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Experimental study on the in-plane thermal conductivity of Au nanofilms

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Progress in Natural Science:Materials International 2007年第2期17卷 212-216页

作者： TAKAHASHI Koji IKUTA Tatsuya FUJII Motoo Fukuoka 812-8581 Graduate School of Engineering Kyushu University Institute for Materials Chemistry and Engineering Japan Kasuga 816-8580

The in-plane thermal conductivity of Au nanofilms with thickness of 23 nm, which are fabricated by the electron beam-physical vapor deposition method and a suspension technology, is experimentally measured at 80-300 K by a one-dimensional steady-state electrical heating method. Strong size effects are found on the measured nanofilm thermal conductivity. The Au nanofilm in-plane thermal conductivity is much less than that of the bulk material. With the increasing temperature, the nanofilm thermal conductivity increases. This is opposite to the temperature dependence of the bulk property. The Lorenz number of the Au nanofilms is about three times larger than the bulk value and decreases with the increasing temperature, which indicates the invalidity of the Wiedemann-Franz law for metallic nanofilms.

关键词： nanofilm in-plane thermal conductivity size effect Wiedemann-Franz law.

Experimental Studies on Thermal and Electrical Properties of Platinum Nanofilms

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Chinese Physics Letters 2006年第4期23卷 936-938页

作者：张兴张清光曹炳阳 FUJII Motoo TAKAHASHI Koji IKUTA Tatsuya Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Tsinghua University Beijing 100084 Institute for Materials Chemistry and Engineering Kyushu University Kasuga 816-8580 Japan Graduate School of Engineering Kyushu University Fukuoka 812-8581 Japan

We experimentally studied the in-plane thermal and electrical properties of a suspended platinum nanofilm in thickness of 15 nm. The measured results show that the in-plane thermal conductivity, the electrical conductivity and the resistance-temperature coefficient of the studied nanofilm are much less than those of the bulk material, while the Lorenz number is greater than the bulk value. Comparing with the results reported previously for the platinum nanofilm in thickness of 28 nm, we further find that the in-plane thermal conductivity, the electrical conductivity and the resistance-temperature coefficient decrease with the decreasing thickness of the nanotilm, while the Lorenz number increases with the decreasing thickness of the nanofilm. These results indicate that strong size effects exist on the in-plane thermal and electrical properties of platinum nanofilms.

关键词： TRANSPORT CONDUCTIVITY SUPERLATTICES PHONON

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金纳米薄膜面向导热系数的实验研究

自然科学进展 2006年第11期16卷 1506-1510页

作者：曹炳阳张清光张兴 Takahashi Koji Ikuta Tatsuya 乔文明 FUJII Motoo 清华大学工程力学系热科学与动力工程教育部重点实验室北京1000841 Graduate School of Engineering Kyushu UniversityFukuoka 812-8581Japan Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan

基于电子束-物理气相沉积法制备纳米薄膜的悬浮工艺,采用一维稳态恒热流加热法实验测量了80—300K厚度为23nm金薄膜的面向导热系数．研究表明金纳米薄膜的面向导热系数有非常显著的尺寸效应：金纳米薄膜的面向导热系数大大低于体材料的... 详细信息

基于电子束-物理气相沉积法制备纳米薄膜的悬浮工艺,采用一维稳态恒热流加热法实验测量了80—300K厚度为23nm金薄膜的面向导热系数．研究表明金纳米薄膜的面向导热系数有非常显著的尺寸效应：金纳米薄膜的面向导热系数大大低于体材料的值,并且导热系数随温度的升高而增大,这一趋势与体材料导热系数的温度依赖性相反；同时,金纳米薄膜的Lorenz数大约为体材料值的3倍,并且随着温度的升高有减小的趋势,表明Wiedemann-Franz定律对于金纳米薄膜不再适用．

关键词：纳米薄膜面向导热系数尺寸效应 Wiedemann-Franz定律

Internet survey on the provision of complementary and alternative medicine in Japanese private clinics: a cross-sectional study

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Journal of Integrative Medicine 2019年第1期17卷 8-13页

作者： Yoshiharu motoo Keiko Yukawa Kazuho Hisamura Kiichiro Tsutani Ichiro Arai Department of Medical Oncology Kanazawa Medical University Department of Health Policy and Technology Assessment National Institute of Public Health Faculty of Health Sciences Tokyo Ariake University of Medical and Health Sciences Department of Pharmaceutical Sciences Nihon Pharmaceutical University

Objective: Although the use of complementary and alternative medicine(CAM) by the general population has been surveyed previously, the provision of CAM by Japanese physicians in private clinics has not been studied. Universal health insurance system was established in Japan in 1961, and most CAMs are not on the drug tariff. We aimed to clarify the current status of CAM provided by physicians at private clinics in Japan.Methods: We conducted an internet survey on 400 directors/physicians of private clinics nationwide on the provision of CAM from February 6 to February 10, 2017. Survey items included attributes of subjects,presence/absence of sections or facilities for provision of CAM, proportions of health insurance coverage for medical practices, and source of information. Private clinic was defined as a clinic run by one physician, with less than 20 beds.Results: Commonly provided CAMs were Kampo(traditional Japanese herbal) medicines(34.8%) and supplements/health foods(19.3%). CAMs on the drug tariff were provided in 46.5% of cases at the clinics, but only 16.5% of cases were provided CAMs which were not on the drug tariff, at different neighboring facilities. Among different specialties, Kampo medicines were prescribed at obstetrics/gynecology(54.0%),orthopedics(44.4%), and dermatology(43.0%). Clinics not providing any CAM accounted for 53.5%.With regard to health insurance coverage, 96.8% of the clinics provided only or mainly health services on the universal national health insurance tariff(29.8% and 67.0%, respectively).Conclusion: Kampo medicines represent the most commonly used CAM in private clinics in Japan, and universal national health insurance coverage is considered to be the reason for the high rate of their use.

关键词： Japan Complementary and alternative medicine Private clinic Internet survey Kampo

Effect of Saikokeishito, a Kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts

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Journal of Integrative Medicine 2014年第6期12卷 495-503页

作者： Takanobu Takata Yoshiharu motoo Naohisa Tomosugi Medical Research Institute of Kanazawa Medical University Department of Medical Oncology Kanazawa Medical University Department of Nephrology Kanazawa Medical University

OBJECTIVE： Saikokeishito（TJ-10） is a Kampo（traditional Japanese herbal） medicine, clinically used for hundreds of years in East Asia. Among its various mechanisms elucidated so far, TJ-10 inhibits the production of transforming growth factor-β1（TGF-β1） and development of pancreatic fi brosis in vivo. Oxidative damage of normal human dermal fi broblasts（NHDFs） in the corium is a cause of human dermal senescence. Our aim was to determine whether TJ-10 protects NHDFs from premature senescence by hydrogen peroxide（H2O2）. METHODS： Premature senescence was induced in NHDFs by 200 μmol/L H2O2 for 4 h. Cell viability and the expressions of p53, AMP-activated protein kinase α1（AMPKα1）, AMPKα2, and 14-3-3 protein sigma（14-3-3 σ） were measured in NHDFs treated with TJ-10 for 48 h before exposure to H2O2 for 4 h. RESULTS： Cell viability after treatment with 200 μmol/L H2O2 for 4 h was similar（about 80%） to after pre-treatment with TJ-10. Ascorbic acid as a control did not protect NHDFs from damage by 200 μmol/L H2O2. Treatment with 200 μmol/L H2O2 tended to up-regulate p53 and to down-regulate SIRT1 and AMPKα1, but had no effect on AMPKα2 and 14-3-3 σ expression. Pretreatment with TJ-10 inhibited H2O2-induced up-regulation of p53 and enhanced AMPKα1 expression. CONCLUSION： It is suggested that Saikokeishito has a protective effect on oxidative stressinduced senescence of NHDFs.

关键词： Saikokeishito medicine,Kampo premature senescence p53 fibroblasts

Standards of Reporting Kampo Products (STORK) in research articles

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Journal of Integrative Medicine 2017年第3期15卷 182-185页

作者： Yoshiharu motoo Takashi Hakamatsuka Nobuo Kawahara Ichiro Arai Kiichiro Tsutani Committee for Evidence-based Medicine Japan Society for Oriental Medicine Tokyo Japan Department of Medical Oncology Kanazawa Medical University Ishikawa 920-0293 Japan Division of Pharmacognosy phytochemistry and Narcotics National Institute of Health Sciences Tokyo 158- 8501 Japan Research Center for Medicinal Plant Resources National Institutes of Biomedical Innovation Health and Nutrition Ibaraki 305-1843 Japan Department of Kampo Medicine Nihon Pharmaceutical University Saitama 362-0806 Japan Faculty of Health Sciences Tokyo Ariake University of Medical and Health Sciences Tokyo 135-0063 Japan

There had been no standardized rules for citing ethical Kampo products used in clinical trials in journal articles. Although the name of a Kampo manufacturer was described in 77.9% of research articles, the name and ratios of crude drug components of Kampo formulas were not described in 77.5% of these papers. Considering the importance of proper characterization of interventions in the Consolidated Standards of Reporting Trials （CONSORT） checklist, we hereby propose the use of the Standards of Reporting Kampo Products （STORK） website, http：//mpdb.***.go.jp/stork, as a reference for Kampo products. This will provide an official source on the internet for verified information on individual Kampo formulations for citation purposes in clinical research articles.

关键词： medicine, Kampo Evidence Reports on Kampo Treatment randomized controlled trial Consolidated Standards of Reporting Trials （CONSORT） Standards of Reporting Kampo Products （STORK）

Traditional Japanese Medicine,Kampo:Its History and Current Status

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Chinese Journal of Integrative Medicine 2011年第3期17卷 85-87页

作者： Yoshiharu motoo Takashi Seki Kiichiro Tsutani The Japan Society for Oriental Medicine Tokyo105-0022 Japan Department of Medical Oncology Kanazawa Medical UniversityUchinadaIshikawa920-0293Japan Department of Traditional Asian Medicine Tohoku University Graduate School of MedicineSendai980-8575Japan Department of Drug Policy and Management Graduate School of Pharmaceutical SciencesThe University of TokyoTokyo113-0033Japan

Traditional Japanese medicine,Kampo,is used by over 80%of medical doctors in Japan.Owing to its high quality and safety,Kampo has been integrated into modern medicine,and there are 345 randomized controlled trials using Kampo in Japan as of 2010.Although there are a number of articles in top journals about basic science research,we can find only small numbers of high-quality clinical evidence.Since undergraduate education on Kampo has been established,integrative approach with the balanced combination of modern medicine and Kampo is expected to generate good clinical evidence in the near future.

关键词： Kampo traditional medicine evidence randomized controlled trial integrative medicine

Microcystin accumulation and biochemical responses in the edible clam Corbicula leana P. exposed to cyanobacterial crude extract

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Journal of Environmental Sciences 2016年第6期28卷 120-130页

作者： Thanh-Luu Pham Kazuya Shimizu Ayako Kanazawa Yu Gao Thanh-Son Dao motoo Utsumi Graduate School of Life and Environmental Sciences University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki 305-8572 Japan Faculty of Life Sciences Toyo University Ora-gun Gunma 374-0193 Japan College of Chemical and Environmental Engineering Shandong University of Science and Technology qingdao 266590 China Ho Chi Minh City University of Technology 268 Ly Thuon9 Kiet St. Dist. 10 Ho Chi Mirth City Viet Nam Vietnam Academy of Science and Technology （VAST) Institute of Tropical Biology 85 Tran Quoc Toan St. Dist. 3 Ho Chi Minh City Viet Nam

We investigated the accumulation and effects of cyanobacterial crude extract（CCE）containing microcystins（MCs） on the edible clam Corbicula leana P. Toxic effects were evaluated through the activity of antioxidant and detoxification enzymes： catalase（CAT）,superoxide dismutase（SOD）, and glutathione-S-transferases（GSTs） from gills, foot, mantle and remaining soft tissues. Clams were exposed to CCE containing 400 μg MC-LReq/L for10 days and were then kept in toxin-free water for 5 days. Clam accumulated MCs（up to 3.41 ± 0.63 μg/g dry weight（DW） of unbound MC and 0.31 ± 0.013 μg/g DW of covalently bound MC）. Detoxification and antioxidant enzymes in different organs responded differently to CCE during the experiment. The activity of SOD, CAT, and GST in the gills and mantle increased in MC-treated clams. In contrast, CAT and GST activity was significantly inhibited in the foot and mostly only slightly changed in the remaining tissues. The responses of biotransformation, antioxidant enzyme activity to CCE and the fast elimination of MCs during depuration help to explain how the clam can survive for long periods（over a week） during the decay of toxic cyanobacterial blooms in nature.

关键词： Bioaccumulation Cyanotoxins Covalently bound microcystins Aqueous extracts

Pancreatitis-associated protein:From a lectin to an anti-inflammatory cytokine

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World Journal of Gastroenterology 2007年第2期13卷 170-174页

作者： Daniel Closa Yoshiharu motoo Juan L Iovanna Department of Experimental Pathology IIBB- CSIC IDIBAPS Barcelona Spain Department of Medical Oncology Kanazawa Medical University Ishikawa Japan INSERM U.624 Stress Cellulaire Marseille France

Pancreatitis-associated protein (PAP) was discovered in the pancreatic juice of rats with acute pancreatitis. PAP is a 16 kDa secretory protein structurally related to the C-type lectins although classical lectin-related function has not been reported yet. Then, it was demonstrated that PAP expression may be activated in some tissues in a constitutive or injury- and inflammation-induced manner. More recently, it has been found that PAP acts as an anti-inflammatory factor in vitro and in vivo. PAP expression can be induced by several pro- and anti-inflammatory cytokines and by itself through a JAK/STAT3-dependent pathway. PAP is able to activate the expression of the anti-inflammatory factor SOCS3 through the JAK/STAT3-dependent pathway. The JAK/STAT3/SOCS3 pathway seems to be a common point between PAP and several cytokines. Therefore, it is reasonable to propose that PAP is a new anti- inflammatory cytokine.

关键词：胰腺炎蛋白质血凝素细胞因子