for this active and extremely stable process of CO_(2) electroreduction via lowering the energy barriers for formation of*OCHO intermediate,suppressing the competitive HER by enhancing the concentration of both K+and CO_(2) at reaction interface,as well as preventing the dissolution and re-deposition of active Bi atoms on surface during catalytic *** work provides new insight into designing highly active and stable electrocatalysts for CO_(2) reduction.

关键词： CO_(2) reduction electrocatalysis Bi-based catalysts acidic electrolyte

Unconventional Nonreciprocal Voltage Transition in Ag_(2)Te Nanobelts

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Chinese Physics Letters 2023年第12期40卷 126-130页

作者：冷鹏亮曹翔宇马强艾临风张钰达张警蕾修发贤 State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory of the Chinese Academy of SciencesHefei 230031China

Nonreciprocal effects are consistently observed in noncentrosymmetric materials due to the intrinsic symmetry breaking and in high-conductivity systems due to the extrinsic thermoelectric effect. Meanwhile, nonreciprocal charge transport is widely utilized as an effective experimental technique for detecting intrinsic unidirectional electrical contributions. Here, we show an unconventional nonreciprocal voltage transition in topological insulator Ag_(2)Te nanobelts. The nonreciprocal voltage develops from nearly zero to giant values under the applied current I_(ac) and external magnetic fields, while remaining unchanged under various current I_(dc). This unidirectional electrical contribution is further evidenced by the differential resistance(dV/dI) measurements. Furthermore, the transition possesses two-dimensional properties under a tilted magnetic field and occurs when the voltage between two electrodes exceeds a certain value. We propose a possible mechanism based on the development of edge channels in Ag_(2)Te nanobelts to interpret the phenomenon. Our results not only introduce a peculiar nonreciprocal voltage transition in topological materials but also enrich the understanding of the intrinsic mechanism that strongly affects nonreciprocal charge transport.

关键词： value reciprocal topological

Humanβ-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long noncoding RNA TCONS_00014506

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1465-1478页

作者： Yu-Xin Zhao Yan Cui Xin-Hong Li Wen-Hong Yang Shi-xiang An Jia-xian Cui Min-Yu Zhang Jing-Kun Lu Xuan Zhang xiu-Mei Wang Li-Li Bao Peng-Wei Zhao Department of Anesthesiology Inner Mongolia Chest HospitalThe Fourth HospitalHohhot 010035Inner Mongolia Autonomous RegionChina College of Humanities and Education Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Radiotherapy The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina School of Basic Medical Science Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Medical Oncology The Affiliated Cancer Hospital of Inner Mongolia Medical UniversityHohhot 010050Inner Mongolia Autonomous RegionChina

BACKGROUND Colorectal cancer has a low 5-year survival rate and high ***β-defensin-1(hBD-1)may play an integral function in the innate immune system,contributing to the recognition and destruction of cancer *** non-coding RNAs(lncRNAs)are involved in the process of cell differentiation and *** To investigate the effect of hBD-1 on the mammalian target of rapamycin(mTOR)pathway and autophagy in human colon cancer SW620 *** CCK8 assay was utilized for the detection of cell proliferation and determination of the optimal drug *** formation assay was employed to assess the effect of hBD-1 on SW620 cell *** was used to screen potentially biologically significant lncRNAs related to the mTOR ***,p-mTOR(Ser2448),Beclin1,and LC3II/I expression levels in SW620 cells were assessed through Western blot *** hBD-1 inhibited the proliferative ability of SW620 cells,as evidenced by the reduction in the colony formation capacity of SW620 cells upon exposure to ***-1 decreased the expression of p-mTOR(Ser2448)protein and increased the expression of Beclin1 and LC3II/I ***,bioinformatics analysis identified seven lncRNAs(2 upregulated and 5 downregulated)related to the mTOR *** lncRNA TCONS_00014506 was ultimately *** the inhibition of the lncRNA TCONS_00014506,exposure to hBD-1 inhibited p-mTOR(Ser2448)and promoted Beclin1 and LC3II/I protein *** hBD-1 inhibits the mTOR pathway and promotes autophagy by upregulating the expression of the lncRNA TCONS_00014506 in SW620 cells.

关键词： Colon cancer Humanβ-defensin-1 LncRNA Mammalian target of rapamycin Autophagy

Activity regulation and applications of metal-organic framework-based nanozymes

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Rare Metals 2024年第3期43卷 900-914页

作者： Ge fang Shou-Xin Bao Gen-xiu Zhou Cui-Cui Ge State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China Suzhou Nanomicro Technology Co. LtdSuzhou 215000China

As a new generation of artificial enzymes,nanozymes show outstanding advantages such as high stability,low cost,and facile synthesis,which endow them with promising applications in biomedical and environmental *** the various reported nanozymes,metal-organic frameworks(MOFs)could mimic the active center of natural enzymes and provide a hydrophobic environment,which makes MOFs attractive alternatives to natural *** to the highly structural diversity and tailorability of MOFs,rational design will contribute to improve the activity of MOF-based nanozymes and promote their potential applications in both biomedical and environmental ***,a comprehensiye suminary of activity regulatory strategies of MOF-based nanozymes is urgently ***,we summarized the activity regulatory strategies of MOFs with intrinsic enzyme-like activities via modulation of metal nodes,ligands,structures and *** the applications of MOF-based nanozymes in biosensing,hazardous degradation,antibacterial,and cancer therapy were also ***,the current challenges and future perspectives were discussed in *** is highly expected that this review will provide a better understanding on the rational design of novel high-performance MOF-based nanozymes.

关键词： Metal-organic frameworks(MOF)-based nanozymes Activity regulation Biosensing Cancer therapy Hazardous degradation Antibacterial

On the superconvergence of a WG method for the elliptic problem with variable coefficients

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Science China Mathematics 2024年第8期67卷 1899-1910页

作者： Junping Wang Xiaoshen Wang xiu Ye Shangyou Zhang Peng Zhu Division of Mathematical Sciences National Science FoundationAlexandriaVA 22314USA Department of Mathematics University of Arkansas at Little RockLittle RockAR 72204USA Department of Mathematical Sciences University of DelawareNewarkDE 19716USA College of Data Science Jiaxing UniversityJiaxing 314001China

This article extends a recently developed superconvergence result for weak Galerkin(WG)approximations for modeling partial differential equations from constant coefficients to variable *** superconvergence features a rate that is two orders higher than the optimal-order error estimates in the usual energy and L^(2)*** extension from constant to variable coefficients for the modeling equations is highly *** underlying technical analysis is based on a sequence of projections and *** results confirm the superconvergence theory for second-order elliptic problems with variable coefficients.

关键词： weak Galerkin finite element methods superconvergence second-order elliptic problems stabilizerfree

New strategies for asymmetric photocatalysis: asymmetric organocatalytic/photoredox relay catalysis for efficient synthesis of polycyclic compounds containing vicinal amino alcohols

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Science China Chemistry 2024年第3期67卷 945-952页

作者： Jia-Lu Zhang Wen-Bo He xiu-Qin Hu Peng-Fei Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Veterinary Etiological Biology College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China

An asymmetric catalytic strategy in photocatalysis utilizing a chirality-induced approach through an organocatalytic/photoredox relay catalysis strategy is successfully achieved for the rapid construction of polycyclic compounds containing vicinal amino alcohols in a one-pot protocol. This methodology facilitates the efficient synthesis of diverse substituted polycyclic tetrahydroquinoline and benzofuran-derived vicinal amino alcohols, each containing five consecutive chiral centers, with high yields,excellent diastereoselectivities and enantioselectivities(up to 95% yield, >20:1 dr and 98% ee), under mild reaction conditions driven by sequential bifunctional squaramide organocatalyst-catalyzed [4+2] annulation and photocatalyst-catalyzed ketyl radical addition cyclization reaction process. Furthermore, investigations into the stereoselectivity mechanism and high-resolution mass spectrometry(HRMS) experiments on free radical trapping have provided evidence for elucidating the detailed mechanism of chirality-induced processes and chiral intermediate conversions in this procedure.

关键词： enantioselective photocatalysis asymmetric organocatalytic/photocatalysis relay catalysis five consecutive chiral centers chirality-induced strategy chirality vicinal amino alcohols

A Heat Flow with Nonzero Potential for a Critical Trudinger-Moser Functional

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Acta Mathematicae Applicatae Sinica 2024年

作者： Peng-xiu YU School of Mathematics Renmin University of China

Let Ω?■2be a smooth bounded domain and H01(Ω) be the standard Sobolev space consisting of functions which vanish on?Ωand whose gradient is in L2(Ω).In this paper,we investigate critical points of the Trudinger-Mo...

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