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虚拟手术联合三维打印导板在下颌骨良性肿瘤切除和颌骨缺损修复重建中的应用

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中华整形外科杂志 2024年第3期40卷 258-263页

作者：付坤高宁杨雷雷刘康彦蔡菁华高振杰陈浩赵斌何巍郑州大学第一附属医院口腔颌面外科郑州450052

目的探讨虚拟手术联合三维(3D)打印导板在下颌骨良性肿瘤切除和颌骨缺损修复重建中的应用效果。方法2013年6月至2020年12月,郑州大学第一附属医院口腔颌面外科行数字化技术辅助下颌骨良性肿瘤切除,同期游离腓骨肌皮瓣修复重建颌骨缺损... 详细信息

目的探讨虚拟手术联合三维(3D)打印导板在下颌骨良性肿瘤切除和颌骨缺损修复重建中的应用效果。方法2013年6月至2020年12月,郑州大学第一附属医院口腔颌面外科行数字化技术辅助下颌骨良性肿瘤切除,同期游离腓骨肌皮瓣修复重建颌骨缺损患者全部纳入该研究,临床资料不全者排除。根据是否在术中使用下颌骨和腓骨截骨导板,分为导板组和非导板组。导板组术前3D打印下颌骨及腓骨截骨导板,术中使用导板完成肿瘤切除和腓骨塑形操作,非导板组仅依据虚拟手术方案和预成钛板完成相应操作。记录腓骨瓣制备情况、手术时间、腓骨瓣临床成活情况,术后1周颌面部螺旋CT影像评价腓骨骨段间及腓骨与下颌骨间密合程度、预成形钛板与腓骨及下颌骨间密合程度和髁状突位置,术后半年视觉模拟评分法(VAS)调查患者术后面部外形满意度。采用SPSS 21.0软件对数据进行统计学分析,手术时间、术后面部外形评价比较采用独立样本t检验,髁突位置、腓骨及下颌骨段间密合程度、钛板与骨段密合程度比较采用卡方检验,P0.05)。结论虚拟手术联合3D打印导板可以进一步缩短手术时间,提高下颌骨良性肿瘤切除颌骨缺损游离腓骨瓣修复重建的精准度。

关键词：骨重建打印,三维计算机辅助手术下颌骨游离组织瓣手术时间虚拟手术

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贝类标本信息管理的数字化处理工作初探

中国科技信息 2011年第8期 101-101页

作者：陈永超黄丹丽陈正建李海云付京花华南农业大学动物科学学院

由于传统贝类标本在保护、查找和统计等方面存在诸多问题,使得贝类标本信息管理的数字化日益迫切。文章介绍了利用华南农业大学教学标本平台,对华南农业大学水产养殖系贝类标本信息管理数字化处理工作进行的初步研究,包括标本的鉴定汇... 详细信息

由于传统贝类标本在保护、查找和统计等方面存在诸多问题,使得贝类标本信息管理的数字化日益迫切。文章介绍了利用华南农业大学教学标本平台,对华南农业大学水产养殖系贝类标本信息管理数字化处理工作进行的初步研究,包括标本的鉴定汇总、标签制作、外观拍摄、标本的信息转化和整合、数据录入等整理工作。

关键词：标本管理数字化贝类

Targeted disruption of Noc4l leads to preimplantation embryonic lethality in mice

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Protein & Cell 2017年第3期8卷 230-247页

作者： Yongli Qin Haifeng Li Lina Jia jinghua Yan George fu Gao Xiangdong Li State Key Laboratory of the Agro-Biotechnology College of Biological Sciences China Agricultural University CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences

Dear Editor,Human Nucleolar complex associated 4 homolog(NOC4L,GenBank accession number NM＿024078) is the human ortholog of yeast Noc4p. However, with few functional studies evaluated, the physiological contributions of NOC4L have yet to be defined. The Noc4p gene in yeast encodes a63-kilodalton(KDa) protein that forms a stable heterodimer with Nop14p, which mediates the maturation and nuclear export of 40S ribosomal subunits(Dlakic and Tollervey,2004; Kuhn et al., 2009; Liu and Thiele, 2001; Milkereit et al.,2003).

关键词： Brown Adipose Tissue Embryonic Lethality Ribosome Biogenesis Preimplantation Embryo Cytoplasmic Granule

Novel 1,3,5-thiadiazine-2-thione derivatives containing a hydrazide moiety:Design, synthesis and bioactive evaluation against phytopathogenic fungi in vitro and in vivo

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Chinese Chemical Letters 2019年第7期30卷 1419-1422页

作者： Xiaobin Wang Xincan fu Min Chen An Wang jinghua Yan Yudong Mei Mengqi Wang Chunlong Yang Jiangsu Key Laboratory of Pesticide Science Nanjing Agricultural University Nanjing 210095 China Department of Chemistry College of Sciences Nanjing Agricultural University Nanjing 210095 China

A series of novel 1,3,5-thiadiazine-2-thione derivatives bearing a hydrazide moiety were designed, synthesized and evaluated for their antifungal activities against Rhizoctonia solani (Rs), fusarium graminearum (Fg), Botrytis cinerea (Bc) and Colletotrichum capsici (Cc). The in vitro antifungal bioassays indicated that most of title compounds displayed good selectivity and specificity aganist Rs relative to Fg, Bc and Cc. Strikingly, the title compound N'-(4-chlorophenyl)-2-(5-phenyl-6-thioxo-1,3,5-thiadiazinan-3-yl)acethydrazide (5b) obviously inhibited the Rs growth in vitro with the EC50 value of 0.24μg/mL, which is approximately 2-folds more effective than the commercialized fungicide carbendazim (0.55 μg/mL). The in vivo anti-Rs effects of title compound 5b were further evaluated on rice leaves with control efficacies of 98.58% at 200 μg/mL and 61.27% at 100 μg/mL. The above researches provide a significant reference for the further structural optimization of 1,3,5-thiadiazine-2-thione derivatives bearing a hydrazide moiety as potential fungicides.

关键词： 1,3,5-Thiadiazine-2-thione Hydrazide Crop protection Antifungal activity Rhizoctonia solani

湖北大老岭自然保护区国有林植被碳储量评估分析

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绿色科技 2024年第8期26卷 96-100,109页

作者：冯敬华丁峰余长蓉张永翠付彦蓉宜昌三峡大老岭自然保护区管理局湖北宜昌443000 三峡大学生物与制药学院湖北宜昌443002

森林蓄积量、森林生物量和森林碳储量是衡量森林生态系统的重要指标,通过碳储量来反映森林的碳汇能力以进一步研究森林植被的生产力。根据湖北大老岭国家级自然保护区国有林2019年森林资源二类调查数据,运用不同树种类型蓄积量和生物量... 详细信息

森林蓄积量、森林生物量和森林碳储量是衡量森林生态系统的重要指标,通过碳储量来反映森林的碳汇能力以进一步研究森林植被的生产力。根据湖北大老岭国家级自然保护区国有林2019年森林资源二类调查数据,运用不同树种类型蓄积量和生物量转换方程参数,对不同森林起源、不同林分类型、不同龄组、不同地域分区的植被碳储量及碳密度进行估算,发现大老岭保护区国有林不同林分类型碳密度高于湖北省同类型森林植被碳密度平均值。分析发现国有林不同龄组的碳储量差异显著,有较高的林分改造空间,建议通过加强森林抚育进一步提升碳汇能力。

关键词：大老岭自然保护区森林蓄积量森林生物量森林碳储量碳密度

坤泰胶囊联合戈舍瑞林治疗中重度子宫内膜异位症腹腔镜术后患者的效果

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中国民康医学 2024年第7期36卷 122-125页

作者：杨丹丹李经华周红英付晓芳新郑华信民生医院解放路院区妇科病区河南郑州451100

目的:观察坤泰胶囊联合戈舍瑞林治疗中重度子宫内膜异位症(EMT)腹腔镜术后患者的效果。方法:选取2020年4月至2023年4月于该院行腹腔镜手术的106例中重度EMT患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各53例。对照组术... 详细信息

目的:观察坤泰胶囊联合戈舍瑞林治疗中重度子宫内膜异位症(EMT)腹腔镜术后患者的效果。方法:选取2020年4月至2023年4月于该院行腹腔镜手术的106例中重度EMT患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各53例。对照组术后予以戈舍瑞林治疗,观察组在对照组基础上联合坤泰胶囊治疗,两组均治疗3个月。比较两组临床疗效,治疗前后性激素[卵泡刺激素(FSH)、雌二醇(E2)、黄体生成素(LH)]水平、子宫动脉血流动力学指标[收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)、阻力指数(RI)]水平、炎性指标[可溶性细胞间黏附分子-1(sICAM-1)、基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率。结果:观察组治疗总有效率为94.34%(50/53),高于对照组的73.58%(39/53),差异有统计学意义(P0.05)。结论:坤泰胶囊联合戈舍瑞林治疗中重度EMT腹腔镜术后患者可提高治疗总有效率,降低性激素和炎性指标水平,改善子宫动脉血流动力学指标水平,效果优于单纯戈舍瑞林治疗。

关键词：子宫内膜异位症坤泰胶囊戈舍瑞林性激素子宫动脉血流动力学不良反应

Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability

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Science China(Life Sciences) 2011年第6期54卷 513-519页

作者： FENG ChunYan GAO Feng LIU YiWei WANG GuiHua PENG Hao MA YanHe YAN jinghua GAO George fu CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of Sciences Beijing 100049China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Laboratory of Structural Microbiology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China

Protein thermostability is an inherent characteristic of proteins from thermophilic microorganisms,and therefore enables these organisms to survive at extreme *** it is well-known that thermostable proteins are critical for the growth of thermophilic organisms,the structural basis of protein thermostability is not yet fully *** histidine-containing phosphocarrier (HPr) protein,a phosphate shuttle protein in the phosphoenolpyruvate-dependent sugar transport system (PTS) of bacterial species,is an ideal model for investigating protein thermostability with respect to its small size and deficiency in disulphide bonds or *** this study,the HPr protein from Thermoanaerobacter tengcongensis (TtHPr) is cloned and *** structure with good quality has been determined at 2.3 resolution,which provides a firm foundation for exploring the thermostable ***,it shows that the crystal structure is conserved and no clue can be obtained from this single ***,detailed comparison of sequence and structure with the homologs from mesoor thermophilic bacteria shows no obvious rule for thermostability,but the extra salt-bridge existing only in thermophilic bacteria might be a better explanation for thermostability of ***,mutations are performed to interrupt the salt-bridge in HPrs in thermophilic *** site-directed mutations and the circular dichroism method,thermostability is evaluated,and the mutational variations are shown to have a faster denaturing rate than for wild-type viruses,indicating that mutations cause instability in the *** the higher-temperature resistance of thermophilic and hyperthermophilic proteins is essential to studies on protein folding and stability,and is critical in engineering efficient enzymes that can work at a high temperature.

关键词： HPr crystal structure thermostability salt-bridge Thermoanaerobacter tengcongensis

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从“浊”论治“脂脑同病”

山西中医药大学学报 2024年第5期25卷 559-562,576页

作者：杨静静张敬华南京中医药大学江苏南京210029 南京中医药大学附属南京中医院江苏南京210022

罹患脑病患者多伴有脂质异常,“脂脑同病”为张敬华老师根据多年临床经验结合各家理论提出的概念,以期为临床中医学脑病的诊疗开辟新思路。其治疗脑病从“浊”入手,认为浊盛正虚为根本病机,治疗当顾护脾胃,祛浊的同时兼顾脏腑功能。将... 详细信息

罹患脑病患者多伴有脂质异常,“脂脑同病”为张敬华老师根据多年临床经验结合各家理论提出的概念,以期为临床中医学脑病的诊疗开辟新思路。其治疗脑病从“浊”入手,认为浊盛正虚为根本病机,治疗当顾护脾胃,祛浊的同时兼顾脏腑功能。将“脂脑同病”分为“脂浊-痰瘀互结-浊毒”3个阶段分阶段施治,同时结合《黄帝内经》“治未病”理念,认为脂浊阶段当“未病先防”,以降脂化浊为主;痰瘀互结阶段当“既病防变”,以痰瘀同治为主;浊毒阶段当“病后防复”,以解毒化浊为主。

关键词：脂脑同病浊邪治法方药顾护脾胃降脂化浊法痰瘀同治解毒化浊法

Heat exchange at air-sea interface in the South China Sea during monsoon periods in 1986

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Chinese Science Bulletin 2006年第19期51卷 2413-2420页

作者： WU Disheng FENG Weizhong XU Jianping YAN jinghua ZHAO Xue ZHOU Shuihua ZHANG Jiwei QIAO Guanyu LIN fu LU Boming South China Sea Forecast Center State Oceanic Administration Guangzhou 510300 China Laboratory of Ocean Dynamic Processes and Satellite Oceanography (LOPSO) State Oceanic Administration Hangzhou 310012 China Guangzhou Tropic Ocean Atmosphere Institute Guangzhou 510080 China

In order to explore the interaction be- tween the sea and monsoon in the South China Sea, the heat exchanges at air-sea interface during mon- soon periods in 1986 were calculated using observa- tional data. It shows that when the summer monsoon bursts and prevails over the South China Sea, the air-sea interface heat exchange is strong and the latent heat rises rapidly in the intertropical conver- gence zone and the tropic cyclone system near 20.49°N, 114.14°E. On May 24, 1986, the sensible heat became positive in the typhoon system. The heating exchange indicates that heat is transported from ocean to atmosphere, with major contribution of latent heat. When the summer monsoon prevails over the South China Sea and the weather is fine, even SST (sea surface temperature) is high, but sensible heat appears to be negative. The heat exchange indicates that heat is transported from atmosphere to ocean, with major contribution of short-wave radiation absorbed by sea surface and sensible heat. When summer monsoon is over and the northeast monsoon prevails over the South China Sea, the heat ex- change at air-sea interface is very strong. The heat- ing exchange shows that the ocean heats the at- mosphere, with major contribution of latent heat when cold air arrives at the sea surface and the sensible heat rises to positive rapidly. Therefore it can be concluded that the heat exchange at air-sea interface is different from the SST in South China Sea. Whenthe summer monsoon prevails over the South China Sea, the main trend is the ocean responding to the atmosphere.

关键词：南海夏季季风海空热传导观测资料