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Tolerance Granulation Based Community Detection Algorithm

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Tsinghua Science and Technology 2015年第6期20卷 620-626页

作者： Shu Zhao Wang ke jie Chen Feng Liu Menghan Huang Yanping Zhang jie Tang key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education Center of Information Support & Assurance TechnologySchool of Computer Science and TechnologyAnhui University School of Computer Science and Technology Tsinghua University

Community structure is one of the most important features in real networks and reveals the internal organization of the vertices. Uncovering accurate community structure is effective for understanding and exploiting networks. Tolerance Granulation based Community Detection Algorithm(TGCDA) is proposed in this paper, which uses tolerance relation(namely tolerance granulation) to granulate a network hierarchically. Firstly, TGCDA relies on the tolerance relation among vertices to form an initial granule set. Then granules in this set which satisfied granulation coefficient are hierarchically merged by tolerance granulation operation. The process is finished till the granule set includes one granule. Finally, select a granule set with maximum granulation criterion to handle overlapping vertices among some granules. The overlapping vertices are merged into corresponding granules based on their degrees of affiliation to realize the community partition of complex networks. The final granules are regarded as communities so that the granulation for a network is actually the community partition of the *** on several datasets show our algorithm is effective and it can identify the community structure more accurately. On real world networks, TGCDA achieves Normalized Mutual Information(NMI) accuracy 17.55% higher than Nfa averagely and on synthetic random networks, the NMI accuracy is also improved. For some networks which have a clear community structure, TGCDA is more effective and can detect more accurate community structure than other algorithms.

关键词： tolerance relation community tolerance granulation

In situ construction of Ni-based N doped porous carbon induced by sulfurization or phosphorization for synergistically enhanced photo/electrocatalytic hydrogen evolution

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Journal of Materials Science & Technology 2024年第12期179卷 66-78页

作者： Desheng Xu Jun ke Hengyu Liu Yafan Bi jie Liu School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205China Department of Environmental Science&Engineering North China Electric Power UniversityBaoding 071003China

Herein,two novel 3D porous Ni-based N doped carbon heterojunctions(NiS_(2)@NC or Ni_(2)P@NC)were suc-cessfully prepared through in situ carbonization and sulfurization or phosphorization by using flower-like Ni-based zeolite imidazolium framework as a *** and photoelectrochemical prop-erties were investigated to explore photoinduced charge separation and transfer in the ***,the photo/electrocatalytic hydrogen evolution performances were evaluated *** contrast to the controlled Ni-ZIF and Ni@NC composites,the expected flower-like NiS_(2)@NC compounds show significantly enhanced photo/electrocatalytic hydrogen evolution performances,which is 13.8 times that of Ni-ZIF and 1.8 times that of Ni@***,a phosphorus-decorated composite(Ni_(2)P@NC)was synthesized for better comparison,which also displays apparently improved photo/electrocatalytic hydrogen evolution *** findings present that the synergistic effect of S doping and semicon-ducting NiS_(2) formation take responsibility for the enhancement of H_(2) generation over the NiS_(2)@NC *** work can provide a new strategy to construct efficient ZIFs-based photo/electrocatalysts with high performance of H_(2) production.

关键词： Solar utilization Zeolite imidazolium framework Carbon Doping Heterojunction Hydrogen evolution

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang ke Chai fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

SUSTAINABLE RURAL LIVELIHOOD AND ECOLOGICAL SHELTER CONSTRUCTION IN UPPER REACHES OF CHANGJIANG RIVER——Case Study of Zhaotong of Yunnan Province

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Chinese Geographical Science 2006年第1期16卷 32-40页

作者： SHENG ke-rong faN jie MA Hai-long Institute of Geographical Sciences arid Natural Resources Research Chinese Academy of Sciences Beijing 100101 P. R. China Graduate School of Chinese Academy of Seiences Beijing 100049 P. R. China

Sustainable livelihood theory provides a comprehensive framework for understanding the interactions between livelihoods of peasant households and regional environment change in low-income areas. Based on field survey and 946 questionnaires from peasant household conducted in the case study area of Zhaotong, Yunnan Province, the paper has analyzed the basic characteristics of the rural livelihoods, including the asset base status, the income-generating activities, the energy consumption pattern, and the fertility behavior, in the upper reaches of the Changjiang (Yangtze) River. The micro-level findings show the conflicts among extensive agricultural development models, rural energy consumption structures heavily relying on biomass and the environment protection. The conversion of cropland to forest and grass program(CCFGP) has exerted an important influence on the livelihoods of the peasant households, but its design has given little considerations to their long-term livelihood sources, which will affect its sustainability to a great extent. From the perspective of sustainable livelihoods framework, the objectives that must be addressed in the ecological shelter construction in the upper reaches of the Changjiang River should include, first, facilitating access of peasant households to credit, technology and public services, second, encouraging the peasant households to adopt agricultural technology with environmental benefits and strengthen resources-conserving investments, and third, paying close attention to the rural energy problems and the long-term livelihood sources of the households with CCFGP. Given the weak asset base and difficulties of livelihood strategies shift, ecological shelter construction in the upper reaches of the Changjiang River will take a long time.

关键词： sustainable livelihood ecological shelter construction Zhaotong

Three-dimensional tracking of GLUT4 vesicles in TIRF microscopy

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 232-240页

作者： Xiang-ping WU jie-yue LI Ying-ke XU ke-di XU Xiao-xiang ZHENG Department of Biomedical Engmeermg Zhejiang University Hangzhou 310027 China College of Information Engineering China Jiliang University Hangzhou 310018 China

TIRF microscopy has provided a means to view mobile granules within 100 nm in size in two *** quantitative analysis of the position and motion of those granules requires an appropriate tracking *** this paper,we present a new tracking algorithm combined with the unique features of *** a fluorescence correction procedure was processed to solve the problem of fluorescence bleaching over *** granules were then segmented from a time-lapse image stack by an adaptive background subtraction *** filter was introduced to estimate and track the granules that allowed reducing searching range and hence greater reliability in tracking *** the tracked granules were located in x-y plane,the z-position was indirectly inferred from the changes in their *** the experiments the algorithm was applied in tracking GLUT4 vesicles in living adipose *** results indicate that the algorithm has achieved robust estimation and tracking of the vesicles in three dimensions.

关键词： GLUT4 Total internal reflection fluorescence (TIRF) microscopy Adaptive background subtraction Kalman filter Fluorescence correction

A controllable stitch layout strategy for random needle embroidery

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第9期15卷 729-743页

作者： jie ZHOU Zheng-xing SUN ke-wei YANG State key Laboratory for Novel Software Technology Nanjing University

Random needle embroidery(RNE) is a graceful art enrolled in the world intangible cultural heritage. In this paper, we study the stitch layout problem and propose a controllable stitch layout strategy for RNE. Using our method, a user can easily change the layout styles by adjusting several high-level layout parameters. This approach has three main features: firstly, a stitch layout rule containing low-level stitch attributes and high-level layout parameters is designed; secondly, a stitch neighborhood graph is built for each region to model the spatial relationship among stitches; thirdly, different stitch attributes(orientations, lengths, and colors) are controlled using different reaction-diffusion processes based on a stitch neighborhood graph. Moreover, our method supports the user in changing the stitch orientation layout by drawing guide curves interactively. The experimental results show its capability for reflecting various stitch layout styles and flexibility for user interaction.

关键词： Random needle embroidery(RNE) Stitch style Stitch layout Stitch neighborhood graph Reaction diffusion

Role of Chinese Herbal Medicines in Regulation of Energy Metabolism in Treating Cardiovascular Diseases

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Chinese Journal of Integrative Medicine 2019年第4期25卷 307-315页

作者： LI jie GUAN Xuan-ke LIU Ru-xiu Department of Cardiology Guang'anmen HospitalChinese Academy of Chinese Medical SciencesBeijing(100053)China

Recently,studying myocardial energy metabolism pathways or improving myocardial metabolism through drugs is another effective strategy for treating ischemic heart *** active components of Chinese herbal medicines(CHMs) have been found to modulate energy metabolism in myocardial cells,cerebral vascular cells,endothelial cells and tumour *** paper reviews the advances in studies on the active components of CHMs that modulating energy metabolism in treating cardiovascular diseases over the past ?ve years.

关键词： biologically active ingredient Chinese herbal medicine cardiovascular disease ischemic heart disease heart failure

Assessment and adjustment of sea surface salinity products from Aquarius in the southeast Indian Ocean based on in situ measurement and My Ocean modeled data

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Acta Oceanologica Sinica 2016年第3期35卷 54-62页

作者： XIA Shenzhen ke Changqing ZHOU Xiaobing ZHANG jie Jiangsu Provincial key Laboratory of Geographic Information Science and Technology Nanjing UniversityNanjing 210023China Collaborative Innovation Center of South China Sea Studies Nanjing 210023China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 210023China Department of Geophysical Engineering Montana Tech of the University of MontanaButteMT 59701USA The First Institute of Oceanography State Oceanic AdministrationQingdao 266061China

The in situ sea surface salinity（SSS） measurements from a scientific cruise to the western zone of the southeast Indian Ocean covering 30°-60°S, 80°-120°E are used to assess the SSS retrieved from Aquarius（Aquarius SSS）.Wind speed and sea surface temperature（SST） affect the SSS estimates based on passive microwave radiation within the mid- to low-latitude southeast Indian Ocean. The relationships among the in situ, Aquarius SSS and wind-SST corrections are used to adjust the Aquarius SSS. The adjusted Aquarius SSS are compared with the SSS data from My Ocean model. Results show that：（1） Before adjustment： compared with My Ocean SSS, the Aquarius SSS in most of the sea areas is higher; but lower in the low-temperature sea areas located at the south of 55°S and west of 98°E. The Aquarius SSS is generally higher by 0.42 on average for the southeast Indian Ocean.（2） After adjustment： the adjustment greatly counteracts the impact of high wind speeds and improves the overall accuracy of the retrieved salinity（the mean absolute error of the Zonal mean is improved by 0.06, and the mean error is-0.05 compared with My Ocean SSS）. Near the latitude 42°S, the adjusted SSS is well consistent with the My Ocean and the difference is approximately 0.004.

关键词： Aquarius sea surface salinity(SSS) in situ SSS My Ocean comparison analysis southeast Indian Ocean

Fluorescent Supramolecular Polymersomes Based on Pillararene/Paraquat Molecular Recognition for pH-controlled Drug Release

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Chinese Journal of Polymer Science 2020年第1期38卷 1-8,I0004页

作者： Run Zhao Yu-Juan Zhou ke-Cheng jie jie Yang Sebastien Perrier Fei-He Huang State key Laboratory of Chemical Engineering Center for Chemistry of High-Performance&Novel MaterialsDepartment of ChemistryZhejiang UniversityHangzhou 310027China Department of Chemistry The University of WarwickCoventry CV47ALUK faculty of Pharmacy and Pharmaceutical Sciences Monash University381 Royal ParadeParkvilleVIC3052Australia Warwick Medical School The University of WarwickCoventry GV47ALUK

Researchers have put significant efforts on developing versatile fluorescent polymeric systems due to their promising biological/biomedical labelling, tracking, monitoring, imaging, and diagnostic applications. However, complicated organic/polymeric synthesis or post-modification of these functionalized platforms is still a big obstacle for their further application and thereby provides clear motivation for exploring alternative strategies for the design and fabrication of easily available fluorescent systems. The marriage of supramolecular polymers and fluorescent imaging can provide a facile and dynamic manner instead of tedious and time-consuming synthesis due to the dynamic and reversible nature of noncovalent interactions. Herein, based on water-soluble pillararene/paraquat molecular recognition, we successfully prepare two amphiphilic polypseudorotaxanes which can self-assemble into supramolecular polymersomes in water. These polymersomes can be reversibly destroyed and reformed by tuning the solution p H. Attributed to the aggregation-induced emission of tetraphenylethylene groups,intense fluorescence can be introduced into the obtained supramolecular polymersomes. Furthermore, p H-triggered release of an encapsulated water-insoluble drug(doxorubicin) from the self-assembled fluorescent supramolecular polymersomes is also investigated.

关键词： Fluorescent polymers Aggregation-induced emission Host-guest interactions Responsiveness