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Maternal zinc deficiency impairs brain nestin expression in prenatal and postnatal mice

Cell Research 2001年第2期11卷 135-141页

作者： WANG fu DI, WEI BIAN, LING WEI KONG, fa JI ZHAO, JUN SHENG GUO, NAI HE JINGI Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue yang Road, Shanghai 200031, China Department of Publ 2Department of Public Health Second Military Medical University Shanghai 200433 China 1Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 1Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 2Department of Public Health Second Military Medical University Shanghai 200433 China 2Department of Public Health Second Military Medical University Shanghai 200433 China 1Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China

Effects of maternal dietary zinc deficiency on prenatal and postnatal brain development were investigated in ICR strain mice. From d 1 of pregnancy (EO) until postnatal d 20 (P20), maternal mice were fed experimental diets that contained 1 mg Zn/kg/day (severe zinc deficient, SZD), 5 mg Zn/kg/day (marginal zinc deficient, MZD), 30 mg Zn/kg/day (zinc adequately supplied, ZA) or 100 mg Zn/kg/day (zinc supplemented, ZS and pair-fed, PF). Brains of offspring from these dietary groups were examined at various developmental stages for expression of nestin, an intermediate filament protein found in neural stem cells and young neurons. Immunocytochemistry showed nestin expression in neural tube 10. 5 d post citrus (dpc) as well as in the cerebral cortex and neural tube from 10.5 dpc to postnatal d 10 (P10). Nestin immunoreactivities in both brain and neural tube of those zinc-supplemented control groups (ZA, ZS, PF) were stronger than those in zinc-deficient groups (SZD and MZD). Western blot analysis confirmed that nestin levels in -pooled brain extracts from each of the zinc-supplemented groups (ZA, ZS, PF) were much higher than those from the zinc-deficient groups (SZD and MZD) from 10.5 dpc to P10. Immunostaining and Western blots showed no detectable nestin in any of the experimental and control group brains after P20. These observations of an association between maternal zinc deficiency and decreased nestin protein levels in brains of offspring suggest that zinc deficiency suppresses development of neural stem cells, an effect which may lead to neuroanatomical and behavioral abnormalities in adults.

关键词： Zinc deficiency nestin brain development neural stem cells.

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Modeling the optimal compensation capacitance of a giant magnetostrictive ultrasonic transducer with a loosely-coupled contactless power transfer system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第10期23卷 757-770页

作者： Tian LAN Ping-fa FENG Jian-jian WANG Jian-fu ZHANG Hui-lin ZHOU State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBejing 100084China'China China Ordnance Industry Navigation and Control Technology Research Institute Beijing 10089China

The giant magnetostrictive rotary ultrasonic processing system(GMUPS)with a loosely-coupled contactless power transfer(LCCPT)has emerged as a high-performance technique for the processing of hard and brittle materials,owing to its high power density.A capacitive compensation is required to achieve the highest energy efficiency of GMUPS to provide sufficient vibration amplitude when it works in the resonance *** this study,an accurate model of the optimal compensation capacitance is derived from a new electromechanical equivalent circuit model of the GMUPS with LCCPT,which consists of an equivalent mechanical circuit and an electrical *** phase lag angle between the mechanical and electrical circuits is established,taking into account the non-negligible loss in energy conversion of giant magnetostrictive material at ultrasonic *** change of system impedance characteristics and the effectiveness of the system compensation method under load are *** idle vibration experiments and machining tests are conducted to verify the developed *** results show that the GMUPS with optimal compensation capacitance can achieve the maximum idle vibration amplitude and smallest cutting *** addition,the effects of magnetic conductive material and driving voltages on the phase lag angle are also evaluated.

关键词： Rotary ultrasonic machining Giant magnetostrictive transducer(GMT) Loosely-coupled contactless power transfer(LCCPT) Electromechanical equivalent circuit Optimal compensation capacitance

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Association of T-helper cell cytokine level with age in patients with biliary atresia: a preliminary study

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World Journal of Pediatrics 2018年第4期14卷 404-409页

作者： fu-Bang Li Xiao-Li Shu Wei-Zhong Gu Xiao-Xia Zhao Shou-Jiang Huang Hong Zhao Ke-Rong Peng Jin-fa Tou Department of Gastroenterology Children's HospitalZhejiang University School of MedicineHangzhouChina Laboratory of Gastroenterology Children's HospitalZhejiang University School of MedicineHangzhouChina Department of Pathology Children's HospitalZhejiang University School of MedicineHangzhouChina Department of General Surgery Children's HospitalZhejiang University School of MedicineHangzhouChina

Background The pathogenesis of biliary atresia (BA) is associated with an inflammatory process involving the biliary tree. This study aimed to investigate the association of T-helper cell cytokine levels with age in patients with BA. Methods Twenty-eight patients with BA were divided into three groups according to their age (factor (TGF)-β1 and liver expression of IL-1β, IL-6, and TGF-β1. Results The serum levels of IL-1β, IL-12p70, IL-6, and IL-10 in patients aged ≥ 3 months were significantly higher than those in patients aged < 2 months. There were no significant age-related differences in the IL-1β, IL-6 and TGF-β1 expres-sion levels in the liver tissue of patients with BA. Conclusions The serum levels of IL-1β, IL-6, IL-10 and IL-12p70 showed significant age-related differences in patients with BA. Interpretation of the role of cytokines in BA needs to take patient's age into consideration.

关键词： Biliary atresia Cytokines Pathogenesis T-helper cell

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基于超结结构的肖特基势垒二极管（英文）

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电子科技大学学报 2015年第1期44卷 134-139页

作者：马奎杨发顺傅兴华贵州大学电子科学系贵州省微纳电子与软件技术重点实验室贵阳550025

在功率半导体器件中,高的反向击穿电压和低的正向导通电阻之间的矛盾关系是影响其发展的主要因素之一,选用超结结构替代功率半导体器件中的传统电压支持层能够有效缓解这一矛盾关系。该文设计和实现了一种超结肖特基二极管,其中的电压... 详细信息

在功率半导体器件中,高的反向击穿电压和低的正向导通电阻之间的矛盾关系是影响其发展的主要因素之一,选用超结结构替代功率半导体器件中的传统电压支持层能够有效缓解这一矛盾关系。该文设计和实现了一种超结肖特基二极管,其中的电压支持层采用P柱和N柱交替构成的超结结构。在器件的制作方面,选用成熟的单步微电子工艺,通过4次N型外延和4次选择性P型掺杂来实现超结结构。为便于对比分析,设计传统肖特基二极管和超结肖特基二极管的电压支持层厚度一致,且超结结构中P柱和N柱的杂质浓度均和传统肖特基二极管的电压支持层浓度一致。测试得到传统肖特基二极管的反向击穿电压为110 V,而超结肖特基二极管的反向击穿电压为229 V。表明采用超结结构作为功率半导体器件的电压支持层能够有效提高反向击穿电压,同时降低器件的正向导通电阻,并且当P柱区和N柱区内的电荷量一致时器件的击穿电压最高。

关键词：击穿电压导通电阻肖特基势垒二极管超结

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Primary tumor prevalence has an impact on the constituent ratio of metastases to the jaw but not on metastatic sites

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International Journal of Oral Science 2011年第3期3卷 141-152页

作者： fu-gui Zhang Cheng-ge Hua Mo-lun shen Xiu-fa Tang State Key Laboratory of Oral Diseases Sichuan University Chengdu 610041 China Department of Head and Neck Oncology West China School of Slomatology Sichuan University Chengdu 610041 China Department of Stomatology The Second People＇s Hospital of Hefei Hefei 230011 China

This article provides an overview of metastases to jaws （M J）, mainly concerning the differences between American and Chinese patients, and exploring the relationship between the primary tumors＇ prevalence （PTP） and constituent ratio of MJ. Information concerning of 399 MJ cases in 215 papers, including one new case in our hospital, was subjected to statistic analysis. The main clinical features of M J, such as constituent ratio of PTP and that of M J, metastatic sites, treatments, and prognosis were summarized. Breast, lung, kidney, prostate and thyroid （in descending order） were the leading primary sites of MJ. furthermore, the constituent ratio of MJ was found to be correlated with that of PTP in all subjects including American and Chinese subjects in our study. As to metastatic sites in the mandible, a specific ＂M＂ shaped pattern appeared regardless of the tumor type or constituent ratio,,; of MJ were in all subjects. Almost all subjects received traditionary palliative treatments, and the prognosis was quite poor. The PTP had a significant impact on the constituent ratio of MJ. However, it was the properties of the microenvironment rather than characteristics or constituent ratios of tumor cells, that decided the metastatic sites in various tumor subjects.

关键词： tumor metastases jaws

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facile synthesis strategy of NicorePtshell electrocatalyst for oxygen reduction reaction

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Journal of Energy Chemistry 2019年第10期28卷 192-196页

作者： Yi Wang Gui-fa Long Jin-Hua Piao Zhi-Yong fu Zhen-Xing Liang Key Laboratory on fuel Cell Technology of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology

Polymer electrolyte membrane fuel cells(PEMFCs), as an energy conversion technology, have attracted extensive attention due to their high conversion efficiency, low emission, high energy density,and fast fuel charging [1,2]. Pt-based catalysts have been acknowledged to be the most effective catalyst for the oxygen reduction reaction(ORR) [3–5]. However, both the source scarcity and high cost of Pt severely hinder the commercial application of the PEMFCs [1,6,7].

关键词： Core-shell structure Spontaneous displacement reaction Oxygen reduction reaction fuel cell

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腔增强吸收光谱技术在大气环境研究中的应用进展

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光谱学与光谱分析 2021年第9期41卷 2688-2695页

作者：陈东阳周力杨复沫王炜罡葛茂发四川大学建筑与环境学院四川成都610065 中国科学院化学研究所北京100190

大气污染是全球性环境问题,针对大气环境污染物检测技术的发展对大气环境研究至关重要。光谱分析方法因其具有特异性选择、高精度、高时间分辨等优势,已被广泛应用于大气污染物检测领域。腔增强吸收光谱(CEAS)技术由腔衰荡光谱(CRDS)技... 详细信息

大气污染是全球性环境问题,针对大气环境污染物检测技术的发展对大气环境研究至关重要。光谱分析方法因其具有特异性选择、高精度、高时间分辨等优势,已被广泛应用于大气污染物检测领域。腔增强吸收光谱(CEAS)技术由腔衰荡光谱(CRDS)技术发展而来,是通过测量透过高精细度谐振腔的光强获得分子吸收信息的高灵敏度探测技术。该技术自提出至今二十余年来,因为成本低、操作简单、灵敏度高、适应性强等优势,成为大气环境研究中痕量气体检测的重要手段。介绍了基于相干和非相干光源的两种CEAS技术原理和基本装置构成,其中,采用LED作为光源的非相干宽带腔增强吸收光谱(IBBCEAS),因其成本更低且能够检测几十纳米带宽的光谱范围,在大气研究领域中应用更加广泛。综述了国内外应用CEAS技术针对大气环境中氮氧化物(NO_(2),NO_(3),N_(2)O_(5),HONO)、挥发性有机物(甲醛,乙二醛,甲基乙二醛,甲烷,乙烯)、卤素单质(I_(2),Br_(2))、含卤素化物(OIO,IO,BrO)、臭氧(O_(3))及气溶胶等污染物的检测工作。同时,从光源、检测器、光腔结构改进、仪器检测灵敏度优化等多个方面对已有工作进行了全面的归纳总结,重点阐述了其在实验室条件下的检测能力,以及实际大气环境下应用的表现。最后从CEAS技术的系统优化和未来应用趋势方面做出了一定的展望。

关键词：腔增强吸收光谱光谱分析大气化学痕量气体检测

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Enabling Extraordinary Rate Performance for Poorly Conductive Oxide Pseudocapacitors

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Energy & Environmental Materials 2020年第3期3卷 405-413页

作者： Mozaffar Abdollahifar Hao-Wen Liu Chia-Hsin Lin Yu-Ting Weng Hwo-Shuenn Sheu Jyh-fu Lee Meng-Lin Lu Yen-fa Liao Nae-Lih Wu Department of Chemical Engineering National Taiwan UniversityTaipei 106Taiwan National Synchrotron Radiation Research Center Hsinchu 30076Taiwan Taiwan Beamline Office at SPring-8 1-1-1 KoutoMikazukiSayoHyogo 679-5198Japan Advanced Research Center for Green Materials Science and Technology National Taiwan UniversityTaipei 10617Taiwan

Pseudocapacitive transition metal oxides(PTMOs)have the advantages of high areal capacitance and material density suitable for high-energy supercapacitor devices,but they are typically marred by insufficient rate performance,which in turn deteriorates cyclic stability at high current *** the example of spinel manganese oxide,herein we demonstrate that a pseudocapacitive oxide electrode of remarkable rate performance and cyclic stability may be realized by adopting oxide nanocrystallites,which are derived based on a novel solution chemistry,and carbon additive(CA)nanoparticles with highly uniform of size *** controlling the particle morphology and size distribution of the active material and conductive additive(CA)in the nanometer range can maximize the density of active material-CA-electrolyte three-phase contact points,thus facilitating synchronized electron and cation flow for the completion of surface faradaic *** resultant Mn3O4 pseudocapacitive electrode exhibits rate capability and cycle stability,including 60%capacity retention at 60 A g-1 and no capacity fade over 100000 cycles under dynamic current densities,far superior to the state-of-the-art PTMO *** electrode design strategy is in general applicable to pseudocapacitors containing poorly conductive active materials.

关键词： high-rate performance pseudocapacitor electrodes single nanoparticles three-phase contact point ultra-long cycle life

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Improvement of Yield and Its Related Traits for Backbone Hybrid Rice Parent Minghui 86 Using Advanced Backcross Breeding Strategies

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Journal of Integrative Agriculture 2013年第4期12卷 561-570页

作者： ZHANG Hong-jun WANG Hui YE Guo-you QIAN Yi-liang SHI Ying-yao XIA Jia-fa LI Ze-fu ZHU Ling-hua GAO Yong-ming LI Zhi-kang National Key facility for Crop Gene Resources and Genetic Improvement Ministry of Agriculture & National Development and Reform Commission/Institute of Crop Sciences Chinese Academy of Agricultural Sciences Rice Research Institute Anhui Academy of Agricultural Sciences International Rice Research Institute College of Agriculture Anhui Agricultural University

How to overcome yield stagnation is a big challenge to rice breeders. An effective method for quickly developing new cultivars is to further improve an outstanding cultivar. In this study, three advanced backcross populations under yield selection that consist of 123 BC2F2：4 introgression lines （ILs） were developed by crossing Minghui 86 （recurrent parent, RP） with three high-yielding varieties （donors）, namely, ZDZ057, fuhui 838, and Teqing, respectively. The progeny testing allowed the identification of 12 promising ILs that had significantly higher mean grain yields than Minghui 86 in two environments. A total of 55 QTLs that affect grain yield and its related traits were identified, which included 50 QTLs that were detected using the likelihood ratio test based on stepwise regression （RSTEP-LRT） method, and eight grain yield per plant （GY） QTLs were detected using ehi-squared （X2） test. Among these QTLs, five QTLs were simultaneously detected in different populations and 22 QTLs were detected in both environments. The beneficial donor alleles for increased GY and its related traits were identified in 63.6% （35 out of 55） of the QTLs. These promising ILs and QTLs identified will provide the elite breeding materials and genetic information for further improvement of the grain yield for Minghui 86 through pyramiding breeding.

关键词： rice (Qryza sativa L.) quantitative trait locus (QTL) selective introgression population yield

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Strain anisotropy models for refined diffraction line profile analysis in cubic metals

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Transactions of Nonferrous Metals Society of China 2020年第8期30卷 2090-2106页

作者： Xiang DAI fu-lin JIANG Jin LIU Luo-yi WU Ding-fa fu Jie TENG Hui ZHANG College of Materials Science and Engineering Hunan UniversityChangsha 410082China Research Center for Steel Kyushu University744 Motooka Nishi-kuFukuoka 819-0395Japan

The present work examined the anisotropy magnitudes obtained from different elastic models of cubic metals(Cu,5383 Al alloy,FCC austenite steel and BCC steel)to explore the origin of strain *** results showed that stable intersections were observed from the modeled and experimental plots of the reciprocal elastic modulus(1/Ehkl)and orientation parameter(Γ).The effectiveness of quasi elasto-plastic model based method in correcting strain anisotropy was further verified in cold-worked *** the important input parameters in dislocation model based diffraction line profile analysis methods,the average diffraction contrast factors(■)of dislocations were observed to depend on elastic *** intersections were found from linear dependence of■onΓ.The conventional input■values indicated distinct dependencies on given elastic constants in diffraction line profile ***,a refined approach was proposed by adopting the optimized intersections as input values,by which more reliable results could be obtained in practical applications.

关键词： metallic materials line profile analysis strain anisotropy dislocations

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