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Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats

Neuroscience Bulletin 2022年第4期38卷 342-358页

作者： Dan Ren Jia-Ni Li Xin-Tong Qiu fa-ping wan Zhen-Yu Wu Bo-Yuan fan Ming-Ming Zhang Tao Chen Hui Li Yang Bai Yun-Qing Li Department of Anatomy Guangxi Medical UniversityNanning 510000China Department of Anatomy Histology and Embryology and K.K.Leung Brain Research CentreFourth Military Medical UniversityXi’an 710032China Department of Anatomy Xuzhou Medical UniversityXuzhou 221004China Department of Cardiology The Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China Department of Neurosurgery General Hospital of Northern Theater CommandShenyang 110016China Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province Haikou 570216China Department of Human Anatomy College of Basic MedicineDali UniversityDali 671000China

Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis(CP),but cortical modulation of painful CP remains ***,we examined the role of the anterior cingulate cortex(ACC)in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid(TNBS).TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in *** data indicated that painful CP induced a significant increase in FOS-expressing neurons in the nucleus tractus solitarii(NTS)and ACC,and some FOS-expressing neurons in the NTS projected to the *** addition,a larger portion of ascending fibers from the NTS innervated pyramidal neurons,the neural subpopulation primarily expressing FOS under the condition of painful CP,rather than GABAergic neurons within the *** rats showed increased expression of vesicular glutamate transporter 1,and increased membrane trafficking and phosphorylation of the N-methyl-D-aspartate receptor(NMDAR)subunit NR2B and theα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor(AMPAR)subunit GluR1 within the *** of NMDAR and AMPAR antagonists into the ACC to block excitatory synaptic transmission significantly attenuated abdominal hyperalgesia in CP rats,which was similar to the analgesic effect of endomorphins injected into the *** inhibiting the excitability of ACC pyramidal cells via chemogenetics reduced both hyperalgesia and comorbid anxiety,whereas activating these neurons via optogenetics failed to aggravate hyperalgesia and anxiety in CP *** together,these findings provide neurocircuit,biochemical,and behavioral evidence for involvement of the ACC in hyperalgesia and anxiety in CP rats,as well as novel insights into the cortical modulation of painful CP,and highlights the ACC as a potential target for neuromodulatory interventions in the treatment of painful CP.

关键词： Chronic pancreatitis Anterior cingulate cortex Nucleus tractus solitaries Hyperalgesia Anxiety

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The decreased endomorphin 2 and μ receptor in spinal cord of the STZ-induced type 1 diabetic rats is associated with painful diabetic neuropathy

The decreased endomorphin 2 and μ receptor in spinal cord o...

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中国神经科学学会第十二届全国学术会议

作者： Zhen-Zhen Kou fa-ping wan Yang Bai Chun-Yu Li Jia-Chen Hu Ya-Yun wang Hui Li Yun-Qing Li Department of Anatomy and K.K.Leung Brain Research Centre The Fourth Military Medical University Collaborative Innovation Center for Brain Science Fudan University

Painful diabetic neuropathy（PDN） is one of the most common complications at the early stage of diabetes mellitus（DM）. Both diabetic patients and animals frequently exhibit increased responsiveness to nociceptive stimuli. Endomorphin 2（EM2） has been implicated in selectively activating m opioid receptor（MOR） and subsequent induce antinociceptive effects in spinal dorsal horn. However, the mechanisms of EM2 and MOR in PDN have yet to be clarified in spinal dorsal horn. Therefore, we aimed to explore the role of EM2-MOR to determine the mechanism involved in the pathogenesis of PDN. The main findings were:（1） STZ-induced diabetic rats exhibited hyperglycemia, body weight loss and mechanical allodynia.（2） In spinal dorsal horn, the expressions of EM2 and MOR decreased in diabetic rats.（3） EM2 protein concentrations decreased in brain, lumbar spinal cord and CSF in diabetic rats, but were unchanged in plasma.（4） The frequency but not amplitude of spontaneous EPSCs（sEPSCs） was significantly higher in diabetic than control rats.（5） Intrathecal injection of EM2 for 14 days from the early stage of DPN alleviate mechanical allodynia and partially attenuated reduced MOR expression via Ser375 phosphorylation in diabetic rats. In summary, our results demonstrate that the impairment of endogenous analgesia system mediated by EM2 via MOR might be involved at the early stage of PDN.

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Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da wan Shuwei Tang Shulin Bai Xiaodong Li Peng Ai wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

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Analysis of Oxides Formed on the Surface of the Alloy 690 in Hydrogenated Supercritical Water

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Acta Metallurgica Sinica(English Letters) 2016年第8期29卷 774-781页

作者： Jin Gao fa-rong wan Guo-ping Cao Kumar Sridharan Todd Allen School of Materials Science and Engineering University of Science and Technology Beijing Department of Materials Science and Engineering University of Wisconsin-Madison

The oxides formed on the surface of the alloy 690 in hydrogenated supercritical water at 400℃ for 1000 h were investigated using scanning electron microscopy,transmission electron microscopy,scanning transmission electron microscopy and energy-dispersive X-ray *** oxides on me surface of the alloy 690 exhibited multi-layer structure：an outer layer consisted of granular crystallites（NiO and NiFe_2O_4） and a compact inner layer（spinel and Cr_2O_3）.Chemical analysis indicated that the outer layer was enriched in nickel but depleted in chromium,whereas the inner layer was enriched in chromium and iron but depleted in *** inner layer was also characterized as layered structure by Fe-rich spinel on top of continuous Cr_2O_3 ***,Cr_2O_3 nodules were readily observed at the oxides/alloy interface.

关键词： Alloy 690 Supercritical water Oxides Corrosion

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Microstructure and Nano-hardness of Pure Copper and ODS Copper Alloy under Au Ions Irradiation at Room Temperature

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Acta Metallurgica Sinica(English Letters) 2016年第11期29卷 1047-1052页

作者： Jing Zhang Yong-Qin Chang Zhi-Meng Guo ping-ping Liu Yi Long fa-Rong wan School of Materials Science and Engineering University of Science and Technology Beijing

The microstructure and nano-hardness of the pure copper and oxide dispersion-strengthened（ODS） copper alloy subjected to 1.4 Me V Au ions irradiation at room temperature were investigated. After irradiation, dislocation-loops form in both materials, while voids can only be generated in the pure copper. Compared with the irradiated pure copper, larger average diameter and lower number density of irradiation-induced dislocation-loops were detected in the ODS copper alloy, revealing that high-density dislocation and large volume of Al2O3 particles existing in the ODS copper alloy can act as effective sinks for the irradiation-induced defects. It was also detected that irradiation hardening in the ODS copper alloy is lower than that in the pure copper. The microstructure and nano-hardness results reveal that the ODS copper alloy has a better irradiation tolerance than the pure copper. In addition, the average diameter of the Al2O3 particles in the ODS copper alloy decreases after irradiation, because the Al–O chemical bonds are decomposed and the atoms are redistributed in the matrix during the irradiation process. This work reveals that the irradiation tolerance of the copper can be effectively enhanced by adding nano-sized Al2O3 particles into the matrix.

关键词： Oxide dispersion-strengthened copper alloy Ions irradiation Microstructure evolution Nano-hardness

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New Chiral Calixarene Derivatives: Syntheses and Their Chiral Recognition Toward Amino Acids by UV-Vis Spectroscopy

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Chemical Research in Chinese Universities 2008年第1期24卷 106-109页

作者： GU Jin-ying HE wan-ping SHI Xian-fa JI Liang-nian Department of Chemistry Tongji University Shanghai 200092 F. R. China Department of Chemistry Sun Yat-sen University Guangzhou 510275 P. R. China

Three novel types of chiral calixarene derivatives 5, 8, and 10 were designed and synthesized by introducing chiral units to parent calixarenes. Their chiralities were confirmed by rotational analysis. Chiral recognition properties of these host compounds towards L- and D-threonine were studied by UV-Vis spectroscopy. The results indicated that calixarene derivatives 5 and 8 exhibited good chiral recognition capabilities toward L- or D-threonine. Although calixarene derivative 10 had no evident chiral recognition ability, the supramolecules of calixarene derivative 10 with L- or D-threonine showed a hypochromic effect or hyperchromic effect respectively. Therefore, calixarene derivative 10 might serve as a good chiral UV-indicator.

关键词： Chiral calixarene Synthesis Amino acid Chiral recognition

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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo wan Tao wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li Jian-Hong Shi Tan Li wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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Limited Effect of Twin Boundaries on Radiation Damage

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Acta Metallurgica Sinica(English Letters) 2016年第1期29卷 72-78页

作者： Jin Gao Zhi-Jun Liu fa-Rong wan Department of Materials Physics and Chemistry School of Materials Science and EngineeringUniversity of Science and Technology Beijing

The different influences of the general grain boundary and the twin boundary on the cavity formation were investigated in copper irradiated by helium at room temperature. Large number of the cavities with sizes smaller than 5 nm formed after irradiation, which were almost homogenously distributed inside the grains. However, the distribution of the cavities varied near the general grain boundary and the twin boundary. Cavities-depleted zone was readily observed near the general grain boundaries, which was rarely observed near the twin boundaries. Meanwhile, decoration of dense cavities within the grain boundary plane was observed. The results suggested the limited influence of the twin boundaries as the point defect sinks compared with the general grain boundaries.

关键词： Transmission electron microscopy Cavities Cavities-depleted zone General grainboundary Twin boundary

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Effect of precipitates on high-temperature strength and irradiation behavior of vanadium-based alloys

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Journal of Iron and Steel Research International 2018年第12期25卷 1270-1277页

作者： Shao-ning Jiang Li-qun Xu fa-rong wan School of Mechanical and Automotive Engineering Qilu University of Technology (Shandong Academy of Science) Jinan 250353ShandongChina School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

The formation of precipitates and their effect on mechanical properties and irradiation damage in V-4CraTi alloys have been investigated using transmission electron microscope,high-temperature tensile tests and high-voltage electron microscope (HVEM).V-4Cr-4Ti alloys were aged for 20-40 h at 873 K,and extremely fine precipitates were produced during the aging process,which coarsened with aging *** results of high-temperature (773,873 and 973 K)tensile tests showed an increase in strength with increasing aging time (i.e:,increasing size of precipitates)while a decrease in the uniform *** was evidence that presence of precipitates strengthened V-4Cr-4Ti *** situ HVEM observations showed that the precipitates restricted the growth rate of dislocation loops induced during electron irradiation at 773 *** interactions between precipitates and irradiation-induced dislocation loops were *** presence of particles alleviated the increase in irradiation hardening up to an irradiation dose of 3.42 dpa (displacement per atom).The precipitates shrank in size during electron irradiation,which was due to the dissolution of constituent atoms of the precipitates into the alloy matrix.

关键词： Aging Precipitate strengthening Electron irradiation Irradiation defect Dislocation loop

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