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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第5期18卷 445-448页

作者： Juan DONG Guo ZHU Tian-cheng WANG fu-shan SHI Department of Veterinary Medicine College of Animal SciencesZhejiang UniversityHangzhou 310058China Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine College of Animal SciencesZhejiang UniversityHangzhou 310058China

目的:研究人参皂甙Rg1对小鼠脂肪干细胞神经样分化的促进作用,并初步探讨其作用机理。创新点:证明了人参皂甙Rg1可以通过mi RNA-124途径促进脂肪干细胞的神经样分化。方法:从BALB/c小鼠腹股沟和睾丸脂肪垫处分离培养脂肪干细胞,利用流... 详细信息

目的:研究人参皂甙Rg1对小鼠脂肪干细胞神经样分化的促进作用,并初步探讨其作用机理。创新点:证明了人参皂甙Rg1可以通过mi RNA-124途径促进脂肪干细胞的神经样分化。方法:从BALB/c小鼠腹股沟和睾丸脂肪垫处分离培养脂肪干细胞,利用流式细胞仪检测分离的脂肪干细胞纯度。试验分为以下五组:磷酸缓冲盐溶液(PBS)组、3-异丁基-1-甲基黄嘌呤(IBMX)组、IBMX+Rg1低剂量组、IBMX+Rg1中剂量组和IBMX+Rg1高剂量组。用细胞免疫组化方法检测了脂肪干细胞向神经样细胞的分化效率,用荧光定量聚合酶链式反应(qP CR)方法检测mi RNA-124的表达变化,用免疫印迹的方法检测巢蛋白(nestin)、βIII-微管蛋白(βIII-tubulin)及羧基端小结构域磷酸酶1(SCP1)的表达水平。结论:免疫组化结果显示,IBMX可以成功诱导小鼠脂肪干细胞向神经样细胞的分化;免疫印迹结果显示,Rg1可以显著提高神经样细胞标记蛋白的表达水平;荧光定量PCR结果显示,Rg1可以促进miRNA-124的表达量,进而降解神经分化抑制因子SCP1的表达,促进脂肪干细胞的神经样分化效率。

关键词：脂肪干细胞人参皂甙Rg1 神经样分化

中国大陆及周边地区现代岩石圈演化动力学模拟

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地球物理学报 2006年第2期49卷 415-427页

作者：郑勇傅容珊熊熊中国科技大学地球与空间科学学院中国科学院测量与地球物理研究所武汉430077

采用有限元方法模拟了近20万年来青藏高原岩石圈形变演化过程,探讨了印度-欧亚大陆的碰撞对中国大陆岩石层形变和应力场的影响以及它们与强地震活动性的关系.结合现代GPS、地震和地质学观测的结果,对比分析了中国大陆在百万年、十万年... 详细信息

采用有限元方法模拟了近20万年来青藏高原岩石圈形变演化过程,探讨了印度-欧亚大陆的碰撞对中国大陆岩石层形变和应力场的影响以及它们与强地震活动性的关系.结合现代GPS、地震和地质学观测的结果,对比分析了中国大陆在百万年、十万年和十年尺度上的形变和构造应力场的基本格局.研究表明:(1)印度-欧亚大陆的碰撞以及印度大陆的持续向北推进、挤压所产生的应力环境,一直主导了以青藏高原为核心的我国西部地域岩石圈构造、运动和演化,但其影响随着远离青藏高原地区而逐渐变小.(2)断层滑移和重力势作用对于青藏高原东西部以及塔里木盆地的影响相当大,它们导致青藏高原岩石层东西向形变速率增大,对青藏高原的中南部地区产生拉张效应,同时导致塔里木盆地出现整体的右旋趋势.(3)青藏高原区域水平方向形变速率和GPS观测结果吻合较好.但在垂直方向上,一些地区计算结果与观测数据相差较大,这说明单纯的挤压作用不是现代青藏高原隆升的惟一机制.现代青藏高原的隆升可能与其他驱动机制,如地幔对流、重力均衡以及剥蚀作用等有关.(4)印度板块的挤压作用基本上决定了中国大陆西部的主压应力场分布.(5)印度板块的碰撞对中国大陆的强地震活动性有重要影响,但华北地区是个例外,该地区的地震活动性很强而印度板块的挤压在该区域产生的影响却很小,说明其他的驱动力在一定程度上活化了华北地块.

关键词：大陆碰撞有限元模拟 GPS 地质观测速度场青藏高原

体育休闲学研究主体领域分析——西方社会学视角下休闲学研究的启示

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武汉体育学院学报 2009年第6期43卷 72-75页

作者：付善民洛阳师范学院体育学院河南洛阳471022

主要采用文献资料法对国内休闲学研究现状及西方休闲学研究进行分析,梳理西方学界对休闲学研究的主线,分析西方社会学视角下的休闲限制及协商、性别与休闲、残疾人与休闲,即西方休闲学研究的三个主要理论假设,提出了体育休闲参与的促进... 详细信息

主要采用文献资料法对国内休闲学研究现状及西方休闲学研究进行分析,梳理西方学界对休闲学研究的主线,分析西方社会学视角下的休闲限制及协商、性别与休闲、残疾人与休闲,即西方休闲学研究的三个主要理论假设,提出了体育休闲参与的促进因素、体育休闲限制研究、不同社会群体的体育休闲、性别与体育休闲等中国体育休闲学研究的主体领域,以促进中国体育休闲学研究的深入。

关键词：体育休闲主体领域休闲限制西方社会学性别残疾人

Use of ultrasound for prediction of difficult laryngoscopy in adult patients

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Chinese Medical Journal 2020年第11期133卷 1369-1370页

作者： Lei Wan fu-shan Xue Liu-Jia-Zi Shao He Yang Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

To the Editor:In a prospective,self-controlled,assessorblinded,observational study,Wang et al[1].evaluated the associations of ultrasound-measured indicators with difficult *** the multivariate logistic regression analyses and the receiving operator characteristic(ROC)curve analysis,they concluded that the magnitude of the angle between the epiglottis and glottis under ultrasound was highly associated with difficult ***,difficult laryngoscopy might occur when this angle was less than 50°.

关键词： patients prediction ultrasound

Non-pharmacological therapy of TCM for the treatment of essential hypertension

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TMR Integrative Medicine 2019年第10期3卷 1-10页

作者： Meng-Lei Li shan-fu Chen Ying-Qiang Zhao Graduate School of Tianjin University of Traditional Chinese Medicine Tianjin China The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China

Non-pharmacotogicat treatment is an important means to control hypertension, with many advantages such as tow cost, tess medication, stable btood pressure, tess compHcations, and improved prognosis. This article reviews the research progress of non-drug treatment of hypertension in Chinese medicine in the past five years, and evaluates traditional Chinese medicine such as TCM Qigong, Wuhuo opera, Ba Duanjin and Taijiquan, and Chinese medicine acupuncture, moxibustion, massage, apptication, acupoint embedding and other traditional Chinese medicine. The effect of external treatment in hypertension control provides guidance for non-drug therapy to control hypertension.

关键词： Primary hypertension Prevention and control TCM Non-drug therapy Chinese medicine external treatment

A Computational Method for Time Cognitive Bias Simulation: Undue Attention Attributed to Information Sequences

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A Computational Method for Time Cognitive Bias Simulation: U...

第三十九届中国控制会议

作者： Yutong Zhou Tangwen Yin Bingxuan Ren shan fu School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University

The cognitive bias from sequential information affects human decision making. Early information tends to catch undue attention in varying degrees, which is one of the key characteristics to be manifested for the uniformity of analysis and synthesis in human-machine systems. In this study, we propose a computational method to simulate and analyze this human feature of time cognition bias. Our method comprises a weight function to quantify the cognition weight of the sequential information, a window function to fulfill the biased weight selection of the information sequence, and a degree function to statistically compute the undue degree of the human cognition. More precisely, the weight function embodies the sequential importance of timing information;the window function reflects human biased selection of cognition weight in a dynamical passband;and the degree function verifies our simulation of time cognitive bias and undue attention thereof. The computational results demonstrate the advances about the workings of cognitive bias and undue attention arising from sequential information. Our computational method is an important part in the modelling and simulation of human-machine systems.

关键词： attention cognitive psychology human model of decision making sequential information time cognition bias

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几何弯曲断层活动性的模拟

地球物理学报 2009年第10期52卷 2509-2518页

作者：薛霆虓傅容珊林峰中国科学技术大学地球和空间科学学院合肥230026 蒙城地球物理国家野外科学观测研究站合肥230026

运用有限元法建立大尺度几何弯曲断层(长约750 km)的二维模型,并利用接触单元技术模拟断层间的作用,模拟了几千年时间尺度内走滑断层的活动,探讨了具有一定几何形态断层对断层系统活动的影响.几何弯曲的断层导致了应力的集中,而且在断... 详细信息

运用有限元法建立大尺度几何弯曲断层(长约750 km)的二维模型,并利用接触单元技术模拟断层间的作用,模拟了几千年时间尺度内走滑断层的活动,探讨了具有一定几何形态断层对断层系统活动的影响.几何弯曲的断层导致了应力的集中,而且在断层的地震事件中起到了抑制作用,但是也为孕育大震提供了条件.和平直断层的模拟结果比较得知,断层的儿何弯曲不仅影响地震破裂长度、改变了地震滑移量,也很大程度影响了能量释放的空间位置,改变了地震轮回周期.此外,弯曲断层应力的不均匀也使主震前往往有前震发生.另外通过模拟可以看出.弯曲断层活动表现出明显的特征地震,使得地震一频次曲线偏离GR公式,说明了对单个断层而言,特征地震可能更能体现断层的地震活动,这对我们进行地震预测和危险性分析有着很重要的参考意义.

关键词：几何弯曲断层有限元断层活动性数值模拟

Comparing Sedation Regimens for Awake Fiberoptic Intubation

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Chinese Medical Journal 2016年第4期129卷 502-503页

作者： Gao-Pu Liu fu-shan Xue Chao Sun Gui-Zhen Yang Department of Anesthesiology Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100144 China

To the Editor： In a single-center, prospective, randomized double-blind clinical study comparing dexmedetomidine- midazolam and sufentanil-midazolam sedation regimens for awake fiberoptic intubation （AFOI） in 50 patients with difficult airways due to limited mouth opening, Li et al show that both dexmedetomidine and sufentanil are effective as an adjuvant for AFOI under airway topical anesthesia combined with midazolam sedation, but respiratory depression is a potential risk in the sufentanil-midazolam regimen. Given that AFOI has been established as the gold standard for difficult airway management, their findings have potentially clinical implications. In our view, however, there are several aspects of this study that need to be clarified and discussed.

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A left-side channel design improving insertion of gastric tube via the supraglottic airway device

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Chinese Medical Journal 2019年第11期132卷 1365-1367页

作者： Jing-Dong Ke Hai-Jun Hou Min Wang fu-shan Xue Department of Anesthesiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

To the Editor:The supraglottic airway device (SAD) with an additional gastric drainage channel may be beneficial for patients needing gastric decompression during surgery, such as laparoscopic cholecystectomy and cesarean delivery. furthermore, addition of gastric drainage channel is a typical feature of second-generation SAD. However, all of second-generation SADs have a gastric tube channel opening at the center of the distal tip. Such a design may cause some difficulty for insertion of the gastric tube if there is an inadequate position of the device tip in the upper esophageal aperture. In normal anatomy, the upper esophageal aperture is actually inclined to the left side of the trachea. Thus, we inferred that it should be much easier to insert a gastric tube into the esophagus, if the gastric drainage channel is placed at the left side of the SAD tip.

关键词： supraglottic airway device (SAD) drainage channel Gastric drainage pathway

Rational Study Design is Important for Assessing Myocardial Protection of Anesthetics

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Chinese Medical Journal 2015年第22期128卷 3123-3124页

作者： Chao Sun fu-shan Xue Rui-Ping Li Gao-Pu Liu Department of Anesthesiology Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100144 China

To the Editor： In a single-center, prospective randomized clinical study including 122 elderly patients undergoing the carotid endarterectomy （CEA）, Wang et al. showed that compared with propofol-based total intravenous anesthesia, low-dose sevoflurane inhalation along with propofol reduced the incidence of postoperative myocardial injury.

关键词： postoperative findings potential