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Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study

World Journal of Clinical Cases 2024年第14期12卷 2359-2369页

作者： Wei-Ming Xu hai-fu Zhang Yong-Hang Feng Shuo-Jun Li Bi-Yun Xie Department of Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and alcohol-related liver disease(Ar-LD)constitute the primary forms of chronic liver disease,and their incidence is progressively increasing with changes in lifestyle habits.Earlier studies have do-cumented a correlation between the occurrence and development of prevalent mental disorders and fatty liver.AIM To investigate the correlation between fatty liver and mental disorders,thus ne-cessitating the implementation of a mendelian randomization(MR)study to elu-cidate this association.METHODS Data on NAFLD and ArLD were retrieved from the genome-wide association studies catalog,while information on mental disorders,including Alzheimer's disease,schizophrenia,anxiety disorder,attention deficit hyperactivity disorder(ADHD),bipolar disorder,major depressive disorder,multiple personality dis-order,obsessive-compulsive disorder(OCD),post-traumatic stress disorder(PTSD),and schizophrenia was acquired from the psychiatric genomics consor-tium.A two-sample MR method was applied to investigate mediators in signifi-cant associations.RESULTS After excluding weak instrumental variables,a causal relationship was identified between fatty liver disease and the occurrence and development of some psychia-tric disorders.Specifically,the findings indicated that ArLD was associated with a significantly elevated risk of developing ADHD(OR:5.81,95%CI:5.59-6.03,P<0.01),bipolar disorder(OR:5.73,95%CI:5.42-6.05,P=0.03),OCD(OR:6.42,95%CI:5.60-7.36,P<0.01),and PTSD(OR:5.66,95%CI:5.33-6.01,P<0.01).Meanwhile,NAFLD significantly increased the risk of developing bipolar disorder(OR:55.08,95%CI:3.59-845.51,P<0.01),OCD(OR:61.50,95%CI:6.69-565.45,P<0.01),and PTSD(OR:52.09,95%CI:4.24-639.32,P<0.01).CONCLUSION Associations were found between genetic predisposition to fatty liver disease and an increased risk of a broad range of psychiatric disorders,namely bipolar disorder,OCD,and PTSD,highlighting the significance of preven-tive measures against psychiatric disorders in patients with fatty liver

关键词： Non-alcoholic fatty liver disease Alcohol-related liver disease Psychiatric disorders Mendelian randomization Single nucleotide polymorphisms

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Chaiqin Chengqi Decoction as an adjuvant treatment for mild/moderately severe hypertriglyceridemic acute pancreatitis: A retrospective study

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World Journal of Clinical Cases 2024年第11期12卷 1918-1928页

作者： hai-fu Zhang Ze-Xuan Su Yong-Hang Feng Shuo-Jun Li Bi-Yun Xie Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

Hypertriglyceridemia is the third leading cause of acute pancreatitis(AP),and its incidence is increasing.Due to its relatively insidious etiology,it is easy to be ignored in the early stages.In China,Chaiqin Chengqi Decoction(CQCQD)has long been employed for treating AP.AIM To evaluate the effectiveness of CQCQD in patients diagnosed with mild/moderately severe hypertriglyceridemic AP(HTG-AP).METHODS In this study,the clinical data of 39 patients with HTG-AP admitted from January 2019 to November 2022 were collected.The changes of blood lipids,gastrointestinal symptoms,and abdominal pain before and after treatment were analyzed and compared between the two groups.RESULTS Twenty patients were treated with the conventional HTG-AP regimen,and 19 patients were additionally treated with CQCQD.After receiving treatment,the triglycerides(TG)level of the CQCQD group was lower than that of the CQCQD group(3.14±0.25 mmol/L vs 4.96±0.47 mmol/L,Pfunction of most patients returned to normal,and the acute gastrointestinal injury score was significantly lower than that of the control group(0.11±0.07 vs 0.42±0.11,Pfunction.

关键词： Hypertriglyceridemic acute pancreatitis Chinese medicine Chaiqin Chengqi Decoction Serum lipid Triglycerides

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High-performance Si/VO_(2)-nanorod heterojunction photodetector based on photothermoelectric effect for detecting human radiation

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Rare Metals 2024年第3期43卷 1177-1185页

作者： fu-hai Guo Lan-Zhong Hao Wei-Zhuo Yu Si-Qi Li Guan-Chu Liu Jing-Yi Hao Yun-Jie Liu College of Science China University of PetroleumQingdao266580China School of Materials Science and Engineering China University of PetroleumQingdao266580China

As a typical candidate of optoelectronic materials,vanadium dioxide(VO_(2))has wide applications in photodetectors(PDs),but is still challenging in largely enhancing the photodetecting performance for low-power human radiation.Herein,high-performance Si/VO_(2)nanorods(NRs)heterojunction PDs based on the photothermoelectric(PTE)effect are presented.The uniform VO_(2)-NRs array films were deposited on Si by using magnetron sputtering technique,and a Si/VO_(2)heterojunctions were fabricated.The device exhibits a four-stage photoresponse and broadband photoresponse from ultraviolet to long-wavelength infrared.Benefited from the unique nanorods structure and the strong PTE effect,the fabricated device exhibits a large enhancement of the photodetecting performance,showing an ultrahigh photodetectivity of 1.6×10^(13)Jones and ultrafast response rates with a risingedge time of~65.0μs,three orders of magnitude higher than other VO_(2)-based devices.furthermore,the device exhibits unique abilities to detect human radiation even when the human fingers are far away from the device surface up to 10.0 cm.Additionally,the fabricated Si/VO_(2)devices can also be applied as breath sensors to distinguish different breathing patterns.These results supply an effective route to design high-performance photodetectors toward detecting human thermal radiation and respiration.

关键词： Vanadium dioxide Heterojunction Photodetector Photothermoelectric Human radiation and respiration sensing

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Photocatalytic Degradation of Rhodamine B by Recyclable Ag Br/Polypyrrole(PPy)Nano-Catalysts

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Journal of Wuhan University of Technology(Materials Science) 2023年第5期38卷 1198-1204页

作者： YIN Xiaogang LIU Xinyun LI Hang WU Huimin fu hai GONG Wei Key Laboratory of functional Materials Chemistry of Gui Zhou Province School of Chemistry and Materials ScienceGui Zhou Normal UniversityGuiyang 550001China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China

We investigated the removal of the organic dye rhodamine B in wastewater with recyclable AgBr/polypyrrole(PPy)nano-photocatalysts.With PPy as an active base for electron transfer,and hexadecyltrimethylammonium bromide(CTAB)as both the soft-templating agent and the bromine source,a series of AgBr/PPy nano-photocatalysts containing various proportions of silver were prepared in a convenient one-step synthesis procedure.The synthesized catalysts were characterized by TG analysis to reveal that,in comparison with pure PPy,the interaction between PPy and AgBr led to increased thermal stability.Chemical combination of PPy and AgBr was observed through XRD and XPS analyses.For the morphology study,the AgBr particles were found to be well dispersed in the PPy nanowire network from SEM results.In the photodegradation experiments,up to 92%rhodamine B was degraded by the AgBr/PPy catalysts in the period of 1 hour under 254 nm UV light.The catalysts could maintain 60%catalytic efficiency after 3 cycles in the recyclability test.

关键词： polypyrrole AgBr photocatalysts rhodamine B

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基于1D-WCWKCNN的痕量甲烷气体浓度检测

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光谱学与光谱分析 2024年第3期44卷 829-835页

作者：阚玲玲朱富海梁洪卫东北石油大学电气信息工程学院黑龙江大庆163318

可调谐激光吸收光谱(TDLAS)技术在检测甲烷气体浓度过程中,甲烷气体透射光强二次谐波信号幅值与痕量甲烷气体浓度值成正比关系。如何准确和快速筛选目标甲烷透射光强二次谐波信号幅值至关重要。通过光电探测器获取1 000个甲烷气体透射... 详细信息

可调谐激光吸收光谱(TDLAS)技术在检测甲烷气体浓度过程中,甲烷气体透射光强二次谐波信号幅值与痕量甲烷气体浓度值成正比关系。如何准确和快速筛选目标甲烷透射光强二次谐波信号幅值至关重要。通过光电探测器获取1 000个甲烷气体透射光强信号样本,解调该透射光强信号获得二次谐波信号。人工在获得多种痕量甲烷气体透射光强和通过透射光强解调二次谐波信号时,存在噪声和人为操作对二次谐波信号的幅值产生影响,从而造成人工筛选二次谐波信号的时间增加。针对传统TDLAS技术筛选痕量甲烷气体二次谐波信号过程中存在高额时间成本的问题,提出了一种基于宽卷积和宽卷积核一维卷积神经网络(1D-WCWKCNN)的痕量甲烷气体浓度检测方法。首先,借助甲烷气体数据集训练1D-WCWKCNN模型,根据训练结果不断调整模型参数。其次,利用宽卷积层和宽卷积核一维卷积层对痕量甲烷气体二次谐波信号进行特征提取,使网络进行一次卷积后能够获得甲烷气体浓度信号中更长序列以及该序列边界信息与气体浓度之间的特征关系。甲烷透射光强二次谐波信号通过6层卷积层提取该信号与甲烷气体浓度关系的深层特征,然后通过6层最大池化层保留该信号与甲烷气体浓度关系的主要特征,再经过Flatten层将前一层处理的痕量甲烷气体透射光强二次谐波信号数据进行一维化处理。最后,根据训练好的1D-WCWKCNN模型通过Dense层输出痕量甲烷气体浓度。利用基于1D-WCWKCNN的痕量甲烷气体浓度检测模型代替了TDLAS技术中人工花费高额时间成本筛选二次谐波信号进行拟合直线对痕量甲烷气体浓度检测的过程。在实际实验中验证了该方法的有效性,实验结果表明利用该方法能够对50~1 000 mg·L^(-1)的痕量甲烷气体浓度进行有效检测,其准确度达到99.85%,与其他方法相比该方法信号特征提取能力强,检测甲烷气体精度高。该方法有助于气体检测领域中待测气体浓度信号的筛选。

关键词：痕量甲烷气体检测 TDLAS技术宽卷积核一维宽卷积

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Argа-Bilig theory in traditional Mongolian medicine:a theoretical and practical perspective

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History & Philosophy of Medicine 2024年第3期6卷 23-28页

作者： Tegele Si Xue-Mei Bao Ming-hai fu Xiu-Mei Wang Laxinamujila Bai NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine(Mongolian Medicine) School of Mongolian MedicineInner Mongolia Minzu UniversityTongliao 028000China.

The concept of Arga and Bilig serves as a foundational principle in both ancient Mongolian philosophy and traditional Mongolian medicine (TMM). Arga, symbolized by brightness and associated with qualities of fire and activity, complements Bilig, symbolized by darkness and representing attributes of water and stillness. Together, these opposing forces permeate all aspects of existence, from the genesis of parenthood to the interplay of day and night. Understanding Arga-Bilig is crucial for diagnosing and treating diseases, as it illuminates the source of imbalance within the body. This review provides an overview of the significance of Arga-Bilig in Mongolian philosophy and its application in TMM, emphasizing the dynamic interplay of these opposing forces and their role in maintaining balance and harmony within the body.

关键词： traditional Mongolian medicine Arga and Bilig theory holistic dynamic interplay

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硫酸钡在硫酸和硫酸钠溶液中的溶解度

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化学教育（中英文） 2024年第1期45卷 107-110页

作者：傅海章甘肃省酒泉市酒泉中学甘肃酒泉735000

计算BaSO_(4)在H_(2)SO_(4)溶液中的溶解度需要考虑H_(2)SO_(4)的第二步电离;计算BaCO_(3)在Na_(2)CO_(3)溶液中的溶解度需要考虑Na_(2)CO_(3)的水解。用离子活度计算难溶电解质在含有相同离子的强电解质溶液中的溶解度,既考虑了同离子... 详细信息

计算BaSO_(4)在H_(2)SO_(4)溶液中的溶解度需要考虑H_(2)SO_(4)的第二步电离;计算BaCO_(3)在Na_(2)CO_(3)溶液中的溶解度需要考虑Na_(2)CO_(3)的水解。用离子活度计算难溶电解质在含有相同离子的强电解质溶液中的溶解度,既考虑了同离子效应又考虑了盐效应对溶解度的影响,使计算结果更为准确可靠,可避免产生一些错误认识。

关键词：硫酸钡硫酸钠硫酸碳酸钡碳酸钠溶解度

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Rare primary squamous cell carcinoma of the intrahepatic bile duct: A case report and review of literature

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World Journal of Clinical Oncology 2024年第7期15卷 936-944页

作者： Qing-Jun Ma fu-hai Wang Ning-Ning Yang Hong-Long Wei Feng Liu Department of General Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of Respiratory and Critical Care Medicine Shandong Provincial Chest Hospital Affiliated to Shandong UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Cholangiocarcinoma is the most common malignancy of the biliary tree and has a poor prognosis.Adenocarcinoma is the most common pathological type of cho-langiocarcinomas,but rare squamous,adenosquamous,and mucinous variants have been reported without adequate clinical data.CASE SUMMARY This report describes a rare case of primary squamous cell carcinoma(SCC)of the intrahepatic bile duct.The patient was admitted with a tumor in the hepatic caudate lobe with no obvious clinical symptoms.Examination revealed hepatitis B surface antigen positivity,a slight increase in alfa-fetoprotein to 16.34 ng/mL,and an irregular slightly heterogeneous enhancing lesion in the hepatic caudate lobe,which was initially thought to be hepatocellular carcinoma.Laparoscopic re-section was performed,and the final pathology suggested a rare primary SCC of the intrahepatic bile duct.Immunohistochemistry indicated positivity for villin,partial positivity for p63,and negativity for hepatocyte,CK7,CK8,CK19,and CK20.The Ki-67 index was approximately 60%.The patient received six cycles of Tegio chemotherapy.A new lesion was detected in the liver after 15 months.The surgery was performed,and the patient was followed-up at a local hospital.To date,no new lesions have been observed.CONCLUSION Surgery is the first choice for resectable lesions,and combined chemotherapy based on pathology is essential for increasing overall survival.

关键词： Squamous cell carcinoma Bile duct Cholangiocarcinoma Clinical characteristics Treatment Case report

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Ionothermal Synthesis and Characterization of Two Polyoxometalate-based Supramolecules

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Chemical Research in Chinese Universities 2016年第4期32卷 527-529页

作者： GAI Beibei HE Hui ZHAO Yanhui MAO Zhu fu hai School of Chemistry and Life Science Changchun University of Technology Changchun 130012 P. R. China

Two novel 3D supramolecular architectures with hexamolybdate and phosphotungstate anions were syn- thesized under ionothermal conditions. The structures were named as [Cut（L1）2]2L2[Mo6O19]（1） and [Cur（L3）2]2.5· H0.5[PW12O40].H2O（2）（L1=2,2＇-bipyridine, L2=4,4＇-bipyridine, L3=2,2＇-biimidazole） and characterized via Fourier transform infrared spectroscopy（FTIR） and FT-Raman spectroscopy analyses. Single-crystal X-ray diffraction analysis revealed that the two compounds crystallized in the space group P1 and were constructed through hydrogen bonding.

关键词： Ionothermal Polyoxometalate Supramolecule

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“三新”背景下高中政治校本作业优化策略

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当代教研论丛 2024年第3期10卷 39-42页

作者：陈福海福清元洪高级中学福建福清350300

校本作业是教师在课改背景下对传统课堂教学模式的一种补充和延伸,以激发学生学习兴趣为目的,在完成学生自主学习任务的同时,培养学生解决问题的能力,促进学生学科核心素养的提升。然而在实际教学中,有些教师对校本作业认识不足、重视不... 详细信息

校本作业是教师在课改背景下对传统课堂教学模式的一种补充和延伸,以激发学生学习兴趣为目的,在完成学生自主学习任务的同时,培养学生解决问题的能力,促进学生学科核心素养的提升。然而在实际教学中,有些教师对校本作业认识不足、重视不够,在一定程度上影响了校本作业效果。基于此,文章从高中政治校本作业现状出发,提出具体优化策略,以期为广大政治教师提供参考。

关键词： “三新”背景高中政治校本作业优化策略

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