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Animal Nutrition 2024年第1期16卷 376-394页

作者： Xiaodan Zhang Huiping Xu Lu Gong jiao Wang Jianyang fu Zengpeng Lv Liangjuan Zhou Xuejun Li Qiong Liu Pingyu Xia Yuming Guo State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and Technology China Agricultural University Beijing 100193 China Beijing Strowin Biotechnology Co. Ltd. Beijing 100094 China

This experiment aimed to discuss and reveal the effect and mechanism of mannanase on intestinal inflammation in broilers triggered by a soybean meal diet. In this experiment, 384 Arbor Acres broilers at 1 d old were randomly divided into 3 treatment groups. The broilers were fed a corn-soybean meal basal diet, a low-energy diet (metabolizable energy reduced by 50 kcal/kg), and a low-energy diet supplemented with 100 mg/kg mannanase for 42 d. The low-energy diet increased feed conversion ratio from 0 to 42 d, reduced ileal villus height and villus height-to-crypt depth ratio and upregulated the expression of nuclear factor kappa B ( NF-κB ) in the ileum ( P furthermore, a low-energy diet reduced the relative abundance of Butyricicoccus in the intestine of broilers and inhibited oxidative phosphorylation and phosphoinositol metabolism. Mannanase increased the relative abundance of Odoribacter , promoted energy metabolism and N-glycan biosynthesis, and increased the activities of GH3 and GH18. It is concluded that mannanase could improve the growth performance of broilers by reducing the expression of NF-κB in the

关键词： Broiler Low-energy diet Mannanase Intestinal inflammatory response Intestinal microbiota Metagenome

Single-incision laparoscopic transabdominal preperitoneal repair in the treatment of adult female patients with inguinal hernia

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 49-58页

作者： Xiao-Jun Zhu Jing-Yi jiao Hui-Min Xue Peng Chen Chang-fu Qin Peng Wang Department of General Surgery The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Hernia and Abdominal Wall Surgery Peking University People's HospitalBeijing 100044China

BACKGROUND Women have a 3%lifetime chance of developing an inguinal hernia,which is not as common in *** to its cosmetic benefits,single-incision laparoscopic transabdominal preperitoneal(SIL-TAPP)inguinal hernia repair is becoming in-creasingly popular in the management of inguinal hernia in ***,there are no studies comparing the safety and applicability of SIL-TAPP repair with conventional laparoscopic transabdominal preperitoneal(CL-TAPP)inguinal hernia repair for the treatment of inguinal hernia in *** To compare the outcomes of SIL-TAPP and CL-TAPP repair in adult female patients with inguinal hernia and to estimate the safety and applicability of SIL-TAPP repair in adult female inguinal hernia *** We retrospectively compared the clinical information and follow-up data of fe-male inguinal hernia patients who underwent SIL-TAPP inguinal hernia repair and those who underwent CL-TAPP inguinal hernia repair at the Affiliated Hos-pital of Nantong University from February 2018 to December 2020 and assessed the long-term and short-term outcomes of both *** This study included 123 patients,with 71 undergoing SIL-TAPP repair and 52 un-dergoing CL-TAPP *** two cohorts of patients and inguinal hernia charac-teristics were similar,with no statistically meaningful *** rate of intraoperative inferior epigastric vessel injury was lower in patients in the SIL-TAPP cohort(0,0%)than in patients in the CL-TAPP cohort(4,7.7%)and was significantly different(P<0.05).In addition,the median[interquartile range(IQR)]total hospitalization costs were significantly lower in patients in the SIL-TAPP cohort[$3287(3218-3325)]than in patients in the CL-TAPP cohort[$3511(3491-3599)].Postoperatively,the occurrence rate of trocar site hernia was lower in the SIL-TAPP cohort(0,0%)than in the CL-TAPP cohort(4,7.7%),and the median(IQR)cosmetic score was significantly higher in the SIL-TAPP cohort[10(10-10)]than in the CL-TAPP cohort[9(9

关键词： Single-incision Groin hernia Female Inguinal hernia Laparoscopic transabdominal preperitoneal inguinal hernia repair

Petrogenesis and tectonic implications of the Silurian adakitic granitoids in the eastern segment of the Qilian Orogenic Belt,Northwest China

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Acta Geochimica 2024年第1期43卷 72-86页

作者： jiao-Long Zhao Xiao-Jun Huang Pei-Qing Hu Zhen-Xi Yang Ying Fan Er-Teng Wang fu-Bo Yang Jing-Yu Zhang School of Earth Sciences Key Laboratory of Mineral Resources in Western China(Gansu Province)Lanzhou UniversityLanzhou 730000China Nuclear Industry 247 Brigade Tianjin North China Geological Survey BureauTianjin 301800China Fourth Institute of Geological and Mineral Exploration of Gansu Provincial Bureau of Geology and Mineral Resources Jiuquan 735000China

Geodynamic mechanism responsible for the generation of Silurian granitoids and the tectonic evolution of the Qilian orogenic belt remains controversial. In this study, we report the results of zircon U–Pb age, and systematic whole-rock geochemical data for the Haoquangou and Liujiaxia granitoids within the North Qilian orogenic belt and the Qilian Block, respectively, to constrain their petrogenesis, and the Silurian tectonic evolution of the Qilian orogenic belt. Zircon U–Pb ages indicate that the Haoquangou and Liujiaxia intrusions were emplaced at423 ± 3 Ma and 432 ± 4 Ma, respectively. The Haoquangou granodiorites are calc-alkaline, while the Liujiaxia granites belong to the high-K calc-alkaline *** are peraluminous in composition and have relatively depleted Nd isotopic [ε_(Nd)(t) =(-3.9 – + 0.6)] characteristics compared with regional basement rocks, implying their derivation from a juvenile lower crust. They show adakitic geochemical characteristics and were generated by partial melting of thickened lower continental crust. Postcollisional extensional regime related to lithospheric delamination was the most likely geodynamic mechanism for the generation of the Haoquangou granodiorite, while the Liujiaxia granites were generated in a compressive setting during continental collision between the Qaidam and Qilian blocks.

关键词： Silurian adakitic granitoids Petrogenesis Tectonic setting Qilian Orogenic Belt

Immune Blot Analysis on Expression of the Mammalian Target of Rapamycin in Goat Fetal Fibroblasts with Recombinant Polyclonal Antibody

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Journal of Integrative Agriculture 2012年第6期11卷 1002-1008页

作者： LIANG Yan LI Shu-yu WANG Xiao-jing WU Man-lin YANG jiao-fu LI Jie HAO Xi-yan HAO Hui-fang BA Yin-ma CHEN Xian-wei WANG Zhi-gang College of Life Science lnner Mongolia UniversityHohhot 010021P.R.China

To detect the mammalian target of rapamycin （mTOR） expressed in Cashmere goat fetal fibroblasts （GFb）, mTOR gene was cloned from Inner Mongolia Cashmere goat （Capra hircus） and expressed in Escherichia coli followed by immunizing mice with the purified recombinant protein as an irnmunogen to produce the anti-goat mTOR recombinant polyclonal antibody. Antiserum was collected from the immunized mice after the fifth immunization and its titer was determined with enzyme-linked immunosorbent assay （ELISA）. The results showed that the recombinant polyclonal antibody had a titer 1：200000 and could react with the roTOR expressed in GFb cells with a specific and sensitive affinity. Western blot showed that mTOR expression and phospho-mTOR （Ser 2448） activity were inhibited when GFb cells were treated with CCI-779, an mTOR specific inhibitor.

关键词： prokaryotic expression recombinant antibody goat mTOR CCI-779

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后戏台时期戏曲传播论略

上海大学学报（社会科学版） 2006年第2期13卷 69-77页

作者：焦福民山东大学文学院山东济南250100

20世纪80年代以来,传播学的兴起为戏曲的研究开辟了新的理论视野。新媒体的繁荣发展进一步消解了戏台在戏曲艺术传播过程中的意义,电影戏曲、电视戏曲和网上戏曲为戏曲艺术的传播与接受带来了新的机遇和挑战。通过从传播学角度审视戏曲... 详细信息

20世纪80年代以来,传播学的兴起为戏曲的研究开辟了新的理论视野。新媒体的繁荣发展进一步消解了戏台在戏曲艺术传播过程中的意义,电影戏曲、电视戏曲和网上戏曲为戏曲艺术的传播与接受带来了新的机遇和挑战。通过从传播学角度审视戏曲艺术的属性,分析电影、电视和互联网给戏曲传受带来的新的特点,可以反思戏曲在现代媒体下的生存状况和前景。

关键词：后戏台时期戏曲传播电影戏曲电视戏曲网上戏曲

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WTO与我国政府采购救济制度的完善

甘肃政法学院学报 2006年第1期 32-37页

作者：焦富民南京大学法学院江苏南京210093

在政府采购阶段,由于常常以采购方的单方行为为主导,因而易导致对供应商利益的损害。因此规制在政府采购阶段受到歧视待遇、并被不合理地排除在外的第三人权利救济制度,对于规范政府采购行为,保障采购阶段第三人的合法权益,促进有利于... 详细信息

在政府采购阶段,由于常常以采购方的单方行为为主导,因而易导致对供应商利益的损害。因此规制在政府采购阶段受到歧视待遇、并被不合理地排除在外的第三人权利救济制度,对于规范政府采购行为,保障采购阶段第三人的合法权益,促进有利于贸易自由化的政府采购市场的形成,就显得特别重要。我国《政府采购法》初步构建了政府采购阶段的救济制度,但还存在一些缺陷与不足,因此加强对WTO《政府采购协定》的救济制度的研究,对于进一步完善我国的政府采购救济制度意义十分重大。

关键词：政府采购救济制度供应商权益

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戏曲网站与戏曲的网络资源

兰州大学学报（社会科学版） 2010年第5期38卷 151-157页

作者：焦福民曲阜师范大学文学院山东曲阜273165

互联网络的飞速发展,为信息传播带来了划时代的变革。戏曲网站是运用互联技术建构的关于戏曲和戏曲信息的发布与交流的平台,是网上戏曲资源的集结点。网络兼容了戏曲资源的多种载体形式。网上戏曲文本信息的传播极大地方便了戏曲资料的... 详细信息

互联网络的飞速发展,为信息传播带来了划时代的变革。戏曲网站是运用互联技术建构的关于戏曲和戏曲信息的发布与交流的平台,是网上戏曲资源的集结点。网络兼容了戏曲资源的多种载体形式。网上戏曲文本信息的传播极大地方便了戏曲资料的阅读与研究。网上戏曲的音像传播,体现出网络对于戏曲电影、电视传播等形式强有力的整合作用。网络传播的交互性使得戏曲网民的声音成为网络戏曲资源的新亮点。互联网上的戏曲信息资源,内容广泛,数量巨大,但整体上庞杂无序,良莠不齐。

关键词：戏曲网站网络戏曲戏曲资源互联网

论日本民法典的基本特点——兼及对中国民法典制定的启示

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扬州大学学报（人文社会科学版） 2007年第4期11卷 73-78页

作者：焦富民扬州大学法学院江苏扬州225009

日本民法典对于日本的民族振兴、经济发展和社会进步有着卓越的贡献。作为亚洲第一部民法典,日本民法典制定以移植摄取、注重实效与兼收并蓄为基本指导思想,融合了西方各国民法典的精华,成功地实现了民事法律制度的本土化与国际性、现... 详细信息

日本民法典对于日本的民族振兴、经济发展和社会进步有着卓越的贡献。作为亚洲第一部民法典,日本民法典制定以移植摄取、注重实效与兼收并蓄为基本指导思想,融合了西方各国民法典的精华,成功地实现了民事法律制度的本土化与国际性、现代化和现实性、法典化和融合性的共生和谐。因此,加强对日本民法典基本特点的研析,可以为正在制定中的中国民法典提供科学的思路与深邃的启迪。

关键词：日本民法典基本特点启示

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论文导读:新生儿败血症与川崎病

中国当代儿科杂志 2022年第12期24卷 1313-1314页

作者：焦富勇王琛玥陕西省川崎病诊疗中心/陕西省人民医院儿童病院陕西西安710068

2022年5月16日发表于European Journal of Pediatrics题为“Neonatal sepsis and Kawasaki disease”这篇文章[1]探讨了新生儿败血症与日后川崎病(Kawasaki disease,KD)发病之间的关系,立题创新,对儿科临床工作有较大的指导意义。现对... 详细信息

2022年5月16日发表于European Journal of Pediatrics题为“Neonatal sepsis and Kawasaki disease”这篇文章[1]探讨了新生儿败血症与日后川崎病(Kawasaki disease,KD)发病之间的关系,立题创新,对儿科临床工作有较大的指导意义。现对其进行解读,供儿科同仁参考。

关键词：新生儿败血症川崎病立题之间的关系 European 儿科

Advances in the differentiation of pluripotent stem cells into vascular cells

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World Journal of Stem Cells 2024年第2期16卷 137-150页

作者： Yi-Chang jiao Ying-Xin Wang Wen-Zhu Liu Jing-Wen Xu Yu-Ying Zhao Chuan-Zhu Yan fu-Chen Liu Department of Neurology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Research Institute of Neuromuscular and Neurodegenerative Diseases Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Mitochondrial Medicine Laboratory Qilu Hospital(Qingdao)of Shandong UniversityQingdao 266103Shandong ProvinceChina Brain Science Research Institute Shandong UniversityJinan 250012Shandong ProvinceChina

Blood vessels constitute a closed pipe system distributed throughout the body,transporting blood from the heart to other organs and delivering metabolic waste products back to the lungs and *** in blood vessels are related to many disorders like stroke,myocardial infarction,aneurysm,and diabetes,which are important causes of death *** research for new appro-aches to disease modeling and effective treatment is needed due to the huge socio-economic burden on healthcare *** mice or rats have been widely used,applying data from animal studies to human-specific vascular physiology and pathology is *** rise of induced pluripotent stem cells(iPSCs)provides a reliable in vitro resource for disease modeling,regenerative medicine,and drug discovery because they carry all human genetic information and have the ability to directionally differentiate into any type of human *** review summarizes the latest progress from the establishment of iPSCs,the strategies for differentiating iPSCs into vascular cells,and the in vivo trans-plantation of these vascular *** also introduces the application of these technologies in disease modeling,drug screening,and regenerative ***,the application of high-tech tools,such as omics analysis and high-throughput sequencing,in this field is reviewed.

关键词： Induced pluripotent stem cell Blood vessels Vascular organoids Endothelial cells Smooth muscle cells Pericytes Tissue engineering vascular graft