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Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis

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Protein & Cell 2023年第2期14卷 137-142页

作者： Mingyue Ma Zhenxing Zhong yuwen Zhu yuan Gu Ruxin Jin Zhipeng Meng yu Wang fa-xing yu Institute of Pediatrics Children's Hospital of Fudan Universityand the Shanghai Key Laboratory of Medical Epigeneticsthe International Co-laboratory of Medical Epigenetics and Metabolismthe State Key Laboratory of Genetic EngineeringInstitutes of Biomedical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Molecular and Cellular Pharmacology and Sylvester Comprehensive Cancer Center University of Miami Miller School of MedicineMiamiFL 33136USA

Dear Editor,Angiogenesis is vital for the development and maintenance of functional organs,and also participates in diverse pathological processes,such as wound healing,oxygen tension,and tumorigenesis(Potente et al.,2011).Thus,understanding the molecular mechanisms responsible for angiogenesis has important clinical implications and may guide strategies for drug development.

关键词： angiogenesis healing organs

USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer

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Protein & Cell 2020年第2期11卷 138-143页

作者： Beiqing Pan Yi Yang Jian Li yu Wang Chuantao fang fa-xing yu Yanhui Xu Fudan University Shanghai Cancer Center Institutes of Biomedical SciencesState Key Laboratory of Genetic EngineeringKey Laboratory of Medical Epigenetics and MetabolismShanghai Medical College of Fudan UniversityShanghai 200032China Children's Hospital and Institutes of Biomedical Sciences Key Laboratory of Medical Epigenetics and MetabolismFudan UniversityShanghai 200032China Key Laboratory of Molecular Medicine Ministry of EducationDepartment of Systems Biology for MedicineSchool of Basic Medical SciencesShanghai Medical College of Fudan UniversityShanghai 200032China Collaborative Innovation Center of Genetics and Development School of Life SciencesFudan UniversityShanghai 200433China CAS Center for Excellence in Molecular Cell Science Chinese Academy of SciencesShanghai 200031China

Dear Editor,The Hippo tumor suppressor pathway plays an important role in development and ***-associated protein(YAP)is a major effector of the Hippo pathway regulating the expression of genes involved in cell proliferation,cell death,and cell differentiation(Pan,2010;Johnson and Haider,2014;Piccolo etal.,2014;yu etal.,2015).In intestine,YAP is mainly expressed in leucine rich repeat containing G protein-coupled receptor 5(LGR5)marked stem cells,and is required for regeneration following tissue damage and the development of colon cancer in mice(Cai etal.,2010;Barry etal.,2013;Wang etal.,2017).Moreover,in colorectal cancer(CRC)specimens,elevated YAP expression and activity is frequently observed(Steinhardt et al.,2008).It has been shown that high YAP expression is associated with cancer metastasis,poor prognosis,resistance to chemotherapy,and greater possibility of relapse(Johnson and Haider,2014;yu etal.,2015).

关键词： al. colorectal intestine

Immediate Glucose Response

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Immediate Glucose Response

Numerical simulation study on the hygrothermal performance of building exterior walls under dynamic wind-driven rain condition

中国生物化学与分子生物学会2016年全国学术会议

作者： fa-xing yu Yan Luo Children's Hospital and Institutes of Biomedical Sciences Fudan University School of Basic Medical Sciences Zhejiang University College of Medicine

Eukaryotic cells can sense glucose and evoke signaling pathways to regulate growth and *** immediate response to glucose is the expression of a set of genes mediated byciscarbohydrate response elements(Cho RE)and their associated transcription factors Mondo Aand Max-like protein X(MLX).Thioredoxin interacting protein(TXNIP),the product of an immediate glucose response gene TXNIP,

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cnki会议

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Building Simulation 2024年第2期17卷 207-221页

作者： xing Hu Huibo Zhang Hui yu School of Design Shanghai Jiao Tong UniversityShanghai200240China

Wind-driven rain(WDR)has a significant influence on the hygrothermal performance,durability,and energy consumption of building *** calculation of WDR loads using semi-empirical models has been incorporated into the boundary conditions of coupled heat and moisture transfer ***,prior research often relied on fixed WDR absorption ratio,which fail to accurately capture the water absorption characteristics of porous building materials under rainfall ***,this study aims to investigate the coupled heat and moisture transfer of exterior walls under dynamic WDR boundary conditions,utilizing an empirically obtained WDR absorption ratio model based on field *** developed coupled heat and moisture transfer model is validated against the HAMSTAD *** findings reveal that the total WDR flux calculated with the dynamic WDR boundary is lower than that obtained with the fixed WDR boundary,with greater disparities observed in orientations experiencing higher WDR *** variations in moisture flow significantly impact the surface temperature and relative humidity of the walls,influencing the calculation of cooling and heating loads by different *** to the transient heat transfer model,the coupled heat and moisture transfer model incorporating dynamic WDR boundary exhibits maximum increases of 17.6%and 16.2%in cooling and heating loads,*** dynamic WDR boundary conditions provide more precise numerical values for surface moisture flux,offering valuable insights for the thermal design of building enclosures and load calculations for HVAC systems.

关键词： wind-driven rain building component hygrothermal model transient simulation cooling and heating loads

Indian monsoon drove the dispersal of the thoracica group of Scytodes spitting spiders

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Zoological Research 2024年第1期45卷 152-159页

作者： yu-fa Luo Shu-Qiang Li School of Life and Environmental Sciences Shaoxing UniversityShaoxingZhejiang 312000China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

We examined the global biogeography of the Scytodes thoracica group of spitting spiders based on 23 years of sampling at the species level(61 species in the thoracica group and 84 species of Scytodes)using DNA data from six *** results indicated that the thoracica group initially dispersed from Southeast Asia to East Africa between 46.5 and 33.0 million years ago,and dispersal events intensified between Southeast/South Asia and East/South Africa from the early to late *** timing of these events indicates that Asian-African faunal exchange of the thoracica group was driven by the Indian monsoon,and the pattern of dispersal suggests that colonialization took root when the Indian monsoon shifted from a North-South direction to an East-West direction from the middle Eocene.

关键词： Geological event Climate change Ballooning organism faunal exchange Species distribution

Staurosporine targets the Hippo pathway to inhibit cell growth

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Journal of Molecular Cell Biology 2018年第3期10卷 267-269页

作者： Xueyan Ma Peixue Li Peihao Chen Jinhui Li Hongling Huang Chao Wang Wenjing Li Jianping Ding yun Zhao fa-xing yu Xiangbing Qi Lei Zhang State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell Science Innovation Center for Cell Signaling Network Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai 200031 China National Institute of Biological Sciences Beijing 102206 China National Center for Protein Science Shanghai State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201210 China School of Ufe Science and Technoloy ShanghaiTech University Shanghai 201210 China Children's Hospital and Institutes of Biomedical Sciences Fudan University Shanghai 200032 China

The Hippo signaling pathway was discovered to control organ size in Drosophila through regulating cell proliferation and apoptosis （yu et al., 2015）. Arising studies over the past two decades have defined the core c... 详细信息

关键词： Staurosporine 小径河马 apoptosis 生长房间指向核心部件

Sparse Modal Decomposition Method Addressing Underdetermined Vortex-Induced Vibration Reconstruction Problem for Marine Risers

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维普期刊数据库

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China Ocean Engineering 2024年第2期38卷 285-296页

作者： DU Zun-feng ZHU Hai-ming yu Jian-xing State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation School of Civil EngineeringTianjin UniversityTianjin 300350China

When investigating the vortex-induced vibration(VIV)of marine risers,extrapolating the dynamic response on the entire length based on limited sensor measurements is a crucial step in both laboratory experiments and fatigue monitoring of real *** problem is conventionally solved using the modal decomposition method,based on the principle that the response can be approximated by a weighted sum of limited vibration ***,the method is not valid when the problem is underdetermined,i.e.,the number of unknown mode weights is more than the number of known *** study proposed a sparse modal decomposition method based on the compressed sensing theory and the Compressive Sampling Matching Pursuit(Co Sa MP)algorithm,exploiting the sparsity of VIV in the modal *** the validation study based on high-order VIV experiment data,the proposed method successfully reconstructed the response using only seven acceleration measurements when the conventional methods failed.A primary advantage of the proposed method is that it offers a completely data-driven approach for the underdetermined VIV reconstruction problem,which is more favorable than existing model-dependent solutions for many practical applications such as riser structural health monitoring.

关键词： motion reconstruction vortex-induced vibration(VIV) marine riser modal decomposition method compressed sensing

Drug delivery with Mn-doped MoO_(2) for photothermalenhanced chemotherapy in fighting cancers

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Rare Metals 2024年第5期43卷 2230-2240页

作者： Ping Zhao Hai-fa Zheng Ju Peng xing-Long Li fazal Raziq Xiao-Jun Liu Hao-Quan yu Jin-Lu Tang Yi-fan Kang Wen-Huan Huang School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900 ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'an 710021China

Although chemotherapy has been intensively applied in cancer treatments,its inadequate therapeutic efficacy and severe side effects are still under constant *** used as anti-tumor drug delivery system(DDS)have attracted tremendous attentions owing to their various intriguing ***,Mn-doped MoO_(2)nanoparticles coated with ZrO_(2)and capped with Bi_(2)O_(3)have been designed as a DDS,namely *** possesses good magnetic properties,great photothermal conversion ability,sensitive tumor microenvironment(TME)responsiveness,and good biocompatibility in hemocompatibility in ***,MMZB has been utilized to load the chemotherapeutic agent daunomycin(DNM)(MMZB@DNM)for chemo-photothermal combined ***@DNM demonstrates a more impressive anti-cancer effect than the individual photothermal or chemotherapy both in vitro and in ***,the analysis of tumor specimen sections and serum levels after the treatment indicates negligible side effects for MMZB@DNM in *** contribution provides a valuable concept in designing therapeutic agents for achieving significantly enhanced tumor treatments,which benefits from the synergistic combination of chemotherapy and photothermal therapy in one single nanoagent.

关键词： Mn-doped MoO_(2) Bi_(2)O_(3) Nanocarrier Photothermal Chemotherapy

Artificial Intelligence and Network Pharmacology Reveal the Medication Rules of Professor Wang yu-Ying in the Treatment of Climacteric Syndrome

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 180-190页

作者： Meng-yuan Hu Tian-xing Yi Qi-Rui Liu Xin-yu Zhang Ai-Ping Chen yu-Ying Wang Yi Lu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina

Objective: The objective of this study was to explore the medication rules and academic ideas of Professor Wang yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Methods: The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence(AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis. Results: The top 16 medicinals used by Professor Wang yu-Ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS: Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses. Conclusions: This study summarized Professor Wang's medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.

关键词： Artificial intelligence climacteric syndrome medication rules network pharmacology Professor Wang yu-Ying