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Chinese Journal of Cancer Research 2011年第3期23卷 208-213页

作者： Xue-song fu ping-ping li Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Integrated Traditional Chinese and Western MedicinePeking University School of OncologyBeijing Cancer Hospital ＆ InstituteBeijing 100142China

Objective：Estradiol （E2） plays an important role in the development of breast *** postmenopausal women,the estrogen can be synthesized via aromatase （CYP19） pathway and steroid-sulfatase （STS） pathway in peripheral tissues,when the production in ovary has *** objective of our study was to explore the effects of Shu-Gan-liang-Xue Decoction （SGLXD） on the expressions of CYP19 and STS in estrogen receptor positive breast cancer MCF-7 and T47D ***：The effects of SGLXD on the cell viability of MCF-7 and T47D were analyzed by MTT *** quantitative real-time RT-PCR and Western blot,we evaluated the mRNA and protein expressions of CYP19 and STS in MCF-7 and T47D cells after SGLXD ***：By MTT assay,the cell viability rates of MCF-7 and T47D were significantly inhibited by SGLXD in a dose-dependent manner,the IC50 values were 40.07 mg/ml for MCF-7 cells and 25.62 mg/ml for T47D cells,*** evidenced by real-time PCR and Western blot,the high concentrations of SGLXD significantly down-regulated the expressions of CYP19 and STS both in the transcript level and the protein ***：The results suggest that SGLXD is a potential dual aromatase-sulfatase inhibitor by simultaneously down-regulating the expressions of CYP19 and STS in MCF-7 and T47D cells.

关键词： Shu-Gan-liang-Xue Decoction (SGLXD) Aromatase (CYP19) Steroid-sulfatase (STS) Breast cancer

Hybrid Estimation of State and Input for linear Discrete Time-varying Systems： A Game Theory Approach

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自动化学报 2008年第6期34卷 665-669页

作者： YOU fu-Qiang WANG fu-li GUAN Shou-ping Key Laboratory of Integrated Automation Process Industry Ministry of Education Northeastern University Shenyang 110004 P. R. China

为线性分离变化时间的系统的 H 混合评价问题在这份报纸被调查，在估计的信号是状态和输入的线性联合的地方。设计目的从骚乱要求最坏的精力获得到是的评价错误不到规定水平。混合评价问题的最佳的答案是僵绳点一二播放器零和微分游戏... 详细信息

为线性分离变化时间的系统的 H 混合评价问题在这份报纸被调查，在估计的信号是状态和输入的线性联合的地方。设计目的从骚乱要求最坏的精力获得到是的评价错误不到规定水平。混合评价问题的最佳的答案是僵绳点一二播放器零和微分游戏。根据微分比赛途径，为混合评价问题的必要、足够的可解决的条件以一个 Riccati 微分方程的答案被提供。而且，如果可解决的条件满足，一个可能的评估者被建议。评估者被印射矩阵的一个获得矩阵和产量描绘，在后者反映在未知输入和输出评价错误之间的内部关系的地方。最后，一个数字例子被提供说明建议途径。

关键词：博奕论线性离散系统时间变化系统智能化系统

Implementation of a Quantum Algorithm for Deutsch- Jozsa Problem with Improved Nuclear Magnetic Resonance Sequences

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Chinese Physics Letters 1999年第9期16卷 692-694页

作者： ZHANG Yan LUO Jun XIAO li fu li-ping QIU Jian-qing ZENG Xi-zhi YE Chao-hui Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071

A quantum algorithm for Deutsch-Jozsa problem was implemented by nuclear magnetic resonance of benzene with heteronuclear decoupling during the readout period. It was demonstrated that decoupling can not only remove the undesired long-range couplings but also save the frequency space taken up by nuclear spins, which was expected to be important when scaling to large systems, and also to enhance the signal-to-noise ratio.

关键词： remove desired scaling

大气细颗粒物化学组分与精液质量的关联性研究

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现代预防医学 2024年第10期51卷 1766-1774页

作者：符乐瑶杨婷婷李福平田润张璐宋贵双廖俊豪曾思漩于川肖成汉刘振谧四川大学华西公共卫生学院/华西第四医院四川大学华西第二医院人类精子库/男科实验室

目的探讨PM2.5化学组分暴露和精液质量间的关联。方法本研究招募1 105名于2019年10月到2021年12月在四川省人类精子库进行精液检查并居住在四川省的捐精志愿者为研究对象，通过研究对象居住地址的经纬度提取采精前0～90天、0～9天、10... 详细信息

目的探讨PM2.5化学组分暴露和精液质量间的关联。方法本研究招募1 105名于2019年10月到2021年12月在四川省人类精子库进行精液检查并居住在四川省的捐精志愿者为研究对象，通过研究对象居住地址的经纬度提取采精前0～90天、0～9天、10～14天、70～90天的PM2.5及其化学组分暴露。采用Spearman秩相关分析评估PM2.5与其化学组分间的相关性。采用线性混合效应模型分析PM2.5化学组分暴露与精液质量参数间的关系。结果 PM2.5与其化学组分间高度正相关。PM2.5、NH4+、SO42-、NO3-、有机物（OM）和黑碳（BC）暴露均与精子总活力降低显著相关（P<0.05）。OM暴露与精子前向运动率降低显著相关（P<0.05）,OM每增加一个四分位数间距（3.1μg/m3）,精子前向运动率的平均值变化-1.166（95%CI:-2.174～-0.171）。结论 PM2.5及其化学组分是精子总活力下降的危险因素。

关键词： PM2.5 精液质量 PM2.5化学组分空气污染

Stereoselectivities in α- and β-Amino Acids Catalyzed Mannich Reactions Involving Cyclohexanone

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Chemical Research in Chinese Universities 2011年第4期27卷 673-677页

作者： WANG Ying fu Ai-ping li Hong-liang TIAN Feng-hui YUAN Shu-ping SI Hong-zong DUAN Yun-bo WANG Zong-hua Institute for Computational Science and Engineering Laboratory of New Fiber Materials and Modern Textile Growing Base for State Key Laboratory College of Chemical and Environmental Engineering Qingdao University Qingdao 266071 P. R. China

The effects of two different amino acid catalysts on the stereoselectivities in the direct Mannich reactions of cyclohexanone,p-anisidine and p-nitrobenzaldehyde were studied with the aid of density functional *** states of the stereo-determining C ＂C bond-forming step with the addition of enamine intermediate to the imine for the L-proline（·-amino acid） and （R）-3-pyrrolidinecarboxylic acid（·-amino acid）-catalyzed processes were reported.B3LYP/6-31G calculations provide a good explanation for the opposite syn *** diastereoselectivities of these two different kinds of catalysts（syn-selectivity for the ·-amino acid catalysts,anti-selectivity for the ·-amino acid catalysts）.Calculated and observed diastereomeric ratio and enantiomeric excess values are in reasonable agreement.

关键词： Syn-and anti-Mannich reaction Stereoselectivity Amino acid Transition state

活性维生素D改善高糖诱导髓核细胞损伤及机制研究

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颈腰痛杂志 2024年第4期45卷 595-600页

作者：刘涛支中正王英杰李富平周付超何志敏侯铁胜同济大学附属上海市第四人民医院脊柱外科上海200434

目的探讨活性维生素D对高糖诱导髓核细胞炎症、氧化应激、自噬和凋亡的影响。方法分别于正常糖(正常糖组)和高糖(高糖组)环境下培养体外人椎间盘髓核细胞(nucleus pulposus cells,NPCs),首次培养及加入活性维生素D后,分别检测髓核细胞... 详细信息

目的探讨活性维生素D对高糖诱导髓核细胞炎症、氧化应激、自噬和凋亡的影响。方法分别于正常糖(正常糖组)和高糖(高糖组)环境下培养体外人椎间盘髓核细胞(nucleus pulposus cells,NPCs),首次培养及加入活性维生素D后,分别检测髓核细胞炎症、氧化应激、自噬和凋亡情况。其中,采用EliSA试剂盒检测IL-1β、TNF-α及H_(2)O_(2),蛋白免疫印迹Western blotting(WB)检测SOD、Caspase3和Atg5、Atg12、LC3等指标。结果与正常糖组相较,高糖组髓核细胞炎症反应及氧化应激增强、细胞自噬降低、凋亡增多,差异均具有统计学意义(P0.05),高糖组髓核细胞氧化应激及炎症反应减弱,自噬增强,细胞凋亡减弱,差异均具有统计学意义(P<0.05)。与高糖+维生素D组相比,加入p38MAPK抑制剂和NF-κB抑制剂可以显著抑制维生素D导致的生化指标变化,且差异具有统计学意义(P<0.05)。结论活性维生素D通过激活p38MAPK和NF-κB信号通路增强高糖环境下髓核细胞自噬并抑制炎症和凋亡来保护髓核细胞,延缓椎间盘退变。

关键词：髓核细胞葡萄糖活性维生素D 自噬炎症凋亡

Mapping out the reaction network of humin formation at the initial stage of fructose dehydration in water

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Green Energy & Environment 2024年第6期9卷 1016-1026页

作者： Xing fu Yexin Hu ping Hu Hui li Shuguang Xu liangfang Zhu Changwei Hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengduSichuan610064China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan611137China

The formation of humins hampers the large-scale production of 5-hydroxymethylfurfural(HMF)in ***,a detailed reaction network of humin formation at the initial stage of fructose-to-HMF dehydration in water is delineated by combined experimental,spectroscopic,and theoretical *** bimolecular reaction pathways to build up soluble humins are *** is,the intermolecular etherification of β-furanose at room temperature initiates the C12 path,whereas the C-C cleavage of a-furanose at 130-150℃ leads to C11 path,and that of open-chain fructose at 180℃ to C11' *** successive intramolecular dehydrations and condensations of the as-formed bimolecular intermediates lead to three types of soluble *** show that the C12 path could be restrained by using HCl or AlCl_(3) catalyst,and both the C12 and C110 paths could be effectively inhibited by adding THF as a co-solvent or accelerating heating rate via microwave heating.

关键词： Carbohydrates 5-hydroxymethylfurfural Reaction network Soluble humins Tautomer

Mutant rs189037 in ataxia-telangiectasia mutated gene had a negative association with metabolic syndrome but not cognitive decline in centenarians

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Genes & Diseases 2024年第3期11卷 106-108页

作者： Long Feng Hongqi Huo Qun li Tao Yang Yali Zhao Pei Zhang ping ping Shihui fu Department of Anesthesiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Nuclear Medicine Department Handan Central HospitalHandanHebei056001China Department of Neurosurgery Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Oncology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Central Laboratory Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China School of life Science Beijing Institute of TechnologyBeijing 100081China General Station for Drug and Instrument Supervision and Control Joint Logistic Support Force of Chinese People's LiberationArmyBeijing 100071China Department of Cardiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Geriatric Cardiology Chinese People's Liberation Army General HospitalBeijing 100853China

Approximately 20%-25%of adults encounter metabolic syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decline(CD)*** with MetS have an 11.48-fold increased incidence of CD compared with those without Mets.^(1) Ataxia-telangiectasia mutated(ATM)gene encodes ATM kinase,which belongs to the phosphatidylinositol 3-hydroxy kinase family.

关键词： ATM development cognitive

A fuzzy Trust Management Mechanism with Dynamic Behavior Monitoring for Wireless Sensor Networks

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China Communications 2024年第5期21卷 177-189页

作者： fu Shiming Zhang ping Shi Xuehong School of Artificial Intelligence Chongqing University of EducationChongqing 400065China School of Communications and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China

Traditional wireless sensor networks(WSNs)are typically deployed in remote and hostile environments for information *** wireless communication methods adopted by sensor nodes may make the network highly vulnerable to various *** encryption and authentication mechanisms cannot prevent attacks launched by internal malicious *** trust-based security mechanism is usually adopted to solve this problem in ***,the behavioral evidence used for trust estimation presents some uncertainties due to the open wireless medium and the inexpensive sensor ***,how to efficiently collect behavioral evidences are rarely *** address these issues,in this paper,we present a trust management mechanism based on fuzzy logic and a cloud ***,a type-II fuzzy logic system is used to preprocess the behavioral evidences and alleviate ***,the cloud model is introduced to estimate the trust values for sensor ***,a dynamic behavior monitoring protocol is proposed to provide a balance between energy conservation and safety *** results demonstrate that our trust management mechanism can effectively protect the network from internal malicious attacks while enhancing the energy efficiency of behavior monitoring.

关键词： behavior monitoring cloud fuzzy trust wireless sensor networks

Dynamic regulation of the irrigation-nitrogen-biochar nexus for the synergy of yield,quality,carbon emission and resource use efficiency in tomato

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Journal of Integrative Agriculture 2024年第2期23卷 680-697页

作者： ping’an Zhang Mo li Qiang fu Vijay PSingh Changzheng Du Dong liu Tianxiao li Aizheng Yang School of Water Conservancy&Civil Engineering Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Effective Utilization of Agricultural Water Resources Ministry of Agriculture and Rural Affairs/Northeast Agricultural UniversityHarbin 150030China Department of Biological and Agricultural Engineering&Zachry Department of Civil&Environmental Engineering Texas A&M UniversityTX 77843-117USA National Water and Energy Center UAE UniversityAI Ain999041United Arab Emirates Heilongjiang Agricultural Engineering Vocational College Harbin 150030China

Integrated water and fertilizer management is important for promoting sustainable development of facility agriculture,and biochar plays an important role in guaranteeing food production,as well as alleviating water shortages and the overuse of *** field experiment had twelve treatments and a control(CK)trial including two irrigation amounts(I1,100%ETm;I2,60%ETm;where ETm is the maximum evapotranspiration),two nitrogen applications(N1,360 kg ha^(−1);N2,120 kg ha^(−1))and three biochar application levels(B1,60 t ha^(−1);B_(2),30 t ha^(−1)and B3,0 t ha^(−1)).A multi-objective synergistic irrigation-nitrogen-biochar application system for improving tomato yield,quality,water and nitrogen use efficiency,and greenhouse emissions was developed by integrating the techniques of experimentation and ***,a coupled irrigation-nitrogen-biochar plot experiment was ***,tomato yield and fruit quality parameters were determined experimentally to establish the response relationships between irrigation-nitrogen-biochar dosage and yield,comprehensive quality of tomatoes(TCQ),irrigation water use efficiency(IWUE),partial factor productivity of nitrogen(PFPN),and net greenhouse gas emissions(NGE).Finally,a multi-objective dynamic optimization regulation model of irrigation-nitrogen-biochar resource allocation at different growth stages of tomato was constructed which was solved by the fuzzy programming *** results showed that the application of irrigation and nitrogen to biochar promoted increase in yield,IWUE and PFPN,while it had an inhibitory effect on *** addition,the optimal allocation amounts of water and fertilizer were different under different *** yield of the S1 scenario increased by 8.31%compared to the B_(1)I_(1)N_(2) treatment;TCQ of the S2 scenario increased by 5.14%compared to the B_(2)I_(2)N_(1) treatment;IWUE of the S3 scenario increased by 10.01%compared to the B1I2N2 treatment;PFPN of the S4 scenario increased by

关键词： irrigation-nitrogen-biochar dynamic regulation multi-dimensional target collaboration tomato sustainability