检索结果-南通市图书馆

Conditional Knockout of Src Homology 2 Domain-containing Protein Tyrosine Phosphatase-2 in Myeloid Cells Attenuates Renal Fibrosis after Unilateral Ureter Obstruction

引用

Chinese Medical Journal 2015年第9期128卷 1196-1201页

作者： Jing-Fei Teng Kai Wang Yao Li fa-jun qu Qing Yuan Xin-Gang Cui quan-Xing Wang Dan-Feng Xu Department of Urology Shanghai Changzheng Hospital Second Military Medical University Shanghai 200003 China Department of Urology General Hospital of Beijing Military Command Beijing 100700 China Department of Urology 309 Hospital of Chinese People's Liberation Army Beijing 100091 China National Key Laboratory of Medical Immunology and Institute of Immunology Second Military Medical University Shanghai 200433 China

Background：Src homology 2 domain-containing protein tyrosine phosphatase-2 （SHP-2） is a kind of intracellular protein tyrosine *** have revealed its roles in various disease,however,whether SHP-2 involves in renal fibrosis remains *** aim of this study was to explore the roles of myeloid cells SHP-2 in renal interstitial ***：Myeloid cells SHP-2 gene was conditionally knocked-out （CKO） in mice using loxP-Cre system,and renal interstitial fibrosis was induced by unilateral ureter obstruction （UUO）.The total collagen deposition in the renal interstitium was assessed using picrosirius red stain.F4/80 immunostaing was used to evaluate macrophage infiltration in renal tubular *** real-time polymerase chain reaction and enzyme linked immunosorbent assay were used to analyze the production of cytokines in the ***-mediated dUTP nick-end labeling stain was used to assess the apoptotic renal tubular epithelial ***：Src homology 2 domain-containing protein tyrosine phosphatase-2 gene CKO in myeloid cells significantly reduced collagen deposition in the renal interstitium after *** infiltration was evidently decreased in renal tubular interstitium of SHP-2 CKO ***,the production of pro-inflammatory cytokines was significantly suppressed in SHP-2 CKO ***,no significant difference was observed in the number of apoptotic renal tubular epithelial cells between wild-type and SHP-2 CKO ***：Our observations suggested that SHP-2 in myeloid cells plays a pivotal role in the pathogenesis of renal fibrosis,and that silencing of SHP-2 gene in myeloid cells may protect renal from inflammatory damage and prevent renal fibrosis after renal injury.

关键词： Fibrosis Inflammation Myeloid Cells Obstructive Nephropathy Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improved closure techniques for laparoscopic partial nephrectomy in moderately complex renal cell carcinoma

引用

Chinese Medical Journal 2021年第2期134卷 228-230页

作者： Qi-Wei Yang Xiu-Wu Pan Jian-Qing Ye Chuan-Min Chu fa-jun qu Lin Li Wei Yang Lei Wang Si-Shun Gan Xin-Gang Cui Department of Urology The Third Affiliated Hospital of Naval Military Medical University(Eastern Hepatobiliary Surgery Hospital)Shanghai 201805China Department of Urology Gongli HospitalShanghai 200135China Department of Urology Changzheng HospitalNaval Military Medical UniversityShanghai 200003China

Laparoscopic partial nephrectomy(LPN)as a minimally invasive nephron-sparing surgery is gradually becoming the preferred surgical treatment for T1a renal carcinoma since it yields faster post-operative recovery and equivalent oncological outcomes to radical nephrectomy.[1]However,it is difficult to perform LPN for complex renal tumors,resulting in a longer warm ischemic time(WIT),which consequently affects the recovery of post-operative renal function.[2]With the development of laparoscopic instruments and techniques and the accumulating experience of surgeons,the WIT during LPN may be shortened using anatomy-based early unclamping(EUC)[1]after the placement of one or two running sutures on the tumor *** this study,we improved the closure techniques for LPN using EUC in patients with complex renal tumors and assessed their effectiveness.

关键词： anatomy operative closure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unraveling brain aging through the lens of oral microbiota

引用

Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical Simulation for Effect of Inlet Cooling Rate on Fluid Flow and Temperature Distribution in Tundish

引用

Journal of Iron and Steel Research International 2012年第7期19卷 12-19页

作者： qu Tian-peng LIU Cheng-jun JIANG Mao-fa CISDI Chongqing Iron and Steelmaking Plant Integration Co Ltd Chongqing 401122China School of Materials and Metallurgy Northeastern UniversityShenyang 110004LiaoningChina

The fluid flow in tundish is a non-isothermal process and the temperature variation of stream from teeming ladle dominates the fluid flow and thermal distribution in tundish. A numerical model was established to investigate the effect of inlet cooling rate on fluid flow and temperature distribution in tundish based on a FTSC （Flexible Thin Slab Casting） tundish. The inlet cooling rate varies from 0. 5 to 0. 25 ~C/rain. Under the present calculation conditions, the following conclusions were made. When the stream temperature from teeming ladle drops seriously （for inlet cooling rate of 0.5℃/min）, there is a ＂backward flow＂ at the coming end of casting. The horizontal flow along the free surface turns to flow along the bottom of tundish. The bottom flow shortens the fluid flow route in tundish and deteriorates the removal effect of nonmetallic inclusions from molten steel. Nevertheless, when the inlet cooling rate decreases to 0.25℃/min, the horizontal flow is sustained during the whole casting period. The present research provides theoretical directions for temperature control in teeming ladle and continuous casting tundish during production of advanced steels.

关键词： tundish thermal distribution unsteady numerical simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

引用

Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing Wu Guang Yin fan‑Zhen Jiao Zhong‑Zhen Yu Jin qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

引用

World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang Liang Li Hao-Yu qu Guang-Yu Chen Meng-Zhou Xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exosomes:the next-generation therapeutic platform for ischemic stroke

引用

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structural Synthesis of Parallel Mechanisms with High Rotational Capability

引用

Chinese Journal of Mechanical Engineering 2018年第4期31卷 73-83页

作者： Xiao-Dong Jin Yue-fa fang Sheng Guo Hai-Bo qu School of Mechanical Electronic and Control EngineeringBeijing

Most parallel mechanisms(PMs) encountered today have a common disadvantage, i.e., their low rotational *** order to develop PMs with high rotational capability, a family of novel manipulators with one or two dimensional rotations is proposed. The planar one-rotational one-translational(1 R1 T) and one-rotational two-translational(1 R2 T)PMs evolved from the crank-and-rocker mechanism(CRM) are presented by means of Lie group theory. A spatial 2 R1 T PM and a 2 R parallel moving platform with bifurcated large-angle rotations are proposed by orthogonal combination of the RRRR limbs. According to the product principle of the displacement group theory, a hybrid 2 R3 T mechanism in possession of bifurcated motion is obtained by connecting the 2 R parallel moving platform with a parallel part, which is constructed by four 3 T1 R kinematic chains. The presented manipulators possess high rotational capability. The proposed research enriches the family of spatial mechanisms and the construction method provides an instruction to design more complex mechanisms.

关键词： Parallel mechanism Rotational capability Lie group theory Bifurcated motion Hybrid mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An overview of emissions of SO2 and NOx and the long-range transport of oxidized sulfur and nitrogen pollutants in East Asia

引用

Journal of Environmental Sciences 2016年第6期28卷 13-25页

作者： Yu qu junling An Youjiang He jun Zheng State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Chinese Research Academy of Environmental Sciences Beijing 100012 China China-ASEAN Environmental Cooperation Center Ministry of Environmental Protection of the People's Republic of ChinaBeijing 100035 China

The long-range transport of oxidized sulfur（sulfur dioxide（SO2） and sulfate） and oxidized nitrogen（nitrogen oxides（NOx ） and nitrate） in East Asia is an area of increasing scientific interest and political concern. This paper reviews various published papers, including ground- and satellite-based observations and numerical simulations. The aim is to assess the status of the anthropogenic emissions of SO2 and NOx and the long-range transport of oxidized S and N pollutants over source and downwind region. China has dominated the emissions of SO2 and NOx in East Asia and urgently needs to strengthen the control of their emissions, especially NOx emissions. Oxidized S and N pollutants emitted from China are transported to Korea and Japan, due to persistent westerly winds, in winter and ***, the total contributions of China to S and N pollutants across Korea and Japan were not found to be dominant over longer time scales（e.g., a year）. The source–receptor relationships for oxidized S and N pollutants in East Asia varied widely among the different studies. This is because：（1） the nonlinear effects of atmospheric chemistry and deposition processes were not well considered, when calculating the source–receptor relationships;（2） different meteorological and emission data inputs and solution schemes for key physical and chemical processes were used; and（3） different temporal and spatial scales were employed. Therefore, simulations using the same input fields and similar model configurations would be of benefit, to further evaluate the source–receptor relationships of the oxidized S and N pollutants.

关键词： Long-range transport Sulfate Nitrate East Asia Source–receptor relationships

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Causes and controlling pattern of sand hazards at the Danghe Reservoir of Dunhuang in Northwest China

引用

Journal of Mountain Science 2016年第11期13卷 1973-1983页

作者： XIE Sheng-bo qu Jian-jun PANG Ying-jun Institute of Desertification Studies Chinese Academy of Forestry Beijing 100091 China

Sand hazards are serious at the Danghe Reservoir of Dunhuang,and efforts to control sand are ineffective because disaster-causing mechanisms are currently *** source of sandy materials,dynamic environment of blown sand,and controlling measures of the reservoir area are investigated using different methods,such as granularity analyses,wind regime and sand transport field observation and analyses,sand drift potential ***,the sandy materials are found to derive chiefly from the Mingsha Mountain on the north side of the reservoir *** addition,sand grain in the range of 0.50-0.25 mm and 0.25-0.10 mm are *** prevailing sand-moving wind originates from the N direction,accounting for 15.38% of the yearly total,which coincides in the same direction with sand source,thereby increasing the severity of sand hazards in the reservoir *** yearly sand DP is 1386.59 VU,the yearly RDP is 567.31 VU,the yearly RDP/DP is 0.41,and the yearly RDD is 183.15°.In the windy season(mainly in summer),sand materials are blown by wind from north to south,and then blocked by the Danghe *** sand materials then move with an approximate east-west trend into the river channel and produce sediment,thereby causing *** propose that the sand-controlling pattern of the Danghe Reservoir is dominated by sand blocking in the outer fringe and sand fixing in the inner *** windbreak and sand fixation to control sandy material movement into the river channel plays an important role in retarding sedimentation and extending the useful life of the Danghe Reservoir.

关键词： Danghe Reservoir Sand source Wind direction Sand drift potential

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：