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Absolute scaling law for temperature data in Rayleigh-Benard convection

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中国科学:技术科学 2010年第3期 337-337页

作者： fu qiang research center of fluid mechanics,institute of science,people’s liberation army univ.rsity of science and technology,nanjing 211101,china

In addition to the hierarchical-structure (H-s) model,this paper further explores the most intensive intermittent structure of Rayleigh-Bénard convection at the high Ra numbers proportional to *** respect to the discovery and by means of the scale,both of Bolgiano,there are two regions of the structure holding the absolute scaling law given by Ching’s *** theoretic analysis of data,this paper indicates that the regions act as two local intensive intermittent structures,by which the statistical absolute scaling performance of region is induced,rather than the statistical result of the entire time series in belief since *** terms of statistical theory,the local structure in fluid,therefore,is the essence governing the absolute scaling performance of region,especially in high intensity.

关键词： Rayleigh-Benard convection Bolgiano scale the most intensive structure absolute scaling law local structure

儿童重症抗NMDAR脑炎的临床特征、治疗及预后分析

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解放军医学杂志 2022年第11期47卷 1125-1132页

作者：韩慰蒋莉洪思琦符跃强卢思为重庆医科大学附属儿童医院神经内科/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿科学重庆市重点实验室重庆400014 重庆医科大学附属儿童医院重症监护室重庆400014

目的总结分析儿童重症抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎的临床特征、治疗及预后情况。方法收集2014年1月-2021年9月重庆医科大学附属儿童医院神经内科及儿童重症监护病房(PICU)收治的20例重症抗NMDAR脑炎患儿的临床资料。分析所有患... 详细信息

目的总结分析儿童重症抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎的临床特征、治疗及预后情况。方法收集2014年1月-2021年9月重庆医科大学附属儿童医院神经内科及儿童重症监护病房(PICU)收治的20例重症抗NMDAR脑炎患儿的临床资料。分析所有患儿的临床特征、治疗及预后情况;采用改良Rankin量表(mRs)评估患儿的短期预后,将其分为预后良好组(mRss≥2分或死亡),并分析其预后影响因素。结果纳入的20例重症抗NMDAR脑炎患儿中,女11例,男9例,发病年龄(9.2±3.7)岁。首发神经系统症状以惊厥发作、精神行为异常为主,主要并发症为意识障碍(85.0%),癫痫持续状态(60.0%),中枢性低通气(40.0%),急性颅内压增高(35.0%),多脏器功能衰竭(20.0%),休克(20.0%),横纹肌溶解(15.0%),其中短期预后良好的患儿无多脏器功能衰竭、休克和横纹肌溶解发生。首次脑电图检查异常19例(95.0%),主要为慢波活动,短期预后良好的患儿均无痫样波及δ刷。所有患儿均接受一线治疗,包括甲泼尼龙、静脉用丙种球蛋白(IVIG)或血浆置换(TPE),2例患儿接受利妥昔单抗二线免疫治疗,免疫治疗前后GCs评分有所改善。出院后进行3个月的短期随访,发现4例患儿死亡,16例存活患儿遗留以认知功能减退(12例,75.0%)、语言障碍(10例,62.5%)及运动障碍(8例,50.0%)为主的神经系统功能障碍,mRs评分为(2.81±1.55)分。近期预后良好组入院到完善抗体检测的时间明显短于近期预后不良组(P=0.032)。结论儿童重症抗NMDAR脑炎除尽早完善抗体检测及脑电图检查、尽快启动免疫治疗外,还应重视呼吸、循环及癫痫持续状态的管理;大部分患儿免疫治疗有效,但近期预后欠佳。

关键词： N-甲基-D-天冬氨酸受体(NMDAR) 儿童重症脑炎抗NMDAR脑炎

Efficacy and safety of shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu shu-wei Duan Hong-tao Yang Yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan shan Lin Zhi-yong Guo Jun Zhu jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo shi-ren sun Ji-feng sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou fu qiang He Guang-yan Cai Xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:shenyankangfu Tablet(sYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of sYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in china and were randomly divided into five groups:sYKFT,losartan potassium 50 mg or 100 mg,sYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the sYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the sYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Psartan potassium 100 mg group,the sYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine *** a superiority threshold of 15%,neither was statistically ***,serum creatinine and serum albumin from the baseline did not change statistically *** average change in TCM syndrome score between the patients who took sYKFT(-3.00[-6.00,-2.00])and who did not take sYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:sYKFT decreased the proteinur

关键词： Herbal medicine,Chinese shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches

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Asian Journal of Urology 2020年第3期7卷 291-300页

作者： Weibin Xie Junming Bi qiang Wei Ping Han Dongkui song Lei shi Dingwei Ye Yijun shen Xin Gou Weiyang He shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina Department of Urology West China HospitalSichuan UniversityChengduChina Department of Urology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Urology Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Urology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Urology First Affiliated Hospital of Army Medical UniversityUrology Institute of People Liberation ArmyChongqingChina Department of Urology The First Hospital of China Medical UniversityShenyangChina Department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhouChina Department of Urology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Urology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Urology General Hospital of Central Theater Command of the People’s Liberation ArmyWuhanChina

Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and *** influence of surgical approaches on overall survival(Os)and cancer-specific survival(Css)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank *** Cox proportional hazard models were used to evaluate the association among Os,Css and risk factors of ***:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent *** significant differences were noted in positive surgical margin rate and 90-day postoperative mortality *** was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital *** was no significant difference in Os and Css according to surgical approaches(pZ0.653,and 0.816,respectively).subgroup analysis revealed that Os and Css were not significantly different regardless of the status of extravesical involvement or LN *** Cox regression analyses showed that the surgical approach was not a significant predictor of Os and ***:Our study showed that MIRC was comparable to conventional ORC in terms of Os and Css.

关键词： Bladder cancer Radical cystectomy Minimally invasive surgery Robotic surgery Laparoscopy

Original article Efficacy and safety of Changfu peritoneal dialysis solution： a multi-center prospective randomized controlled trial

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Chinese Medical Journal 2013年第22期126卷 4204-4209页

作者： ZHOU Jian-hui NI Zhao-hui MEI Chang-lin YU Xue-qing LIU fu-you MIAO Li-ning LIU Zhi-hong YUAN Wei-jie ZHANG Ai-ping LIN Hong-li CHEN Meng-hua CHEN Jiang-hua ZHANG Jin-yuan HE Ya-ni CHEN Jian ZHAO Jiu-yang DING Xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU Wen-hu XING Chang-ying WANG Rong DENG Yue-yi CAO Xue-ying CAI Guang-yan MOU shan MAO Zhi-guo YANG Xiao LIU Hong sUN jing YU Yu-sheng LIU Jun sHI shu-mei LI Long-kai TIAN Na ZHANG Xiao-hui ZHOU Wei YANG Jie ZHANG Yong sUN jing-di JI Jun ZHANG Tao YAN Yan LIU Xiao-gang WANG Gang ZHANG Li ZHANG Hong LUO Jian-hua CHEN Xiang-mei Department of Nephrology State Key Laboratory of Kidney Disease Chinese People's Liberation Army General Hospital Beijing 100853 China Renal Division Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Background A multi-center large scale study is needed to confirm the efficacy and safety of domestic peritoneal dialysis （PD） solutions. some researchers believe that 6 Lid is enough for adequate dialysis, but there is no multi-center prospective study on Chinese population to confirm this. In this study, we evaluated the efficacy and safety of domestic PD solution （Changfu） and its difference between 6 L and 8 L dosage. Methods Adult PD patients who had taken PD therapy for at least one month were selected and divided into four groups according to two dialysis solution brands and two dialysis dosages, i.e., 6 L dose with Changfu dialysis solution, 6 L dose with Baxter dialysis solution, 8 L dose with Changfu dialysis solution, and 8 L dose with Baxter dialysis solution. After 48 weeks, the changes of primary and secondary efficacy indices were compared between different types and different dosages. We also analyzed the changes of safety indices. Results Changes of Kt/V from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of creatinine clearance rate （Ccr）. Normalized protein catabolic rate （nPCR） from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of net ultrafiltration volume （nUF） and estimated glomerular filtration rate （eGFR）. Changes of nPCR from baseline to 48 weeks between 6 L and 8 L showed no statistical differences; so did those of nUF and eGFR. The decline of Kt/V from baseline to 48 weeks in 6 L group was more than that in 8 L group. Change of Ccr was similar. During the 48-week period, the mean Kt/V was above 1.7/w, and mean Ccr was above 50 L.1.73 m-2.w1. More adverse events were found in Changfu group before Changfu Corporation commenced technology optimization, and the statistical differences disappeared after that. Conclusions The domestic PD solution （Changfu） was proven to be as effective as Baxter dialysis solution. During 48- week period, a dosage o

关键词： Changfu peritoneal dialysis solution efficacy safety

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并列超空泡射弹弹道特性研究

水下无人系统学报 2020年第2期28卷 202-208页

作者：刘富强罗凯黄闯古鉴霄董兴杰蒲汉平西北工业大学航海学院陕西西安710072 中国船舶重工集团公司第705研究所陕西西安710077 中国人民解放军63759部队吉林长春130051

为了研究不同间距并列射弹对射弹的流体动力特性和弹道特性的影响,文中基于流体体积函数(VOF)多相流模型,采用多重参考系和动网格及移动计算域技术,建立射弹入水仿真模型,对单射弹和并列射弹的入水自由减速过程进行数值仿真。结果表明:... 详细信息

为了研究不同间距并列射弹对射弹的流体动力特性和弹道特性的影响,文中基于流体体积函数(VOF)多相流模型,采用多重参考系和动网格及移动计算域技术,建立射弹入水仿真模型,对单射弹和并列射弹的入水自由减速过程进行数值仿真。结果表明:并列发射工况下,射弹受到侧向力,有攻角航行时空泡形态发生明显偏移,射弹更容易穿刺空泡,并且并列间距越小,穿刺距离越长;并列射弹的阻力系数明显高于单发射弹,当并列间距为75mm时,阻力系数增加34.92%;并列射弹的运动稳定性受到并列间距的影响,在并列间距为50 mm弹径工况中,并列射弹发生颠覆,弹道失稳;随着并列间距的增大该影响逐渐减弱,当并列间距为100 mm弹径时,并列射弹弹道稳定。研究结果可为并列超空泡射弹的工程应用提供参考。

关键词：并列超空泡射弹弹道特性流体动力数值仿真

sex differences in the scored Patient-Generated subjective Global Assessment in 19,528 cancer patients

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Journal of Nutritional Oncology 2023年第1期8卷 38-46页

作者： Wang Yan-Li Wu Tian-Tian fu Zhen-Ming Guo Zeng-Qing Lin Yuan shi Ying-Ying Hu Wen Ba Yi Li su-Yi Li Zeng-Ning Wang Kun-Hua Wu jing He Ying Yang Jia-Jun Xie Cong-Hua Zhou fu-Xiang song Xin-Xia Chen Gong-Yan Ma Wen-Jun Luo su-Xia Chen Zi-Hua Cong Ming-Hua Ma Hu Zhou Chun-Ling Wang Wei Luo Qi shi Yong-Mei Qi Yu-Mei Jiang Hai-Ping Guan Wen-Xian Chen Jun-qiang Chen Jia-Xin Fang Yu Zhou Lan Feng Yong-Dong Tan Rong-shao Li Tao Ou Jun-Wen Zhao Qing-Chuan Wu Jian-Xiong Lin Xin Yang Liu-Qing Zhang Qi Jia Ping-Ping Li Wei Xu Hong-Xia shi Han-Ping song Chun-Hua The Investigation on Nutrition status and Clinical Outcome of Common Cancers(INsCOC)Group Chinese society of Nutritional Oncology Department of Epidemiology and statistics College of Public HealthZhengzhou UniversityZhengzhouHenanChina Cancer center Renmin Hospital of Wuhan UniversityWuhanHubeiChina Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianChina Department of Gastrointestinal surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanningGuangxiChina Department of surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Clinical Nutrition West China Hospital of Sichuan UniversityChengduSichuanChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjinChina Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefeiAnhuiChina Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Gastrointestinal surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Zhongshan Chenxinghai Hospital(Affiliated Zhongshan Chenxinghai Hospital of Guangdong Medical univ.rsity) ZhongshanGuangdongChina Department of Clinical Nutrition The First People's Hospital of KashiKashiXinjiangChina Department of Clinical Nutrition Chongqing General HospitalChongqingChina Department of Colorectal and Anal surgery Huizhou Municipal Central HospitalHuizhouGuangdongChina Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtaiHebeiChina The First Department of the Tumor Hospital of Harbin Medical univ.rsity HarbinHeilongjiangChina Department of Nutrition Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Department of Oncology Affiliated

Background:The scored Patient-Generated subjective Global Assessment(PG-sGA)has been widely used to assess the nutritional status of cancer *** purpose of this study is to compare the differences in PG-sGA scores and the 7 domain scores of the PG-sGA in male and female cancer ***:This study was conducted at 72 hospitals from July 2013 to December 2018,a part of the Investigation on Nutritional status and its Clinical Outcomes of Common *** PG-sGA was recorded to evaluate the nutritional status of patients.A total of 19,528 patients with 13 common malignancies were included in this *** t test and the χ^(2) test were applied to analyze the sex diferences in the 7 domain *** Cancer Genome Atlas(TCGA)database was used to analyze the expression levels of symptom-related ***:There were significant sex dfferences in the PG-sGA(P=0.032),notably in patients with gastric cancer(male vs female:9.09±4.86 vs 9.58±5.07,P=0.005)and esophageal cancer(9.64±4.90 vs 10.46±4.96,P=0.011)and the average total PG-sGA of female patients was slightly higher than that of male patients(7.64±4.98 vs 7.77±5.14).The differences were mainly related to the weight,eating,symptom,as well as activity and physical function scores in the stratified *** causes of the sex differences were the rates of nausea,vomiting,dry mouth,and other symptoms,in both gastric and esophageal cancer *** of the TCGA database suggested that most of the related genes were sex neutral,except for genes related to dysphagia in gastric cancer(VEGFC was higher in female patients,VEGFA and VEGFB higher in male patients).Conclusions:There are sex differences in the PG-sGA scores in patients with various tumor types(female patients generally had higher scores than male patients),with differences mainly in the weight,eating,symptom,as well as activity and physical function *** sex differences in PG-sGA scores might be due to the differences i

关键词： PG-sGA sex differences Malnutrition Cancer patients TCGA database

CACA Guidelines for Holistic Integrative Management of Breast Cancer

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Holistic Integrative Oncology 2022年第1期1卷 76-126页

作者： Jiong Wu Daiming Fan Zhimin shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang shusen Wang Xiaojia Wang shu Wang Haibo Wang Tao Wang Xiang Wang jing Wang Jia Wang Biyun Wang Li fu Hongyuan Li Yehui shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu qiang Liu qiang sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping shen Zhenzhou shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer society,Chinese Anti-Cancer Association Key Laboratory of Breast Cancer in shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai Medical College of Fudan UniversityShanghaiChina Department of Oncology Shanghai Medical College of Fudan UniversityShanghaiChina Department of Gastroenterology Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina state key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anChina National Cancer center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Endocrine and Breast surgery The First Affliated Hospital of Chongqing Medical UniversityYuzhongChongqingChina Medicine-Oncology The Affliated Hospital of Military Medical Sciences(The 307th Hospital of Chinese People’s Liberation Army)BeijingChina Breast Disease center Shandong Cancer HospitalJinanChina Department of Breast surgery The First Affliated Hospital of China Medical UniversityShenyangChina The 3rd Department of Breast Cancer China Tianjin Breast Cancer PreventionTreatment and Research CenterTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of CancerTianjinChina Harbin Medical univ.rsity Cancer Hospital HarbinChina Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai Medical College of Fudan UniversityShanghaiChina sun Yat-sen univ.rsity Cancer center GuangzhouChina Zhejiang Cancer Hospital HangzhouChina Breast center Peking University People’s HospitalBeijingChina Department of Breast center The Affliated Hospital of Qingdao UniversityShandongChina Department of Oncology Fifth Medical Center of Chinese PLA General HospitalBeijingChina Department of Breast surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Departmen

Purpose:Breast cancer is now the most common malignant tumor *** one-fourth of female cancer patients all over the world sufer from breast *** about one in six female cancer deaths worldwide is caused by breast *** terms of absolute numbers of cases and deaths,china ranks frst in the *** CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in ***:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and ***:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer ***:We to standardize the diagnosis and treatment of breast cancer in china through the formulation of the CACA Guidelines.

关键词： Epidemiology of breast cancer Breast cancer screening Breast cancer diagnosis Early breast cancer treatment Advanced breast cancer treatment Traditional Chinese medicine treatment of breast cancer

Extension Protocol for the Investigation on Nutrition status and Clinical Outcome of Patients with Common Cancers in china(INsCOC)study:2021 update

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Journal of Nutritional Oncology 2022年第2期7卷 64-74页

作者： Hong Xia Xu Chun Hua song Liang Yu Yin Chang Wang Zhen Ming fu Zeng Qing Guo Yuan Lin Ying Ying shi Wen Hu Yi Ba su Yi Li Zeng Ning Li Kun Hua Wang jing Wu Ying He Jia Jun Yang Cong Hua Xie fu Xiang Zhou Xin Xia song Gong Yan Chen Wen Jun Ma su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping shi The Investigation on Nutrition status and Clinical Outcome of Common Cancers(INsCOC)Group Department of Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer center of the First Hospital of Jilin univ.rsity Changchun 130021Jilin China Cancer center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina Department of Gastrointestinal surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of surgery The First Affiliated Hospital of SunYat-Sen UniversityGuangzhou 510080GuangdongChina Department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Nutrition and Metabolism of Oncology The First Affiliated Hospital of University of Science and Technology of ChinaAnhui Provincial Cancer HospitalHefei 230031AnhuiChina Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina Department of Gastrointestinal surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunming 650032YunnanChina Department of Clinical Nutrition The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006ZhejiangChina Department of Clinical Nutrition Chongqing General HospitalChongqing 400014China Department of Colorectal and Anal surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Department of Oncology Xingtai Peo

Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of *** society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition status and Clinical Outcome of Patients with Common Cancers in china(INsCOC study)since *** is an extension to the previous 2013-2020 study *** study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of *** and study design This is an observational,multi-centered,hospital-based prospective cohort *** collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital ***-up will be conducted for 1-20 years after *** primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of *** factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-sGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance status scores).This clinical study protocol was approved by local Ethics Committees of

关键词： Cancer Malnutrition Nutritional status Nutritional assessment survival Patient-Generated subjective Global Assessment