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Genomic analysis of Nypa fruticans elucidates its intertidal adaptations and early palm evolution

Journal of Integrative Plant Biology 2024年第4期66卷 824-843页

作者： Weihong Wu Xiao Feng Nan Wang Shao Shao Min Liu fa si Linhao Chen Chuanfeng Jin Shaohua Xu Zixiao Guo Cairong Zhong Suhua Shi Ziwen He State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Greater Bay Area Institute of Precision Medicine School of Life SciencesFudan UniversityGuangzhou 511462China Hainan Academy of Forestry(Hainan Academy of Mangrove) Haikou 571100China

Nypa fruticans(Wurmb),a mangrove palm species with origins dating back to the Late Cretaceous period,is a unique species for investigating long-term adaptation strategies to intertidal environments and the early evolution of ***,we present a chromosome-level genome sequence and assembly for *** integrated the genomes of *** and other palm family members for a comparative genomic analysis,which confirmed that the common ancestor of all palms experienced a whole-genome duplication event around 89 million years ago,shaping the distinctive characteristics observed in this *** also inferred a low mutation rate for the *** genome,which underwent strong purifying selection and evolved slowly,thus contributing to its stability over a long evolutionary ***,ancient duplicates were preferentially retained,with critical genes having experienced positive selection,enhancing waterlogging tolerance in ***,we discovered that the pseudogenization of Early Methionine-labelled 1(EM1)and EM6 in *** underly its crypto-vivipary characteristics,reflecting its intertidal *** study provides valuable genomic insights into the evolutionary history,genome stability,and adaptive evolution of the mangrove *** results also shed light on the long-term adaptation of this species and contribute to our understanding of the evolutionary dynamics in the palm family.

关键词： crypto-vivipary genome stability long-term adaptation mangrove Nypa fruticans palm

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全断面硬岩地层盾构刀具使用寿命延长研究

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工程建设与设计 2024年第9期 212-214页

作者：王思发中铁十四局集团隧道工程有限公司济南250000

针对长距离全断面硬岩地层掘进工况下,盾构刀具易发生磨损失效,缩短刀具工作寿命的问题,结合穗莞深城际铁路机场站-固戍工作区间,分析9 m级泥水盾构机掘进过程中,刀具磨损的基本规律以及磨损失效的原因。为延长盾构刀具的使用寿命,基于... 详细信息

针对长距离全断面硬岩地层掘进工况下,盾构刀具易发生磨损失效,缩短刀具工作寿命的问题,结合穗莞深城际铁路机场站-固戍工作区间,分析9 m级泥水盾构机掘进过程中,刀具磨损的基本规律以及磨损失效的原因。为延长盾构刀具的使用寿命,基于硬岩地层下刀具磨损的基本规律,从刀具更换标准、刀具防松装置、刀具零部件替换以及刀具耐磨工艺等多方面加以改进,提出一系列减少刀具磨损的有效措施。

关键词：长距离全断面硬岩刀具磨损使用寿命

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麦积山石窟松鼠科动物种群数量特征及其危害

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兰州大学学报（自然科学版） 2024年第2期60卷 214-221页

作者：李隆贺东鹏陈章武发思朱非清胡军舰岳永强敦煌研究院国家古代壁画与土遗址保护工程技术研究中心古代壁画保护国家文物局重点科研基地甘肃敦煌736200 甘肃莫高窟文化遗产保护设计咨询有限公司甘肃敦煌736200 兰州大学细胞活动与逆境适应教育部重点实验室兰州730000 敦煌研究院麦积山石窟艺术研究所甘肃天水741020

2021年9月-2022年9月,采用红外相机技术对世界文化遗产麦积山石窟松鼠科动物的种群密度、活动轨迹、昼夜节律及鼠害特点进行调查.结果表明,在石窟及其周边活动的松鼠科动物为岩松鼠与复齿鼯鼠,均为文物致害种;通过Schnabel法与最小已知... 详细信息

2021年9月-2022年9月,采用红外相机技术对世界文化遗产麦积山石窟松鼠科动物的种群密度、活动轨迹、昼夜节律及鼠害特点进行调查.结果表明,在石窟及其周边活动的松鼠科动物为岩松鼠与复齿鼯鼠,均为文物致害种;通过Schnabel法与最小已知存活数估计法计算的岩松鼠种群密度分别为(3.64±0.26)、(3.64±0.24)只/hm^(2),与基于遇见率法测算的种群密度(3.08±0.19)只/hm^(2)之间无显著性差异;基于遇见率法测算的岩松鼠与复齿鼯鼠种群密度(7.33±1.26)只/hm^(2)之间有显著性差异.两种致害物种分布范围广泛,能利用石窟栈道进行活动,可沿石窟崖体东西侧多方位、洞窟门窗以及露天大佛等位置进行攀爬.对石窟文物的破坏主要包括爬行过程造成的机械损伤、排泄物污染以及在洞窟内部与外围筑巢.在两种物种反复污染的栈道外围区域及靠近崖体的高频活动位置采取布设超声波驱避器、定期喷洒化学驱避剂等防护措施.

关键词：松鼠科动物种群密度红外相机技术防治措施麦积山石窟

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Microsatellite analysis of variation among wild, domesticated, and genetically improved populations of blunt snout bream （Megalobrama amblycephala）

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Zoological Research 2014年第2期35卷 108-117页

作者： Shou-Jie TANG si-fa LI Wan-Qi CAI Yan ZHAO Key Laboratory of Freshwater Aquatic Genetic Resources Shanghai Ocean UniversityMinistry of Agriculture

In the present study,the genetic diversity of one selected strain(Pujiang No.1),two domesticated populations(GA and HX)and four wild populations(LZ,YN,SS and JL)of blunt snout bream(Megalobrama amblycephala)was analyzed using 17microsatellite *** results showed that an average of 4.88-7.65 number of alleles(A);an average of 3.20-5.33 effective alleles(Ne);average observed heterozygosity(Ho)of 0.6985-0.9044;average expected heterozygosity(He)of 0.6501-0.7805;and the average polymorphism information content(PIC)at *** FST value between populations ranged from0.0307-0.1451,and Nei’s standard genetic distance between populations was *** expected heterozygosities in the domesticated populations(GA and HX)were significantly lower than those found in three wild populations(LZ,SS and JL),but no difference was detected when compared with the wild YN ***,no difference was found between the four wild populations or two domesticated *** expected heterozygosity in Pujiang No.1 was higher than the two domesticated populations and lower than the four wild *** pairwise FST value between populations,permutation test P-values were significant between the GA,HX and PJ populations,but not between the four wild *** results showed that the expected heterozygosity in the selected strain of blunt snout bream,after seven generations of selective breeding,was lower than that of wild populations,but this strain retains higher levels of genetic diversity than domesticated *** genetic differences and differentiation amongst wild populations,domesticated populations and the genetically improved strain of blunt snout bream will provide important conservation criteria and guide the utilization of germplasm resources.

关键词：野生种群遗传改良团头鲂微卫星分析微卫星标记分析遗传多样性等位基因数变异

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Shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway

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Chinese Journal of Integrative Medicine 2024年第5期30卷 421-432页

作者： YUE Tong-tong CAO Ying-jie CAO Ya-xuan LI Wei-xia WANG Xiao-yan si Chun-ying XIA Han ZHU Ming-jun TANG Jin-fa WANG He The First Clinical Medical College of Henan University of Chinese Medicine Zhengzhou 450046China Department of Pharmacy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China Department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China

Objective: To investigate the main components and potential mechanism of Shuxuening Injection(SXNI) in the treatment of myocardial ischemia-reperfusion injury(MIRI) through network pharmacology and in vivo research. Methods: The Traditional Chinese Medicine Systems Pharmacology(TCMSP) and Pharm Mapper databases were used to extract and evaluate the effective components of Ginkgo biloba leaves, the main component of SXNI. The Online Mendelian Inheritance in Man(OMIM) and Gene Cards databases were searched for disease targets and obtain the drug target and disease target intersections. The active ingredient-target network was built using Cytoscape 3.9.1 software. The STRING database, Metascape online platform, and R language were used to obtain the key targets and signaling pathways of the anti-MIRI effects of SXNI. In order to verify the therapeutic effect of different concentrations of SXNI on MIRI in rats, 60 rats were first divided into 5 groups according to random number table method: the sham operation group, the model group, SXNI low-dose(3.68 mg/kg), medium-dose(7.35 mg/kg), and high-dose(14.7 mg/kg) groups, with 12 rats in each group. Then, another 60 rats were randomly divided into 5 groups: the sham operation group, the model group, SXNI group(14.7 mg/kg), SXNI+LY294002 group,and LY294002 group, with 12 rats in each group. The drug was then administered intraperitoneally at body weight for 14 days. The main biological processes were validated using in vivo testing. Evans blue/triphenyltetrazolium chloride(TTC) double staining, hematoxylin-eosin(HE) staining, terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis were used to investigate the efficacy and mechanism of SXNI in MIRI rats. Results: Eleven core targets and 30 Kyoto Encyclopedia of Genes and Genomes(KEGG) pathways were selected. Among these, the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) pathway was

关键词： myocardial ischemia reperfusion injury PI3K/AKT signaling pathway Shuxuening Injection apoptosis Ginkgo biloba leaves

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Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng si-Jing Wang Lin Guo Pan-Pan Ma Xiao-Long Ye Ming-Lin Pan Bo Hang Jian-Hua Mao Antoine M Snijders Yi-Bing Lu Da-fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(Ufa)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** Ufas,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 Ufa ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and Ufa profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

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Effects of diamond particle size on microstructure and properties of diamond/Al-12si composites prepared by vacuum-assisted pressure infiltration

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China Foundry 2024年第4期21卷 360-368页

作者： Jia-ping Fu Can-xu Zhou Guo-fa Mi Yuan Liu School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454100HenanChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Diamond/aluminium composites have attracted attention in the field of thermal management of electronic packaging for their excellent *** order to solve the interfacial problem between diamond and aluminium,a novel process combining pressure infiltration with vacuum-assisted technology was proposed to prepare diamond/aluminum *** effect of diamond particle size on the microstructure and properties of the diamond/Al-12si composites was *** results show that the diamond/Al-12si composites exhibit high relative density and a uniform *** thermal conductivity and coefficient of thermal expansion increase with increasing particle size,while the bending strength exhibits the opposite *** the average diamond particle size increases from 45μm to 425μm,the thermal conductivity of the composites increases from 455 W·m^(-1)·K^(-1)to 713 W·m^(-1)·K^(-1)and the coefficient of thermal expansion increases from 4.97×10^(-6)K^(-1)to 6.72×10^(-6)K^(-1),while the bending strength decreases from 353 MPa to 246 *** research demonstrates that high-quality composites can be prepared by the vacuum-assisted pressure infiltration process and the thermal conductivity of the composites can be effectively improved by increasing the diamond particle size.

关键词： diamond/aluminum composites thermal conductivity electronic packaging vacuum-assisted pressure infiltration

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基于交通业务特征理解的车路协同可信交互方法

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交通运输工程学报 2022年第4期22卷 348-360页

作者：上官伟查园园付瑶郑四发柴琳果北京交通大学电子信息工程学院北京100044 北京交通大学轨道交通控制与安全国家重点实验室北京100044 中国移动研究院北京100053 清华大学车辆与运载学院北京100084

为保障车路协同环境下信息的可信交互,分析了车车、车路协同信息交互流程和不同模式下的交互需求,设计了车路协同可信交互架构;构建了车辆行为状态推演模型与路径扰动因子量化模型,设计了车辆主体可信度计算方法与等级评估规则,实现了... 详细信息

为保障车路协同环境下信息的可信交互,分析了车车、车路协同信息交互流程和不同模式下的交互需求,设计了车路协同可信交互架构;构建了车辆行为状态推演模型与路径扰动因子量化模型,设计了车辆主体可信度计算方法与等级评估规则,实现了车辆主体行为可信认证;通过对交通业务的有效特征理解构建了消息紧急度量化模型,利用低分辨率筛选策略初步过滤了消息报文,基于支持向量机(SVM)对消息内容进行了深度理解,形成了多分辨率交互内容认知方法;使用包含OMNeT++和SUMO仿真模拟器的Veins搭建了仿真测试环境,针对不同网联自动驾驶车辆(CAV)渗透率下的开放道路和交叉口场景开展了仿真试验,对提出的车路协同可信交互方法进行了测试验证。研究结果表明:结合交通业务特征理解能够有效改善车路协同信息交互的可信度判别,提出的方法对信标位置消息的平均认知正确率可以达到90.91%,相比基于时效性检测的可信交互方法提高了8.68%;在安全效率消息可信交互验证试验中,随着恶意车辆比例的增加,传统基于投票机制的车路协同可信交互方法逐渐失效,而提出的方法在保证单次认证时延小于13 ms的条件下,平均正确率达到94.96%,较传统基于反向传播(BP)神经网络的方法提高了3.05%,且CAV渗透率越大,可信交互检测结果的准确率越高,漏报率越低,能够满足车路协同可信交互需求。

关键词：车路协同可信交互交通业务特征理解行为状态推演路径扰动因子量化多分辨率认知

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Reduction of atrial fibrillation in remotely monitored pacemaker patients： results from a Chinese multicentre registry

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Chinese Medical Journal 2013年第22期126卷 4216-4221页

作者： CHEN Ke-ping DAI Yan HUA Wei YANG Jie-fu LI Kang LIANG Zhao-guang SHEN fa-rong CHEN si-lin SUYan-gang DING Yan-sheng ZHANG Shu Chinese Acad Med Sci Fuwai Hosp Clin EP Lab Beijing 100037 Peoples R China Chinese Acad Med Sci Fuwai Hosp Arrhythm Ctr Beijing 100037 Peoples R China Peking Union Med Coll Beijing 100037 Peoples R China Beijing Hosp Dept Cardiol Beijing 100730 Peoples R China Capital Med Univ Xuan Wu Hosp Dept Cardiol Beijing 100053 Peoples R China Harbin Med Univ Affiliated Hosp 1 Dept Cardiol Harbin 150001 Heilongjiang Peoples R China Zhejiang Hosp Dept Cardiol Hangzhou 310013 Zhejiang Peoples R China Guangdong Gen Hosp Dept Cardiol Guangzhou 510100 Guangdong Peoples R China Fudan Univ Zhongshan Hosp Dept Cardiol Shanghai 200032 Peoples R China Peking Univ Hosp 1 Dept Cardiol Beijing 100034 Peoples R China

Background Many recipients of implantable cardiac electronic devices have atrial fibrillation （AF） occurrences after device implantation, even if there is no previous history of AF, and some of the episodes are asymptomatic. The purpose of this study was to evaluate trends in AF burden following early AF detection in patients treated with pacemakers equipped with automatic, daily Home Monitoring function. Methods Between February 2009 and December 2010, the registry recruited 701 pacemaker patients （628 dual-chamber, 73 biventricular devices） at 97 clinical centers in China. Daily Home Monitoring data transmissions were analyzed to screen for the AF burden. In-office follow-ups were scheduled for 3 and 6 months after implantation. Upon first AF （i.e., mode-switch） detection in a patient, screening olAF burden by Home Monitoring was extended for the next 180 days. Results At least one episode of AF was observed in 22.9% of patients with dual-chamber pacemakers and in 28.8% of patients with biventricular pacemakers. The first AF detection in a patient occurred, on average, about 2 months before scheduled follow-up visits. In both pacemaker groups, mean AF burden decreased significantly （P〈0.05） over 180 days following first AF detection： from 12.0% to 2.5% in dual-chamber and from 12.2% to 0.5% in biventricular pacemaker recipients. The number of patients with an AF burden 〉10% per month was significantly reduced over 6 months of implantation in both dual chamber （38 patients in the first month vs. 21 patients in month 6, P〈0.05） and biventricular （7 patients in the first month vs. 0 patient in months 4-6, P〈0.05） pacemaker recipients. Conclusions Automatic, daily Home Monitoring of patients treated with cardiac pacemakers allows early detection of AF, and there is a gradual and significant decrease in AF burden.

关键词： home monitoring atrialfibrillation burden pacemaker cardiac resynchronization device

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垃圾填埋场斜坡上土工合成材料受力分析

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岩土力学 2008年第9期29卷 2350-2354页

作者：许四法杨杨浙江工业大学建筑工程学院杭州310032

为了评价垃圾填埋场防渗系统材料界面之间的摩擦特性以及土工合成材料端部的应力,进行了模拟试验和有限元分析。采用直接剪切试验,获得了土与短纤维无纺布、短纤维无纺布与HDPE土工膜以及短纤维无纺布与TPO(PE)界面的摩擦角和黏聚力;采... 详细信息

为了评价垃圾填埋场防渗系统材料界面之间的摩擦特性以及土工合成材料端部的应力,进行了模拟试验和有限元分析。采用直接剪切试验,获得了土与短纤维无纺布、短纤维无纺布与HDPE土工膜以及短纤维无纺布与TPO(PE)界面的摩擦角和黏聚力;采用离心模拟试验,得到了伴随土压缩引起的短纤维无纺布和土工膜端部拉应力。试验结果表明:材料界面之间的摩擦角较大,但黏聚力不大;伴随填埋高度的增加,短纤维无纺布和土工膜端部的拉应力也随之增大。运用有限元对土压缩引起的短纤维无纺布和土工膜端部拉应力以及界面的摩擦应力分布进行了分析,并与试验结果进行了对比,分析结果表明:两者基本一致,碾压机械下方土工膜界面之间摩擦应力比较大。

关键词：垃圾填埋场土工合成材料摩擦应力拉应力有限元解析

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