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Biological Evaluation of Lysionotin:a Novel Inhibitor of 5-Lipoxygenase for Anti-glioma

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Chinese Journal of Integrative Medicine 2024年第9期30卷 826-834页

作者： SHAO Xin-xin CHEN Cong LIU Jie LI Qing-jun HE Shan QI Xiang-hua fu Xian-jun WANG zhen-guo The First Clinical College of Medicine Shandong University of Traditional Chinese MedicineJinan250355China Institute for Literature and Culture of Chinese Medicine Shandong University of Traditional Chinese MedicineJinan250355China Key Laboratory of Classical Theory of Traditional Chinese Medicine Ministry of EducationShandong University of Traditional Chinese MedicineJinan250355China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China Experimental Center Shandong University of Traditional Chinese MedicineJinan250355China Neurology Department Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan250014China Marine Traditional Chinese Medicine Research Center Qingdao Academy of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineQingdao266114Shandong ProvinceChina

Objective:To explore the potential mechanism of lysionotin in treating ***:First,target prediction based on Bernoulli Naïve Bayes profiling and pathway enrichment was used to predict the biological activity of *** binding between 5-lipoxygenase(5-LO)and lysionotin was detected by surface plasmon resonance(SPR)and molecular docking,and the inhibitory effects of lysionotin on 5-LO and proliferation of glioma were determined using enzyme inhibition assay in vitro and cell viability analysis,***,the pharmaceutical effect of lysionotin was explored by cell survival rate analysis and liquid chromatography with tandem mass spectrometry(LC-MS/MS).The protein expression,intracellular calcium ion concentration and cytoskeleton detection were revealed by Western blot,flow cytometry and fluorescence labeling,***:Target prediction and pathway enrichment revealed that lysionotin inhibited 5-LO,a key enzyme involved in the arachidonic acid metabolism pathway,to inhibit the proliferation of *** docking results demonstrated that 5-LO can be binding to lysionotin through hydrogen bonds,forming bonds with His600,Gln557,Asn554,and *** analysis further confirmed the interaction between 5-LO and ***,enzyme inhibition assay in vitro and cell survival rate analysis revealed that 50%inhibition concentration of lysionotin and the median effective concentration of lysionotin were 90 and 16.58µmol/L,respectively,and the results of LC-MS/MS showed that lysionotin inhibited the production of 5S-hydroperoxy-eicosatetraenoic acid(P<0.05),and moreover,the LC-MS/MS results indicated that lysionotin can enter glioma cells well(P<0.01)and inhibit their *** blot analysis demonstrated that lysionotin can inhibit the expression of 5-LO(P<0.05)and downstream leukotriene B4 receptor(P<0.01).In addition,the results showed that lysionotin affected intracellular calcium ion concentration by inh

关键词： 5-lipoxygenase inhibitor lysionotin 5-lipoxygenase leukotriene B4 calcium ion cytoskeleton

Mitogenome-based phylogeny of mosquitoes(Diptera:Culicidae)

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Insect Science 2024年第2期31卷 599-612页

作者： De-Hong Chen Shu-Lin He Wen-Bo fu zhen-Tian Yan Yun-Jian Hu Huan Yuan Ming-Bin Wang Bin Chen Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyChongqing Normal UniversityChongqingChina

Mosquitoes are of great medical significance as vectors of many deadly *** have been widely used in phylogenetic studies,but mitogenome knowledge within the family Culicidae is limited,and Culicidae phylogeny is far from *** this study,we surveyed the mitogenomes of 149 Culicidae species,including 7 newly sequenced *** analysis of 149 mosquito mitogenomes shows gene composition and order to be identical to that of an ancestral insect,and the AT bias,length variation,and codon usage are all consistent with that of other reported Dipteran *** analyses based on the DNA sequences of the 13 protein-coding genes from the 149 species robustly support the monophyly of the subfamily Anophelinae and the tribes Aedini,Culicini,Mansonini,Sabethini,and *** resolve ambiguous relationships between clades within the subfamily Culicinae,we performed topological tests and show that Aedini is a sister to Culicini and that Uranotaenini is a sister to(Mansonini)+(Toxorhynchitini+Sabethini).In addition,we estimated divergence times using a Bayesian relaxation clock based on the sequence data and 3 fossil calibration *** results show mosquitoes diverged during the Early Jurassic with massive Culicinae radiations during the Cretaceous,coincident with the emergence of angiosperms and the burst of mammals and ***,this study,which uses the largest number of Culicidae mitogenomes sequenced to date,comprehensively reveals the mitogenome characteristics and mitogenome-based phylogeny and divergence times of Culicidae,providing information for further studies on the mitogenome,phylogeny,evolution,and taxonomic revision of Culicidae.

关键词： characterization Culicidae evolution mitogenomes mosquitoes phylogeny

A Trade-off between Solvation and Collision Activation in Steering Competing E2 and S_(N)2 Dynamics

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Precision Chemistry 2024年第1期2卷 40-48页

作者： Hongyi Wang Xu Liu Siwei Zhao Gang fu Wenqing zhen Li Yang Jiaxu Zhang State Key Laboratory of Urban Water Resource and Environment MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and StorageSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001P.R.China College of Chemistry Liaoning UniversityShenyang 110036P.R.China

The prototypical E2 elimination and SN2 sub-stitution reactions between microsolvated fluoride and ethyl bromide show unexpected dynamic behaviors in mechanistic evolution driven by solvation and collision *** the steric effects,the gas-phase selectivity favors an E2 pathway barely dependent on collision ***,base solvation steers the reaction in an effective way toward substitution at a near-thermal energy,whereas the governing high-energy events retain *** dynamics simulations reproduce exper-imental findings and uncover a crucial solute-solvent coupling in determining such competing ***,collision activation can tune the underlying atomistic dynamics essentially in the reactant entrance channel and cause a mechanism *** features for the ubiquitous competing E2/SN2 dynamics remain quite unknown,providing unique insight into reaction selectivity for complex chemical networks.

关键词： E2/S_(N)2 Competition Atomistic Dynamics Reaction Mechanisms Microsolvation Collision Activation

Petrogenesis and tectonic implications of the Silurian adakitic granitoids in the eastern segment of the Qilian Orogenic Belt,Northwest China

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Acta Geochimica 2024年第1期43卷 72-86页

作者： Jiao-Long Zhao Xiao-Jun Huang Pei-Qing Hu zhen-Xi Yang Ying Fan Er-Teng Wang fu-Bo Yang Jing-Yu Zhang School of Earth Sciences Key Laboratory of Mineral Resources in Western China(Gansu Province)Lanzhou UniversityLanzhou 730000China Nuclear Industry 247 Brigade Tianjin North China Geological Survey BureauTianjin 301800China Fourth Institute of Geological and Mineral Exploration of Gansu Provincial Bureau of Geology and Mineral Resources Jiuquan 735000China

Geodynamic mechanism responsible for the generation of Silurian granitoids and the tectonic evolution of the Qilian orogenic belt remains controversial. In this study, we report the results of zircon U–Pb age, and systematic whole-rock geochemical data for the Haoquangou and Liujiaxia granitoids within the North Qilian orogenic belt and the Qilian Block, respectively, to constrain their petrogenesis, and the Silurian tectonic evolution of the Qilian orogenic belt. Zircon U–Pb ages indicate that the Haoquangou and Liujiaxia intrusions were emplaced at423 ± 3 Ma and 432 ± 4 Ma, respectively. The Haoquangou granodiorites are calc-alkaline, while the Liujiaxia granites belong to the high-K calc-alkaline *** are peraluminous in composition and have relatively depleted Nd isotopic [ε_(Nd)(t) =(-3.9 – + 0.6)] characteristics compared with regional basement rocks, implying their derivation from a juvenile lower crust. They show adakitic geochemical characteristics and were generated by partial melting of thickened lower continental crust. Postcollisional extensional regime related to lithospheric delamination was the most likely geodynamic mechanism for the generation of the Haoquangou granodiorite, while the Liujiaxia granites were generated in a compressive setting during continental collision between the Qaidam and Qilian blocks.

关键词： Silurian adakitic granitoids Petrogenesis Tectonic setting Qilian Orogenic Belt

CPL-active hybrid copper(Ⅰ)halides enabled by cation inclusion with chiral crown-ether

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Science China Chemistry 2024年第10期67卷 3283-3290页

作者： Peng Fan Li-Xuan Cai Xiao-Fang Duan Fan Yin Chen-Chen Li Zhong-Hua Deng Xiao-zhen Li Qing-fu Sun College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Strait Institute of Flexible Electronics(future Technologies) Fujian Key Laboratory of Flexible ElectronicsFujian Normal University and Strait Laboratory of Flexible ElectronicsFuzhou 350117China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China fujian College University of Chinese Academy of SciencesFuzhou 350002China

Chiral hybrid metal halides with high photoluminescence quantum yield(PLQY)and superior dissymmetry factor(g_(lum))are promising candidates for circularly polarized luminescence(CPL)emitting ***,it is a great challenge to achieve both high g_(lum)and large ***,we report a new supramolecular strategy to fabricate chiral hybrid Cu(Ⅰ)-halides with nearunity quantum yields and intense CPL *** dissymmetry factor can be dramatically modulated by tuning the hostguest *** to the chirality and variable conformations of the host-guest complexes,a series of chiral[G@L^(R/S)]_(2)Cu_(4)I_(6)have been *** incorporation of different cations within the chiral L^(R/S)hosts leads to variations of packing modes along the c-axis and different extent of distortions in the[Cu_(4)I_(6)]_(2)-*** them,[H_(3)O@L^(R/S)]+cations are stacked based on Van der Waals interactions and hierarchically self-assemble into a right/left-handed helix in[H_(3)O@L^(R/S)]_(2)Cu_(4)I_(6),which results in a high g_(lum)of-7×10^(-3)and a large PLQY of 96.92%.Notably,[G@L^(R/S)]_(2)Cu_(4)I_(6)shows promising applications in single-component white light emitting diodes(WLEDs),exhibiting a maximum dissymmetry factor of-1.2×10^(-3).The effective host-guest complexation and oriented hierarchical self-assembly provide an effective strategy for the development of high-performance CPL materials.

关键词： host-guest interaction circularly polarized luminescence copper iodide cluster hierarchical self-assembly chirality

Intermediate-mass black holes in Green pea galaxies(IMBH-GP)I:A candidate sample from LAMOST and SDSS

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 147-161页

作者： Ruqiu Lin zhen-Ya zheng Fang-Ting Yuan Jun-Xian Wang Chunyan Jiang Ning Jiang Lingzhi Wang Linhua Jiang Xiang Ji Shuairu Zhu Xiaodan fu Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences South America Center for Astronomy(CASSACA) National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China

The scaling relation of central massive black holes(M_(BH)s)and their host galaxies is well-studied for supermassive BHs(SM_(BH)s,M_(BH)≥10^(6)M_(⊙)).However,this relation has large uncertainties in the mass range of the intermediate-mass BHs(IM_(BH)s,M_(BH)~10^(3)-10^(6)M_(⊙)).Since Green pea(GP)galaxies are luminous compact dwarf galaxies,which may be likely to host less massive SM_(BH)s or even IM_(BH)s,we systematically search for M_(BH)s in a large sample of 2190 GP galaxies at z<0.4,selected from LAMOST and SDSS spectroscopic ***,we report a newly discovered sample of 59 M_(BH) candidates with broad Hα*** sample has a median stellar mass of 108.83±0.11M_(⊙)and hosts M_(BH)s with single-epoch virial masses ranging from M_(BH)~10^(4.7)to 10^(8.5)M_(⊙)(median 105.85±0.64M_(⊙)).Among the 59 M_(BH) candidates,36 have black hole masses M_(BH)≤10^(6)M_(⊙)(IM_(BH) candidates),one of which even has M_(BH)■10^(5)M_(⊙).We find that the M_(BH)-M_(*)relation of our M_(BH) sample is consistent with the M_(BH)-M_(bulge)relation for SM_(BH)s,while is above the M_(BH)-M_(*)relation for M_(BH)s in dwarf galaxies in the same mass ***,we show that 25 M_(BH) candidates,including 4 IM_(BH) candidates,have additional evidence of black hole activities,assessed through various methods such as the broad-line width,BPT diagram,mid-infrared color,X-ray luminosity,and radio *** studies show that it is very promising to find IM_(BH)s in GP galaxies,and the BH sample so obtained enables us to probe the connection between the M_(BH)s and compact dwarf galaxies in the low-redshift Universe.

关键词： SMBHs IMBHs Green pea galaxies compact dwarf galaxies

Recent advances in p-block metal chalcogenide electrocatalysts for high-efficiency CO_(2) reduction

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eScience 2024年第2期4卷 43-56页

作者： Fanrong Chen Ze-Cheng Yao zhen-Hua Lyu Jiaju fu Xiaoling Zhang Jin-Song Hu Beijing National Laboratory for Molecular Sciences(BNLMS) Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China College of Chemistry&Chemical Engineering Yan'an UniversityShaanxi Key Laboratory of Chemical Reaction EngineeringYan'an 716000China School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

Electrocatalytic CO_(2) reduction(ECR)to high-value fuels and chemicals offers a promising conversion technology for achieving sustainable carbon *** recent years,although great efforts have been made to develop highefficiency ECR catalysts,challenges remain in achieving high activity and long durability *** advantage of the adjustable structure,tunable component,and the M–Ch(M¼Sn,In,Bi,etc.,Ch¼S,Se,Te)covalent bonds stabilized metal centers,the p-block metal chalcogenides(PMC)based electrocatalysts have shown great potential in converting CO_(2) into CO or *** addition,the unique p-block electron structure can suppress the competitive hydrogen evolution reaction and enhance the adsorption of ECR *** to systematically understand the structure–activity relationship of PMC-based ECR catalysts,this review summarizes the recent advances in designing PMC electrocatalysts for CO_(2) reduction based on the fundamental aspects of heterogeneous ECR process,including advanced strategies for optimizing the intrinsic activity and improving the loading density of catalytic sites,constructing highly stable catalysts,and tuning product.

关键词： Electrocatalytic CO_(2)reduction P-block metal chalcogenides Catalyst design strategies High-performance electrocatalysts

Enhancing Green Ammonia Electrosynthesis Through Tuning Sn Vacancies in Sn‑Based MXene/ MAX Hybrids

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Nano-Micro Letters 2024年第5期16卷 154-168页

作者： Xinyu Dai zhen‑Yi Du Ying Sun Ping Chen Xiaoguang Duan Junjun Zhang Hui Li Yang fu Baohua Jia Lei Zhang Wenhui Fang Jieshan Qiu Tianyi Ma Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials of Liaoning Province College of ChemistryInstitute of Clean Energy ChemistryLiaoning UniversityShenyang 110036People’s Republic of China State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601People’s Republic of China School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia State Key Laboratory of High‑Efficiency Utilization of Coal and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021NingxiaPeople’s Republic of China School of Science RMIT UniversityMelbourneVIC 3000Australia Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China College of Chemical Engineering State Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Renewable energy driven N_(2) electroreduction with air as nitrogen source holds great promise for realizing scalable green ammonia ***,relevant out-lab research is still in its ***,a novel Sn-based MXene/MAX hybrid with abundant Sn vacancies,Sn@Ti_(2)CTX/Ti_(2)SnC–V,was synthesized by controlled etching Sn@Ti_(2)SnC MAX phase and demonstrated as an efficient electrocatalyst for electrocatalytic N2 *** to the synergistic effect of MXene/MAX heterostructure,the existence of Sn vacancies and the highly dispersed Sn active sites,the obtained Sn@Ti2CTX/Ti_(2)SnC–V exhibits an optimal NH_(3) yield of 28.4μg h^(−1) mg_(cat)^(−1) with an excellent FE of 15.57% at−0.4 V versus reversible hydrogen electrode in 0.1 M Na_(2)SO_(4),as well as an ultra-long ***,this catalyst represents a satisfactory NH3 yield rate of 10.53μg h^(−1) mg^(−1) in the home-made simulation device,where commercial electrochemical photovoltaic cell was employed as power source,air and ultrapure water as feed *** as-proposed strategy represents great potential toward ammonia production in terms of financial cost according to the systematic technical economic *** work is of significance for large-scale green ammonia production.

关键词： Green ammonia synthesis N2 electroreduction Renewable energy Sn MXene/MAX hybrid

Atomically dispersed Mn-N_(x) catalysts derived from Mn-hexamine coordination frameworks for oxygen reduction reaction

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Carbon Energy 2024年第5期6卷 114-126页

作者： Guoyu Zhong Liuyong Zou Xiao Chi zhen Meng Zehong Chen Tingzhen Li Yongfa Huang Xiaobo fu Wenbo Liao Shaona zheng Yongjun Xu Feng Peng Xinwen Peng Guangdong Provincial Key Laboratory of Distributed Energy Systems School of Chemical Engineering and Energy TechnologyDongguan University of TechnologyDongguanChina State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhouChina Department of Chemistry Centre for Advanced 2D Materials(CA2DM)National University of SingaporeSingaporeSingapore School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhouChina

Metal-organic frameworks recently have been burgeoning and used as precursors to obtain various metal-nitrogen-carbon catalysts for oxygen reduction reaction(ORR).Although rarely studied,Mn-N-C is a promising catalyst for ORR due to its weak Fenton reaction activity and strong graphitization ***,we developed a facile strategy for anchoring the atomically dispersed nitrogen-coordinated single Mn sites on carbon nanosheets(MnNCS)from an Mn-hexamine coordination *** atomically dispersed Mn-N_(4) sites were dispersed on ultrathin carbon nanosheets with a hierarchically porous *** optimized MnNCS displayed an excellent ORR performance in half-cells(0.89 V *** hydrogen electrode(RHE)in base and 0.76 V *** in acid in half-wave potential)and Zn-air batteries(233 mW cm^(−2)in peak power density),along with significantly enhanced *** functional theory calculations further corroborated that the Mn-N_(4)-C(12)site has favorable adsorption of*OH as the rate-determining *** findings demonstrate that the metal-hexamine coordination framework can be used as a model system for the rational design of highly active atomic metal catalysts for energy applications.

关键词： carbon nanosheets electrocatalyst metal-organic frameworks Mn-N_(4) oxygen reduction reaction Zn-air batteries