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Optimization-based particle filter for state and parameter estimation

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Journal of Systems Engineering and Electronics 2009年第3期20卷 479-484页

作者： Li fu Qi fei Shi Guangming Zhang Li School of Electronic Engineering Xidian Univ. Xi'an 710071 P. R. China

In recent years, the theory of particle filter has been developed and widely used for state and parameter estimation in nonlinear/non-Gaussian systems. Choosing good importance density is a critical issue in particle filter design. In order to improve the approximation of posterior distribution, this paper provides an optimization-based algorithm （the steepest descent method） to generate the proposal distribution and then sample particles from the distribution. This algorithm is applied in 1-D case, and the simulation results show that the proposed particle filter performs better than the extended Kalman filter （EKF）, the standard particle filter （PF）, the extended Kalman particle filter （PF-EKF） and the unscented particle filter （UPF） both in efficiency and in estimation precision.

关键词： importance density particle filter extend Kalman filter

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贾玫教授从痰论治肿瘤相关性失眠经验

世界中西医结合杂志 2024年第7期19卷 1326-1329页

作者：崔鑫玮黄雯霞付韵霏王一珺贾玫北京中医药大学东直门医院血液肿瘤科北京100700

肿瘤相关性失眠(Cancer related insomnia,CRI)是肿瘤诊治过程中出现的睡眠障碍,发病率明显高于正常人群,约52.6%~67.4%,严重影响患者生活质量。贾玫教授长期从事抗肿瘤及其相关并发症的治疗,从痰论治CRI取得了良好的临床效果,认为“痰... 详细信息

肿瘤相关性失眠(Cancer related insomnia,CRI)是肿瘤诊治过程中出现的睡眠障碍,发病率明显高于正常人群,约52.6%~67.4%,严重影响患者生活质量。贾玫教授长期从事抗肿瘤及其相关并发症的治疗,从痰论治CRI取得了良好的临床效果,认为“痰阻气血水三道”为其基本病因,“痰阻气滞伤肝”“痰阻血瘀伤心”“痰阻水泛伤肾”为其核心病机。以疏肝、养心、温肾并重为治则,使气机、血脉、水道并调,痰浊得化,睡眠自安,为临床诊治CRI提供新思路。

关键词：贾玫肿瘤相关性失眠痰浊名医经验

Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis

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Journal of Pharmaceutical Analysis 2024年第2期14卷 259-275页

作者： Xue Bai Rongzhan fu Yannan Liu Jianjun Deng Qiang fei Zhiguang Duan Chenhui Zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi'an710069China Biotech&Biomed Research Institute Northwest UniversityXi'an710069China School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an710069China

The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer(CRC).However,the effect of ginsenoside Rk3(Rk3)on CRC and gut microbiota remains ***,the purpose of this study is to explore the potential effect of Rk3 on CRC from the perspective of gut microbiota and immune *** results reveal that treatment with Rk3 significantly suppresses the formation of colon tumors,repairs intestinal barrier damage,and regulates the gut microbiota imbalance caused by CRC,including enrichment of probiotics such as Akkermansia muciniphila and Barnesiella intestinihominis,and clearance of pathogenic *** metabolomics data demonstrate that Rk3 can modulate the metabolism of amino acids and bile acids,particularly by upregulating glutamine,which has the potential to regulate the immune ***,we elucidate the regulatory effects of Rk3 on chemokines and inflammatory factors associated with group 3 innate lymphoid cells(ILC3s)and T helper 17(Th17)signaling pathways,which inhibits the hyperactivation of the Janus kinase-signal transducer and activator of transcription 3(JAK-STAT3)signaling *** results indicate that Rk3 modulates gut microbiota,regulates ILC3s immune response,and inhibits the JAK-STAT3 signaling pathway to suppress the development of colon *** importantly,the results of fecal microbiota transplantation suggest that the inhibitory effect of Rk3 on colon tumors and its regulation of ILC3 immune responses are mediated by the gut *** summary,these findings emphasize that Rk3 can be utilized as a regulator of the gut microbiota for the prevention and treatment of CRC.

关键词： Colorectal cancer Ginsenoside Immune cells Gut microbiota

Nanocomposite: Keggin-type Co_(4)-polyoxometalate@cobaltporphyrin linked graphdiyne for hydrogen evolution in seawater

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Nano Research 2024年第3期17卷 1281-1287页

作者： Jiejie Ping Danyang He fei Wang Nan Wang Yi-cheng fu Zihao Xing Zhiyu Jia Guo-Yu Yang Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Facluty of Chmeistry Northeast Normal UniversityChangchun 130024China Peking University Third Hospital Beijing 100190China

Polyoxometalate-based nanocomposites with electrocatalytic activity have been applied in hydrogen evolution reactions(HER).Seawater as the main water resource on the earth should be developed as the water electrolysis to prepare high-purity *** this paper,we used two synthesis strategies to prepare the nanocomposite Co_(4)-POM@Co-PGDY(Co_(4)-POM:the Kegging-type microcrystals of K_(10)[Co_(4)(PW_(9)O_(3)4)2]and Co-PGDY:cobalt-porphyrin linked graphdiyne)with excellent activity for ***-PGDY as the porous material is applied not only as the protection of microcrystals towards the metal ion in seawater but also as the co-electrocatalyst of Co_(4)-***_(4)-POM@Co-PGDY exhibits excellent HER performance in seawater electrolytes with low overpotential and high stability at high ***,we have observed a key H_(3)O+intermediate emergence on the surface of nanocomposite during hydrogen evolution process in seawater by Raman synchrotron radiation-based Fourier transform infrared(SR-FTIR).The results in this paper provide an effective strategy for preparing polyoxometalate-based electrocatalysts with high-performance toward hydrogen evolution reaction.

关键词： polyoxometalate graphdiyne seawater hydrogen evolution reaction

An Effective Approach for the Preparation of High Performance Thermal Conductive Polymer Composites Containing Liquid Metal

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Chinese Journal of Polymer Science 2024年第7期42卷 992-1001,I0010页

作者： Xin Chen Xue-Zhong Zhang Yi-fei Yuan Chuan-Liang Chen Lian-Hu Xiong Qiang fu Hua Deng College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China Department of Materials Science and Engineering Sichuan University-Pittsburgh InstituteSichuan UniversityChengdu610065China

The preparation of high-performance thermal conductive composites containing liquid metals(LM)has attracted significant ***,the stable dispersion of LM within polymer solution and effective property contribution of liquid metals remains significant challenges that need to be *** by the properties of the dendritic structure of the tree root system in grasping the soil,“shear-induced precipitation-interfacial reset-reprotonation”processing strategy is proposed to prepare nanocomposites based on aramid micron fibers(AMFs)with hierarchical dendritic *** to the combination of van der Waals force provided by hierarchical dendritic structure,electrostatic interaction between AMFs and LM,coordinative bonding of―NH to LM,together with interfacial re-setting and multi-step protonation,several features can be achieved through such strategy:conducive to the local filler network construction,improvement of interfacial interaction,improvement of the stability of filler dispersion in the solvent,and enhancement of mechanical and thermal properties of the *** resulting AMFsp H=4/LM films demonstrate a thermal conductivity of 10.98 W·m^(-1)·K^(-1)at 70%filler content,improvement of 126.8%compared to ANFs/LM film;while maintaining a strength of~85.88 MPa,improvement of 77%compared to AMFs/LM *** also possess insulation properties,enable heat dissipation for high power *** work provides an effective strategy for the preparation of high performance polymer composites containing liquid metal.

关键词： Shear-induced Reprotonation AMFs LM Filler dispersion

Application of tissue engineering in the treatment of stress urinary incontinence

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Chinese Medical Journal 2009年第5期122卷 571-576页

作者： SONG Xiao-fei fu Qiang XU Yue-min Department of Urology Shanghai Sixth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200233 China

Stress urinary incontinence is one of the most common diseases in urology. The main treatments for stress urinary incontinence are pharmacotherapy, physicobehavioral therapy and ***, the results of present methods are not satisfactory. Tissue engineering is a newly emerging technology that may provide a novel method for the treatment of stress urinary incontinence.

关键词： stress urinary incontinence tissue engineering muscle-derived stem cells adipose-derived stem cells myoblast fibroblast

Preparation of Fe-As alloys by mechanical alloying and vacuum hot-pressed sintering:microstructure evolution,mechanical properties,and mechanisms

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Rare Metals 2024年第8期43卷 3876-3892页

作者： fei Chai fei-Ping Zhao Zhan Hu Shi-Yi Wen Ben-Hammouda Samia Ze-Lin fu Xin-Ting Lai Yan-Jie Liang Xiao-Bo Min Li-Yuan Chai School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control&Treatment of Heavy Metal Pollution Institute of Environmental EngineeringCentral South UniversityChangsha 410083HunanChin State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Department of Building Civiland Environmental EngineeringConcordia UniversityMontreal H3G 1M8Canada

Arsenic materials have attracted great attention due to their unique ***,research concerning iron-arsenic(Fe-As) alloys is very scarce due to the volatility of As at low temperature and the high melting point of ***,a new Fe-As alloy was obtained by mechanical alloying(MA) followed by vacuum hot-pressed sintering(VHPS).Moreover,a systematic study was carried out on the microstructural evolution,phase composition,leaching toxicity of As,and physical and mechanical properties of Fe-As alloys with varying weight fractions of As(20%,25%,30%,35%,45%,55%,65%,and 75%).The results showed that pre-alloyed metallic powders(PAMPs) have a fine grain size and specific supersaturated solid solution after MA,which could effectively improve the mechanical properties of Fe-As alloys by VHPS.A high density(> 7.350 g·cm^(-3)),low toxicity,and excellent mechanical properties could be obtained for FeAs alloys sintered via VHPS by adding an appropriate amount of As,which is more valuable than commercial Fe-As *** Fe-25% As alloy with low toxicity and a relatively high density(7.635 g·cm^(-3)) provides an ultra-high compressive strength(1989.19 MPa),while the Fe-65% As alloy owns the maximum Vickers hardness(HVo.5 899.41).After leaching by the toxicity characteristic leaching procedure(TCLP),these alloys could still maintain good mechanical performance,and the strengthening mechanisms of Fe-As alloys before and after leaching were *** in the grain size,micro structure,and phase distribution induced significant differences in the compressive strength and hardness.

关键词： Mechanical alloying Vacuum hot-pressed sintering High-pressure Arsenic-iron alloys Mechanical properties

医学专科生孤独感、应对方式和社会支持现状及其关系研究

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黔南民族医专学报 2024年第1期37卷 72-76页

作者：华灿城付丹菲周洪丽龙海燕苏娟余跃生黔南民族医学高等专科学校贵州都匀558013

目的:了解医学专科生孤独感、应对方式和社会支持现状及其关系,为开展心理健康教育、心理疏导提供理论依据。方法:在知情的情况下,采用UCLA孤独量表、应对方式问卷和社会支持评定量表对贵州某医高专1430名学生进行问卷调查;采用t检验、... 详细信息

目的:了解医学专科生孤独感、应对方式和社会支持现状及其关系,为开展心理健康教育、心理疏导提供理论依据。方法:在知情的情况下,采用UCLA孤独量表、应对方式问卷和社会支持评定量表对贵州某医高专1430名学生进行问卷调查;采用t检验、χ^(2)检验和多元逐步回归分析对调查数据进行统计学处理。结果:医学专科生孤独感总分为(44.303±7.805),低、中、高度孤独感所占比例分别为27.06%、69.93%和3.01%;孤独感存在性别和年级差异(P<0.01);孤独感与解决问题、求助和社会支持各维度呈负相关(P<0.01),与自责、幻想、退避和合理化呈正相关(P<0.01);多元逐步回归分析结果显示:自责、求助、退避、社会支持以及性别、家庭人均收入、善于交际、专业兴趣、环境适应程度和远离父母等是影响孤独感的主要因素(P<0.05或P<0.01)。结论:医学专科生的孤独感处于中等水平,家庭、学校和社会应给予更多的社会支持,引导其积极应对生活事件,消除孤独情绪体验。

关键词：孤独感应对方式社会支持影响因素多元逐步回归分析医学专科生

Fine-tuning growth in gold nanostructures from achiral 2D to chiral 3D geometries

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Nano Research 2024年第7期17卷 6654-6660页

作者： Lili Tan Zhi Chen Chengyu Xiao Zhiyong Geng Yinran Jin Chaoyang Wei fei Teng Wenlong fu Peng-peng Wang State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Enriching the library of chiral plasmonic structures is of significant importance in advancing their applicability across diverse domains such as biosensing,nanophotonics,and ***,employing triangle nanoplates as growth seeds,we synthesized a novel class of chiral-shaped plasmonic nanostructures through a wet chemical strategy with dipeptide as chiral inducers,including chiral tri-blade boomerangs,concave rhombic dodecahedrons,and *** structural diversity in chiral plasmonic nanostructures was elucidated through their continuous morphological evolution from two-dimensional to threedimensional *** fine-tuning of chiroptical properties was achieved by precisely manipulating crucial synthetic parameters such as the amount of chiral molecules,seeds,and gold precursor that significantly influenced chiral structure *** findings provide a promising avenue for enriching chiral materials with highly sophisticated structures,facilitating a fundamental understanding of the relationship between structural nuances and chiroptical properties.

关键词： plasmonic nanostructures geometric chirality circular dichroism fine-tuning