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激光与红外 2008年第9期38卷 921-924页

作者：李宇晔王新柯张平李海涛陈艳江李福利耿玉珍首都师范大学物理系北京100037

使用太赫兹时域光谱技术研究了太赫兹脉冲对模拟沙尘的透射特性,得到不同沙尘条件下信号的透射光谱。同时还进行了沙尘条件下传送成像信号实验,得到比较清晰的像。结果表明太赫兹脉冲能够在沙尘条件下传输太赫兹图像。

关键词：太赫兹时域光谱技术太赫兹成像太赫兹通讯沙尘暴

青少年特发性脊柱侧凸患者凸凹侧椎旁肌肌电比值与Cobb角、顶椎偏距、冠状面平衡距离的相关性

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中国组织工程研究 2022年第9期26卷 1402-1406页

作者：王帅王连成张书豪李富丽董佳兴张亚杰天津中医药大学研究生院天津市301617 天津医院康复科天津市300202 天津体育学院社会体育与健康科学学院天津市301617

背景:国外关于青少年特发性脊柱侧凸患者的表面肌电研究报道结果尚有争议,急需相关研究来完善脊柱侧凸患者椎旁肌肌电理论体系。目的:分析青少年特发性脊柱侧凸患者站立位静息状态下脊柱两侧椎旁肌肌电变化规律,并对患者凸凹侧椎旁肌肌... 详细信息

背景:国外关于青少年特发性脊柱侧凸患者的表面肌电研究报道结果尚有争议,急需相关研究来完善脊柱侧凸患者椎旁肌肌电理论体系。目的:分析青少年特发性脊柱侧凸患者站立位静息状态下脊柱两侧椎旁肌肌电变化规律,并对患者凸凹侧椎旁肌肌电比值与Cobb角、顶椎偏距、冠状面平衡距离的相关性进行分析。方法:选取天津医院脊柱侧凸专病门诊青少年特发性脊柱侧凸患者21例,所有患者在站立位静息状态下用T7550表面肌电记录仪记录脊柱两侧椎旁肌均方根值,分析其变化规律及与侧凸患者冠状面参数之间的相关性。研究方案的实行符合《赫尔辛基宣言》及天津医院对研究的相关伦理要求,参与研究的患者及监护人对测试及试验过程均知情同意。结果与结论:①青少年特发性脊柱侧凸患者站立位静息状态下主弯凸侧与凹侧均方根值差异有显著性意义(P=0.005);患者凸侧椎旁肌的均方根均值大于凹侧的均方根均值;顶椎凸侧椎旁肌均方根值显著大于凹侧;②患者站立位静息状态下凸凹侧均方根值比值与Cobb角具有强的正相关性(r=0.620,P=0.003);与顶椎偏距有中等强度相关性(r=0.443,P=0.044);与冠状面平衡距离无相关性(r=-0.430,P=0.052);③结果说明,青少年特发性脊柱侧凸患者维持身体站立位时凹凸侧椎旁肌肌张力明显不平衡,凸侧肌张力更强,且在顶椎区域最为明显;椎旁肌凸凹侧均方根值比值随Cobb角、顶椎偏距的增大而增大;随着侧凸加重、顶椎偏离中线越远,维持躯干于直立状态所需的凹凸侧肌肉张力差异越明显。

关键词：青少年特发性脊柱侧凸椎旁肌表面肌电冠状面参数相关性 Cobb角顶椎偏距冠状面平衡

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting Lv Hongfu li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

基于数据降维和SVM的大学生心理健康状态评价

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微型电脑应用 2021年第5期37卷 79-81页

作者：李馥利金敏王雨佳商洛学院化学工程与现代材料学院陕西商洛726000 商洛学院健康管理学院陕西商洛726000 中航工业西安航空计算技术研究所陕西西安710062

针对传统的大学生心理健康状态评价方法存在计算复杂和准确率低的缺点,提出了一种基于数据降维和支持向量机的大学生心理健康状态评价方法。选择精神病性、偏执、敌对、恐怖、焦虑、抑郁、强迫症状、人际关系敏感和躯体化等9个维度的指... 详细信息

针对传统的大学生心理健康状态评价方法存在计算复杂和准确率低的缺点,提出了一种基于数据降维和支持向量机的大学生心理健康状态评价方法。选择精神病性、偏执、敌对、恐怖、焦虑、抑郁、强迫症状、人际关系敏感和躯体化等9个维度的指标作为LLE-SVM模型的大学生心理健康状态评价模型的输入,将大学生心理健康状态作为LLE-SVM模型的输出,建立LLE-SVM的大学生心理健康状态评价模型。与SVM、BPNN和DT相比较,LLE-SVM能够有效提高大学生心理健康状态评价准确率。

关键词：支持向量机心理健康状态评价神经网络局部线性嵌入算法

An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： lingxiao li Jing li Yanqi Song Sujuan Qin Qiaoyan Wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian li Jun WANG Xianhui CAO Laifu GONG Jian li Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

An NIR-Ⅱ-emissive Ru(Ⅱ) metallacycle for efficient and safe immunotherapy

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Science China Chemistry 2025年第1期68卷 5-7页

作者： Chonglu li Jianbo Zhan Biao Dong Institute of Health Inspection and Testing Hubei Provincial Center for Disease Control and Prevention State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University

Immunotherapy, as a groundbreaking cancer treatment, has gained considerable attention for its utilization of the body’s immune system to combat tumors [1]. This therapy induces tumor cell apoptosis, triggering a sustained anti-tumor immune response and effectively preventing tumor recurrence and metastasis [2]. The fundamental principle lies in inducing tumor cell death through specific treatment modalities, leading to the release of a cascade of signaling molecules and antigens, thereby mobilizing the immune system to actively identify and attack tumor cells [3].

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超长链单不饱和脂肪酸的生物合成和代谢工程

生物技术通报 2015年第12期31卷 42-49页

作者：田德雨王士安王立昊王家林李福利青岛科技大学化工学院发酵工程实验室青岛266061 中国科学院青岛生物能源与过程研究所青岛市单细胞油脂工程实验室青岛266101

超长链单不饱和脂肪酸(Very long chain monounsaturated fatty acid,VLCMFA)是指主碳链上碳原子数大于或等于20,有且只有一个不饱和双键的脂肪酸。VLCMFA较多的存在于各种油料植物及少数微藻中,目前发现的有鳕油酸(C20∶1)、芥酸(C22... 详细信息

超长链单不饱和脂肪酸(Very long chain monounsaturated fatty acid,VLCMFA)是指主碳链上碳原子数大于或等于20,有且只有一个不饱和双键的脂肪酸。VLCMFA较多的存在于各种油料植物及少数微藻中,目前发现的有鳕油酸(C20∶1)、芥酸(C22∶1)、神经酸(C24∶1)和西门木烯酸(C26∶1)。VLCMFA具有独特的工业用途和潜在药用保健功效。主要综述VLCMFA的生物合成和代谢工程研究进展,旨为应用开发提供参考。

关键词：脂肪酸超长链单不饱和脂肪酸芥酸神经酸代谢工程