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N-连接寡糖中岩藻糖α(1-6)-葡萄糖胺二糖骨架的区域及立体选择性合成

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北京化工大学学报（自然科学版） 2013年第3期40卷 44-49页

作者：鲍光明 TANAKA Katsunori 袁厚群王小莺梅天笑 fukase koichi 江西农业大学动物科技学院南昌330045 大阪大学理学研究科化学系江西农业大学理学院南昌330045

岩藻糖α(1-6)-氨基葡萄糖是N-glycans基本结构骨架中的重要组成部分,在该二糖的合成上,本研究利用兼有保护羟基、"armed activation"(武装活化)、区域和立体选择性功能的苄基,以甲基-2-O-苄基-3,4-二-O-乙酰-1-硫-β-L-硫代吡喃岩藻糖... 详细信息

岩藻糖α(1-6)-氨基葡萄糖是N-glycans基本结构骨架中的重要组成部分,在该二糖的合成上,本研究利用兼有保护羟基、"armed activation"(武装活化)、区域和立体选择性功能的苄基,以甲基-2-O-苄基-3,4-二-O-乙酰-1-硫-β-L-硫代吡喃岩藻糖苷(2)为供体,在三氟甲磺酸甲酯(MeOTf)和2,6-二-叔-丁基-4-甲基吡啶(DTBMP)催化作用下,实现了对烯丙基-3-苄基-2-脱氧-2-(2,2,2-三氯乙氧)甲酰胺基-α-D-吡喃葡萄糖苷(3)的6-位羟基的α糖基化,从而简便有效地构建了岩藻糖α(1-6)-氨基葡萄糖胺二糖骨架(1)。该工作有望推动含岩藻糖的N-连接寡糖的构建。

关键词：区域选择立体选择岩藻糖 N-链接寡糖糖基化

Discovery and application of 6π-azaelectrocyclization to natural product synthesis and synthetic biology

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中国科学：化学 2012年第2期42卷 197-197页

作者： TANAKA Katsunori KATSUMURA Shigeo fukase koichi Department of Chemistry Graduate School of ScienceOsaka University1-1 MachikaneyamaToyonakaOsaka560-0043Japan Department of Chemistry and Open Research Center on Organic Tool Molecules School of Science and TechnologyKwansei Gakuin UniversityGakuen 2-1SandaHyogo 669-1337Japan

关键词：合成生物学天然产物应用生物分子工程取代基效应不对称合成吲哚生物碱赖氨酸

Assessing efficacy of standard impregnation techniques on die-cast aluminum alloys using X-ray micro-CT

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China Foundry 2024年第3期21卷 276-286页

作者： Ajith Bandara koichi Kan Katanaga Yusuke Natsuto Soga Akifumi Koike Toru Aoki Hamamatsu TSC Chuo Hatsumei Institute322 lida-choMinami-kuHamamatsu435-0028Japan Graduate School of Medical Photonics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan ANSeeN Inc Johoku 3-5-1HamamatsuShizuoka432-8561Japan Research Institute of Electronics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan

Utilizing lightweight Al alloys in various industrial applications requires achieving precise pressure tightness and leak *** pressure impregnation(VPI)with thermosetting polymers is commonly used to address leakage defects in die-cast Al *** this study,the efficacy of the VPI technique in sealing alloy parts was investigated using a combination of nondestructive micro X-ray computed tomography(micro XCT)and a standard leak *** results demonstrate that the commonly used water leak test is insufficient for determining the sealing ***,micro XCT shows distinct advantages by enabling more comprehensive *** reveals the presence of a low atomic number impregnates sealant within casting defects,which has low grey contrast and allows for visualizing primary leakage paths in *** effective atomic number of impregnated resin is 6.75 and that of Al alloy is 13.69 by dual-energy X-ray *** research findings will contribute to enhancing the standard VPI process parameters and the properties of impregnating sealants to improve quality assurance for impregnation in industrial metals.

关键词： nondestructive testing Al alloy die-casting vacuum pressure impregnation micro X-ray computed tomography duel-energy X-ray CT

Controlling a peristaltic robot inspired by inchworms

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Biomimetic Intelligence & Robotics 2024年第1期4卷 88-96页

作者： Yanhong Peng Hiroyuki Nabae Yuki Funabora koichi Suzumori Department of Information and Communication Engineering Graduate School of EngineeringNagoya UniversityNagoya 464-8601Japan Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan

This study presents an innovative approach in soft robotics,focusing on an inchworm-inspired robot designed for enhanced transport *** explore the impact of various parameters on the robot’s performance,including the number of activated sections,object size and material,supplied air pressure,and command execution *** a series of controlled experiments,we demonstrate that the robot can achieve a maximum transportation speed of 8.54 mm/s and handle loads exceeding 100 g,significantly outperforming existing models in both speed and load *** findings provide valuable insights into the optimization of soft robotic design for improved efficiency and adaptability in transport *** research not only contributes to the advancement of soft robotics but also opens new avenues for practical applications in areas requiring precise and efficient object *** study underscores the potential of biomimetic designs in robotics and sets a new benchmark for future developments in the field.

关键词： McKibben artificial muscles Bionics Soft robotics Soft actuator Bio-inspired robotics

High-temperature corrosion of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho)environmental barrier coating materials by volcanic ash

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1628-1638页

作者： Ayahisa Okawa Son Thanh Nguyen Tadachika Nakayama Thi-Mai-Dung Do Hisayuki Suematsu Shu Yin Takuya Hasegawa Tsuneo Suzuki Takashi Goto koichi Niihara Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan Department of Creative Engineering National Institute of TechnologyKushiro 084-0916Japan Extreme Energy-Density Research Institute Nagaoka University of TechnologyNagaoka 940-2188Japan Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan

Rare-earth silicates are promising environmental barrier coatings(EBCs)that can protect SiC_(f)/Si C_(m)substrates in next-genera tion gas turbine ***,RE_(2)Si_(2)O_(7)(RE=Yb and Ho)shows potential as an EBC due to its coefficient of thermal expansion(CTE)compatible with substrates and high resistance to water vapor *** target operating temperature for next-generation tur bine blades is 1400°*** is inevitable during adhesion to molten volcanic ash,and thus,understanding the corrosion behavior o the material is crucial to its *** study investigates the high-temperature corrosion behavior of sintered RE_(2)Si_(2)O_(7)(RE=Yb and Ho).Samples were prepared using a solid-state reaction and hot-press *** were then exposed to volcanic ash at 1400°C for 224,and 48 *** 48 h of exposure,volcanic ash did not react with Yb_(2)Si_(2)O_(7)but penetrated its interior,causing *** Ho_(2)Si_(2)O_(7)was partially dissolved in the molten volcanic ash,forming a reaction zone that prevented volcanic ash melts from penetrating the *** increasing heat treatment time,the reaction zone expanded,and the thickness of the acicular apatite grains increased The Ca:Si ratios in the residual volcanic ash were mostly unchanged for Yb_(2)Si_(2)O_(7)but decreased considerably over time for Ho_(2)Si_(2)O_(7).Th Ca in volcanic ash was consumed and formed apatite,indicating that RE^(3+)ions with large ionic radii(Ho>Yb)easily precipitated apatit from the volcanic ash.

关键词： environmental barrier coating volcanic ash rare-earth disilicate corrosion

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混合磁悬浮系统零功率抗偏载控制方法研究

机械工程学报 2024年第8期60卷 360-369页

作者：赵川孙凤金俊杰徐方超张明 OKA koichi 沈阳工业大学机械工程学院沈阳110870 高知工科大学系统工学部高知7828502日本

针对混合磁悬浮洁净传送装置无法兼顾零功率和抗偏载悬浮的问题,提出一种磁铁可动式混合磁悬浮系统,并设计了其零功率抗偏载控制策略。该系统中一个磁极固定,其他两个磁铁可绕悬浮圆盘中心轴线转动,通过调节气隙长度和磁铁转动角度克服... 详细信息

针对混合磁悬浮洁净传送装置无法兼顾零功率和抗偏载悬浮的问题,提出一种磁铁可动式混合磁悬浮系统,并设计了其零功率抗偏载控制策略。该系统中一个磁极固定,其他两个磁铁可绕悬浮圆盘中心轴线转动,通过调节气隙长度和磁铁转动角度克服偏载引起的扰动力和扰动力矩,从而实现零稳态电流和抗偏载悬浮。首先建立系统的线性变参数模型,分析该系统实现零功率水平悬浮需要满足的条件。零功率抗偏载控制策略在比例-微分控制器中引入电流和气隙偏差的积分反馈,并应用质心观测器反求磁体转动角度,求解方法分别采用雅可比逆变换解析求解和查表法内插取值两种方法。试验结果表明,该系统能够在偏载条件下保持零功率水平悬浮,应用雅可比的连续控制策略具有更好的纠偏特性,稳态时电流波动范围小。

关键词：混合磁悬浮零功率控制抗偏载特性离散控制

Severe aconite poisoning successfully treated with veno-arterial extracorporeal membrane oxygenation:A case report

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World Journal of Clinical Cases 2024年第2期12卷 399-404页

作者： Saeko Kohara Yoshito Kamijo Ryoko Kyan Ichiro Okada Eiju Hasegawa Soichiro Yamada koichi Imai Asuka Kaizaki-Mitsumoto Satoshi Numazawa Department of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical CenterTokyo 1900014Japan Department of Clinical Toxicology Saitama Medical UniversitySaitama 3500495Japan Saitama Prefectural Institute of Public Health Saitama Prefectural Institute of Public HealthSaitama 3550133Japan Division of Toxicology Department of PharmacologyToxicology and TherapeuticsShowa University School of PharmacyTokyo 1428555Japan

BACKGROUND Most species of aconite contain highly toxic aconitines,the oral ingestion of which can be fatal,primarily because they cause ventricular *** describe a case of severe aconite poisoning that was successfully treated through venoarterial extracorporeal membrane oxygenation(VA-ECMO)and in which detailed toxicological analyses of the aconite roots and biological samples were performed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).CASE SUMMARY A 23-year-old male presented to the emergency room with circulatory collapse and ventricular arrhythmia after ingesting approximately half of a root labeled,“Aconitum japonicum Thunb”.Two hours after arrival,VA-ECMO was initiated as circulatory collapse became refractory to antiarrhythmics and *** hours after arrival,an electrocardiogram revealed a return to sinus *** patient was weaned off VA-ECMO and the ventilator on hospital days 3 and 5,*** hospital day 15,he was transferred to a psychiatric *** other half of the root and his biological samples were toxicologically analyzed using LC-MS/MS,revealing 244.3 mg/kg of aconitine and 24.7 mg/kg of mesaconitine in the *** on admission contained 1.50 ng/mL of *** hospital day 2,neither were *** on admission showed 149.09 ng/mL of aconitine and 3.59 ng/mL of mesaconitine,but these rapidly decreased after hospital day *** The key to saving the life of a patient with severe aconite poisoning is to introduce VA-ECMO as soon as possible.

关键词： Aconite poisoning Fatal arrhythmia Veno-arterial extracorporeal membrane oxygenation Aconitine Mesaconitine Case report

A Revised Classification of Primary Iron Overload Syndromes

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 346-356页

作者： Yasuaki Tatsumi Motoyoshi Yano Shinya Wakusawa Hiroaki Miyajima Tetsuya Ishikawa Shinsaku Imashuku Atsuko Takano Wataru Nihei Ayako Kato koichi Kato Hisao Hayashi Kentaro Yoshioka Kazuhiko Hayashi Department of Medical Biochemistry Faculty of Pharmaceutical SciencesToho UniversityFunabashiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiJapan Department of Medical Technology Shubun UniversityIchinomiyaJapan Department of Medicine and Neurology Tenryu Kohseikai ClinicHamamatsuJapan Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Department of Laboratory Medicine Uji-Tokushukai Medical CenterUjiJapan Department of Medicine Saiseikai Takaoka HospitalTakaokaJapan Department of Medicine Aichi-Gakuin University School of PharmacyNagoyaJapan Department of Gastroenterology FNPS Meijo HospitalNagoyaJapan

Background and Aims:The clinical introduction of hepcidin25(Hep25)has led to a more detailed understanding of its relationship with ferroportin(FP)and divalent metal transporter1 in primary iron overload syndromes(PIOSs).In 2012,we proposed a classification of PIOSs based on the Hep25/FP system,which consists of prehepatic aceruloplasminemia,hepatic hemochromatosis(HC),and posthepatic FP disease(FP-D).However,in consideration of accumulated evidence on PIOSs,we aimed to renew the ***:We reviewed the 2012 classification and retrospectively renewed it according to new information on ***:Iron-loading anemia was included in PIOSs as a prehepatic form because of the newly discovered erythroferrone-induced suppression of Hep25,and the state of traditional FP-D was remodeled as the BIOIRON *** key molecules responsible for prehepatic PIOSs are low transferrin saturation in aceruloplasminemia and increased erythroferrone production by erythroblasts in iron-loading *** PIOSs comprise four genotypes of HC,in each of which the synthesis of Hep25 is inappropriately reduced in the *** Hep25 synthesis is adequate in posthepatic PIOSs;however,two mutant FP molecules may resist Hep25 differently,resulting in SLC40A1-HC and FP-D,*** phenotypes are diagnosed using laboratory tests,including circulating Hep25,followed by suitable *** sequencing of the candidate genes may be outsourced to gene centers when *** kits for the prevalent mutations,such as C282Y,may be the first choice for a genetic analysis of HC in ***:The revised classification may be useful worldwide.

关键词： Ethnicity Ferroportin Hemochromatosis Hepcidin25 Iron overload syndrome

Initial experience with robot-assisted adrenalectomy for giant adrenal tumors

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Asian Journal of Urology 2024年第3期11卷 507-508页

作者： Takayuki Ohzeki Hiroyuki Kita Remon Kunishige Taiji Hayashi Tsukasa Nishioka koichi Sugimoto Takafumi Minami Kazutoshi Fujita Department of Urology Izumi City General Hospital4-5-1 WakechoIzumiOsaka 594-0073Japan Department of Urology Kaizuka City Hospital10-20 Hori 3-chomeKaizukaOsaka 594-0073Japan Department of Urology Kindai University Faculty of Medicine377-2 Ohno-HigashiOsaka-SayamaOsaka 589-8511Japan

Dear Editor,Adrenocortical carcinomas and adrenal cysts,including pseudocysts,are uncommon tumors[1,2].No consistent approach to surgery for large adrenal tumors including cysts,has been established,and especially when malignancy is suspected,consideration is still given to the option of *** robot-assisted surgery,we successfully performed the resection of a giant adrenal pseudocyst and a giant adrenocortical carcinoma,as reported previously[3],underlining the advantages of robot-assisted surgery for large adrenal tumors.

关键词： adrenal tumors surgery