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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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High-temperature mechanical properties of near-eutectoid steel

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International Journal of Minerals,Metallurgy and Materials 2013年第9期20卷 829-834页

作者： Jun fu fu-ming Wang Fang hao Gui-xiang Jin State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The high-temperature mechanical properties of near-eutectoid steel were studied with a Cleeble-1500 simu- lation machine. Zero strength temperature （ZST）, zero ductility temperature （ZDT）, hot ductility curves, and strength curves were measured. Two brittle zones and one plastic zone were found in the temperature range from the melting point to 600℃. Embrittlement in zone I is caused by the existence of liquid film along dendritic interfaces. Ductility loss in zone Ⅲ mainly results from precipitates and inclusions as well as S segregation along grain boundaries. Pearlite transformation also accounts for ductility deterioration in the temperature range of 700-600℃. Moreover, the straightening temperature of the test steel should be higher than 925℃ for avoiding the initiation and propagation of surface cracks in billets.

关键词： carbon steel eutectic alloys high temperature properties mechanical properties brittleness straightening billets

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Efficient matrix inversion based on VLIW architecture

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Journal of Systems Engineering and Electronics 2014年第3期25卷 393-398页

作者： Li Zhang fu Li Guangming shi School of Electronic Engineering Xidian University

Matrix inversion is a critical part in communication, signal processing and electromagnetic system. A flexible and scalable very long instruction word （VLIW） processor with clustered architecture is proposed for matrix inversion. A global register file （RF） is used to connect al the clusters. Two nearby clusters share a local register file. The instruction sets are also designed for the VLIW processor. Experimental results show that the proposed VLIW architecture takes only 45 latency to invert a 4 × 4 matrix when running at 150 MHz. The proposed design is roughly five times faster than the DSP solution in processing speed.

关键词： matrix inversion very long instruction word (VLIW),latency register file (RF) cluster.

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An experiment study of vortex induced vibration of a steel catenary riser under steady current

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Journal of Hydrodynamics 2020年第5期32卷 834-844页

作者： Tie Ren Yu-wang Xu Jungao Wang hao-jie Ren Meng-meng Zhang shi-xiao fu Yao-song Chen State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Centre for Advanced ship and Deep-Sea Exploration Shanghai 200240China Marine Design and Research Institute of China Shanghai 200011China Norweigian Public Road Administration StavangerNorway

The vortex induced vibration(VIV)of marine risers has been investigated by many researchers in experimental studies of a straight flexible riser model as well as a rigid cylinder to reveal the dynamic response characteristic and the mechanics behind ***,due to the limitation of experimental apparatus,very few studies are about the VIV of a steel catenary riser(SCR)which is with a complex *** investigate the VTV features and to further develop the corresponding numerical predictions of a SCR under steady current,a large-scale model test of a SCR was towed in an ocean basin at various *** Bragg grating strain sensors are instrumented on the riser model to measure both in-plane and out-of-plane *** characteristics of oscillating amplitude and dominating frequency response,the phenomenon of mode competition and travelling wave and the fatigue damage of the steel catenary riser in inline and cross-flow direction under steady current are analyzed.

关键词： Vortex induced vibration(VTV) steel catenary riser(SCR) experimental study

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Effects of Defocus Distance on Three-Beam Laser Internal Coaxial Wire Cladding

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Chinese Journal of Mechanical Engineering 2021年第4期34卷 56-77页

作者： Shaoshan Ji Fan Liu Tuo shi Geyan fu shihong shi School of Mechanical and Electrical Engineering Soochow UniversitySuzhou 215000China School of Optoelectronic Science and Engineering Soochow UniversitySuzhou 215000China.

Three-beam laser internal coaxial wire feeding cladding is regarded as a promising additive manufacturing technique because it is highly efficient and *** this study,the effects of the defocus distance on cladding using a three-beam laser with internal wire feeding are experimentally and numerically studied.A process map indicating the surface characteristics at different defocus distances with various parameter combinations was *** transmission characteristics including laser intensity,beam size,and laser spot distance of the three-beam laser at different defocus distances were analyzed using TracePro *** on the TracePro results as heat source,a three-dimensional transient finite element(FE)thermal model was formulated to predict the thermal field,temperature history and molten pool shape at different defocus distances.A molten pool with a flat bottom and low melting depth is generated when the defocus distance is−2.5 mm,whereas when this distance is−1.5 mm,a pool with a valley-shaped bond and high melting depth is *** simulated results of the temperature cycle and clad geometry are both validated and found to well agree with experimental *** influence of the defocus distance on the microstructure and microhardness are discussed based on the temperature history and cooling *** the increase in the absolute defocus distance,the height and dilution of the clad decreased,whereas the width *** addition,the effects of defocus distance with various parameter combinations on clad geometry were explored using the formulated FE model.

关键词： Three beams laser Wire cladding Finite element analysis Defocus distance

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Identifying and Quantifying Pixel-Level Uncertainty among Major Satellite Derived Global Land Cover Products

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Journal of Meteorological Research 2020年第4期34卷 806-821页

作者： hao GAO Gensuo JIA Yu fu National Satellite Meteorological Center China Meteorological AdministrationBeijing 100081 Key Laboratory of Regional Climate–Environment for Temperate East Asia(RCE-TEA) Chinese Academy of SciencesBeijing 100029 Climate Change Research Center Chinese Academy of SciencesBeijing 100029

Accurate global land cover(GLC), as a key input for scientific communities, is important for a wide variety of applications. In order to understand the current suitability and limitation of GLC products, the discrepancy and pixellevel uncertainty in major GLC products in three epochs are assessed in this study by using an integrated uncertainty index(IUI) that combines the thematic uncertainty and local classification accuracy uncertainty. The results show that the overall spatial agreements(Ao values) between GLC products are lower than 58%, and the total areas of forests are very consistent in major GLC products, but significant differences are found in different forest *** misclassification among different forest classes and mosaic types can account for about 20% of the total disagreements. The mean IUI almost reaches 0.5, and high uncertainty mostly occurs in transition zones and heterogeneous areas across the world. further efforts are needed to make in the land cover classifications in areas with high uncertainty. Designing a classification scheme for climate models, with explicit definitions of land cover classes in the threshold of common attributes, is urgently needed. Information of the pixel-level uncertainty in major GLC products not only give important implications for the specific application, but also provide a quite important basis for land cover fusion.

关键词： global land cover(GLC) discrepancies thematic similarity local accuracy pixel-level uncertainty

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A Line Search SQP-type Method with Bi-object Strategy for Nonlinear Semidefinite Programming

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 388-409页

作者： Wen-hao fu Zhong-wen CHEN School of Mathematical Sciences Suzhou University of Science and TechnologySuzhou 215009China School of Mathematical Sciences Soochow UniversitySuzhou 215006China

We propose a line search exact penalty method with bi-object strategy for nonlinear semidefinite *** each iteration,we solve a linear semidefinite programming to test whether the linearized constraints are consistent or *** search direction is generated by a piecewise quadratic-linear model of the exact penalty *** penalty parameter is only related to the information of the current iterate *** line search strategy is a penalty-free *** and local convergence are analyzed under suitable *** finally report some numerical experiments to illustrate the behavior of the algorithm on various degeneracy situations.

关键词： nonlinear semidefinite programming bi-object strategy global convergence rate of convergence

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Effect of increased nitrogen content on continuous cooling transition of γ→α in hot-deformed low-C Mo-V-Ti steels

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Journal of Iron and Steel Research International 2019年第7期26卷 733-742页

作者： Xin-ping Xiao Gen-hao shi Shu-ming Zhang Yu-wei Gao Qing-feng Wang fu-cheng Zhang State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 Hebei China Qinhuangdao Vocational and Technical College Qinhuangdao 066100 Hebei China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan University Qinhuangdao 066004 Hebei China

The two-stage controlled rolling and cooling at 0.5-50℃/s of low-carbon Mo-V-Ti steels with the increasing nitrogen content from 0.0032 to 0.0081 and 0.0123 wt.% were simulated through a Gleeble 3500 system. The continuous cooling transition (CCT) of γ→α in each steel was estimated via microstructure characterization and CCT diagram. The results indicated that CCT diagram for each steel was divided into three regions of γ→ferrite,γ→pearlite and γ→ bainite, and the increasing N content elevated all the starting temperatures for γ→α. Consequently, the polygonal ferrite (PF) and pearlite formed in each steel cooled at 1℃/s and, however, the increasing N content led to slightly coarser ferrite grain and pearlite colony. With the increased cooling rate to 10 and 30℃/s, a mixed microstructure of acicular ferrite (AF), granular bainite (GB) and lath bainite (LB) formed in 32N steel and in contrast, the mixture of PF+AF+GB in 8IN and 123N steels. The increasing N content promoted (Ti,V)(C,N) precipitation, enhanced the intragranular PF/AF nucleation, increased martensite/austenite constituent and depressed LB. In addition, the mechanisms dominating the effect of increasing N on this CCT of γ→α were discussed.

关键词： V-N microalloyed steel Continuous cooling transition Microstructure Precipitation Intragranular ferrite

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Computation method and control strategy of rotating separation flows in hydraulic machinery

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Journal of Hydrodynamics 2022年第6期34卷 1006-1020页

作者： Chao-yue Wang fu-jun Wang hao Wang hao-ru Zhao Zhi-feng Yao Ruo-fu Xiao College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System Beijing100083China Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China

Rotating separation flow(RSF)in hydraulic machinery is characterized by the large flow separations and complex vortical structures induced by the effects of strong rotation,large curvature and multiple wall surfaces,and conducting efficient engineering computation and putting forward effective control strategy for the RSF are important topics in the inner flow *** meet these engineering requirements,the studies on computational method and control strategy of the RSF are conducted in this *** terms of the computational method,the time-scale-driven(TSD)hybrid unsteady Reynolds-averaged Navier-Stokes/large eddy simulation(URANS/LES)modelling strategy is clarified,and an adaptive TSD hybrid model is established based on the RSF characteristics in hydraulic machinery,thereby avoiding the problem of non-monotonic grid convergence and improving the ***,a novel vortex-feature-driven idea suitable for the RSF is further developed inspired by *** terms of the control strategy,the secondary flow generation mechanism in a rotor domain is revealed,and the relationship between natural secondary flows and blade loading distributions is *** the basis of it,an active control strategy with general significance is proposed,and a general alternate loading technique(GALT)is *** aspects can provide generalized paradigms with expandable potential,which are of benefit to the efficient computation and effective control of the RSF in hydraulic machinery.

关键词： Rotating separation flow hydraulic machinery engineering computation turbulence model flow control blade loading

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Quasi-periodically Forced Logistic Map with Weak Liouvillean Frequency

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2411-2435页

作者： Jin hao LIANG Lin Lin fu Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037P.R.China School of Mathematics and Statistics Shaoguan UniversityShaoguan 512005P.R.China

Consider a class of quasi-periodically forced logistic maps T×[0,1]■:(θ,x)→(θ+ω,c(θ)x(1-x))(T=R/Z),whereωis an irrational frequency and c(θ)is a specific bimodal *** prove that under weak Liouvillean condition on frequency,the strange non-chaotic attractor occurs with negative Lyapunov *** extends the result in[Bjerklov,CMP,2009].

关键词： Quasi-periodically forced logistic map strange non-chaotic attractor weak Liouvillean frequency Lyapunov exponent

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