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Paternal transgenerational glucose intolerance with epigenetic alterations in second generation offspring of GDM

Asian Journal of Andrology 2013年第4期15卷 451-452页

作者： guo-lian Ding He-Feng Huang Women's Hospital School of Medicine ZhejiangUniversity Hangzhou 310006 China

Gestational diabetes mellitus （GDM） has been shown to be associated withhigh risk of diabetes in offspring. In addi tion to intergenerational transmission （F1 offspring）, intrauterine hyperglycemia also has effects on the second generation （F2 off spring）. However, the mechanisms involved and the possibilities of transgenerational transmission are still unclear. In a recent study published in Diabetes, we have uti lized GDM mouse model to identify hyper glycemic intrauterine environment causing a high risk of diabetes in offspring by alter ing epigenetic modification. furthermore, the results indicate that the abnormality of phenotype and imprinted genes expression are more obvious in male offspring than that of female. The changes of epigenetics in sperm may contribute to transgenera tional transmission. A growing body of research suggests that exposure to the abnormal environment in uterus can lead to chronic health problems later in life.1 Intrauterine hyperglycemia is a major characteristic of GDM and has been suggested as an important determinative fac tor for the risk of diabetes in adulthood, it1 addition to the effects of genetic factors.2 The mechanism involved in the association between intrauterine hyperglycemia and a high risk of diabetes in offspring remains unclear.3 In mammals, epigenetic reprogram ming is involved in germ cells and early embryonic development.4＇5 Because erasure and establishment of the genomic imprints for some imprinted genes begin when migra tory primordial germ ceils enter the embry onic genital ridge through gametogenesis, epigenetic abnormalities that occur duringthis phase may be involved in transgenera tional transmission.6 In the study, Ding et al.7 established a GDM mouse model of intrauterine hypergly cemia. The female （9） and male （or） F1 adults of control and GDM mice were intercrossed to obtain F2 offspring of four groups：（i） C0＂ C9; （ii） CCYGDMg; （iii） GDMCrCg; and （iv） GDMcYGDMg. We found that intrau terine hypergl

关键词： Paternal transgenerational intolerance

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The Maximum and Minimum Degree of the Random r-uniform r-partite Hypergraphs

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Acta Mathematicae Applicatae Sinica 2016年第4期32卷 867-874页

作者： Ai-lian CHEN Hao LI fu-ji ZHANG College of Mathematics and Computer Science Fuzhou University Fuzhou 350108 China Laboratoire de Recherche en Informatique UMR 8623 C. N. R. S. -Universite de Paris-sud 91405-Orsay cedex France School of Mathematical Sciences Xiamen University Xiamen 361005 China

In this paper we consider the random r-uniform r-partite hypergraph model H（n1, n2,…, nr; n, p） which consists of all the r-uniform r-partite hypergraphs with vertex partition {V1,V2,…, Vr} where ｜Vi｜ = ni = ni（n）（1 ≤ i ≤ r） are positive integer-valued functions on n with n1 ＋n2 ＋… ＋nr =n, and each r-subset containing exactly one element in Vi （1 ≤ i ≤ r） is chosen to be a hyperedge of Hp ∈H（n1,n2,…,nr;n,p） with probability p = p（n）, all choices being independent. Let △V1 = △V1 （H） and δv1 = δv1（H） be the maximum and minimum degree of vertices in V1 of H, respectively; Xd,V1 = Xd,V1 （H）, Yd,V1 = Yd,V1 （H）, Zd,V1 = Zd,V1 （H） and Zc,d,V1=Zc,d,V1 （H） be the number of vertices in V1 of H with degree d, at least d, at most d, and between c and d, respectively. In this paper we obtain that in the space H（n1, n2,…, nr; n,p）, Xd,V1, Yd,V1, Zd,V1, and Zc,d,V1all have asymptotically Poisson distributions. We also answer the following two questions. What is the range of p that there exists a function D（n） such that in the space H（n1, n2,…,nr; n, p）, lim n→＋∞ P（△v1 = D（n）） = 1？ What is the range of p such that a.e., Hp ∈ H（n1,n2,...,nr;n,p） has a unique vertex in V1 with degree Av1（Hp）？ Both answers are p = o（logn1/N）, where N = r ∏ i=2 ni. The corresponding problems on δv1（Hp） also are considered, and we obtained the answers are p ≤ （1＋o（1））（logn1/N） andp=o （log n1/N）, respectively.

关键词： maximum degree minimum degree degree distribution random uniform hypergraphs

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The Degree Distribution of the Random Multigraphs

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Acta Mathematica Sinica,English Series 2012年第5期28卷 941-956页

作者： Ai lian CHEN fu Ji ZHANG Hao LI College of Mathematics and Computer Science Fuzhou University School of Mathematical Sciences Xiamen University Laboratoire de Recherche en Informatique UMR 8623C.N.R.S.-Universitde Paris-sud

In this paper, as a generalization of the binomial random graph model, we define the model of multigraphs as follows： let G（n; {pk}） be the probability space of all the labelled loopless multigraphs with vertex set V = {v1, v2, ..., vn }, in which the distribution of tvi,vj, the number of the edges between any two vertices vi and vj is P{tvi,vj =k}=Pk, k=0, 1,2,...and they are independent of each other. Denote by Xd = Xd（G）,Yd = Yd（G）, Zd = Zd（G） and Zcd = Zcd（G） the number of vertices of G with degree d, at least d, at most d and between c and d. In this paper, we discuss the distribution of Xd, Yd, Zd and Zcd in the probability space G（n; （Pk））.

关键词： Degree distribution random multigraph degree sequence

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Preparation of porous structures on copper microchannel surfaces by laser writing

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Science China(Technological Sciences) 2019年第12期62卷 2261-2270页

作者： DENG DaXiang CHEN XiaoLong CHEN liang lian YunSong fu Ting School of Mechanical Engineering and Automation Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Department of Mechanical&Electrical Engineering Xiamen UniversityXiamen 361005China Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan 430081China

A laser writing method is developed to fabricate porous structures on copper microchannel wall surfaces for enhanced microchannel heat sinks(MHSs). The formation feasibility together with its mechanism of such porous structures is explored by the comparison of dry and wet laser writing process, i.e., in both air atmosphere and under de-ionized water. Rectangular microchannels with ripples-like porous structures on the wall surfaces, which consisted of numerous micro-holes and micro-cavities,have been successfully formed in the dry laser writing process. Nevertheless, the microchannel wall surfaces were hardly altered in wet conditions. Besides, the effect of laser fluence on the formation of porous structures on the microchannels was also assessed in both dry and wet conditions. In dry laser writing process, the microchannel depth and surface roughness of wall surface increased monotonically, whereas the microchannel bottom width decreased continuously with increasing the laser fluence. On the other hand, the microchannel wall kept almost unchanged with smooth surfaces with increasing laser fluence in wet conditions.

关键词： laser writing porous surface microchannel heat sinks surface morphology

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Combustion instability of pilot flame in a pilot bluff body stabilized combustor

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Chinese Journal of Aeronautics 2015年第6期28卷 1606-1615页

作者： fu Xiao Yang fujiang guo Zhihui National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics School of Energy and Power Engineering Beihang University

Combustion instability of pilot flame has been investigated in a model pilot bluff body stabilized combustor by running the pilot flame only. The primary objectives are to investigate the pilot flame dynamics and to provide bases for the study of the interaction mechanisms between the pilot flame and the main flame. Dynamic pressures are measured by dynamic pressure transduc- ers. A high speed camera with CH＊ bandpass filter is used to capture the pilot flame dynamics. The proper orthogonal decomposition （POD） is used to further analyze the high speed images. With the increase of the pilot fuel mass flow rate, the pilot flame changes from stable to unstable state grad- ually. The combustion instability frequency is 136 Hz when the pilot flame is unstable. Numerical simulation results show that the equivalence ratios in both the shear layer and the recirculation zone increase as the pilot fuel mass flow rate increases. The mechanism of the instability of the pilot flame can be attributed to the coupling between the second order acoustic mode and the unsteady heat release due to symmetric vortex shedding. These results illustrate that the pilot fuel mass flow rate has significant influences on the dynamic stability of the pilot flame.

关键词： Combustion instability High speed image Pilot flame Proper orthogonal decom-position (POD) Vortex shedding

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Current status of Helicobacter pylori eradication and risk factors for eradication failure

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World Journal of Gastroenterology 2020年第32期26卷 4846-4856页

作者： Tian-lian Yan Jian-guo Gao Jing-Hua Wang Dan Chen Chao Lu Cheng-fu Xu Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND The Helicobacter pylori(***)eradication rate is decreasing in the general population of *** To evaluate the *** eradication status in real-world clinical practice and to explore factors related to eradication *** Patients with *** infection who were treated with standard 14-d quadruple therapy and received a test of cure at a provincial medical institution between June 2018 and May 2019 were *** and clinical data were *** rates were calculated and compared between regimens and *** analysis was performed to identify predictors of eradication *** Of 2610 patients enrolled,eradication was successful in 1999(76.6%)***-containing quadruple regimens showed a higher eradication rate than other quadruple therapy regimens(83.0%vs 69.0%,Pfurazolidone-containing regimens achieved the highest eradication rate(80.8%).Esomeprazole-containing regimens showed a higher eradication rate than those containing other proton pump inhibitors(81.8%vs 74.9%,P=0.001).Multivariate regression analysis found that older age,prior therapy,and use of omeprazole or pantoprazole were associated with an increased risk of eradication CONCLUSION The total eradication rate is 76.6%.Amoxicillin-containing regimens are superior to other ***,prior therapy,and use of omeprazole or pantoprazole are independent risk factors for eradication failure.

关键词： Helicobacter pylori Eradication Quadruple therapy Proton pump inhibitor Retrospective study

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Integrated lifting line/surface panel method for optimal propeller design with consideration of hub effect

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Journal of Hydrodynamics 2019年第6期31卷 1218-1230页

作者： Wen-yu Sun guo-fu Huang China Ship Scientific Research Center Wuxi 214082China

An optimal marine propeller design method is proposed,which integrates the lifting line and surface panel method and is characterized by the use of the surface panel method to take the hub effect into *** developing an integrated approach instead of an iterative method for the calculation of the interaction between the hub and the designed blades,the hub effects on the optimal circulation can be accounted for throughout the theoretical design *** new integrated method provides a fast and accurate enough method to model the straight forward hub surface,in the optimal propeller design.A systematic design procedure from the basic design inputs to the blade geometry determination is performed and the designed propellers are validated by the surface panel method and the RANS *** design and analysis cases are considered by different approaches with comparison and *** a comparative study including different hub geometries is also performed to reveal the mechanism of the hub effect on the distributions of the propeller optimal loads.

关键词： Optimal circulation design lifting line method surface panel method hub effect

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An extended chirp scaling algorithm for spaceborne sliding spotlight synthetic aperture radar imaging

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Chinese Journal of Aeronautics 2014年第4期27卷 892-902页

作者： guo Jiao Xu Youshuan fu Longsheng College of Mechanical and Electronic Engineering Northwest A&F University Shanghai Institute of Satellite Engineering

A system impulse response with low sidelobes is critical in synthetic aperture radar（SAR） images because sidelobes contribute to noise and interfere with nearby scatterers. However,the conventional tricks of sidelobe suppression are unable to be exactly applied to the case of spaceborne sliding spotlight SAR due to great azimuth shifts in both time and frequency domains. In this paper, an extended chirp scaling algorithm is presented for spaceborne sliding spotlight SAR data imaging. The proposed algorithm firstly uses the spectral analysis（SPECAN） technique to avoid the azimuth spectrum folding effect and then employs the chirp scaling（CS） algorithm to achieve data focusing, i.e., the so-called two-step approach. To suppress the sidelobe level, an efficient strategy for the azimuth spectral weighting which only involves matrix multiplications and short fast Fourier transformations（FFTs） is proposed, which is a post-process executed on the focused SAR image and particularly simple to be implemented. The SAR image processed by the proposed extended CS algorithm is very precise and perfectly phase-preserving. In the end, computer simulation results verify the analysis and confirm the validity of the proposed algorithm.

关键词： Chirp scaling (CS) Sidelobe suppression Sliding spotlight Spectral analysis (SPECAN) Synthetic aperture radar(SAR)

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All-Solid-State Multi-Wavelength Laser System from 208 to 830 nm

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Chinese Physics Letters 2001年第4期18卷 537-538页

作者： ZHAO Shang-Hong CHEN guo-fu ZHAO Wei WANG Yi-Shan YU lian-Jun College of Telecommunication University of Air Force EngineeringXi’an 710077 State Key Laboratory of Transient Optics and Technology Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710068

Four-wavelength lasers from near-infrared to deep-ultraviolet range,532,830,415 and 208 nm,have been developed in one all-solid-state laser *** laser system is pumped by a diode-Q-YLF laser at 532 nm,a Ti:sapphire laser and the nonlinear second-harmonic-generation crystals LBO and BBO are used to generate different *** average powers(repetition rate 1 kHz)of 1.1 W at 830 nm,380 mW at 415 nm,and 39 mW at 208 nm are obtained when the pumping power is 3.6 *** main characteristics of this system are presented.

关键词： pumped pumping laser

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基于TCE教学模式的卫生统计学实验课教学效果评价

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蚌埠医学院学报 2011年第10期36卷 1122-1124页

作者：贾贤杰付连国吴学森庄颖韩慧姚荣英周纯先蚌埠医学院预防医学系安徽蚌埠233030

目的:评价预防医学专业本科生卫生统计学实验课程中开展统计学基础理论+案例分析+错误辨析(TCE)教学模式的教学改革效果。方法:将蚌埠医学院2007级预防医学专业4个班99人分为教改组(49人)和传统组(50人),传统组实施常规教学模式,教改组... 详细信息

目的:评价预防医学专业本科生卫生统计学实验课程中开展统计学基础理论+案例分析+错误辨析(TCE)教学模式的教学改革效果。方法:将蚌埠医学院2007级预防医学专业4个班99人分为教改组(49人)和传统组(50人),传统组实施常规教学模式,教改组《卫生统计学》实验课实施TCE教学模式,采用试卷考核与问卷调查、访谈相结合的方法评估教学效果。结果:教改组的学生考试成绩优于传统组(P<0.01);2组之间的体会和反馈在交流能力、自学能力、表达能力、获取信息能力、解决问题能力及对自己所在的实验课程教学满意度的差异均有统计学意义(P<0.01),且均以TCE教改组的肯定回答比例为高。结论:TCE教学模式可激发学生学习《卫生统计学》的兴趣,提高学生分析和解决实际问题的能力,进而促进学生对知识的掌握和运用。

关键词：教育,医学卫生统计学实验课程教学改革 TCE教学模式

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