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A novel clinical artificial intelligence model for disease detection via retinal imaging

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The Innovation 2024年第2期5卷 11-12页

作者： Yidian fu Liang Ma Sheng Wan Shengfang Ge zhi Yang department of Ophthalmology Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011China PCA Lab Key Lab of Intelligent Perception and Systems for High-Dimensional Information of Ministry of EducationNanjing 210000China Jiangsu Key Lab of Image and Video Understanding for Social Security School of Computer Science and EngineeringNanjing University of Science and TechnologyNanjing 210000China

Artificial intelligence(AI)is an emerging field in which computerized systems are used to carry out complex tasks in place of *** AI algorithms have been developed for disease diagnosis and prediction and treatment recommendation across various clinical data types,e.g.,chest X-rays,electrocardiograms,and other radiological images.1 In ophthalmology,particularly,great progress has been made in AI systems over the past *** fundus photography(CFP)and optical coherence tomography(OCT),which are readily available in routine clinical practice,are both mainstream and useful retinal imaging modalities in *** September 2023,the 2023 Lasker-debakey Clinical Medical Research Award was awarded to three scientists for their work on OCT for accurate retinal disease detection.

关键词： clinical routine diagnosis

Durable K-ion batteries with 100% capacity retention up to 40,000 cycles

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Carbon Energy 2024年第5期6卷 201-212页

作者： Xianlu Lu Zhao Liang zhi Fang Dongdong Zhang Yapeng Zheng Qiao Liu Dingfa fu Jie Teng Weiyou Yang Institute of Micro/Nano Materials and devices Ningbo University of TechnologyNingboZhejiangChina College of Materials Science and Engineering Hunan UniversityChangshaChina College of Mechanical and Vehicle Engineering Hunan UniversityChangshaChina

Currently,the major challenge in terms of research on K-ion batteries is to ensure that they possess satisfactory cycle stability and specific capacity,especially in terms of the intrinsically sluggish kinetics induced by the large radius of K+***,we explore high-performance K-ion half/full batteries with high rate capability,high specific capacity,and extremely durable cycle stability based on carbon nanosheets with tailored N dopants,which can alleviate the change of volume,increase electronic conductivity,and enhance the K+ion *** as-assembled K-ion half-batteries show an excellent rate capability of 468 mA h g^(−1) at 100 mA g^(−1),which is superior to those of most carbon materials reported to ***,the as-assembled half-cells have an outstanding life span,running 40,000 cycles over 8 months with a specific capacity retention of 100%at a high current density of 2000 mA g^(−1),and the target full cells deliver a high reversible specific capacity of 146 mA h g^(−1) after 2000 cycles over 2 months,with a specific capacity retention of 113%at a high current density of 500 mA g^(−1),both of which are state of the art in the field of K-ion *** study might provide some insights into and potential avenues for exploration of advanced K-ion batteries with durable stability for practical applications.

关键词： carbon nanosheet cycle stability K-ion batteries rate performance specific capacity

In-situ synthesis of quantum dots in the nucleus of live cells

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National Science Review 2024年第3期11卷 172-182页

作者： Yusi Hu zhi-Gang Wang Haohao fu Chuanzheng Zhou Wensheng Cai Xueguang Shao Shu-Lin Liu Dai-Wen Pang State Key Laboratory of Medicinal Chemical Biology Frontiers Science Centre for New Organic MatterTianjin Key Laboratory of Biosensing and Molecular Recognition Research Centre for Analytical Sciences College of Chemistry School of Medicine and Frontiers Science Centre for Cell Responses Nankai University Haihe Laboratory of Sustainable Chemical Transformations

The cell nucleus is the main site for the storage and replication of genetic material, and the synthesis of substances in the nucleus is rhythmic, regular and strictly regulated by physiological processes. However,whether exogenous substances, such as nanoparticles, can be synthesized in situ in the nucleus of live cells has not been reported. Here, we have achieved in-situ synthesis of CdSxSe1-xquantum dots（QDs） in the nucleus by regulation of the glutathione（GSH） metabolic pathway. High enrichment of GSH in the nucleus can be accomplished by the addition of GSH with the help of the Bcl-2 protein. Then, high-valence Se is reduced to low-valence Se by glutathione-reductase-catalyzed GSH, and interacts with the Cd precursor formed through Cd and thiol-rich proteins, eventually generating QDs in the nucleus. Our work contributes to a new understanding of the syntheses of substances in the cell nucleus and will pave the way for the development of advanced ‘supercells’.

关键词： glutathione live cell nucleus quantum dot intracellular synthesis

Fine-tuning growth in gold nanostructures from achiral 2D to chiral 3D geometries

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Nano Research 2024年第7期17卷 6654-6660页

作者： Lili Tan zhi Chen Chengyu Xiao zhiyong Geng Yinran Jin Chaoyang Wei Fei Teng Wenlong fu Peng-peng Wang State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Enriching the library of chiral plasmonic structures is of significant importance in advancing their applicability across diverse domains such as biosensing,nanophotonics,and ***,employing triangle nanoplates as growth seeds,we synthesized a novel class of chiral-shaped plasmonic nanostructures through a wet chemical strategy with dipeptide as chiral inducers,including chiral tri-blade boomerangs,concave rhombic dodecahedrons,and *** structural diversity in chiral plasmonic nanostructures was elucidated through their continuous morphological evolution from two-dimensional to threedimensional *** fine-tuning of chiroptical properties was achieved by precisely manipulating crucial synthetic parameters such as the amount of chiral molecules,seeds,and gold precursor that significantly influenced chiral structure *** findings provide a promising avenue for enriching chiral materials with highly sophisticated structures,facilitating a fundamental understanding of the relationship between structural nuances and chiroptical properties.

关键词： plasmonic nanostructures geometric chirality circular dichroism fine-tuning

Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients:An Open-Label,Multicenter,and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第8期30卷 675-683页

作者： HE Qiu LIN fu-xin SU Jin-ye ZHUO Ling-yun ZHU Qing SUN Xiao-chuan JIANG Rong-cai YAO zhi-gang WANG Lei DANG Yan-wei LIU de-zhong LIU Yang FANG Wen-hua WANG Fang-yu LIN Yuan-xiang WANG An-xin WANG deng-liang KANG de-zhi department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou350209China Clinical Research and Translation Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China fujian Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China department of Neurosurgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province215000China department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400000China department of Neurosurgery Tianjin Medical University General HospitalTianjin300000China department of Neurosurgery The Third Hospital of ShijiazhuangShijiazhuang050000China department of Neurosurgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangHubei Province443000China department of Neurosurgery Yichang Central People’s HospitalYichangHubei Province443000China department of Neurosurgery Xiangyang No.1 People’s Hospital Affiliated to Hubei University of MedicineXiangfanHubei Province441100China department of Neurosurgery Zhoukou Central HospitalZhoukouHenan Province466000China department of Neurosurgery The Third Hospital of MianyangMianyangSichuan Province621000China department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijing100000China Beijing Municipal Key Laboratory of Clinical

Objective: To investigate whether Naoxueshu Oral Liquid(NXS) could promote hematoma absorption in post-craniotomy hematoma(PCH) patients. Methods: This is an open-label, multicenter, and randomized controlled trial conducted at 9 hospitals in China. Patients aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL, or intraventricular hemorrhage following cranial surgery were enrolled. They were randomly assigned at a 1:1 ratio to the NXS(10 m L thrice daily for 15 days) or control groups using a randomization code table. Standard medical care was administered in both groups. The primary outcome was the percentage reduction in hematoma volume from day 1 to day 15. The secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7, the absolute reduction in hematoma volume from day 1 to day 7 and 15, and the change in neurological function from day 1 to day 7 and 15. The safety was closely monitored throughout the study. Moreover, subgroup analysis was performed based on age, gender, history of diabetes, and etiology of intracerebral hemorrhage(ICH). Results: A total of 120 patients were enrolled and randomly assigned between March 30, 2018 and April 15, 2020. One patient was lost to follow-up in the control group. Finally, there were 119 patients(60 in the NXS group and 59 in the control group) included in the analysis. In the full analysis set(FAS) analysis, the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group [median(Q1, Q3): 85%(71%, 97%) vs. 76%(53%, 93%), P0.05). furthermore, no adverse events were reported during the study. In the FAS analysis, the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups:

关键词： post-craniotomy hematoma Naoxueshu Oral Liquid hematoma absorption randomized controlled trial Chinese medicine

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A Remark on the Affine Coordinates for KdV Tau-functions

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Chinese Quarterly Journal of Mathematics 2024年第3期39卷 324-330页

作者： fu zhi-peng University of Science and Technology of China Hefei 230026China

We give a proof of an explicit formula for affine coodinates of points in the Sato’s infinite Grassmannian corresponding to tau-functions for the KdV hierarchy.

关键词： Sato’s infinite Grassmannian KdV hierarchy Affine coordinates

湖南省南岳原生性森林群落的研究——Ⅴ.物种多样性与相对多度分布格局

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中南林学院学报 2005年第6期25卷 17-23页

作者：左家哺傅德志彭代文湖南环境生物学院湖南衡阳421005 中国科学院植物研究所北京香山100093

对湖南省南岳原生性森林群落植物物种进行了研究.结果表明,其多样性水平比较高,接近山地季雨林的水平,其中,群落草本层的多样性水平最低,乔木层和灌木层的较高.在5种不同的原生性森林群落类型中,乔木层和草本层的物种多样性以类型3(包石... 详细信息

对湖南省南岳原生性森林群落植物物种进行了研究.结果表明,其多样性水平比较高,接近山地季雨林的水平,其中,群落草本层的多样性水平最低,乔木层和灌木层的较高.在5种不同的原生性森林群落类型中,乔木层和草本层的物种多样性以类型3(包石栎+锐齿槲栎+甜槠+多脉青冈-箬竹-求米草群丛)的最高, 以类型4(甜槠-花竹+云和新木姜子-淡竹叶+莎草群丛)的最低;灌木层物种多样性以类型3(包石栎+锐齿槲栎+甜槠+多脉青冈-箬竹-求米草群丛)的最高, 类型2(长叶石栎+多脉青冈-尾叶山茶-求米草群丛)的最低.植物物种相对多度分布格局的测定结果表明,分割线段模型中的序列-多度模型适宜于拟合乔木层物种与其个体数量之间的关系,对数级数分布模型适宜于拟合乔木层和灌木层;其α指数值较高,说明群落物种多样性水平较高,接近山地季雨林.分析表明, 测定群落植物物种多样性时, 如果仅用1～2个公式计算, 可能会出现错误的结果;此外, 提出了几何级数分布模型--极大值算法.

关键词：林学森林群落物种多样性物种相对多度分布格局几何级数分布极大值法南岳

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Near-infrared non-fused electron acceptors for efficient organic photovoltaics

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Chinese Chemical Letters 2024年第4期35卷 436-441页

作者： Wenxiang Ma Xinyu He Tianyi Chen de-Li Ma Hongzheng Chen Chang-zhi Li State Key Laboratory of Silicon and Advanced Semiconductor Materials Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

developing narrow-bandgap organic semiconductors is important to facilitate the advancement of organic photovoltaics(OPVs). Herein, two near-infrared non-fused ring acceptors(NIR NFRAs), PTBFTT-F and PTBFTT-Cl have been developed with A-π_A-π_D-D-π_D-π_A-A non-fused structures. It is revealed that the introduction of electron deficient π-bridge(π_A) and multiple intramolecular noncovalent interactions effectively retained the structural planarity and intramolecular charge transfer of NFRAs, extending strong NIR photon absorption up to 950 nm. further, the chlorinated acceptor, with the enlarged π-surface compared to the fluorinated counterpart, promoted not only molecular stacking in solid, but also the desirable photochemical stability in ambient, which are helpful to thereby improve the exciton and charge dynamics for the corresponding OPVs. Overall, this work provides valuable insights into the design of NIR organic semiconductors.

关键词： Organic photovoltaic Near-infrared Non-fused electron acceptor Noncovalent interaction Stability

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Casual associations between blood metabolites and colon cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1995-2005页

作者： Ke-Yue Hu Yi-Quan Cheng zhi-Long Shi fu-Peng Ren Gang-Feng Xiao department of Hematology and Oncology Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal *** To investigate causal associations between blood metabolites and colon *** The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal *** primary method of analysis used was the inverse variance weighted *** further validate the results several sensitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile *** additional analyses were conducted to ensure the reliability and robustness of the *** After rigorous selection for genetic variation,486 blood metabolites were included in the MR *** found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],N-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyrosine[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],N-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],Succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of sensitivity analyses were performed to confirm the rigidity of the *** This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk *** other five blood metabolites are protective factors.

关键词： Metabolites Colon cancer Mendelian randomization Genome-wide association studies Casual